Catalysts
·
2026
·Vol. 16
·期 7
·634
·
IF 4.5
Yue Zhao,Ling An,Hui Zhang,Tong Zhang,Xing Zhang,Li Huang,Song Jin,Wei Wang,Ning Li
4-Hydroxycyclopent-2-enone (HCP), a chemical substance with a unique molecular structure and distinct physical properties, is an important intermediate for the synthesis of natural products, chemicals, and liquid fuels, demonstrating exceptionally high application value. This study introduces a novel approach for HCP synthesis via the rearrangement of furfuryl alcohol (FAL). A series of ZnAl-based hydrotalcite (HT) catalysts was prepared and characterized by SEM, XPS, XRD, NH3-TPD, and CO2-TPD. HCP is efficiently synthesized by the rearrangement of furfuryl alcohol in water at a relatively low temperature of 205 °C. Using a 10 wt.% aqueous solution of furfuryl alcohol as the raw material, the yield of HCP remained stable at 80.2% under the selected reaction conditions (ZnAl-HT-1: 1–500 °C as catalyst, 205 °C, and 5 min). It is worth noting that when the concentration of furfuryl alcohol solution was reduced to 5%, the conversion of furfuryl alcohol reached 100%, and the HCP yield reached an excellent 92.5%. The exceptional performance observed can be primarily attributed to several key factors associated with the ZnAl-HT-1: 1–500 °C catalyst: its expansive specific surface area and ample pore volume, the distinctive layered structure inherent to hydrotalcites, and its well-balanced acid–base properties, featuring optimal densities of acid and base sites with a uniform distribution of acidic and basic active centers that cooperate synergistically to promote the reaction.
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高影响因子
CHEMICAL ENGINEERING & TECHNOLOGY
·
2026
·Vol. 49
·期 9
·e70305
·
IF 2
Yingqian Wang,Yongyi Wu,Cheng Peng,Wenbin Li,Donghui Zhang
The separation of methane and nitrogen is critical for upgrading low-grade natural gas. However, their similar physicochemical properties render efficient separation extremely challenging. This study explores the application of Engelhard titanosilicate-4 for N 2 /CH 4 separation. Framework thermal contractibility is tailored by regulating crystallization time. Thermal activation enables precise pore-size modulation, affording a superior separation selectivity of 15.1. Furthermore, the material properties are evaluated through structural characterization, adsorption isotherm measurements, and kinetic tests. Finally, in the simulation of a two-bed six-step vacuum pressure swing adsorption (VPSA) process, the obtained methane product has a purity exceeding 95%, validating the promising practical application potential of this adsorbent.
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高影响因子
THERMOCHIMICA ACTA
·
2026
·
IF 3.6
Junlei Song,Meng Li,Zhiran Wang,Yuexin Shao,Binbin Zhang,Hua Fang,Xiong Cao
Molecular perovskite energetic material (H 2 dabco)[NH 4 (ClO 4 ) 3 ] (DAP-4) is promising for solid propellants; however, its high ignition delay limits practical application. In this work, silver(I) fluoride (AgF) was introduced as a catalyst to prepare DAP-4/AgF composites. Their thermal decomposition and combustion performance were systematically investigated using X-ray diffraction, scanning electron microscopy, differential scanning calorimetry, thermogravimetry, Flynn–Wall–Ozawa isoconversional analysis, combustion testing, and X-ray photoelectron spectroscopy. AgF was uniformly dispersed on DAP-4 particle surfaces. Increasing AgF content progressively lowered the decomposition temperature and reduced the mean apparent activation energy from 295.35 to 119.07 kJ/mol. Combustion performance initially improved and then declined, with DAP-4/AgF-1 showing the strongest response, a combustion heat of 11078 ± 84 kJ/kg, and a strand burning rate of 6.77 mm/s. The combined results are consistent with a possible AgF-associated interface-assisted modification of the overall decomposition process.
