Asian Journal of Pharmaceutical Sciences
·
2020
·
IF 3.968
Xiaoqi Sun,Di Liu,Xiaoyu Xu,Yifeng Shen,Yanjuan Huang,Zishan Zeng,Meng Xia,Chunshun Zhao
Hypoxia is a typical feature of solid tumors, which highly limits the application of the oxygen-dependent therapy. Also, the dense and hyperbaric tumor tissues impede the penetration of nanoparticles into the deep tumor. Thereby, we designed a novel localized injectable hydrogel combining the photothermal therapy (PTT) and the thermodynamic therapy (TDT), which is based on the generation of free radicals even in the absence of oxygen for hypoxic tumor therapy. In our study, gold nanorods (AuNRs) and 2,2′-Azobis[2-(2-imidazalin-2-yl)propane] dihydrochlaride (AIPH) were incorporated into the hydrogel networks, which were formed by the copolymerization of hydrophobic N-isopropyl acrylamide (NIPAM) and hydrophilic glycidyl methacrylate modified hyaluronic acid (HA-GMA) to fabricate an injectable and near-infrared (NIR) responsive hydrogel. The crosslinked in situ forming hydrogel could not only realize PTT upon the NIR laser irradiation, but also generate free radicals even in hypoxic condition. Meanwhile the shrink of hydrogels upon thermal could accelerate the generation of free radicals to further damage the tumors, achieving the controlled drug release on demand. The designed hydrogel with a sufficient loading capacity, excellent biocompatibility and negligible systemic toxicity could serve as a long-acting implant for NIR-triggered thermo-responsive free radical generation. The in vitro cytotoxicity result and the in vivo antitumor activity illustrated the excellent therapeutic effect of hydrogels even in the absence of oxygen. Therefore, this innovative oxygen-independent platform combining the antitumor effects of PTT and TDT would bring a new insight into hypoxic tumor therapy by the application of alkyl free radical.
✓ 已验证
DOI
PubMed
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2019
·
IF 4.959
Weijun Xu,Jinlei Wang,Junmin Qian,Guanghui Hou,Yaping Wang,Lijie Ji,Aili Suo
Combination of different therapy modalities with multiple tumoricidal mechanisms has emerged as a promising anticancer strategy. Herein, we reported an aldehyde/catechol-functionalized hyaluronic acid (DAHA) and hydroxyethyl chitosan (HECS) decorated gold nanorod (GNR) platform for combined chemo-photothermal therapy of breast cancer. The DAHA was synthesized by conjugating dopamine onto oxidized hyaluronic acid. The nanoplatform was prepared by successively modifying GNR with DAHA via Au-catechol bonds, conjugating DOX onto DAHA moiety through Schiff base linkage, and coating HECS interlayer for charge-reversal and hyaluronic acid corona for tumor cell targeting. The resulting nanoplatform GNR-HA DOX CH exhibited acid-triggered surface charge-reversal and pH/NIR dual-responsive drug release behaviors. The nanoplatform could be efficiently internalized into MCF-7 breast cancer cells and displayed greater cancer cell killing than individual modalities. Therefore, polysaccharide decoration could ensure the co-delivery of GNR and DOX into cancer cells, and the developed GNR-HA DOX CH holds great potential for breast cancer treatment.
✓ 已验证
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2018
·
IF 5.158
Jiwen Luo,Weijie Deng,Feng Yang,Zeqi Wu,Mantuo Huang,Mengyuan Gu
A functionalized paper based on gold nanoparticles (Au NPs) conjugated graphene oxide (GO) was developed for near-infrared (NIR) laser triggered photothermal ablation against infectious bacterial pathogens. Firstly, quaternized carboxymethyl chitosan (QCMC) not only acted as reducing agent to synthesize Au NPs, but also functioned as coupling agent to link up Au NPs with GO. Au-QCMC-GO(+) was supposed to synergistically intensify the photothermal effect, which was then mixed with nanocellulose to form a functionalized paper via vacuum filtration. The photothermal efficiency, antibacterial treatment and mechanical property of Au-QCMC-GO(+)/nanocellulose paper were investigated. Excited by NIR laser irradiation, Au-QCMC-GO(+)/nanocellulose paper generated a temperature rise over 80 °C, sufficient for photothermal ablation upon both Gram-positive bacteria ( Bacillus subtilis and Stapylococcus aureus ) and Gram-negative bacteria ( Escherichia coli and Pseudomonas aeruginosa ). Additionally, Au-QCMC-GO(+)/nanocellulose paper showed a remarkable enhancement in tensile strength, bursting index and tear index compared to those of pure nanocellulose paper.
