SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2026
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IF 4.8
Chenchen Wang,Xiaolei Song,Diantao Chen,Junyu Su,Yong Wang,Cheng Huang,Wei Wei
Considering the irreversible nature of Alzheimer's disease (AD), early diagnosis is of great importance for AD treatment. Both β-amyloid (Aβ) and monoamine oxidase B (MAO-B) are potential biomarkers for AD. This study developed a surface-enhanced Raman scattering (SERS) sensor using gold-nanocube (OX-AuNCs) to detect Aβ42 and MAO-B. OX-AuNCs, a type of gold-nanocube with open gaps, achieved a Raman enhancement factor of 8.99 × 10 8 due to numerous hot spots. The specific affinity between Thioflavin T (ThT) and Aβ42 inhibits ThT's intramolecular rotation, reducing its SERS signal. This reduced signal showed a linear correlation with Aβ42 concentrations from 66.70 pM to 0.20 μM, achieving a limit of detection (LOD) at 44.30 pM, while also distinguishing different aggregation levels of Aβ42. Interestingly, SERS intensity of phenethylamine (PEA) also decreased significantly when interacting with MAO-B. A linear relationship was found between the change in PEA intensity and MAO-B concentration (0.01–20.00 μg mL −1 ), yielding an LOD of 5.00 ng mL −1 . The proposed SERS sensor effectively detected two potential AD biomarkers, Aβ42 and MAO-B, in artificial cerebrospinal fluid (ACSF) and human serum with satisfactory recovery rates, respectively. These results show promise for clinical diagnosis and drug screening for AD.
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MICROCHEMICAL JOURNAL
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2026
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IF 5.2
Dengying Long,Min Huang,Mao Jiang,Wei Huang
A dual-mode ratiometric optical strategy is developed for determination of PFOA. • PFOA induces RhB aggregation via hydrophobic interactions, realizing spectral signal regulation. • The sensing strategy does not require any probe preparation process. • Homogeneous intermolecular reactions make the analytical method stable and reliable. Owing to its persistent “forever chemical” nature, perfluorooctanoic acid (PFOA) poses long-term environmental and health risks even under strict regulation, requiring low-cost continuous monitoring. In this work, a dual-mode ratiometric optical strategy was developed for colorimetric and fluorescent detection of PFOA using commercially available rhodamine B without complex synthesis. Under acidic conditions (pH = 1.0), PFOA induces the aggregation of rhodamine B through electrostatic and hydrophobic interactions, leading to the attenuation of monomer signals (UV–Vis absorption peak at 557 nm, fluorescence emission peak at 586 nm) and the enhancement of aggregate signals (UV–vis absorption peak at 593 nm, scattering peak at 557 nm). Accordingly, a dual-mode ratiometric optical sensing platform is constructed for the quantitative detection of PFOA. The limit of detection was 4.6 μM for colorimetry and 3.1 μM for fluorescence. This sensing strategy is not suitable for quantitative analysis of trace PFOA in drinking water due to its sensitivity limitations. However, it may be applicable for monitoring of the discharge of PFOA-containing wastewater from factories and emergency responses to sudden PFOA pollution incidents due to its low cost, stable signal, and ease of on-site operation, offering a practical alternative to complex nanomaterial-based sensors for high-concentration scenarios. Owing to its persistent “forever chemical” nature, perfluorooctanoic acid (PFOA) poses long-term environmental and health risks even under strict regulation, requiring low-cost continuous monitoring. In this work, PFOA induces the aggregation of rhodamine B through hydrophobic interactions under acidic conditions, leading to the attenuation of monomer signals (UV–vis absorption peak at 557 nm, fluorescence emission peak at 586 nm) and the enhancement of aggregate signals (UV–vis absorption peak at 593 nm, scattering peak at 557 nm). Accordingly, a dual-mode ratiometric optical sensing platform is constructed for the quantitative detection of PFOA. Download: Download high-res image (97KB) Download: Download full-size image
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2026
·Vol. 37
·期 3
·229
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IF 3.2
Guo Jing,Zhao Xiaomei,Wang Qi,Wu Rui,Zhu Lexuan,Zhang Xin,Zhang Xinke,Gu Yuke
Morphological engineering is utilized to modify the microstructure and electronic structure of bismuth oxychloride; this led to a remarkable enhancement in photocatalytic performance. In this research, H-BOC nanosheets with concave-pore defects were synthesized via a glycol-mediated solvothermal etching method. Photocatalytic activity was examined using Rhodamine B (RhB, 20 mg·L⁻ 1 ) as the target contaminant under visible-light exposure. H-BOC displayed superior photocatalytic performance within 4 min, achieving a degradation rate of 99% and a reaction rate constant of 0.9643 min –1 , significantly higher than those of T-BOC (53% and 0.1556 min –1 ). The results indicate that the incorporation of concave-pore defects not only improves visible-light absorption and reduces hole migration distance but also enhances charge separation and effectively suppresses the recombination of photogenerated electron–hole pairs. This acceleration in reaction kinetics was further confirmed by trapping experiments and EPR analyses, which reveal that superoxide (•O 2 ⁻) and hydroxyl radicals (•OH) were the dominant reactive species. Furthermore, high-performance liquid chromatography–mass spectrometry (HPLC–MS) and the toxicity estimation software tool (T.E.S.T) were employed to investigate the degradation mechanisms, pathways, and the toxicity of RhB and its intermediates. This study presents a novel approach for designing and developing high-performance photocatalysts.