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高影响因子
SHOCK WAVES
·
2026
·Vol. 36
·期 1
·9
·
IF 1.8
Zhang L.,Zhao C.,Xu Z.,Shi Y.,An E.,Liang J.,Cao X.
Boron (B) is considered as a high-energy additive for solid propellants owing to its high mass and volumetric calorific values. DAP-4, a novel solid energetic material, exhibits excellent detonation performance and strong oxidizing properties, making it a promising high-energy oxidizer for solid propellants. To explore the ignition and combustion characteristics of DAP-4-based boron-containing high-energy materials, mixed powders of DAP-4 and nanometric boron (nano-B) materials with varying mass ratios were prepared through mechanical blending. X-ray diffraction (XRD) analysis confirmed the crystalline structure of the DAP-4/nano-B mixed powder and the absence of additional compounds or phases. Scanning electron microscope (SEM) observations revealed that nano-B particles effectively adhered to the surface of the DAP-4 particles, with the density of attached nanometric boron increasing as its content in the samples increased. Elemental mapping and Energy Dispersive X-ray Spectroscopy (EDS) further validated this surface modification. TG-Differential Scanning Calorimetry (DSC) analysis indicated good compatibility between DAP-4 and nano-B, with minimal mutual influence during thermal decomposition under heating. The ignition and combustion characteristics of the DAP-4/nano-B mixed powders were investigated using a shock tube at temperatures of 2200–3100 K and pressures of 0.1 MPa and 0.5 MPa. Results showed that both ignition delay time and burn time decreased with increasing temperature, whereas pressure had a negligible effect. As the boron content increased from 0 to 30%, the ignition delay time decreased, while the burn time initially decreased and then increased. Overall, the addition of nano-B effectively enhanced the combustion of DAP-4/nano-B mixed powders. In practice applications, the ignition and combustion performance of DAP-4 can be tailored by adjusting the mass fraction of boron powder.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Jiaji Yue,Yuhao Deng,Weichao Sun,Shenglong Li,Mengni Zhu,Fangyue Cheng,Zhen Dai,Hongxi Shang,Jinling Zhang,Jianfei Tang
An IL-4-loaded allomelanin nanoparticle (IL-4@AMNPs) is developed. • IL-4@AMNPs scavenge ROS and reprogram macrophages toward M2 phenotype. • The nanoplatform shows sustained intra-articular retention over 144 h. • IL-4@AMNPs alleviate cartilage degradation and inflammation in OA rats. • A synergistic redox-immune modulation strategy for disease-modifying OA therapy. Osteoarthritis (OA) is a prevalent degenerative joint disorder characterized by chronic synovitis and progressive cartilage destruction, in which excessive reactive oxygen species (ROS) play a central pathogenic role. Herein, we reported the design of allomelanin-like nanoparticles loaded with interleukin-4 (IL-4@AMNPs) as a multifunctional nanoplatform. Benefiting from the intrinsic antioxidant activity of AMNPs, the system efficiently scavenges excessive ROS, while the incorporated IL-4 exerts anti-inflammatory and M2-polarizing effects. In a rat model of OA, intra-articular administration of IL-4@AMNPs markedly attenuated cartilage erosion, reduced ROS accumulation, and downregulated matrix metalloproteinase-3 (MMP-3) expression. Furthermore, IL-4@AMNPs suppressed the expression of pro-inflammatory cytokines (IL-1β, TNF-α and IL-6), restored the anti-inflammatory cytokine IL-10, and reprogrammed macrophages from the M1 toward the M2 phenotype, thereby reshaping the joint immune microenvironment. Both in vitro and in vivo safety assessments confirmed the excellent biocompatibility and systemic safety of IL-4@AMNPs. Collectively, this study demonstrated that IL-4@AMNPs disrupt the pathological interplay between oxidative stress and inflammation, achieving synergistic chondroprotection via dual ROS scavenging and IL-4-mediated macrophage reprogramming and offering a promising disease-modifying nanotherapeutic strategy for OA treatment. Download: Download high-res image (121KB) Download: Download full-size image
