Desalination and Water Treatment
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2014
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IF 0.987
Mengying Gan,Yongqiang Huang,Yunlei Zhang,Jianming Pan,Weidong Shi,Yongsheng Yan
Ag/halloysite nanotubes/Fe3O4 (Ag/HNTs/Fe3O4) nanocatalyst was synthesized in our work. The structure of the as-prepared composite catalyst was that Fe3O4 nanoparticles with the size of 5.0–8.0 nm were loaded in the internal hollow lumen of HNTs and Ag nanoparticles with a mean diameter of 20 nm were randomly deposited on the external surface of HNTs/Fe3O4. The resultant Ag/HNTs/Fe3O4 exhibited satisfied catalytic activity (with conversion of 100% in 38 min) to the reduction of 4-nitrophenol (4-NP) with sodium borohydride. The catalytic activity was markedly enhanced when the catalysts concentration was increased (the rate constant was gradually increased from 0.40 to 20.18 × 10−3 s−1). Also, the advantage of the obtained magnetic composite catalyst in terms of their fast separation and simple reuse was identified through five successive catalytic and separation process cycles. It could be concluded that Ag/HNTs/Fe3O4 showed satisfied catalytic activity, recoverability, and reusability, which showed great potential for practical application for water treatment.
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高影响因子
APPLIED SURFACE SCIENCE
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2017
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IF 3.387
Shuo Wang,Ruixin Ma,Chengyan Wang,Shina Li,Hua Wang
This report details the development of a simple, non-vacuum, mild route for the fabrication of CFTS and CFTSSe thin films. This work investigates the synthesis of CFTS powder using solid-phase synthesis. Subsequently, the stable colloidal ink was prepared and blade-coated onto Mo-coated substrates followed by an annealing process under an Ar atmosphere. Thin films of this material were converted into CFTS and CFTSSe thin films by sintering and exposing them in sulfur or selenium vapor. The structures of the CFTS and CFTSSe were observed to be consistent with the stannite phase. The crystal lattice parameters of the CFTS and CFTSSe post-annealed films were determined by their respective X-ray diffraction patterns and Raman scattering measurements. The band gaps of CFTS and CFTSSe films, as determined by UV–vis absorption, were estimated to be 1.32 eV and 1.22 eV with an error of ±0.02 eV. The corresponding CFTS and CFTSSe films showed a clear photoresponse without current transients, which is promising for future photovoltaic applications.
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高影响因子
CHEMISTRY OF MATERIALS
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2023
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IF 8.6
Zhilong Song,Jia Yan
The analysis of exhaled human breath has great significance for early noninvasive diagnosis. However, highly sensitive and selective detection against part-per-billion (ppb) biomarkers in exhaled human breath (RH ≥80%) at room temperature remains a challenge. SnO2 quantum wires (QWs) consisting of a few hundreds to thousands of atoms are demonstrated to be promising for low-power consumption gas sensors to achieve an on-chip electronic nose. Here, we propose a low-temperature doping strategy in realizing the synthesis of the transition metal (Mn, Cr, V)-doped SnO2 QWs. The doped SnO2 QWs with sub-4 nm diameters as chemiresistive gas sensors enable us to improve the adsorption activities, achieving enhanced room-temperature sensing properties toward the trace biomarkers (e.g., acetone, formaldehyde, and H2S) with the state-of-the-art limit of detection of 2.6, 1.5, and 1.3 ppb, respectively. These transition metal-doped SnO2 QWs are then integrated as a sensor array, enabling gas identification at different relative humidities by using machine learning algorithms. Moreover, systematical characterizations combined with density functional theory (DFT) calculations are conducted to figure out the effect of doping on SnO2 QW properties for the sensitive and selective ppb-level gas detection. The engineering of transition metal-doped SnO2 QWs helps us to extend the library for the design of low-power consumption gas sensors in more broad applications.
