ULTRASONICS SONOCHEMISTRY
·
2024
·
IF 8.7
Baowei Yang,Xiandong Zhai,Runzhe Mei,Pu Wang,Yicheng Mei
A convenient and efficient method for undergraduate student experiments involves the one-pot synthesis of phenytoin from benzoin. This method utilized ultrasonic irradiation in the presence of basic catalyst at room temperature and atmospheric pressure, resulting in shortened reaction times, good yields, and excellent reproducibility. By employing a low-cost ultrasonic cleaner for ultrasonic irradiation in student experiments, the need for expensive equipment investment during the teaching process can be minimized. Consequently, this approach is suitable for widespread promotion and application in undergraduate education.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SENSORS
·
2024
·Vol. 24
·期 13
·4264
·
IF 3.4
Xu-Fan Wang,Yi-Fan Duan,Yue-Qian Zhu,Zi-Jing Liu,Yu-Chen Wu,Tian-Hao Liu,Ling Zhang,Jian-Feng Wei,Guo-Chang Liu
The properties of nanopipettes largely rely on the materials introduced onto their inner walls, which allow for a vast extension of their sensing capabilities. The challenge of simultaneously enhancing the sensitivity and selectivity of nanopipettes for pH sensing remains, hindering their practical applications. Herein, we report insulin-modified nanopipettes with excellent pH response performances, which were prepared by introducing insulin onto their inner walls via a two-step reaction involving silanization and amidation. The pH response intensity based on ion current rectification was significantly enhanced by approximately 4.29 times when utilizing insulin-modified nanopipettes compared with bare ones, demonstrating a linear response within the pH range of 2.50 to 7.80. In addition, insulin-modified nanopipettes featured good reversibility and selectivity. The modification processes were monitored using the I-V curves, and the relevant mechanisms were discussed. The effects of solution pH and insulin concentration on the modification results were investigated to achieve optimal insulin introduction. This study showed that the pH response behavior of nanopipettes can be greatly improved by introducing versatile molecules onto the inner walls, thereby contributing to the development and utilization of pH-responsive nanopipettes.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
EUROPEAN POLYMER JOURNAL
·
2024
·
IF 5.8
Sheng Ding,Shaoqin He,Lian Shen,Qingliang Yang,Gensheng Yang
Gelatin methacryloyl (GelMA) hydrogels have become a key biomaterial in various biomedical fields, such as tissue regeneration engineering and drug delivery, due to their exceptional biocompatibility and customizable physical and chemical characteristics. The resemblance of GelMA to the extracellular matrix and its ability to be cured with light make it a popular choice for researchers. This research delves into how the material properties of GelMA hydrogels, specifically the density of the molecular network (DMN), impact their performance in different applications. By preparing GelMA hydrogels with different degrees of substitution (DS) and concentrations, and utilizing these attributes as key measurable parameters for determining DMN, we conducted a comprehensive evaluation of properties relevant to biological applications. We also suggest strategies for optimizing these properties. Through the application of the DMN theory, we show that precise control over material properties allows for tailored customization of GelMA hydrogels for specific tissue engineering and drug delivery purposes. This study offers valuable insights into the optimization of GelMA hydrogel properties to advance the field of tissue engineering and improve customization of cellular microenvironments.
