Chinese Journal of Integrative Medicine
·
2025
·
IF 2.5
Liu Shu-yan,Zhang Xiao-wei,Gao Gai,Liu Chang-xin,Chen Hui,Fu Zhong-xue,Xu Jiang-yan,Wang Zhen-zhen,Zhang Zhen-qiang,Xie Zhi-shen
Objective To investigate the therapeutic potential of pseudolaric acid B (PAB) on non-alcoholic fatty liver disease (NAFLD) and its underlying molecular mechanism in vitro and in vivo . Methods Eight-week-old male C57BL/6J mice ( n =32) were fed either a normal chow diet (NCD) or a high-fat diet (HFD) for 8 weeks. The HFD mice were divided into 3 groups according to a simple random method, including HFD, PAB low-dose [10 mg/(kg·d), PAB-L], and PAB high-dose [20 mg/(kg·d), PAB-H] groups. After 8 weeks of treatment, glucose metabolism and insulin resistance were assessed by oral glucose tolerance test (OGTT) and insulin tolerance test (ITT). Biochemical assays were used to measure the serum and cellular levels of total cholesterol (TC), triglycerides (TG), aspartate aminotransferase (AST), alanine aminotransferase (ALT), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C). White adipose tissue (WAT), brown adipose tissue (BAT) and liver tissue were subjected to hematoxylin and eosin (H&E) staining or Oil Red O staining to observe the alterations in adipose tissue and liver injury. PharmMapper and DisGeNet were used to predict the NAFLD-related PAB targets. Peroxisome proliferator-activated receptor alpha (PPARα) pathway involvement was suggested by Kyoto Encyclopedia of Genes and Genomes (KEGG) and search tool Retrieval of Interacting Genes (STRING) analyses. Luciferase reporter assay, cellular thermal shift assay (CETSA), and drug affinity responsive target stability assay (DARTS) were conducted to confirm direct binding of PAB with PPARα. Molecular dynamics simulations were applied to further validate target engagement. RT-qPCR and Western blot were performed to assess the downstream genes and proteins expression, and validated by PPARα inhibitor MK886. Results PAB significantly reduced serum TC, TG, LDL-C, AST, and ALT levels, and increased HDL-C level in HFD mice ( P <0.01). Target prediction analysis indicated a significant correlation between PAB and PPARα pathway. PAB direct target binding with PPARα was confirmed through luciferase reporter assay, CETSA, and DARTS ( P <0.05 or P <0.01). The target engagement between PAB and PPARα protein was further confirmed by molecular dynamics simulations and the top 3 amino acid residues, LEU321, MET355, and PHE273 showed the most significant changes in mutational energy. Subsequently, PAB upregulated the genes expressions involved in lipid metabolism and mitochondrial biogenesis downstream of PPARα ( P <0.05 or P <0.01). Significantly, the PPARα inhibitor MK886 effectively reversed the lipid-lowering and PPARα activation properties of PAB ( P <0.05 or P <0.01). Conclusion PAB mitigates lipid accumulation, ameliorates liver damage, and improves mitochondrial biogenesis by binding with PPARα, thus presenting a potential candidate for pharmaceutical development in the treatment of NAFLD.
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POLYMER BULLETIN
·
2025
·
IF 4
Wang Ying,Ibupoto Fahim Ahmed,Li Jie
In the current study, the waste hemp fibre (HF)-reinforced sandwich-structured green laminates with biobased epoxy/benzoxazine resin were developed and subjected to simulated weathering for several sets of humidity (50–90%) and temperature (20–40 °C). Effects of each set of simulated weathering conditions on moisture absorption and mechanical and thermal properties of sandwich-structured green laminates were systematically studied. The developed laminates showed moderate mechanical and thermal properties. The findings showed gradual enhancements in moisture absorption as the humidity and temperature were increased in the simulated weathering conditions. Moreover, experimental investigation established apparent adverse effects on tensile and flexural properties; samples exposed at 40 °C and 90% humidity yielded the lowest strength and modulus values, resulting in a 23.58 and 13.59% decline in tensile and flexural strengths, respectively. The impact strength results confirmed considerable differences compared to tensile and flexural properties; the recorded value (18.23 ± 0.26 kJ/m 2 ) after exposure to the simulated weathering at 40 °C and 90% humidity was 2.71 kJ/m 2 higher than the control specimen. Thermal stability analysis was conducted in terms of initial degradation temperature (T 5 and T 10 ), char yield, limiting oxygen index, and heat resistance index (HRI) values for the control sample, which were recorded as 344.8, 419.8 °C, 47.81%, 36.62%, and 206.58 °C, respectively. After exposure to the simulated weathering at 40 °C and 90% humidity, a significant decline was observed in all parameters. The heat tolerance of the composite specimen was recorded as 165 °C.
