INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
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2021
·
IF 3.764
Shupanxiang Chen,Bo Jia,Yu Peng,Xiao Luo,Yangqiang Huang,Bo Jin,Hongxia Gao,Zhiwu Liang,Xiayi Hu,Yefeng Zhou
In this study, attapulgite (AT) was treated by high-temperature roasting and hydrochloric acid to form HcAT. It was then modified with 3-aminopropyltrimethoxysilane (APS) through the grafting method to synthesize a new adsorbent, which exhibits relatively low regenerative energy consumption in CO2 adsorption and desorption processes. Scanning electron microscopy (SEM), N2 adsorption–desorption, Fourier transform infrared spectroscopy, X-ray diffraction, and thermogravimetric analysis were selected to support the research. The CO2 adsorption process on the adsorbent was studied at different APS loadings and different temperatures. The maximal amount of CO2 adsorbed on the adsorbent is 1.81 mmol/g at 313 K when the APS mass fraction is 30%. The Freundlich isotherm model shows a great correlation with the CO2 adsorption isotherm obtained from the experimental data, and R2 reached up to 0.996. The isosteric heat while CO2 adsorbed on 30%APS-HcAT is calculated as 62.63 kJ/mol. The regeneration cyclic stability of 30%APS-HcAT is excellent, while the CO2 adsorption capacity only decreased by 3.2% after 10 cycles. The energy consumption in the CO2 desorption process was also calculated as 26.875 kJ/mol. Three different kinetic models were selected to fit the experimental data, and two models showed a great fit, which were the pseudo-second and Avrami’s fractional order models. The activation energy of 30%APS-HcAT was 38.826 kJ/mol, which can be calculated from the experimental data, and this value is higher compared with those of the other sorbents modified by the impregnation method and also much lower than the value of the chemical absorption process between traditional amine solvents and CO2.
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ORGANIC ELECTRONICS
·
2021
·
IF 3.721
Pengfei Zhao,Rongxue Ji,Jie Lao,Wen Xu,Chunli Jiang,Chunhua Luo,Hechun Lin,Hui Peng,Chun-Gang Duan
Owe to their advantages of unique electronic structure, physical flexibility and easy processability, conducting polymers are considered as one of the most competitive candidates for organic synaptic devices. However, conventional organic synaptic devices are based on electric modulation or three-terminal structure which are not conducive to construction of neural networks with high integration density. Here, a two-terminal organic optoelectronic device based on poly(3-hexylthiophene) (P3HT) is prepared via a simple spin-coating method. The fabricated synaptic device shows sensitive response to the light stimuli and successfully simulates the basic functions of biological synapse, such as excitatory postsynaptic current (EPSC), pair-pulse facilitation (PPF). Furthermore, the capabilities of simulating “learning-experience” behavior, detecting and memorizing the integrated optical information are also realized by this artificial synapse.
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Surfaces and Interfaces
·
2022
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IF 6.137
Qiang Yang,Jing Guo,Yuanfa Liu,Fucheng Guan,Fanchen Sun,Xueyong Gong
In order to compound gelatin (GEL) with poly(3-hydroxybutyrate-co-4-hydroxybutyrate) (P(3,4HB)) to improve the hydrophilicity and biocompatibility, a simple and convenient method for preparing P(3,4HB)/GEL composite nanofibrous (P/G-CNF) was proposed. Alkyl Polyglycoside (APG) was used as an emulsifier to prepare a stable P(3,4HB)/GEL composite solution, and novel P/G-CNF was prepared by electrospinning. The intermolecular interaction, micromorphology and porosity, crystallization and mechanical properties , hydrophilicity and cytocompatibility of P/G-CNF were characterized. The results reveal that P(3,4HB), APG and GEL form many hydrogen bonds . When the m(P(3,4HB):GEL) is 10:2, the as-prepared nanofibrous exhibit the best micromorphology with a diameter and porosity of 604 nm and 68.33%. With the increasing GEL content, the crystallization and mechanical properties of P(3,4HB)/GEL composite nanofibrous scaffold (P/G-CNS) are further enhanced and decline after reaching the maximum. The hydrophilicity of P/G-CNS is significantly improved by introducing GEL. The cell proliferation rate of P/G-CNS is higher than 100%, of which the cytotoxicity grade is 0, indicating that it is non-cytotoxic. The P/G-CNS has excellent cytocompatibility and provides better cell attachment, growth and proliferation, showing promising application prospects for tissue regeneration and biomedical materials .