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APPLIED CATALYSIS B-ENVIRONMENTAL
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2026
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IF 19.7
Jing Zhang,Yixuan Gao,Hongna Li,Sihui Zhan
B–N doping disrupts π-conjugation and localizes electrons in biochar. • B–N sites and carbon vacancies promote axial electron transfer and PMS adsorption. • BN-Cv-Biochar enables highly selective 1 O 2 generation and rapid SMX degradation. • BN-Cv-Biochar/PMS system markedly reduces the phytotoxicity of treated water. Selective activation of peroxymonosulfate (PMS) to produce singlet oxygen ( 1 O 2 ) is desirable for efficient water purification. Graphitized biochar is a promising catalyst, but its extended π-conjugated structure favors in-plane charge delocalization and hinders axial electron transfer, leading to low 1 O 2 selectivity. Herein, we fabricated a boron-nitrogen (B–N) conjugated doped carbon-vacancy biochar (BN-Cv-Biochar) to modulate the local π-electronic system. B–N doping breaks the extended π-conjugation, creating polarized active sites and localized electrons that strengthen axial electron transfer and selective PMS adsorption. The degradation rate constant of sulfamethoxazole (SMX) of BN-Cv-Biochar is 1.68 and 4.45 times higher than that of pristine (Biochar) and nitrogen-doped carbon-vacancy biochar (N-Cv-Biochar), respectively. Experimental and theoretical results reveal that B–N sites coupled with carbon vacancies optimize the electronic environment, reduce the energy barrier for 1 O 2 generation, and preferentially promote 1 O 2 -dominated PMS activation. Product analysis clarifies the SMX degradation pathway, and toxicity assays using radish seedlings confirm the reduced toxicity of treated water. This work provides a novel strategy to tune the π-conjugated structure of biochar for high-performance carbon catalysts in advanced oxidation processes. Download: Download high-res image (201KB) Download: Download full-size image
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INTERNATIONAL IMMUNOPHARMACOLOGY
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2026
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IF 5.6
Yuezhang Sun,Haonan Zou,Aimin Cui,Hao Dong,Abulizi Pawuziya,Pengfei Zhao,Jian Wang,Wai Keung Leung,Qi Wang
Aging is closely associated with the progression of periodontitis, yet the mechanisms link between fibroblast dysfunction and periodontal tissue destruction remains unclear. This study investigates the role of fibroblast activation protein (FAP) in aging-related periodontitis and explores its therapeutic potential. In aging mice, we observed significant fibroblast dysfunction in periodontal tissues, characterized by FAP upregulation ( p < 0.0001). Elevated FAP expression exacerbated periodontal destruction by enhancing collagenase activity and promoting osteoclast differentiation (p < 0.0001). Mechanistically, FAP activation in senescent gingival fibroblasts triggered the nuclear factor kappa B (NF-κB) signaling pathway ( p < 0.01), driving inflammatory bone resorption. Pharmacological inhibition of FAP, both in vitro and in vivo, effectively attenuated periodontal inflammation, suppressed osteoclast activity ( p < 0.0001), and preserved alveolar bone integrity in aging mice ( p < 0.0001). These findings highlight FAP as a critical mediator of aging-related periodontal deterioration and propose FAP-targeted therapy as a novel strategy for mitigating periodontitis in the elderly. This study provides new insights into the interplay between fibroblast senescence, immune regulation, and tissue remodeling in age-related oral inflammatory diseases, offering a promising avenue for therapeutic intervention.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2026
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IF 9.1
Hanlu Wang,Guodong Zhang,Xingming Zhang,Shuisen He,Rujin Zhou,Xingye Zeng,Yanbin Jiang