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高影响因子
JOURNAL OF MEDICINAL CHEMISTRY
·
2025
·
IF 6.8
Lulu Zheng,Jiaqi Cao,Lin Ma,Shiyan Chen,Xiansheng Cao,Ruixiang Luo,Yuhan Wang,Di Ke,Ping Huang,Guang Liang,Lingfeng Chen
Alterations in the fibroblast growth factor receptor 3 (FGFR3) gene have been noted in human diseases, including bladder cancer and urothelial carcinoma (UC). Erdafitinib was approved for the treatment of UC but is limited by the progression of on-target gatekeeper resistance mutations. Several heterobifunctional FGFR degraders have been developed as potential therapeutic agents to block FGFR1 or FGFR2 signaling. However, to date, none of the FGFR3-active degraders have been identified. Herein, we report the discovery of LC-MF-4, the first efficient FGFR3 degrader, for the treatment of cancers harboring FGFR3 alterations. Proteomic analysis revealed that LC-MF-4 exhibits exceptional proteomic selectivity for FGFR3 degradation. In FGFR3-TACC3 fusion-positive cells, LC-MF-4 exerted its effects by suppressing the expression of genes involved in mitochondrial biogenesis and ATP synthesis. This study demonstrated robust antitumor activity of LC-MF-4 in the Ba/F3-FGFR3-TACC3 xenograft model, highlighting its potential for the treatment of FGFR3-altered cancers.
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PubMed
高影响因子
JOURNAL OF CHEMICAL SCIENCES
·
2025
·Vol. 137
·期 3
·1-13
·
IF 2
He Jun,Dou Jianing,Song Wenchao,Song Tao,Chen Jiaqi,Lin Xuan
CeO 2 /chitosan/expanded graphite (CeO 2 /CS/EG) was prepared by hydrothermal synthesis and used for the heterogeneous catalytic ozonation of 4-chlorophenol (4-CP) in wastewater. The catalysts were characterized by XRD, SEM, EDS, BET, XPS and FT-IR. In order to study the catalytic activity of CeO 2 /CS/EG, the catalytic performance of CeO 2 /CS/EG/O 3 system was compared with other reaction systems, and the effects of catalyst dosage, pH, initial 4-CP concentration, O 3 concentration and co-existing ions on the degradation of 4-CP in this system were investigated. The results showed that CeO 2 /CS/EG/O 3 system showed high catalytic activity for 4-CP degradation. Under the optimal conditions (pH > 6.5, catalyst dosage 1.0 g L –1 , initial concentration of 4-CP 100 mg L –1 , ozone concentration 2.5 mg L –1 , reaction time 30 min), the removal rate and mineralization rate of 4-CP reached 99.4% and 70.2%, respectively. This degradation process conformed to first-order reaction kinetics. After five consecutive catalytic cycles, the removal rate of 4-CP was still above 97%, showing the excellent stability and reusability of CeO 2 /CS/EG. The ·OH was identified as the main reactive species causing 4-CP degradation through free radical scavenging experiments. According to the main intermediates measured by the HPLC-MS technique, five possible degradation processes of 4-CP catalytic ozonation were deduced. Graphical abstract CeO 2 /chitosan/expanded graphite (CeO 2 /CS/EG) were prepared by hydrothermal synthesis and used for heterogeneous catalytic ozonation of 4-chlorophenol (4-CP) in wastewater. The results showed that the removal efficiency of 4-CP and total organic carbon (TOC, a key parameter representing the total carbon content in organic compounds that indicates mineralization degree) reached 99.4 and 70.2% under optimal conditions. Besides, OH ⋅ was identified as the main substance causing 4-CP degradation.