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JOURNAL OF NATURAL PRODUCTS
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2021
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IF 4.05
Yaling Hui,Ting Tang,Jing Wang,Huanhuan Zhao,Hong-Ying Yang,Junmin Xi,Baoxin Zhang,Jianguo Fang,Kun Gao,Yueting Wu
Nonsmall cell lung cancer (NSCLC) has been a fatal and refractory disease worldwide. Novel therapeutic developments based on fundamental investigations of anticancer mechanisms underlie substantial foundations to win the fight against cancer diseases. In this study, we isolated a natural product fusaricide (FCD) from an endophytic fungus of Lycium barbarum, identified as Epicoccum sp. For the first time, we discovered that FCD potently inhibited proliferation in a variety of human NSCLC cell lines, with relatively less toxicity to normal cells. Our study exhibited that FCD induced apoptosis, caused DNA damage and cell cycle arrest in G0/G1 phase, and activated caspase-3 as well as other apoptosis-related factors in human NSCLC NCI-H460 cells. FCD was proven to be an iron chelator that actively decreased levels of cellular labile iron pool in NCI-H460 cells in our study. FeCl3 supplement reversed FCD-induced apoptosis. The upregulation of transferrin receptor 1 (TfR1) and downregulation of ferritin heavy chain (FTH) expression were observed after FCD treatment. In summary, our study highlighted the potential anticancer effects of FCD against human NSCLCs and demonstrated that the FCD-mediated apoptosis depended on binding to intracellular iron.
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PubMed
高影响因子
JOURNAL OF MOLECULAR STRUCTURE
·
2023
·
IF 3.8
Ke Yuan,Wencai Huang,Tao Zhang,Li Lv,Yan Wang,Zongpeng Zou,Shengwei Tang
Ionic Liquids (ILs) of 1,3-bis-(3-sulfonic acid)propyl imidazolium bisulfate ([PS 2 Im]HSO 4 ) can be used as acid catalyst for its specific acidity. However, it is difficult to obtain high-purity ILs by the reported synthetic methods. The preparation of [PS 2 Im]HSO 4 with N-trimethylsilylimidazole (TSIm) as raw material was studied. The results show that 1-(3-sulfonic acid)propyl-3-H-imidazolium bisulfate ([PSImH]HSO 4 ) and 1,3-bis-H-imidazolium bisulfate ([ImH]HSO 4 ) are easily formed in the process of preparing [PS 2 Im]HSO 4 from TSIm. Some TSIm is encapsuled in the formed solid intermediate 1-(propyl-3-sulfonate)-3-trimethylsilylimidazolium ([TSIm]PS), it leads to the formation of [ImH]HSO 4 . The solid intermediate [TSIm]PS can not be completely depleted in the following reaction for the formation of 1-(3-trimethylsilyl sulfonate)propyl-3-(propyl-3-sulfonate) limidazolium ([PSTSIm]PS). The residual solid intermediate [TSIm]PS leads to the formation of [PSImH]HSO 4 . A novel process using sodium imidazolate (ImNa) as raw material was proposed. [PS 2 Im]HSO 4 was successfully prepared with a purity of 96.2 mol.% and a yield of 69 %. The synthesis mechanism of high purity [PS 2 Im]HSO 4 was revealed by experimental research and DFT computation. Intermediate 1-(3-sodium sulfonate)propyl imidazole (PSNaIm) is formed by the reaction of ImNa and 1,3-PS with a molar ratio of 1:1. PSNaIm can easily be dissolved in DMSO and react with 1,3-PS to obtain 1-(3-sodium sulfonate)propyl-3-(propyl-3-sulfonate) imidazolium ([PSNaIm]PS). After cation exchange and reaction with sulfuric acid, high purity [PS 2 Im]HSO 4 is easily obtained. The results provide a guidance for the synthesis of high-purity imidazole-based ILs containing dual-acidic functional groups.
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
·
2023
·Vol. 120
·期 45
·e2309032120
·
IF 11.1
Kaiyuan Yu,Qianqian Li,Xuan Sun,Xianping Peng,Qiang Tang,Hongyu Chu,Lu Zhou,Bangmao Wang,Zhemin Zhou,Xueqin Deng,Jianming Yang,Junqiang Lv,Ran Liu,Chunhui Miao,Wei Zhao,Zhi Yao,Quan Wang
Tryptophan and its derivatives perform a variety of biological functions; however, the role and specific mechanism of many tryptophan derivatives in intestinal inflammation remain largely unclear. Here, we identified that an Escherichia coli strain (Ec-TMU) isolated from the feces of tinidazole-treated individuals, and indole-3-lactic acid (ILA) in its supernatant, decreased the susceptibility of mice to dextran sulfate sodium–induced colitis. Ec-TMU and ILA contribute to the relief of colitis by inhibiting the production of epithelial CCL2/7, thereby reducing the accumulation of inflammatory macrophages in vitro and in vivo. Mechanistically, ILA downregulates glycolysis, NF-κB, and HIF signaling pathways via the aryl hydrocarbon receptor, resulting in decreased CCL2/7 production in epithelial cells. Clinical evidence suggests that the fecal ILA level is negatively correlated with the progression indicator of inflammatory bowel diseases. These results demonstrate that ILA has the potential to regulate intestinal homeostasis by modulating epithelium–macrophage interactions.