The morphology and microstructure of zeolite membranes are crucial for improving their separation performance. This can be achieved by creating a thin and uniform seed layer, which can then be intergrown into a continuous and dense membrane. Herein, we show a simple vacuum-filtration method to provide closely packed MFI zeolite crystal seed layers on porous substrates (α-Al 2 O 3 ). Then, a continuous, dense, and twin free MFI zeolite membrane was rapidly prepared based on the pre-set crystal seed layer using the microwave-assisted secondary growth method. XRD confirmed the high crystallinity of the prepared MFI zeolite membranes, with a crystal preferred orientation (CPO) index of 0.91, demonstrating excellent b -axis orientation. In the pervaporation separation experiments of xylene isomers (PX/OX), the as-prepared membrane exhibited superior separation performance at 90 °C and 90 kPa. The permeation flux and separation factor were 1931.8 g m −2 h −1 and 4.74, respectively, which were significantly better than MFI zeolite membranes prepared by traditional hydrothermal methods. Quantum chemical calculations further revealed the screening mechanism, where PX was more likely to diffuse through the MFI channels due to its smaller molecular size and weaker adsorption energy. This work provides new insights for the development of energy-efficient and high-performance xylene isomer separation membrane materials.
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JOURNAL OF SOLID STATE CHEMISTRY
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2026
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IF 3.2
Yaqi Li,Wenda Zhang,Yunzhen Jiang,Yibo Gao,Xiaoyan Yang,Xiaojun Kuang
Twinn-to-shift structure transformation of Ba 8 NiNb 6 O 24 hexagonal perovskite was achieved under high temperature and high pressure. • The high-pressure shifted phase remains stable at ambient pressure from room temperature to 1100 °C. • B-site cation size difference is a key factor governing the critical pressure for the structure transition. • Pressure-driven polymorphism provides a new strategy for structural regulation of hexagonal perovskites. Ba 8 NiNb 6 O 24 , adopting an eight-layer twinned hexagonal perovskite structure, transformed to shifted hexagonal perovskites under high pressure and high temperature. This pressure-induced phase transformation is interpreted by comparison with the phase transformations induced by previously reported chemical substitutions. In the shifted structure, B-site vacancy ordering completely empties the central layers of the face-sharing octahedral trimers. This removes the strong B–B electrostatic repulsion within the FSO units and is the main driving force for the pressure-induced stabilization of the shifted structure. In contrast, the differences in the chemical bonding character of d 0 Nb 5+ , d 0 Ta 5+ , and d 10 Sb 5+ drive the twin-to-shift transformation induced by chemical substitution in Ba 8 MNb x Ta 6− x O 24 and Ba 8 MNb x Sb 6− x O 24 (M = Zn, Co). High pressure induces a twin-to-shift structural transformation in B-site deficient hexagonal perovskite Ba 8 NiNb 6 O 24 , revealing B-site cation size difference as the key factor governing the critical transition pressure. Download: Download high-res image (395KB) Download: Download full-size image
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FISH & SHELLFISH IMMUNOLOGY
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2026
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IF 4.2
Liwen Zhu,Chanchan Lin,Jing Cen,Wa Gao,Yueshuang Ji,Jing Xu,Hao Feng,Zhen Xu,Carolina Tafalla,Jun Zou,Junya Wang
A monoclonal antibody against native grass carp IgM showed cross-reactivity with multiple cyprinid species. • Bacterial and viral infections induced expansion and local aggregation of splenic IgM + B cells in two cyprinid species. • Bacterial and viral infections promoted the proliferation of splenic IgM + B cells in two cyprinid species. Humoral immunity is a central component of host defense in teleost fish, yet the dynamics of IgM + B cells during infection remain poorly understood. In this study, we generated and characterized a monoclonal antibody (mAb) against native IgM protein purified from grass carp ( Ctenopharyngodon idella ) sera. This mAb specifically recognized the recombinant grass carp IgM heavy chain expressed in the HEK293 cells and showed cross-reactivity with IgM molecules from multiple cyprinid species, including rare minnow, zebrafish, black carp, and common carp, but not with IgM from largemouth bass. Flow cytometric analysis showed that IgM + B cells were abundant in the spleen and