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高影响因子
Antioxidants
·
2025
·Vol. 14
·期 6
·698
·
IF 6.6
Ziyun Hu,Yuxin Li,Di Xu,Huihui Meng,Wenya Liu,Qian Xu,Benxing Yao,Junsong Wang
Ferroptosis, an iron-dependent form of regulated cell death characterized by lipid peroxidation, plays a crucial role in acetaminophen (APAP)-induced hepatotoxicity. While 4-octyl itaconate (4-OI) demonstrates protective effects against APAP toxicity, its molecular mechanisms remain to be fully elucidated. Through an innovative integration of untargeted metabolomics and pathway analysis, we unveil a novel dual mechanism by which 4-OI prevents APAP-induced ferroptosis. We discovered that 4-OI stabilizes SLC7A11 through OTUB1-mediated deubiquitination, thereby restoring cystine import and glutathione (GSH) synthesis. In addition, 4-OI activates the Nrf2 pathway, orchestrating a comprehensive antioxidant response by upregulating the key proteins involved in both glutathione metabolism and iron homeostasis, including GPX4, FTH1, FTL1, and FPN1. This coordinated action effectively prevents the accumulation of toxic iron and lipid peroxides. Our findings not only elucidate the protective mechanisms of 4-OI but also establish it as a promising therapeutic candidate for ferroptosis-related diseases through its unique ability to simultaneously modulate the SLC7A11-GPX4 antioxidant axis and iron homeostasis.
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PubMed
高影响因子
PLANT SCIENCE
·
2015
·
IF 3.607
Chao Huang,Qing-Bo Yu,Xin-Bo Yuan,Zi-Ran Li,Jing Wang,Lin-Shan Ye,Ling Xu,Zhong-Nan Yang
The fructokinase-like protein2 (FLN2) is a component of the PEP complex. FLN2 knockout mutants displayed a delayed greening phenotype on sucrose-containing medium. Our previous work indicated that partial PEP activity is essential for its greening phenotype. In this study, we further report that sufficient Rubisco accumulation is critical for fln2-4 greening. Sugar serves many important functions, such as an energy source and signaling molecule. Through pharmacological experiments using a sugar analog and sugar signaling inhibitor, we demonstrate that sugar serves as energy to support the fln2-4 greening. Seed-reserve and photosynthetic CO 2 -fixation are the primary energy sources for early seedling growth . No obvious differences were observed in the seed-reserve of the wild-type and fln2-4 by comparing their seed size and dark-germination, indicating that the defective carbon fixation may account for the energy deficit in fln2-4 during its early seedling growth. The Rubisco content was low in fln2-4 , but it rapidly accumulated during the greening of fln2-4 . Expression of a nuclear-encoded rbcL gene facilitates Rubisco accumulation and partially complements the mutant defects. These results suggest that the Rubisco accumulation is critical for fln2-4 greening. In summary, the rapid Rubisco accumulation that depends on sufficient PEP activity is important for normal seedling growth.
研究领域:
植物学
·
分子生物学
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高影响因子
MACROMOLECULAR RAPID COMMUNICATIONS
·
2025
·
IF 4.3
Ying Zhao,Min Wang,Guangming Liao,Yezhen Chen,Yukun Hu,Longyu Tian,Zaijun Lu
With the rapid development of communication technologies, there is an urgent need for materials that simultaneously possess excellent dielectric properties and high thermal stability to ensure efficient signal transmission. In this study, a molecular-level microphase structure modulation strategy is proposed, in which vinyl-functionalized calix[4]arene-modified polysulfone oligomers are used to prepare a series of novel polysulfone-based crosslinked networks (VPSU-VC4As). This method demonstrates remarkable efficiency in enhancing the thermal stability and dielectric properties of the materials. After incorporating 4-tert-Butylcalix[4]arene, the glass transition temperature (T g ) of the thermosets increases from 193°C to 231°C, with T d5 exceeding 350°C and an increased char yield. Meanwhile, the dielectric constant (D k ) and dielectric loss (D f ) of the thermosets are significantly reduced (D k = 2.61 and D f = 4.6 × 10 −3 at 1 GHz). Studies reveal that this improvement is attributed to the nanoporous structure of VC4A and the presence of bulky tert-butyl groups, which increase the free volume of the polymer, reduce its density, and enhance hydrophobicity. The material also exhibits a dielectric breakdown strength of 6.97–7.77 kV/mm and a tensile strength of 27–64 MPa. This work not only confirms the unique advantages of calix[4]arene in developing low-k materials but also further optimizes the dielectric properties of polysulfone through molecular design, providing a new strategy for the development of low-dielectric materials.