✓ 已验证
DOI
高影响因子
CHEMISTRY OF MATERIALS
·
2024
·
IF 7.2
Zurong Liao,Małgorzata Sójka,Jiyou Zhong,Jakoah Brgoch
Materials emitting near-infrared (NIR) light play a crucial role in the development of phosphor-converted light-emitting diodes (pc-LEDs) for applications ranging from fundamental science like spectroscopic analysis to highly applied uses like night vision and biological imaging. One class of materials that has garnered significant interest for these technical spaces is Cr3+-activated garnets due to their high efficiency and ability to operate at relatively high temperatures. However, their limited emission beyond 800 nm impedes their use as optimal blue LED-pumped NIR-emitting materials. In this study, we present a new garnet-type NIR phosphor, Na2CaZr2Ge3O12:Cr3+, that addresses this challenge─the material exhibits a long-wavelength emission (λem,max = 832 nm) and good thermal quenching resistance while maintaining an excellent internal quantum efficiency (IQE = 98%). These properties are attributed to a crystal environment reconstruction, where a crystal structure distortion is coupled to a weak crystal field, which is uncommon for most rigid garnet-type phosphors. Furthermore, the fabricated NIR pc-LED devices using this material demonstrate superior performance compared with devices employing well-known efficient NIR phosphors operating in this emission range. The light source is subsequently demonstrated in applications spanning night vision, bioimaging, and nondestructive analysis. This study not only provides insights into the luminescence properties of Cr3+-activated garnet materials with desirable performance but also highlights the practical application of NIR-emitting garnet phosphors.
✓ 已验证
DOI
高影响因子
International Journal of Nanomedicine
·
2020
·
IF 5.115
Li He,Fangzhen Qing,Maode Li,Daitian Lan
Purpose The aim of this study was to develop an “all-in-one” nanoplatform that integrates at the second near-infrared (NIR-II) region dye IR1061 and anticancer drug paclitaxel (PTX) into an apoferritin (AFN) nanocage (IR-AFN@PTX). Simultaneously, folic acid (FA), tumor target molecule, was conjugated onto IR-AFN@PTX to be IR-AFN@PTX-FA for tumor-targeted and pH/NIR-II-triggered synergistic photothermal-chemotherapy.Methods IR1061 was firstly reacted with PEG and then conjugated with AFN to be IR-AFN. Then, FA was conjugated onto the surface of IR-AFN to be IR-AFN-FA. At last, PTX was incorporated into IR-AFN-FA to fabricate a nanoplatform IR-AFN@PTX-FA. The NIR-II photothermal properties and pH/NIR-II triggered drug release were evaluated. The ability of IR-AFN@PTX-FA to target tumors was estimated using optical bioluminescence. In vitro and in vivo synergistic therapeutic effects of pH/NIR-II-triggered and tumor-targeted photothermal-chemotherapy were investigated in 4T1 tumor model.Results IR-AFN@PTX-FA showed excellent water solubility and physiological stability, which significantly enhanced the solubility of both IR1061 and PTX. After 5 min of laser irradiation at 1064 nm, IR-AFN@PTX-FA exhibited an effective photothermal effect compared with laser irradiation at 808 nm, even when blocked with 0.6 cm thick chicken breast. Cellular uptake experiments showed IR-AFN@PTX-FA utilized clathrin-mediated and caveolae-mediated endocytosis pathways to enter 4T1 cells, and was then delivered by the endosome to the lysosome. NIR-II laser irradiation and pH could synergistically trigger PTX release, inducing significant tumor inhibition in vitro and in vivo.Conclusion As a novel “all-in-one” nanoplatform, IR-AFN@PTX-FA was found to selectively target tumors and showed very efficient NIR-II photothermal effects and pH/NIR-II triggered drug release effects, showing a remarkable, synergistic photothermal-chemotherapy effect.