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IONICS
·
2025
·
IF 2.6
Mise Youpo,Wang Shaohua,Shi Wen,Yin Yakun,An Juan,Zhou Xuejiao,Xia Wentang,Yang Wenqiang
This study presents a green strategy for synthesizing amorphous cobalt sulfide (Co–S) bifunctional electrocatalysts via a choline chloride–ethylene glycol deep eutectic solvent (DES) under ambient conditions, addressing ionic coordination dynamics and defect engineering for enhanced solid–state ionic/electronic transport in energy conversion. By modulating the equilibrium between Co 2+ and S₂O₃ 2- ions in Ethaline, we fabricated monodisperse Co–150S nanoparticles (~ 78 nm) with tailored sulfur content (S/Co = 1.9), an amorphous architecture, and abundant oxygen vacancies. These structural features synergistically optimized ionic diffusion pathways and electronic conductivity, achieving exceptional hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) activities in alkaline media. The Co–150S/NF electrode demonstrated a volcano-like sulfur-dependent activity profile, achieving the highest electrochemically active surface area (ECSA, 3.7 cm 2 ) and ultralow overpotentials of − 105 mV (HER) and 277 mV (OER) at 10 mA cm⁻ 2 , comparable to benchmark Pt/C and RuO₂ catalysts. Post-electrolysis characterization revealed dynamic structural reorganization during HER and OER operations, involving over 80 at% sulfur depletion and the formation of metastable Co-rich phases that maintained catalytic functionality. In overall water splitting, the system required only 1.62 V to drive 10 mA cm⁻ 2 with minimal activity decay (1.5 mV h⁻ 1 over 26 h). Mechanistic investigations revealed that sulfur incorporation initiates a multiscale optimization process: (i) DES–mediated ionic confinement prevents particle aggregation, promoting uniform nanosphere formation; (ii) modulation of the electronic structure through nonstoichiometric Co–S coordination; and (iii) defect engineering through the enrichment of oxygen vacancies. This study provides insights into ionic coordination mechanisms in non–aqueous solvents and defect–mediated ion transport in amorphous solids, suggesting a potential strategy for developing electrocatalysts applicable to related energy storage technologies.
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Journal of Translational Medicine
·
2025
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IF 7.5
Ying Feng,Jiamei Yue,Si Fan,Jiayan Wu
Background EMS (Endometriosis) is characterized by the presence of functional endometrial tissue outside the uterus and is one of the most common gynecological disorders. SOX18 (SYR-related high-mobility group box 18) is a transcription factor whose expression is higher in ectopic endometrial tissues than in eutopic endometrial tissues. However, its role in EMS has not been confirmed. Methods Here, immunohistochemistry (IHC) staining was used to analyze the expression pattern of SOX18 in EMS. Next, the effects of SOX18 on cell viability, migration and invasion were investigated. Dual-luciferase reporter assay, chromatin-immunoprecipitation (ch-IP) and DNA pull-down were employed to verify SOX18 binding to the OTUB1 (OTU domain-containing ubiquitin aldehyde binding protein 1) promoter. In addition, co-immunoprecipitation (co-IP) was used to analyze the binding of OTUB1 to YAP1 (Yes-associated protein 1). Allograft mouse model of EMS was established to explore the role of SOX18 in vivo. Results In vitro results demonstrated that upregulation of SOX18 promoted the proliferation, migration and invasion of Ishikawa cells and induced the EMT process, while knockdown of SOX18 showed the opposite effect. In vivo results also confirmed that SOX18 overexpression led to the deterioration of EMS, as reflected by significant pathological changes in mice. Mechanistically, our data proved that SOX18 directly bound to the OTUB1 promoter region and activated its transcription. Further investigation demonstrated that OTUB1 deubiquitinated YAP1 and enhanced its protein stability. Rescue experiments suggested that SOX18 modulated YAP1 expression through upregulating OTUB1, indicating the role of SOX18-OTUB1-YAP1 axis in EMS. Conclusions These discoveries underscore that SOX18 contributes to the pathogenesis of EMS through promoting OTUB1 transcription and activating Hippo/YAP1 signaling pathway, which may provide a new therapeutic target for EMS. Supplementary Information The online version contains supplementary material available at 10.1186/s12967-025-06677-y.