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JOURNAL OF POLYMER SCIENCE
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2026
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IF 3.9
Xianxin Guo,Jinrong Li,Zimeng Li,Ting He,Tianyu Liu,Xiaomin Zhao
The plastic pollution crisis highlights the urgent demand for bio-based biodegradable polymers. Polyamide 4 (PA4) is a promising candidate, yet its application is severely limited by an extremely narrow thermal processing window (≈2°C). This work broadens this window through Lewis acid (LA) complexation modification and investigates the influence of CaCl 2 on the crystallization kinetics of PA4. Results show that specific LA, particularly CaCl 2 , acts as multifunctional modifiers. CaCl 2 interacts with the amide groups of PA4 and modifies the intermolecular hydrogen-bonding network. This unique interaction significantly increases ductility (elongation at break rises from 99% to 211%) while maintaining tensile strength and approximately maintaining the thermal degradation temperature, and most critically, broadens the thermal processing window from 2°C to 24°C primarily by lowering the melting temperature. Advanced nonisothermal crystallization kinetics analysis reveals a novel concentration-dependent dual mechanism of CaCl 2 : chain-complexation dominates at low loadings, while heterogeneous nucleation prevails at 7 wt.%, substantially reducing the crystallization activation energy (Δ E = −23.36 KJ mol −1 ). This clarifies the precise pathway for regulating PA4 crystallization via additives. In summary, this study elucidates the precise pathway for regulating PA4 crystallization via additives, providing a reference for the thermal processing applications of materials with limited thermal processing windows. Graphical We demonstrate that Lewis acid complexation, especially with CaCl 2 , broadens the processing window of bio-based polyamide 4 from 2°C to 24°C primarily by lowering the melting temperature while approximately maintaining the thermal degradation temperature. This modification also maintains tensile strength while revealing a concentration-dependent mechanism in crystallization kinetics, offering new insights for preparing high-performance biodegradable polymers.
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ANALYTICAL LETTERS
·
2022
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IF 2.267
Lanying Xu,Yingying Huang,Bingshan Zhao,Limin Ren,Tao Long
β-Cyclodextrin modified magnetic microspheres were synthesized and used as an effective adsorbent for the solid-phase extraction of three phenols from water samples. Scanning electron microscopy and Fourier transform infrared spectrometry were used to characterize the adsorbents. The major parameters affecting the extraction and desorption efficiencies, such as adsorbent dosage, extraction time, pH, ionic strength, and eluent type were systematically optimized. Under these conditions, three phenols in water samples were extracted and determined by high performance liquid chromatography (HPLC) with diode array detection (DAD). Limits of detection (LODs) of 0.04–0.34 ng mL−1 and limits of quantification (LOQs) from 0.13 to 1.14 ng mL−1 were achieved with good repeatability (relative standard deviation <7.5%). The developed method was applied for the determination of 2,4-dichlorophenol, 2,4-dinitrophenol and bisphenol A in spiked Yangtze River water, and the recoveries were from 81.0% to 94.9%. The results demonstrated that the combination of magnetic solid-phase extraction (MSPE) with HPLC-DAD is suitable for the determination of trace phenolics in environmental water.
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高影响因子
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
·
2019
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IF 4.833
Wen-Jing Zhu,Ben-Wen Cui,Hui Min Wang,Ji-Xing Nan,Hu-Ri Piao,Li-Hua Lian,Cheng Hua Jin
Six series of 4-(benzo[ c ][1,2,5]thiadiazol-5-yl)-3(5)-(6-methylpyridin-2-yl)- pyrazoles 18a – d , 19a – d , 22a – d and 3(5)-(6-methylpyridin-2-yl)-4-(thieno[3,2,- c ]- pyridin-2-yl)pyrazoles 20a – d , 21a – d , 23c , 23d have been synthesized and evaluated for their activin receptor-like kinase 5 (ALK5) and p38α mitogen activated protein (MAP) kinase inhibitory activities in enzymatic assays. Among these compounds, the most active compound, 22c , inhibited ALK5 phosphorylation with an IC 50 value of 0.030 μM in the enzymatic assay. Compound 22c showed four-fold more potent activity against ALK5 kinase than the clinical candidate, compound LY-2157299 . The selectivity index of 22c against p38α MAP kinase is 235, which is much higher than that of LY-2157299 (4) and equally selective to that of EW-7197 (218). Compound 22c effectively suppressed protein and mRNA expression of collagen I and α-SMA in TGF-β-induced LX-2 human hepatic stellate cell (HSC), this result shows that compound 22c has the ability to inhibit the activation of HSC. Compound 22c is expected to be a preclinical candidate for the treatment of hepatic fibrosis .