研究领域:
生物医学工程
·
药学
·
肿瘤学
✓ 已验证
DOI
高影响因子
Small
·
2024
·
IF 13
Muhammad Hassan,Yi Tan Su,Sania Zafar Iqbal,Raziq Nawaz,Yucai Wang,Wei Jiang
Near-infrared-II (NIR-II) fluorescence imaging-guided photothermal therapy (PTT) represents a cutting-edge approach for precise tumor diagnosis and treatment, providing real-time therapeutic efficacy evaluation. However, a significant challenge lies in the creation of phototheranostic agents that provide robust imaging and efficient photothermal conversion. To address this, a donor- π -acceptor (D- π -A) structure heptamethine cyanine derivative, IR1116, that confers a strong intramolecular charge transfer effect is developed. To enhance its applicability, IR1116 is formulated with DSPE-PEG to create a water-dispersible NIR-II phototheranostic nanoheater, NP IR1116 . This nanoheater benefits from the incorporation of an electron-withdrawing group, leading to reduced photooxidation activity and significantly improved photostability. NP IR1116 exhibits strong NIR-II absorption and fluorescence, peaking at 1004 and 1116 nm, respectively, as well as a photothermal conversion efficiency of 79% under 1064 nm lasers. In vitro and in vivo studies showed the efficacy of NP IR1116 in tumor imaging via NIR-II fluorescence and its ability to effectively induce tumor cell apoptosis under 1064 nm laser irradiation. These findings underscore the potential of NP IR1116 in NIR-II fluorescence imaging-guided PTT for tumor treatment, paving the way for further advancements in NIR-II dye development and bioimaging technologies.
✓ 已验证
DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2021
·Vol. 9
·期 35
·7216-7228
·
IF 6.331
Kaimin Du,Shuang Zhao,Jing Feng,Xuan Gao,Kai Liu,Xiaozhen Wang,Manli Zhang,Yao Li,Yu Lu,Hongjie Zhang
The integration of chemodynamic therapy (CDT) and photothermal therapy (PTT) has played a huge role in improved anticancer treatments. Here, a novel multifunctional nanoplatform based on Cu2−xS conjugated NaYF4:Yb/Er@NaYF4:Yb upconversion nanoparticles (UCNPs) was proposed and designed. In the UCNPs–Cu2−xS nanocomposites, UCNPs with excellent luminescent properties and a high X-ray attenuation coefficient can serve as an upconversion luminescence (UCL) and computer tomography (CT) imaging contrast agent; meanwhile, Cu(II) in the Cu2−xS nanodots enables the nanocomposites to have a magnetic resonance imaging (MRI) ability owing to the presence of unpaired electrons. Moreover, the Cu2−xS nanodots with a strong absorbance in the NIR II biowindow not only could be employed as a stable photothermal agent under NIR laser irradiation, but also could be used as a photothermal-enhanced Fenton nanocatalyst to respond to over-expressed H2O2 in the tumor microenvironment (TME) and generate toxic hydroxyl radicals (˙OH) to effectively kill cancer cells. Furthermore, the UCNPs–Cu2−xS nanocomposites possess negligible cytotoxicity and a high photothermal conversion efficiency (43.8%) in the NIR-II biowindow (1064 nm), indicating that they possess great potential for the UCL/CT/MR multi-modal imaging guided synergistic enhanced CDT/PTT of cancer.