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高影响因子
FOOD CHEMISTRY
·
2023
·
IF 8.8
Chixuan Yao,Yaozhong Hu,Qisijing Liu,Jing-Min Liu,Xuemeng Ji,Huan Lv,Shuo Wang
To improve the performance of peanut allergen Ara h 3 detection, depending on boron and nitrogen carbon dots (B/ N -CDs), a nanobody (Nb) mediated dual-mode immunoassay was established, which combines the dominance of colorimetry with ratiometric fluorescence techniques. With the catalysis of Horseradish peroxidase (HRP), the oxidization of o-phenylenediamine (o-PD) in the presence of H 2 O 2 , leading to the production of yellow 2,3-diaminophenolazine (DAP) with an absorption peak at 431 nm. Owing to inner filter effect (IFE), DAP quenched the fluorescence of B/ N -CDs at 426 nm, and it emerged a new emission peak at 549 nm. The fluorescence intensity ratio and absorption intensity can be utilized for quantitative analysis of Ara h 3 concentration. Under optimal conditions, the detection limits were 6.61 and 9.79 ng·mL −1 , respectively. The dual-mode immunoassay was assessed containing specificity, stability, reproducibility, and practicability. This method paved the way for sensitive detection of Ara h 3 without background Interference.
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高影响因子
Journal of Analytical Science and Technology
·
2023
·Vol. 14
·期 1
·1-8
·
IF 2.4
Xu Ting,Qingru Zeng,Fu Qing,Wang Zhaojie,Liu Xin,Xiao Shensheng,Jiang Xiaoming,Lu Yuepeng,Gong Zhiyong,Wu Yongning,Fang Min
Using amino silica modified with fluorescein isothiocyanate (FITC), a quick fluorescence analysis technique is used for the detection of 3-monochloropropane-1,2-diol (3-MCPD). At 100 °C and pH 8.5, FITC-modified amino silica exhibits the lowest fluorescence intensity in the presence of 3-MCPD. This can predominantly be explained mostly explained by 3-MCPD’s capacity to occupy the amino group that FITC normally binds to. The fluorescence intensity of FITC-modified amino silica was greatly quenched by 3-MCPD’s reaction with the amino group under alkaline conditions, and the fluorescence intensity is different at different reaction times, reaction pH, and reaction temperature. The effects of various 3-MCPD concentrations on the optical characteristics of FITC-modified amino silica were also investigated. Fluorescence analysis is used to obtain a linear range from 0.025 to 1.0 mg/L for 3-MCPD detection under optimal experimental conditions, with a detection limit of 0.025 mg/L and a correlation coefficient of 0.9915. The quantity of 3-MCPD in soy sauce was measured under ideal conditions. Using the optimized conditions, the contents of 3-MCPD in soy sauce were determined. These results suggest that this method is sensitive to 3-MCPD and may have a substantial application in the rapid detection of food contaminants particularly, where the quality and safety of food products are of paramount concern.
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APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
·
2021
·Vol. 105
·期 5
·2033-2042
·
IF 4.813
Wang Xiao,Xu Na,Li Qinglin,Chen Shengqi,Cheng Hui,Yang Mo,Jiang Ting,Chu Jun,Ma Xiaojing,Yin Dengke
Liver cancer, one of the most common types of cancer in the world, is the second leading cause of death for cancer patients. For liver cancer, there is an urgent need for an effective treatment with no or less toxic side effects. Lactonic sophorolipids (LSL), as a potential anticancer drug, has attracted wide attention of pharmaceutical researchers with its good biological activities. The effects of LSL and cell death inhibitors were measured by MTT test on HepG2 cells. Meanwhile, the morphology of the cells was observed under a microscope. The apoptosis rate was detected by flow cytometry, and the expression levels of enzyme activity of Caspase-3 and Caspase-9 were measured by detection kits. Meanwhile, mRNA levels of Apaf-1 , Caspase-3 , Bax , and Bcl-2 were measured by quantitative real-time RT-PCR; protein levels of Caspase-3, Cleaved Caspase-3, Bax, and Bcl-2 were measured by western blot. LSL can inhibit the proliferation of cells, and it is possible to induce apoptosis in cells. The HepG2 cells with LSL co-culture exhibited typical apoptotic morphology, and the expression levels of enzyme activity of Caspase-3 and Caspase-9 increased ( P < 0.05). We also found that LSL increases cell apoptosis rate and regulates the expression of genes and proteins associated with apoptosis through the Caspase-3 pathway. These results indicate that LSL may be one of the potential drug candidates to inhibit the proliferation and induce apoptosis in HepG2 cells.