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PubMed
高影响因子
Science China-Life Sciences
·
2026
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IF 9.6
Ye Hanyi,Jin Wei,Feng Yifan,Wu Ze,Sun Shuhui,Cui Mengyao,Lv Shun,Jin Bing,Liu Chang,Wang Siming,Li Ying,Dong Zhengqi
Breast cancer remains a therapeutic challenge due to its high malignancy and the lack of safe and effective treatments. Immune checkpoint inhibitors targeting cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) have demonstrated remarkable efficacy against various malignancies by enhancing antitumor immunity when used in combination with chemotherapy. However, conventional antibody-based therapies are associated with adverse effects. Plant-derived microRNAs capable of regulating gene expression represent a highly promising alternative strategy, with substantial potential in disease treatment. In this study, we identified that miR152, a plant-derived microRNA from Taxus×media Rehder, has antitumor activity. Our results demonstrated that miR152 exerts antitumor immune activity by silencing CTLA-4 expression in regulatory T cells. Furthermore, we observed that miR152 maintains a favorable safety profile in normal cells at therapeutic doses, while eliciting direct cytotoxic effects on specific cancer cell lines at higher concentrations. In a mouse tumor model, the combination of anti-CTLA-4 miRNA with doxorubicin significantly improved the efficacy of both monotherapies. Mechanistically, miR152 augmented the antitumor immune response by reducing the proportion of Treg cells within the T-cell compartment and increasing the proportion of CD8 + cytotoxic T cells at tumor sites, enhancing the secretion of Th1- and M1-associated cytokines and suppressing interleukin-10 production. This study reveals for the first time that plant-derived miR152 may serve as a cancer immunotherapy agent in combination with a chemotherapeutic drug to inhibit cancer growth in mammals.
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PubMed
高影响因子
Sustainability
·
2026
·Vol. 18
·期 16
·8079
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IF 4.1
Hao Liu,Deli Wu,Yufan Chen,Chengsi Hou,Guojie Ye,Zhengwei Zhou,Yue Wang
4-Chlorophenol (4-CP) is a persistent and highly toxic pollutant commonly found in groundwater. However, its efficient degradation remains challenging due to the rapid agglomeration of conventional zero-valent iron (ZVI) nanoparticles, their narrow pH operating range, and the environmental risks associated with synthetic chelating agents. To address these limitations, this study presents a rationally designed catalytic system integrating cyclodextrin polymer (CDP)-supported bimetallic Cu-Fe nanoparticles (Cu-Fe-CDP) with citric acid (CA) as a green complexing agent. The porous CDP matrix effectively mitigates nanoparticle agglomeration and provides abundant active sites, while the Fe-Cu bimetallic coupling accelerates electron transfer and iron corrosion. Critically, CA acts as a biocompatible ligand that sustains Fe(II)/Fe(III) redox cycling, expands the effective pH range, and enhances hydroxyl radical (·OH) generation. The system achieves 92.13% degradation of 4-CP within 80 min at pH 9.0 and nearly complete removal at pH values between 3.0 and 7.0. Mechanistic studies, including electron paramagnetic resonance (EPR) spectroscopy and radical quenching tests, confirm the dominance of ·OH radicals (82.67% inhibition by TBA) and the essential role of surface Fe(II)/Fe(III) cycling. The catalyst exhibits excellent reusability, broad-spectrum activity toward multiple pollutants, and sustained performance in real water matrices and long-term column tests with minimal metal leaching. This work demonstrates a chemically robust strategy for chlorophenol remediation using green citric acid and biodegradable CDP without exogenous oxidant addition, showing promise for further development toward practical applications.
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高影响因子
Energetic Materials Frontiers
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2026
·
IF 4.7
Hua Fang,Peng-fei Zhu,Jin-xiang Yang,Xiao-le Sun,Xiong Cao,Xue-yong Guo
The DAP-4/RDX mixture was prepared by solvent suspension method. The thermal decomposition, combustion and micro-explosion experiments were carried out. The results showed that the thermal decomposition peak temperature of DAP-4/RDX was lower than that of DAP-4. RDX reduces the activation energy required for the thermal decomposition of DAP-4, reduces the maximum flame temperature but prolongs the combustion duration. The combustion peak pressure and pressurization rate of DAP-4/RDX samples are lower than those of DAP-4, and the maximum is reduced from 415.65 kPa and 68.95 kPa·ms -1 to 322.58 kPa and 23.07 kPa·ms -1 . The intensity of laser-loaded shock wave is increased after the introduction of RDX under the same conditions. The detonation heat and detonation velocity of DAP-4/RDX measured by micro-explosion are higher than those of DAP-4, the increased intensity of laser-loaded shock wave is consistent with the improved detonation heat and velocity, jointly reflecting the enhanced detonation performance of RDX to DAP-4/RDX.