✓ 已验证
产品关联
DOI
高影响因子
ADVANCED MATERIALS
·
2025
·
IF 26.8
Feiyan Gao,Xinlong Liu,Zhongyi Ma,Mei Tang,Zhongjie Tang,Jin Wu,Min Luo,Yaqin Tang,Xiaoyou Wang,Bochu Wang,Betty Y.S. Kim,Zhaogang Yang,Wen Jiang,Peng Tang,Chong Li
The perioperative period is crucial for determining postoperative tumor recurrence and metastasis. Various factors in postoperative lesions can diminish the therapeutic effect of conventional chemoradiotherapy, while emerging immunotherapy is restricted. The combination use of inflammatory inhibitors during treatment is also controversial. Here, a modular microneedle prepared from engineered keratin proteins is reported, which spatially and temporally differentiates the microenvironment of immune cell activation required for immunotherapy from that of wound healing. The recombinant keratin-84-T-based needle root layer, mainly retained in the epidermis, facilitated dendritic cell recruitment to achieve maximum antigen presentation of loaded vaccines. Meanwhile, the recombinant keratin-81-1Aα-based needle tip layer, located within the dermis, rapidly mitigated inflammatory responses while promoting tissue repair and regeneration. Unlike simply mixing immunotherapy and wound treatment, this spatiotemporal segmentation approach maximized the efficacy of immune therapeutics while promoting wound healing, making it suitable for application throughout the perioperative period.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry C
·
2024
·
IF 5.7
Siyuan Li,Xianglin Zhang,Yanfei Yang,Xin Li,Hongbo Xu,Juyan Zhao,Lorenzo Pattelli,Lei Pan,Jiupeng Zhao,Yao Li
Due to the extreme reflectivity requirements of radiative cooling coatings, these materials often employ ceramic nanoparticles such as TiO2 due to their high refractive index and scattering efficiency. However, the bandgap of TiO2 (3.2 eV) is lower than the energy of the most energetic solar light, leading to significant absorption in the UV range (0.25–0.4 μm) and subsequent oxidation aging and yellowing of particles and/or organic binders. To overcome the conflict between high reflective efficiency and UV durability, formulations using high-bandgap materials can be used despite their lower refractive index. In this work, we describe an optimized PRC-Al2O3 coating by adjusting the ratio of low refractive index alumina particles to sodium methylsilicate adhesive. The PRC-Al2O3 exhibits a high solar reflectance above 0.96 and a high mid-infrared emissivity of 0.91, enabling it to achieve a maximum theoretical cooling power of 109 W m−2. Following continuous UV irradiation with a power of 0.7 kW m−2 for 72 hours, only a marginal 0.2% decline in solar reflectance compared to the unaged coatings. The resulting anti-aging cooling paint is scalable and can be spray-coated onto outdoor structures and containers, providing durable radiative cooling towards real-world applications.
✓ 已验证
产品关联
DOI
高影响因子
Materials Today Bio
·
2024
·
IF 8.7
Yibiao Wang,Xiaomei Fu,Yang Zhu,Mingjing Lin,Renduan Cai,Yang Zhu,Tiantian Wu
Intratumor bacteria, which are involved with complex tumor development mechanisms, can compromise the therapeutic efficiencies of cancer chemotherapeutics. Therefore, the development of anti-tumor agents targeting intratumor bacteria is crucial in overcoming the drug inactivation induced by bacteria colonization. In this study, a double-bundle DNA tetrahedron-based nanocarrier is developed for intratumor bacteria-targeted berberine (Ber) delivery. The combination of aptamer modification and high drug loading efficacy endow the DNA nanocarrier TA@B with enhanced delivery performance in anti-tumor therapy without obvious systemic toxicity. The loaded natural isoquinoline alkaloid Ber exhibits enhanced antimicrobial, anticancer, and immune microenvironment regulation effects, ultimately leading to efficient inhibition of tumor proliferation. This intratumor bacteria-targeted DNA nanoplatform provides a promising strategy in intervening the bacteria-related microenvironment and facilitating tumor therapy.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Advanced Optical Materials
·
2024
·
IF 8
Yaoguo Shen,Wanrui Niu,Yingjie Luo,Yingwu Zhou,Xiaoling Xue,Liqin Liu
Organic planar groups have recently been used to construct nonlinear optical materials because of their large hyperpolarizability, and then most of the products have birefringence which is unfavorable to phase matching. Here, a new organic–inorganic hybrid nonlinear optical crystal (C 8 H 6 BrN 2 O)NO 3 is synthesized by combining the π-conjugated organic [C 8 H 6 BrN₂O] + cation and inorganic [NO 3 ] − anion as the fundamental building blocks. Surprisingly, it not only shows a large second-harmonic generation response of 3.8 times that of the commercial K 2 HPO 4 crystals, but also has a moderate birefringence of 0.08 at 550 nm. Furthermore, it demonstrates high thermal stability up to 220 °C despite its hybrid material characteristics. Single crystal structure analysis and theoretical calculations confirm that the specific arrangement of NLO-active [C 8 H 6 BrN₂O] + groups with halogen branch chains and strong hydrogen bonding between two π-conjugated groups leads to moderate birefringence and large frequency-doubling effect. These findings provide a method to explore hybrid nonlinear optical crystals.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF LOSS PREVENTION IN THE PROCESS INDUSTRIES