Key points
• LSL, which is of good biological activities such as anti-bacterium, virus elimination, and inflammatory response elimination, has been firstly used to intervene in vitro to investigate its effect on HepG2 cell proliferation. • LSL can inhibit the proliferation of cells, and it is possible to induce apoptosis in HepG2 cells through the Caspase-3 pathway. • The mechanism of LSL action on HepG2 cell proliferation was firstly also discussed, which provides a certain experimental reference for the clinical treatment of liver cancer. Graphical abstract
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高影响因子
TRANSPORT IN POROUS MEDIA
·
2021
·Vol. 144
·期 1
·133-148
·
IF 3.019
Dai Caili,Chu Zhongzhong,Jiang Qihui,Wu Yining,He Long,Zhao Mingwei
Polymer solution has extremely extensive applications in many natural and industrial processes, especially in oilfield development field, such as polymer flooding, fracturing and water shut-off. Thus, the study of flow behaviors of polymer in formation pores is significantly important. In this paper, the flow behaviors of the polymer droplets in the 3-D pore throat structure were systematically studied. Additionally, the influencing factors (polymer concentration, molecular weight and pore throat ratio, for instance) were investigated. As the increasing of polymer concentration and molecular weight, the polymer droplets were more difficult to break, which means the critical flow rate decreased and the average sizes of the first daughter droplets (FDD) were longer synchronously. Moreover, with the increase in pore throat ratio, the critical flow rate increased and the length of the FDD decreased. In addition, the prediction models of the length of the FDD with polymer concentration and pore throat ratio were established, respectively. The prediction model revealed that the length of the FDD satisfied an exponential relationship with the polymer concentration and a linear relationship with the pore throat ratio. Finally, the average size of droplets after macroscopic core flooding experiment was 8 μm and 17 μm when the polymer concentration was 0.01% and 0.1%, respectively. The results were consistent with the breakup behaviors of polymer droplets in the microscopic pore throat structure.
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Food Quality and Safety
·
2021
·
IF 3.102
Xie Jiahong,Cui Haoxin,Xu Yang,Xie Lianghua,Chen Wei
ObjectivesThis study was conducted to investigate the xanthine oxidase (XO) inhibitory activities of 18 monomeric anthocyanins from berry fruits and roselle, and to illustrate the underlying mechanism of the most active anthocyanin delphinidin-3-O-sambubioside.Materials and MethodsEighteen monomeric anthocyanins were prepared and purified in our laboratory. The inhibitory properties of anthocyanins were investigated by in vitro inhibitory activity studies and fluorescence quenching studies; the inhibitory mechanism was explored through kinetic studies, fluorescence quenching studies, circular dichroism analysis and computational docking simulations.ResultsXO inhibitory activities of anthocyanins were related to the structures of B rings and glycosides. Among all the tested anthocyanins, delphinidin-3-O-sambubioside showed the most potent inhibitory activity with an IC50 of 17.1 μM, which was comparable to the positive control allopurinol. Spectroscopic results revealed that delphinidin-3-O-sambubioside could spontaneously interact with XO and induce conformational changes. Computational docking study indicated that delphinidin-3-O-sambubioside could bind to XO with a proper orientation, stably formed π–π interactions and hydrogen bonds with key residues, thus preventing the substrate from entering the active pocket.ConclusionsIn brief, our study identified delphinidin-3-O-sambubioside as a potent XO inhibitor from natural anthocyanins, which is potentially applicable for prevention and treatment of hyperuricemia.
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Molecular Catalysis
·
2020
·
IF 3.687
Kaikai Liu,Tiefeng Wang,Minghan Han
The catalytic isomerization of 2-methyl-3-butenenitrile (2M3BN), a model reaction in the DuPont process, has been performed using NiL 4 (L=tri- O - p -tolyl phosphite) as a catalyst. The lowered catalytic activity in the isomerization with coexistence of 2-pentenenitrile (2PN) and 2-methyl-2-butenenitrile (2M2BN) indicates that both 2PN and 2M2BN are the catalyst inhibitors , and the quantitative relationship between the conversion of 2M3BN and the content of 2M2BN and 2PN is provided. DFT calculation results suggest that the inhibition effect is attributed to the generation of dead-end intermediates (2PN)NiL 2 and (2M2BN)NiL 2 , both of which take nickel atom out of the catalytic cycle in the isomerization process. To suppress the inhibition effect, new catalytic intermediates are rationally designed based on their computational %V bur . An efficient method that adding extra ligand 1, 5-bis(diphenylphosphino)pentane (dppp5) to the NiL 4 catalyst is selected experimentally. Compared to the results obtained with NiL 4 as catalyst, the (dppp5)NiL 2 increases the conversion of 2M3BN from 74.5 % to 93.4 % at 3 h of reaction and provides a high selectivity to 3PN (> 98 %) at optimal conditions.
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