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CATALYSIS LETTERS
·
2025
·Vol. 155
·期 7
·1-14
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IF 2.4
Li Shunming,Hu Pengyu,Qu Jingzong,Zhou Jie,Wang Zibo,Wang Yanan,Sun Tao,Chen Anran
Hydrogen evolution reaction (HER) in alkaline media demands cost-effective and highly active electrocatalysts to replace noble metals. Herein, we report a ternary MoS₂/Ni₃S₂/Ni(OH)₂ nanoflower composite supported on nickel foam (NF) via a facile one-step electrodeposition strategy. This method enables precise control of MoS₂ morphology while mitigating aggregation-induced active site blockage. The synergistic interplay among MoS₂ (exposing edge sites), conductive Ni₃S₂, and Ni(OH)₂ (modulating electronic structure) significantly enhances HER kinetics. Notably, the optimal catalyst (5-min deposition) achieves ultralow overpotentials of 48 mV at 10 mA cm⁻² and 175 mV at 100 mA cm⁻² in 1.0 M KOH, surpassing most reported Ni- or Mo-based catalysts. Furthermore, it exhibits exceptional stability with negligible activity loss after 5000 cycles and 72-hour continuous operation. XPS analysis reveals that a high Mo⁴⁺/Mo⁶⁺ ratio facilitates electron delocalization, accelerating hydrogen intermediate desorption. This work establishes a new paradigm in HER catalyst design through interface-engineered ternary systems. By unifying electronic synergy theory with the SPRE synthesis method, we overcome the activity-stability trade-off plaguing binary catalysts. The demonstrated 500-hour stability at industrial current densities (100 mA cm⁻²) positions this approach as a transformative solution for scalable green hydrogen production. Graphical
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WATER AIR AND SOIL POLLUTION
·
2025
·Vol. 236
·期 9
·1-18
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IF 3
Huang Xiong,Pan Yuanfeng,Cai Pingxiong
To address the prevailing issue of arsenic contamination in water bodies, a novel composite microsphere (Fe-CB) was developed for the effective removal of As(V) ions from aqueous solutions. This microsphere was prepared using a sol–gel-titration-freeze-drying method, with chitosan and ferric chloride as raw materials, polyethyleneimine as a modifier and glutaraldehyde as a cross-linking agent. The effects of pH, adsorbent dosage, initial heavy metal concentration, and contact time on the performance of the adsorbent were investigated by a series of adsorption experiments. It was showed that pH played a significant role in determining the adsorption efficiency, while temperature had a relatively minor influence. The adsorption isothermal of As(V) on Fe-CB was best described by Langmuir isotherm model, whereas the dynamic adsorption process fitted the pseudo-second-order or secondary kinetic model well. Notably, the theoretical maximum adsorption capacity was 80.97 mg/g. Furthermore, regeneration experiments demonstrated that Fe-CB maintained a regeneration rate of over 85% even after five cycles, highlighting its excellent recyclability. This study underscores the potential of Fe-CB as an efficient and reusable adsorbent for the removal of As(V) ions from contaminated waters.