·
2025
·
IF 4.2
Yueshuang Xia,Wenling Guan,Chengjie Dong,Yutong Wang,Chenxiang Zhang,Weijia Tian
This study aims to improve the explosion suppression performance of bicarbonate powders (KHCO₃ and NaHCO₃) against combustible dust and enhance their anti-caking properties by loading bicarbonate onto the surface of 4A zeolite. Using wet impregnation and evaporative crystallization, KHCO₃ and NaHCO₃ particles were successfully attached to the tetrahedral structure of 4A zeolite, resulting in composite dust explosion inhibitors, Zeolite-KHCO₃ and Zeolite-NaHCO₃, with large specific surface areas. The inhibition efficiencies of bicarbonate and 4A zeolite-loaded bicarbonate on wheat starch explosions were tested using a 150 cm Hartmann tube. The anti-caking properties of the composite were also evaluated under high humidity conditions. Results showed that Zeolite-KHCO₃ exhibited enhanced explosion suppression efficiency compared to KHCO₃, with a minimum complete inerting ratio (MIR) of 0.05, while Zeolite-NaHCO₃ exhibited an MIR of 0.12, consistent with NaHCO₃. The accelerated caking tests revealed that in contrast to KHCO₃ and NaHCO₃, Zeolite-KHCO₃ and Zeolite-NaHCO₃ exhibited superior anti-caking properties due to the drying effect of zeolite, with a caking rate of less than 0.1. These findings indicate that 4A zeolite-loaded bicarbonates can drastically reduce the caking tendency of bicarbonate while maintaining or enhancing its explosion suppression efficiency.
✓ 已验证
产品关联
DOI
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2024
·
IF 4.3
Ying Zhao,Xiao-jia Li,Ji-wen Chen
Raman spectroscopy is a powerful analytical method, but when the composition of the test sample is intricate, the original spectral data may contain noise and fluorescence background interference, making it more difficult to extract Raman spectral information from the original spectra. Especially the fluorescence background signal, which is typically several orders of magnitude stronger than the Raman signal, can even overwhelm or obscure the Raman signals, thereby impeding the qualitative or quantitative analysis of the Raman spectra. One effective method for removing the fluorescence background is shift excitation Raman differential spectroscopy (SERDS), which typically involves measuring two raw Raman spectra using slightly different excitation wavelengths, combined with reconstruction algorithms, to obtain Raman spectra free from fluorescence interference. For this purpose, a reconstruction method based on Tikhonov regularized least squares (TRLS) was developed in this study, which mitigated the oscillations caused by the direct unconstrained least squares (DULS) reconstruction method. The method was verified and optimized using four groups of artificial datasets with different characteristics. By selecting an appropriate value for parameter α , the relative standard deviation (RSD) of the reconstructed datasets was lower than that of the artificial datasets in most cases. Additionally, we evaluated the performance of the TRLS reconstruction algorithm based on a quantitative model of real Raman spectral datasets, assessing the algorithm’s performance from three perspectives: the root mean square error ( RMSE ), the correlation coefficient (R), and the ratio of prediction to deviation (RPD). The quantitative results indicate that using the TRLS method for reconstruction enhances both prediction accuracy and practicality. In summary, findings from both simulated data and actual experiments demonstrate that the TRLS-based reconstruction method substantially improves the stability and reliability of differential Raman spectra reconstruction.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ChemNanoMat
·
2024
·Vol. 10
·期 12
·e202400157
·
IF 2.6
Guohua Pan,Hanxiao Bao,Jinguo Zhang,Jue Hou,Jun Zhou,Hongzhen Bai,Guping Tang
Manganese dioxide (MnO 2 ) nanoparticles are increasingly recognized for their potential in biomedical applications, particularly in the realm of hypoxic cancer therapy, due to their unique physicochemical characteristics. This investigation introduces a novel, template-free synthesis strategy. The reducing groups inherent in bovine serum albumin (BSA) facilitate a redox reaction with potassium permanganate (KMnO 4 ), while the abundance of functional groups in BSA is instrumental in the formation of MnO 2 . The transmission electron microscopy (TEM) analysis has characterized the synthesized MnO 2 nanoparticles, termed BM NPs, as spherical particles with a mean diameter of 210 nm and zeta potential of −40.1 mV measured by dynamic light scattering (DLS). The Fourier transform infrared (FT-IR) spectrum of BM NPs exhibits the characteristic peak of MnO 2 at 1113 cm −1 and 620 cm −1 . Furthermore, the elemental composition of BM NPs has been ascertained through energy-dispersive X-ray (EDX) elemental mapping analysis. Though concentration of BM NPs up to 200 μg/mL, the survival rate of 4T1 cells remained approximately 75 %. Given that BM NPs at a concentration of 100 μg/mL significantly alleviate cellular hypoxia, the high oxygen-generating capacity of these nanoparticles is proved, suggesting their suitability as a drug delivery system, especially in the context of hypoxic tumor microenvironments.