研究领域:
生物医学工程
·
肿瘤治疗学
·
材料科学
✓ 已验证
DOI
高影响因子
Fundamental Research
·
2022
·
IF 0
Hongguang Liao,Yanji Chu,Shenglong Liao,Yonglin He,Yingchao Ma,Yapei Wang
Photothermal therapy has aroused great attention and showed promising potential in minimally invasive tumor ablation, but the clinical translation is still stifled by the concerns of unwanted injury to normal tissues. The safety concerns might be completely solved only when the two security obstacles of “material-toxicity” and “photo-toxicity” were overcome simultaneously. Herein, a completely non-toxic food-grade photothermal transduction agent (PTA) with double safety guarantees was invented, which shows an absolute transformation of the photothermal effect from “0” to “1” after being triggered by an acidic tumor microenvironment. Inspired by the classical starch-iodine test, a preprogrammed [starch-KI-KIO 3 ] complex was prepared in large quantities through a modified wet-milling procedure. It's demonstrated that a macroscopic consecutive reaction could be triggered by low pH to produce the starch-iodine complex which can generate lethal temperature under the near-infrared light irradiation. Meanwhile, the PTA shows excellent biocompatibility with no “material-toxicity” owing to the raw materials drawn from our daily food. Animal experiments reveal that the tumor microenvironment can activate the switch of photothermal effect from “0” to “1” successfully, which is thus responsible for the discriminative photo-damage to the tumor region while no “photo-toxicity” to normal tissue. The good treatment efficacy confirms the feasibility of such photothermal transduction agents with double safety guarantees in clinical applications.
研究领域:
医学
·
生物材料科学
✓ 已验证
DOI
JOURNAL OF NANOPARTICLE RESEARCH
·
2020
·Vol. 22
·期 9
·1-14
·
IF 2.132
Zhang Jun-Zheng,Tang Huan,Chen Xing-Zhu,Su Qianqian,Xi Wen-Song,Liu Yuan-Yuan,Liu Yuanfang,Cao Aoneng,Wang Haifang
Narrow bandgap Ag 2 Te quantum dot (QDs) hold great promise in the fields of bioimaging, chemo-/bio-detection, and thermoelectric materials, but their biosafety has not been well estimated yet. In this study, we studied the biodistribution and toxicity of polyethylene glycol–coated Ag 2 Te QDs (Ag 2 Te QDs-PEG) in mice after a single intravenous injection. After entering the mice, Ag 2 Te QDs-PEG displayed a short circulation time in the blood (half-life was less than 2 h), and mainly accumulated in the liver and spleen. The stability of Ag 2 Te QDs-PEG in the mice depended on accumulation organ and time. Ag 2 Te QDs-PEG were stable in the spleen within 28 days but decomposed in the liver after 7 days. The decomposed Ag 2 Te QDs-PEG were eliminated from the body via different routes, as Ag was detected only in feces while Te was found only in urine. Meanwhile, Ag 2 Te QDs-PEG did not show obvious adverse effects on the body weights, organ indices, biochemical parameters, the levels of essential metal Cu and Zn in organs, and organ pathological investigations during 28 days. In addition, the important effects of anion to the fates of silver chalcogenide QDs in vivo was demonstrated by comparing the distributions of the Ag 2 Te QDs and other two silver chalcogenide QDs (Ag 2 S and Ag 2 Se). Our findings indicate Ag 2 Te QDs have good biocompatibility in mice, which is a guarantee for their safe applications in the future.
✓ 已验证
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2026
·
IF 6
Qi Chen,Rongyi Kuang,Yinyue Cao,Zezhong Yang,Siran Tao,Binchang Wu,Lin Huang,Bo-Mei Liu,Jing Wang
The second near-infrared window (NIR-II, 1000-1700 nm) phosphor-converted LEDs (pc-LEDs) show great potential for portable spectroscopic detection. However, high-performance long-wavelength (>1350 nm) NIR-II phosphors that combine broadband emission, high thermal stability, and efficient blue-light excitation, are still relatively scarce. Herein, a Lu 3 Ga 5 O 12 :Cr 3+ ,Ni 2+ phosphor was developed via a Cr 3+ sensitization strategy. Cr 3+ and Ni 2+ stably occupy the [GaO 6 ] octahedral sites, enabling efficient energy-transfer from Cr 3+ to Ni 2+ . The optimal sample exhibits broadband NIR-II emission at 1427 nm with an FWHM of 277 nm, an EQE of 23.1%, and excellent thermal stability (I 373K /I 293K = 81.5%). The pc-LED based on this NIR-II phosphor achieves penetration imaging and non-destructive identification of daily necessities. More notably, rapid spectral differentiation of common plastics (PA, PE, PP, PVC and PET) was successfully realized using the NIR-II luminescence of the as-prepared phosphor. This work provides guidance for constructing high-performance NIR-II phosphors and promotes the practical deployment of NIR spectroscopy in resource recycling.