head kidney of grass carp, accounting for 35.40 ± 3.15% and 27.63 ± 3.97% of total leukocytes, respectively. Using this antibody, we further investigated IgM + B-cell responses in grass carp and rare minnow after infection with Aeromonas hydrophila or grass carp reovirus genotype II. Both bacterial and viral infections significantly enhanced the proliferation and local aggregation of splenic IgM + B cells. Moreover, EdU + proliferating cells were preferentially enriched within localized IgM + B-cell clusters in the spleens of infected fish. Taken together, our work provides a useful antibody tool for studying B-cell responses and reveals that bacterial and viral infections induce proliferation and localized aggregation of splenic IgM + B cells in teleost fish, highlighting infection-induced remodeling of splenic IgM + B-cell responses.
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Catalysts
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2025
·Vol. 15
·期 7
·610
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IF 4
Wei Wang,Jiaqi Liu,Guang Shi,Shiqi Wu,Nan Zhang,Ruixia Yuan
Spherical Cu2O nanoparticles were obtained by reducing copper acetate in N,N-dimethylformamide (DMF) system using glucose as the reducing agent and polyvinylpyrrolidone (PVP) as the surfactant, with which spherical PdCu nanocatalysts were thus synthesized by disproportionation. The catalyst was used for the activation of peroxymonosulfate (PMS) and showed an excellent degradation effect on rhodamine B and methylene blue-contained printing and dyeing wastewater with good stability. Additionally, the surface morphology analysis of the catalyst was carried out by SEM and TEM. The structure was characterized by XRD and FT-IR. The valence state and composition of the catalyst were characterized by XPS. The catalytic performance of the prepared catalysts was investigated with methylene blue and rhodamine B used as target pollutants. The results showed that the catalytic reduction efficiency of PdCu nanocatalyst for the two pollutants could reach 99% at 20 °C, when catalyst concentration was 60 mg/L and PMS concentration was 1.0 g/L and 0.6 g/L, respectively. The degradation efficiency of the catalyst was significantly reduced when Cl−,HCO3−and HA were present in the water. The degradation efficiency was above 90% when the pH was in the range of 5–11. The excellent performance of the PdCu/PMS system in the treatment of RhB-contained wastewater was further confirmed by taking into account of the data of free radical quenching experiment and the results of electron paramagnetic resonance (EPR) experiment. After three cycles, the removal rate of MB and RhB could still be maintained at more than 90%, which proved its excellent recyclability due to its remarkable stability and efficiency.
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International Journal of Applied Ceramic Technology
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2025
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IF 2.3
Yuetong Li,Qiuwan Shen,Tianyun Zhao,Shian Li
A series of B-site-doped copper spinel CuGaBO 4 (B = Co, Fe, Al, Ni) catalysts were synthesized and evaluated for methanol steam reforming (MSR). The surface morphology, elemental composition, and structural properties of the catalysts were characterized using x-ray diffractometer, scanning electron microscopy (SEM), energy dispersive spectroscopy, x-ray photoelectron spectrometer, and Brunner-Emmet-Teller (BET) surface area analysis. The SEM results reveal that the fresh catalysts consist of small particles stacked together, forming a porous structure with a particle size range of approximately 20–50 nm. BET analysis further confirms the presence of an ordered porous structure, which contributes to a higher BET surface area and pore volume. The O 1s spectrum reveals the presence of surface-adsorbed oxygen (O ads ), which helps to enhance catalytic activity and methanol conversion. In addition, it was found that the CuGaFeO 4 catalyst exhibited the highest methanol conversion at 90%, hydrogen production at 6.87 mmol/min/g cat , and the CO selectivity was below 0.37%. After a subsequent 40 h stability test, the methanol conversion was still able to reach 85% and the hydrogen production was around 6 mmol/min/g cat .