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Polymer Materials
·
2024
·
IF 4.4
Xiaoyan Song,Siyuan Yu,Junxia Deng,Jia Liu,Jinfeng Xing
The ideal hemostatic dressing should not only achieve the effect of hemostasis but also maintain a suitable moist environment and sufficient physical and mechanical strength and avoid secondary injury to the wound. Here, a stretchable, adhesive, and antibacterial hydrogel (SAQH) for wound hemostasis is facilely prepared by photopolymerization under green LED irradiation, in which acrylamide (AAM) and methacryloylethylsulfobetaine (SBMA) are used as the skeleton and quaternized carboxymethyl chitosan (QCCS) is used as the procoagulant component. The introduction of the macromolecular cross-linking agent methacryloyl hyaluronic acid (HA-GMA) enhances biocompatibility and avoids the addition of small molecular toxic cross-linking agents. The introduction of inorganic nanoparticle hydroxyapatite (HAP) into the hydrogel system not only improves the mechanical properties of the polymer network but also releases calcium ions from HAP to achieve a good coagulation-promoting effect. SAQH hydrogels have excellent mechanical properties (the maximum stress can reach 237 kPa), good adaptability, sufficient tissue adhesion, and effective antibacterial properties. In the mouse liver injury model, hydrogels can adhere to the bleeding site to reduce blood loss, and they will not cause secondary bleeding when removed. This research develops a potential hemostatic hydrogel with broad applicable prospects.
✓ 已验证
产品关联
DOI
高影响因子
PROGRESS IN ORGANIC COATINGS
·
2025
·
IF 7.3
Zhaowen Tian,Ruiyu Ma,Yiqing Chen,Suning Li,Hongwei Zhao,Yanqiu Zhang,Qingdong Li,Xueyuan Zhang,Baigang An
Amphiphobic coatings have great potential in anti-corrosion coatings, oil-water separation, and so on. These are usually achieved by building multistage micron/nanometer roughness or re-entrant curvature surface through low surface energy materials. However, the complexity and mechanical brittleness of amphiphobic coatings derived from surface micro/nano structures have long posed challenges to their practical application. Here, we constructed a hierarchical structure coating with amphiphobic properties using polydopamine/polyethylenimine (PDE) as a connecting layer between the 1H,1H,2H,2H-perfluorodecyltriethoxysilane (PFDTES)-modified epoxy coating (POS-EP) and the carboxylated carbon nanotube (CNTs-COOH) modified epoxy coating (CNTs-EP) via dip-coating technology. CNTs-COOH addition reduces the porosity defects in the epoxy resin and impart hydrophilicity to the coating, demonstrating excellent underwater oleophobicity (OCA = 134.6°), thereby preventing the POS-EP coating from being eroded by oily organic substances in aqueous environments. PFDTES is employed to enhance the hydrophobicity of the epoxy resin, improving the coating's impermeability and corrosion resistance, with a water contact angle of 127.2° on its smooth surface. Surface morphology and elemental analysis confirm the seamless connection of the hydrophobic and hydrophilic layers facilitated by the PDE transition layer. Consequently, the amphiphobic coating with the hierarchical structure exhibits outstanding anti-corrosion performance. Compared to the epoxy resin coatings, the amphiphobic coating's resistance ( R c ) and low-frequency modulus (|Z| 0.01Hz ) are improved by 2 to 4 orders of magnitude after 60 days of immersion testing in 3.5 wt% NaCl and 18 days of neutral salt spray tests. Even the coating suffered the local damages, the synergistic effects between the amphiphobic interface can still hinder the attacks of corrosion media, and thus continues to supply good anti-corrosion properties. Given its low cost, scalability, and durability, this novel coating is expected to pave new avenues for the construction of various amphiphobic coatings.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）