JOURNAL OF ALLOYS AND COMPOUNDS
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2024
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IF 5.8
Sen Qiao,Chaoming Rao,Haiyan Chen,Min Xiong,Qiuhua Xu,Suqin Ci
The construction of crystalline-amorphous coupling structure is one of the effective strategies to enhance the performance of oxygen evolution reaction (OER) and urea oxidation reaction (UOR). Herein, NiFe-LDH/NiMoO 4 /NF with high oxygen evolution and urea oxidation performance was successfully prepared by electrodeposition of amorphous substances on the crystalline precursor of hydrothermal synthesis. Remarkably, the NiFe-LDH/NiMoO 4 /NF displays exceptional electrocatalytic performance for OER and UOR, with a potential of only 1.57 V vs. RHE at 100 mA cm −2 and the Tafel slope of 54.4 mV dec −1 for OER, high UOR activity with a potential of 1.45 mV@100 mA cm −2 and the Tafel slope of 20.4 mV dec −1 in 1.0 M KOH with 0.33 M urea solution. In a hybrid acid-base electrolysis system for urea oxidation-assisted H 2 production using NiFe-LDH/NiMoO 4 /NF as the anode electrode and Pt/C/NF as the cathode electrode, the process requires a cell voltage of only 0.55 V vs . RHE at 10 mA cm −2 . Moreover, this hybrid acid/base system demonstrates stable operation for 110 h with minimal attenuation at a current density of 100 mA cm −2 . These results indicate a facile strategy for the design of electrodes with crystalline-amorphous coupling structures for energy conversion.
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Journal of Water Process Engineering
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2024
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IF 6.3
Jiangnan Li,Xiaoyu Ji,Deliang Zhu,Hongyan Tang
In water treatment, chlorination degradation and membrane fouling inevitably induce severe damage to polyamide nanofiltration (PA-NF) membranes, significantly shortening membrane service life. In this study, zwitterionic polyester layer without chlorination active site was constructed on the polyamide membranes by interfacial polymerization of 4,6-dihydroxypyrimidine (DHP) with 1,3,5-benzenetricarbonyl trichloride (TMC) and subsequent quaternization. Therefore, desalination NF membranes with enhanced chlorine resistance and antifouling performance were fabricated using a facile approach. ATR-FTIR and XPS characterizations confirmed the existence of zwitterionic polyester layer. After chlorination at 12,000 ppm·h under three pH conditions (4.0, 7.0, and 10.0), the salt rejection of zwitterionic polyester NF membrane (QPE-NF membrane) was all higher than 97.50 %. The chlorination treatment did not significantly alter the chemical structures and surface morphologies of QPE-NF membranes, as indicated by ATR-FTIR and SEM analyses. The flux recovery ratio (FRR) of QPE-NF membranes for bovine serum albumin (BSA) was 90.75 %, indicating good antifouling performance. The QPE-NF membranes possessed enhanced chlorine resistance and antifouling properties as well as improved desalination performance. This was ascribed to the absence of chlorination active sites in the zwitterionic polyester layer, serving as a barrier to chlorine attack. Meanwhile, the zwitterions formed an additional hydration layer by electrostatic interactions, which further enhanced surface hydrophilicity. This study presented a facile approach to fabricate polyester desalination NF membranes with chlorine resistance and antifouling properties.
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JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
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2024
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IF 3.3
Jun-qi Zhan,Jun-xin Wu,Jing-jing Fu,Gao-shang Li,Fang Wu,Yue-wen Chen
BACKGROUND Giant salamander protein peptide is a peptide with rich functional properties. Giant salamander protein peptide KGEYNK (KK-6) is a peptide with both antioxidant and anti-inflammatory properties. The antioxidant and anti-inflammatory mechanisms of KK-6 are still unclear. When we studied the functional mechanism of KK-6, we found that the antioxidant property of KK-6 has a synergistic and promoting effect on anti-inflammatory properties. RESULTS KK-6 enhances cellular resistance to LPS via the MAPK/NF-κB signaling pathway, leading to increased levels of inflammatory factors: interleukin-1β (764.81 ng mL −1 ), interleukin-6 (1.06 ng mL −1 ) and tumor necrosis factor-α (4440.45 ng mL −1 ). KK-6 demonstrates potent antioxidant properties by activating the Nrf2 signaling pathway, resulting in elevated levels of antioxidant enzymes (glutathione peroxidase: 0.03 μg mL −1 ; superoxide dismutase: 0.589 μg mL −1 ) and a reduction in the concentration of the oxidative product malondialdehyde (967.05 μg mL −1 ). CONCLUSION Our findings highlight the great potential of KK-6, a peptide extracted from giant salamander protein, as a remedy for intestinal inflammation. Through its dual role as an antioxidant and anti-inflammatory agent, KK-6 offers a promising avenue for alleviating inflammation-related damage and oxidative stress. This study lays the foundation for further exploration of giant salamander products and highlights their importance in health and novel food development. © 2024 Society of Chemical Industry.