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International Journal of Nanomedicine
·
2025
·
IF 6.5
Weiwei Wang,Lei Wang,Qingqing Fan,Jingyan Xu,Yifan Li,Jiale Xu,Bei Zhao,Dan Ge,Longying Xiong,Yanping Wu,Yun Zhu,Min Chen
Background A significant proportion of patients fail to respond adequately to the standard R-CHOP regimen for diffuse large B-cell lymphoma (DLBCL). Rapid proliferation requires energy and the interaction between H+ ions and mitochondria suggests that regulating acid secretion in tumor cells may be a therapeutic strategy for DLBCL. This study constructed a macrophage membrane-coated liposomal formulation (MM-Lipid@Vpz) for the targeted delivery of vonoprazan to combat DLBCL, which enables the evasion of the reticuloendothelial system, ensuring enhanced specificity in tumor targeting.Methods The vonoprazan was delivered by encapsulating liposomes with pre-isolated macrophage membranes, targeted to DLBCL cells and evaluated for changes in cell function. The cellular transcriptome was collected to analyze the mechanism of drug action. An in vivo DLBCL nude mouse subcutaneous tumor model was also established to validate in vitro drug efficacy. In addition, MM-Lipid@Vpz was combined with doxorubicin (Dox) in this study to investigate the effect of action between the two.Results Lipid@Vpz was prepared by mixing lecithin, cholesterol, DSPE-PEG2000 and vonoprazan at a mass ratio of 100:30:1:10 and dissolving them in anhydrous ethanol. After fusing the macrophage membrane with Lipid@Vpz by extrusion, the particle size increased to 135.37 ± 12.55 nm and the zeta potential changed to −20.42 ± 1.37 mV. Compared with Lipid@Vpz, MM-Lipid@Vpz significantly increased the intracellular internalization efficiency of vonoprazan by 4.42 times and increased the tumor accumulation in mice by 60.10%. In addition, MM-Lipid@Vpz induced apoptosis in SU-DHL-8 cells at a rate 1.26 times that of Lipid@Vpz and increased the intracellular reactive oxygen species (ROS) level to 1.18 times that of Lipid@Vpz by disrupting mitochondrial oxidative phosphorylation (OXPHOS) and altering mitochondrial morphology. When combined with existing first-line agents such as Dox, MM-Lipid@Vpz manifested synergistic antitumor effects, further augmenting tumor suppression and potentially mitigating drug resistance.Conclusion Bionic macrophage membrane-encapsulated vonoprazan preparations inhibit DLBCL cellular energy metabolism both in vivo and ex vivo by affecting mitochondrial OXPHOS, which provides data to support the improvement of the prognosis of patients with DLBCL by precise metabolic disruption.
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ENERGY & FUELS
·
2025
·
IF 5.3
Chen Chen,Cengceng Du,Zhenyu Wang,Xin Chen,Yiming Wang,Na Ju,You Fu,Zilong Liu,Mingjie Jia,Shenyin Luo,Guangwen Xu,Junli Xu,Hong-bin Sun
The development of economical and efficient catalysts for the hydrogen evolution reaction (HER) is critical for achieving low-energy water splitting. This study demonstrates that self-supported Cu–Co–B/NF, synthesized via the one-pot NaBH4 reduction, is converted into the active species Cu–Co(OH)2 during the HER process. This in situ conversion was verified through XRD, HRTEM, XPS, and other characterization techniques. This noble-metal free catalyst exhibits exceptional HER performance. It requires overpotentials of only 32 mV and 148 mV to achieve the current densities of 10 mA cm–2 and 500 mA cm–2, respectively, and maintains stability for over 200 h at a current density of 200 mA cm–2. The density functional theory (DFT) calculations reveal that the Co(OH)2 holds the active site, while the introduction of copper optimizes both the hydrogen adsorption free energy (ΔGH*) and the d-band center, thereby enhancing the catalytic activity. More than water electrolysis, an Al–H2O battery employing Cu–Co–B/NF as the positive electrode achieves a high open-circuit voltage (1.29 V) and a maximum power density of 11.17 mW cm–2.
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