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高影响因子
ACS Applied Materials & Interfaces
·
2026
·
IF 8.2
Wensai Lu,Guanggui Cheng,Hongwei Hu,Yu Ding,Ya Yang,Jianning Ding
Perovskite solar cells (PSCs) hold the potential to surpass crystalline silicon cells in terms of cost, fabrication process, and ultimate efficiency. However, defects in the bulk and buried interfaces lead to carrier recombination centers and induce ion migration, severely limiting device efficiency and stability. In this study, we employed (thiomorpholine-4-yl)methyl trifluoroborate potassium (TMM-K) with multiple passivation sites to achieve synergistic passivation of the perovskite bulk and buried interfaces. This passivator not only improved the crystallinity of perovskite but also facilitated interfacial band alignment, enhancing charge extraction and suppressing interfacial recombination. As a result, the efficiency of PSCs increased from 21.22% to 22.67% on a 4 cm2 area. Moreover, the hydrophobic nature of TMM-K significantly enhanced the stability of the perovskite films, providing valuable insights for the commercial development of PSCs.
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PubMed
高影响因子
FREE RADICAL BIOLOGY AND MEDICINE
·
2026
·
IF 8
Zeng-Yang Wang,Xin-Jie Zhao,Shuo Gao,Yuan-Xin Liao,Hao-Cheng Chen,Meng-Ge Zhang,Cheng-Cheng Li,Zhi-Jie Sun,De-Li Dong
PDE4 inhibitors roflumilast and rolipram extend lifespan and improve fitness in C. elegans ; roflumilast attenuates cellular senescence in mouse embryonic fibroblasts. • Roflumilast and rolipram enhance mitochondrial function and reduce ROS levels by activating PKA signaling. • PDE4/cAMP/PKA signaling pathway-mediated anti-aging effects are conserved. Aging is driven by multiple factors such as mitochondrial dysfunction and oxidative stress, leading to various age-related diseases. Phosphodiesterase-4 (PDE4) is a subfamily of phosphodiesterases and specifically hydrolyzes cAMP. PDE4 inhibitors have been approved for the treatment of several diseases and shown to improve aging-related conditions. However, the precise effects and underlying mechanisms of PDE4 inhibitors on lifespan and cellular senescence remain unclear. Here, we report that two PDE4 inhibitors (roflumilast and rolipram) extend C . elegans lifespan and that roflumilast attenuates passage-induced cellular senescence in mouse embryonic fibroblasts (MEFs). We further demonstrate that protein kinase A (PKA) activation mediates PDE4 inhibitors’ anti-aging effects by improving mitochondrial function and alleviating oxidative stress, and that the mechanism is conserved in C. elegans and MEFs. Our findings provide evidence that PDE4 inhibitors possess anti-aging potential. Download: Download high-res image (205KB) Download: Download full-size image
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COLLOIDS AND SURFACES B-BIOINTERFACES
·
2026
·
IF 5.9
Xueli Hou,Fang Jian,Jinyao Xu,Fanfan Zhang,Shengyue Wu,Dexin Xia,Lin An
A multifunctional pH‑responsive calix[4]arene‑based carrier CMP with dual hydrophobic alkyl substituents and biotin‑PEG chains was constructed for co‑delivery of DOX and Ce6. • The blank calixarene matrix acts as a supramolecular chemotherapeutic agent with certain intrinsic antitumor activity, while co-loaded DOX and Ce6 elicit prominent in vitro chemo-photodynamic suppression. • The biotin‑targeted DOX@CMP@Ce6 nanosystem achieves potent in vivo tumor inhibition along with favorable biosafety. Conventional nanoplatforms often suffer from complicated fabrication, poor structural controllability, insufficient tumor targeting, and unsatisfied therapeutic efficacy. To address these issues, herein we rationally design and construct a novel calix[4]arene derivate CMP, whose upper rim is functionalized with pH-responsive biotin-PEG hydrophilic chains, and lower rim is dually modified with hydrophobic alkyl chains and antitumor pharmacophores. This “all-in-one” supramolecule can not only serve as an excellent supramolecular chemotherapeutic agent itself, but also act as a versatile carrier to co-deliver doxorubicin (DOX) and chlorin e6 (Ce6). The nanoplatform therefore integrates two types of chemotherapeutic modalities and biotin-targeted photodynamic therapy for multi-modal tumor treatment. Notably, in vivo experiments demonstrate that the resultant DOX@CMP@Ce6 nanosystem achieves a 90.5% tumor growth inhibition rate, while displaying biotin-mediated tumor tropism, excellent biocompatibility, and robust triple-modality combinatorial therapeutic effects. Collectively, this work provides key insights into the rational construction of multifunctional supramolecular platforms, reinforcing the broad prospects of calixarene derivatives for nanomedical applications.
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