✓ 已验证
产品关联
DOI
高影响因子
Biomedical Materials
·
2026
·Vol. 21
·期 3
·035011
·
IF 3.9
Yuxiang Gao,Siyu Huang,Jiaxing Li,Lijun Zhu,Zhong Du,Jiabao Xiong,Nuernisha Alifu
Triple-negative breast cancer (TNBC) is one of the most aggressive breast cancer subtypes with high metastatic and recurrence rates. However there is still a lack of effective targeting nanoprobes (NPs) which is leading to suboptimal targeted therapy. Cell membrane-encapsulation methods are one of the ideal targeting strategy, which could enhance the biocompatibility through endogenous membrane components while enabling functional integration of targeting and imaging capabilities. In this study, fluorescent dye-clinical indocyanine green (ICG) was successfully encapsulated by TNBC cell membranes via dual biolayer method to form M-ICG NPs. The M-ICG NPs exhibited well cellular uptake for TNBC tumor cells via active targeting capability after homologous cancer cell membrane coating. Meanwhile, strong near-infrared (NIR) fluorescence signals were detected at the tumor sites from mice post-injection of M-ICG NPs at 24 h, indicating that their effective targeted tumor accumulation enables good tumor-specific labeling with strong NIR fluorescence emission. Furthermore, the M-ICG NPs retain the excellent optical and photothermal properties of ICG. Under 808 nm laser irradiation, via infrared imaging, the process of temperature monitoring up to 55°C within 12 min was recorded, exhibiting a strong photothermal effect, which lays a foundation for constructing a multifunctional nanoplatform with tumor-specific targeting, excellent biocompatibility and structural stability.
✓ 已验证
DOI
高影响因子
Laser & Photonics Reviews
·
2026
·
IF 9.7
Chenxi Xu,Kejie Li,Jiaqi Zhao,Dongxu Guo,Tianqi Sheng,Zuoling Fu
Luminescent thermometry in the second near-infrared (NIR-II) window holds significant promise for non-invasive. However, its practical application is severely hindered by thermal quenching at elevated temperatures, which limits the development of highly sensitive NIR-II thermometers capable of thermally enhanced emission. Here, we present a rationally designed integer phonon-matching strategy that enables NIR thermal enhancement specifically in singly Er 3+ -doped Ca 2 YNbO 6 double perovskite hosts. Through combined experimental investigations and rate equation modeling, we reveal that efficient multi-phonon relaxation (MPR) between the Er 3+ : 4 I 11/2 and 4 I 13/2 levels is activated when the electronic energy gap corresponds to an integer multiple ( n ≤ 5) of the dominant phonon energy. This resonant phonon-matching condition facilitates highly efficient MPR with increasing temperature, leading to a pronounced 1.66-fold enhancement in the Er 3+ NIR-II emission. Furthermore, we demonstrate the simultaneous occurrence of NIR thermal enhancement and ratiometric temperature sensing in Ca 2 YNbO 6 : Yb 3+ /Er 3+ /Ho 3+ /Pr 3+ crystals, achieving an exceptional relative sensitivity of 0.87% K −1 at 398 K. These findings not only circumvent the thermal quenching limitations of NIR-II phosphors but also establish phonon engineering as a versatile strategy for designing thermally enhanced luminescence, opening new avenues for flexible monitoring of pipeline integrity and organic compound leakage based on differential NIR-II luminescence absorption.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）