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Probiotics and Antimicrobial Proteins
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2025
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IF 4.4
Wu Yuehua,Liu Zhaoyi,Zhang Hongyang,Zhou Lixiao,Liang Weijuan,Su Peng,Zeng Zhijun,Zhao Feng,Qiu Jingfu,Chen Chengzhi
Obesity is a common health problem marked by the accumulation of excess body fat beyond the range characteristics of a healthy weight, affecting millions worldwide. Although advancements have been made in the realm of probiotic therapy for obesity, studies on the combined use of probiotics for the treatment of obesity have yet to be well explored. In this study, we investigated the potential of Parabacteroides goldsteinii ( P. goldsteinii ) and Bacteroides sartorii ( B. sartorii ) combinations and their microencapsulated forms for treating obesity. We identified different probiotic strains by 16S rRNA analysis in obese and healthy mice. The activity of these probiotics was evaluated in vitro under simulated gastrointestinal conditions. In vivo, the effects of probiotics on obese mice were assessed by monitoring body weight, glucose tolerance, colon integrity, and various molecular markers. Our results suggested that P. goldsteinii and B. sartorii were shown to be less abundant in obese mice ( P < 0.05). Compared with the control group mice, the obese phenotypes of the probiotics intervention group mice were significantly improved ( P < 0.05). Further results showed that compared with the control group mice, the expression of the FTO in the liver tissue of the probiotics intervention group mice was downregulated ( P < 0.05), while the expression of the Ampk gene was upregulated ( P < 0.05), indicating that probiotic intervention had reduced the expression of obesity-related genes in mice and had alleviated their obese condition. Furthermore, Microcapsule was remarkably effective in maintaining the viability of probiotics and facilitating their persistence, leading to a significant reduction in weight gain in mice compared with controls within just one week ( P < 0.05). Taken together, our study demonstrates that the intervention using the combination of P. goldsteinii and B. sartorii is more effective in treating obesity than using either probiotic alone. The encapsulation approach further enhances the anti-obesity efficacy of the combined probiotic mixture.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2026
·Vol. 24
·期 1
·145
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IF 12.6
Zhao Jianguo,Lou Wanqing,Wang Yixin,Wang Lu,Jin Xiaoqian,Wang Chenyang,Yao Jiangmeng,Zhang Jinjin,Zhuang Wenjuan,Wei Jiayi,Lin Dajun,Guo Yishun,Shao Yi,Wang Bailiang,Jiang Zipei
During keratitis treatment, oxidative stress and inflammation often result in corneal neovascularisation, scarring, and reduced light transmittance. In this study, single-atom Pt/CeO 2 is synthesized, exhibiting significantly enhanced catalase-like and superoxide dismutase-like activities for the elimination of superoxide anions (•O 2 − ), hydrogen peroxide (H 2 O 2 ), and hydroxyl radicals (•OH). Doping single-atom Pt onto CeO 2 increases the Ce 3+ concentration in the Ce 3+ /Ce 4+ ratio from 39.12% to 58.66%, as confirmed by electron spin resonance, high-resolution transmission electron microscopy, X-ray photoelectron spectroscopy, and Raman spectroscopy. In vitro studies demonstrate that single-atom Pt/CeO 2 effectively reduces intracellular ROS levels in H 2 O 2 -activated human corneal epithelial cells. Additionally, it exerts an anti-inflammatory effect on LPS-stimulated RAW264.7 macrophages, significantly decreasing the expression of interleukin-1β, interleukin-6, and tumour necrosis factor-α. In vivo, in an LPS-induced keratitis animal model, single-atom Pt/CeO 2 accelerates corneal ulcer healing and preserves corneal light transmittance, attributed to its anti-inflammatory properties, enzyme-like activities, and ability to promote cell migration. This study offers a novel approach for treating various inflammatory and autoimmune diseases. Graphical
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CELLULOSE
·
2026
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IF 4.6
Guo Yuqian,Cheng Yun,Zhao Yumeng,Qian Xinyu,Hou Leilei,Chen Linghua,Yang Shuo,Zhang Hongjie
The method of N-methyl-morpholine-N-oxide (NMMO) as a green and efficient solvent for dissolving fibers to prepare lyocell fibers is well known. Although we all know that the chemical composition, morphology, and pore structure of fibers determine the dissolution time of NMMO solution, it is difficult to evaluate the greatest impact factor on dissolution efficiency among the comprehensive factors. Herein, the relationship among the pore structure (specific surface area), swelling performance (maximum NMMO-retention value), and dissolution performance (dissolution time) of cellulose fibers in aqueous NMMO solution was quantitatively investigated. The novelty of this work is the quantitative evaluation of the impact of a single influencing factor (porous characteristics) on the swelling and dissolution properties. The porous characteristics of cellulose were effectively regulated without changing significant chemical structure using freeze-drying and hot-dried at 80 ℃ and 105 ℃ methods. Compared to hot-dried treatment, the freeze-dried cellulose fibers exhibited the high specific surface area (11.12 m 2 /g), highest NMMO-retention value (612%), the shortest dissolution time (40 min), which was shortened by 20 min. Higher specific surface area corresponded to the higher swell extent and dissolution efficiency by facilitating the diffusion of NMMO solution in cellulose fibers. Improving the porous characteristics of cellulose fibers not only effectively increased the NMMO retention value and swell extent but also shortened dissolution time without affecting the rheological properties of cellulose-NMMO solutions. Graphical abstract