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高影响因子
Pathogens
·
2026
·Vol. 15
·期 6
·567
·
IF 3.8
Zixiang Wang,Qianwen Deng,Ziyu Huang,Zixing Lin,Haohui Zhu,Janak L. Pathak,Ying Wang,Min Nie
Porphyromonas gingivalis(P. gingivalis) is a primary pathogen in periodontitis, yet its elimination is limited by complex anatomical structures. Photodynamic therapy (PDT) is a promising adjunct, but its antimicrobial efficacy is compromised in the acidic microenvironment induced byP. gingivalis. Given that 2′,4′,5′,7′-tetraiodofluorescein (TIF) exhibits robust and stable photodynamic activity under acidic conditions, this study investigated the antibacterial effect of TIF-mediated PDT (TIF-PDT) againstP. gingivalis.P. gingivalisATCC 33277 was treated with TIF (5, 10, 20, and 40 μM), light (525 nm), or both. Reactive oxygen species (ROS) generation was assessed at pH 4.5 or 7.4. Bacterial viability and membrane integrity were evaluated by colony-forming unit (CFU) assay and LIVE/DEAD staining. CFU assays demonstrated that TIF-PDT groups achieved an approximately 4-log reduction in bacterial viability compared to the DEMI, Light, and TIF groups, with no dark cytotoxicity and light-alone effects. LIVE/DEAD staining revealed bright yellow fluorescence in the TIF-PDT (40 μM), indicating membrane damage and significantly lower survival rates than controls. TIF-PDT at 10, 20, and 40 μM produced ROS under both neutral and acidic conditions, exhibited low dark cytotoxicity, and demonstrated potent antibacterial activity againstP. gingivalisin vitro, suggesting its potential as an acid-tolerant photosensitizer for periodontitis adjunctive therapy.
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PubMed
高影响因子
Energy Storage Materials
·
2019
·
IF 0
Jianwei Zhang,Shuanjin Wang,Dongmei Han,Min Xiao,Luyi Sun,Yuezhong Meng
A novel single ion conducting polymer electrolyte is synthesized via a facile and efficient one-step ultraviolet initiated thiol-ene click reaction. The monomers of lithium (4-styrenesulfonyl) (trifluoromethanesulfonyl) imide, pentaerythritol tetrakis (2-mercaptoacetate) and pentaerythritol tetraacrylate are polymerized to be a crosslinked network structured polymer within a polypropylene nonwoven fabric supporting membrane by a photo-initiated thiol-ene click reaction. Upon solvent soaking, the obtained single ion conducting polymer electrolyte exhibits high ionic conductivity (0.84 mS cm −1 at room temperature), very high lithium ion transference number of 0.93, wide electrochemical window up to 5.2 V (vs. Li + /Li) and well compatibility with lithium metal anode . The corresponding LiFePO 4 /Li cell assembled with the prepared polymer electrolyte shows excellent rate capability and prominent cycling performance with the capacity retention rate of 83% after 400 cycles at 1 C. Therefore, the synthesized single ion conducting polymer electrolyte owns great potential for practical application in lithium ion batteries .
研究领域:
材料科学
·
电化学
·
储能技术
·
聚合物化学
·
锂离子电池
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危险品化学品经营许可证（带存储）