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JOURNAL OF MATERIALS SCIENCE
·
2026
·Vol. 61
·期 9
·5804-5816
·
IF 3.9
Cheng Li-Qian,Wang Pengcheng,Li Qingna,Wang Zhiping,Jiang Yuqi,Zhu Dongze
The electrocaloric effect (ECE) has attracted considerable attention for its promising application in next-generation solid-state cooling systems due to its high efficiency, environmental friendliness, and potential for device miniaturization. In this study, rare-earth element Sm was introduced to dope in the relaxor ferroelectric ceramics based on 0.7 Pb(Mg 1/3 Nb 2/3 )O 3 –PbTiO 3 (PMN–30PT) to enhance the ECE response and broaden the working temperature range. The Sm doping effectively enhanced the breakdown strength, reduced leakage current, and refined grain morphology was also observed, contributing to improved electrical reliability. The Sm-doped sample achieved an adiabatic temperature change of 1.38 K under an electric field of 40 kV cm −1 . Moreover, an inferred broad effective temperature span ( T span ) of 62 °C was obtained, indicating excellent wide temperature reliability. These results demonstrate that appropriate Sm doping not only enhances the EC response but also broadens its operational temperature window, offering valuable insights for the design of high-performance electrocaloric ceramics for energy-efficient and environmentally friendly solid-state cooling applications.
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Nature Communications
·
2026
·
IF 15.7
Huang Shengfei,Li Meng,Xu Huiru,Shu Tianyu,Jia Honglin,Li Zhenlong,Yang Yutong,Zhao Xin,Guo Baolin
Non-compressible hemorrhage remains the chief cause of battlefield mortality and civilian trauma death. Here, we propose a hemostatic strategy based on ultrafast self-gelling self-expanding powder of polyacrylic acid (PAA), polyethyleneimine (PEI) and foaming agent, which achieves non-compressible hemorrhage hemostasis through the multiple synergistic effects of expansion plugging, self-gelling adhesion and activating the coagulation factors. The hemostatic powder integrates rapid physical crosslinking with spontaneous gas foaming, exhibits a fast gelation rate, high expansion ratio, strong tissue adhesion, and activation of red blood cells, platelets, and fibrin. The optimized formulation (PP/PT5-TXA30) achieves superior hemostatic performance compared to commercial powders in rat liver volumetric defect, femoral artery and vein transection, as well as complete transection of the subclavian artery and vein in rabbits. Notably, in a lethal porcine model of complete subclavian artery and vein transection, PP/PT5-TXA30 achieves superior performance of non-compressible hemorrhage compared to gauze and XStat™. Additionally, PP/PT5-TXA30 accelerates full-thickness skin wound healing. This work demonstrates a strategy based on ultra-fast self-gelling and self-expanding mechanisms for developing hemostatic materials for non-compressible hemorrhage.
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Nature Communications
·
2026
·
IF 18.1
Tian Jinshu,Fang Ling,Ouyang Ni,Xia Liwei,Wang Zhi,Cai Haiting,Feng Qilong,Jiang Xinru,Zhao Jia,Tan Mingwu,Zhang Lili,Wang Yong,Li Xiaonian,Zhu Yihan
The reverse water-gas shift reaction (RWGSR) is essential for converting CO 2 into fuels using renewable hydrogen, but it remains challenged by the difficulty of simultaneously maximizing catalyst activity, selectivity, and stability. These limitations stem from thermodynamic constraints – specifically, the Gibbs-Curie-Wulff theorem - which restricts the synthetic accessibility of high-energy micro-faceted nanocrystals via conventional methods. To address this, we introduce a near-surface “quasi-hyperbaric” ammonia strategy that integrates atmospheric-pressure processing with in-situ ammonia decomposition. This approach enables the controlled synthesis of molybdenum nitride nanocrystals with preferentially exposed high-energy (112) microfacets. These facets promote CO 2 activation through a hydrogen-assisted redox mechanism, driven by geometrically confined and stabilized Mo-N/M-O hybrid active sites. The resulting catalyst outperforms the benchmark Pt/CeO₂, which typically suffers from CO selectivity below 92%. Our catalyst achieves near-equilibrium conversion (56%) at a space velocity (24000 ml/g cat /h), with 100% CO selectivity and outstanding stability (≤ 1% deactivation over 250 hours).
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