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American Journal of Translational Research
·
2020
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IF 3.375
Xiugui Wei,Hongyuan Wang,Xuemei Sun,Xiukun Huang,Wanpeng Xu,Yingqin Liang,Lin Liu,Siyan Mo,Xing Lin,Jun Lin
The purpose of this study is to evaluate the protective effect of 4-hydroxy-2(3H)-benzoxazolone from Acanthus ilicifolius (HBAI) on acute liver injury induced by acetaminophen in mice and its mechanism. Mice were continuously treated with HBAI (200, 100, 50 mg/kg) once a day for 10 days. After that, the mice were fasted for 8 hours, followed by intraperitoneal injection of acetaminophen (300 mg/kg). The results showed that HBAI pretreatment significantly reduced acetaminophen-induced liver tissue congestion, hepatocyte apoptosis and necrosis, and inflammatory cell infiltration. HBAI could effectively reduce the levels of serum alanine aminotransferase, aspartate aminotransferase, total bilirubin, reactive oxygen species and malondialdehyde. Interestingly, the activities of liver catalase, superoxide dismutase, glutathione and glutathione reductase were enhanced by HBAI pretreatment. Moreover, HBAI pretreatment alleviated acetaminophen-induced hepatocyte apoptosis by regulating the expression of Bcl-2 family proteins and the mitochondrial function. Further study showed that HBAI pretreatment effectively promoted the expression of Nrf2 and its signal downstream HO-1, NQO1, GCLC, GCLM, and MGST-1, suggesting the activation of the Nrf2/HO-1 signaling pathway. Meanwhile, HBAI attenuated the phosphorylation of NF-κBp65, IKKα/β, and IκBα, as well as the expression of NF-κBp50, which indicated that HBAI blocked the signal transduction of NF-κB pathway. In conclusion, HBAI protects against acetaminophen-induced acute liver injury by inhibiting the NF-κB and activating Nrf2/HO-1 signaling pathways.
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JOURNAL OF ETHNOPHARMACOLOGY
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2025
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IF 5.4
Yan Zhou,Tian Wen,Shan Yang,Binru Meng,Jing Wei,Jing Zhang,Lun Wang,Xiaofei Shen
Ethnopharmacological relevance Cichorium intybus is a traditional medicinal herb for hepatitis treatment in China and Europe. Sesquiterpene lactones are the main active ingredients in C. intybus . However, their structure-activity relationship (SAR) and molecular mechanisms of anti-inflammatory and hepatoprotective effects require further elucidation. Aim of the study To identify new sesquiterpene lactones from C. intybus , and further evaluate their anti-inflammatory effects, SAR, and mechanisms of anti-inflammatory and hepatoprotective properties. Methods Identification of sesquiterpene lactones from C. intybus using chromatographic fractionation, NMR, and mass spectrometry. The repression of inflammation was evaluated in RAW264.7 macrophages incubated with LPS. Western blotting was employed to investigate the anti-inflammatory mechanisms. The hepatoprotective effect was measured in LPS/D-galactosamine (D-GalN)-induced acute hepatitis in mice. Results We identified 3 new sesquiterpene lactones and 15 known analogues from C. intybus . SAR analysis showed that the α-methylene-γ-lactone moiety was essential for their anti-inflammatory properties. Furthermore, 8-deoxylactucin was identified as the most potent anti-inflammatory component in LPS-induced RAW264.7 macrophages by reduction of nitric oxide production via inhibiting iNOS expression, and suppression of IL-1β, IL-6, and TNF-α expression. Mechanistically, 8-deoxylactucin not only blocked LPS-induced IKKα/β phosphorylation, IκBα phosphorylation and degradation, and NF-κB nuclear accumulation, but also enhanced NRF2 expression and nuclear translocation, HO-1 and NQO1 expression, and reduced ROS generation in vitro . In vivo , 8-deoxylactucin mitigated LPS/D-GalN-induced acute hepatitis, which manifested as reduction in inflammatory infiltration, live injury, serum levels of AST and ALT, and production of pro-inflammatory cytokines and 4-hydroxynonenal. Conclusion 8-Deoxylactucin, the sesquiterpene lactone isolated from C. intybus , exerted anti-inflammatory and hepatoprotective effects by blocking NF-κB activation and enhancing NRF2 activation.
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DESALINATION
·
2024
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IF 8.3
Xinyuan Yi,Shumin Yang,Xin He,Zhiwei Wang,Min Rui,Yulin Tang
The addition of scale inhibitors is one of the effective methods to alleviate membrane fouling on nanofiltration (NF). In this study, two effective poly-epoxysuccinic acid-based scale inhibitors, namely, valine-poly-epoxysuccinic acid (Val-PESA) and histidine-poly-epoxysuccinic acid (His-PESA), were synthesized by grafting copolymerization . Results showed that Val-PESA and His-PESA could significantly retard the formation of CaSO 4 scaling and effectively mitigate membrane fouling . His-PESA had a better scale inhibition effect on CaSO 4 compared to Val-PESA. The inhibition efficiency was maintained at 96.0 % after 20 h operation for Val-PESA and His-PESA. In addition, the inhibition performance of Val-PESA and His-PESA in the batch test was basically the same as in the NF process. Combining the results of the inhibition tests and the relevant characterizations by scanning electron microscopy, X-ray photoelectron spectroscopy, and X-ray diffraction, the scale inhibition mechanism was mainly ascribed to enhanced chelation, dispersion and lattice distortion effect. This study sheds light on the designing of novel and efficient scale inhibitors for NF processes.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2025
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IF 6.2
Ziwei Gao,Jinyang Ren,Chang Ke,Deyu Yang,Kexing Wang,Qi Wang,Xinyan Chen,Cong Chang,Zhenpeng Qiu,Chao Cai,Zhongshi Zhou,Yan Meng
An inulin-type fructan (CPS0.2B) from an edible traditional Chinese medicine (TCM) named Codonopsis pilosula was found to exhibit immunological enhancement both in vitro and in vivo. However, the commercial inulin, which has an almost identical molecular weight and monosaccharide composition as CPS0.2B, exhibited almost no biological activity in vitro. We found that this difference was attributed to the smaller particle size of CPS0.2B, facilitating enhanced cellular uptake through endocytosis. Further investigation into the corresponding immune-enhancing effect using THP-1 macrophage cells indicated that CPS0.2B can effectively activate the MAPK and NF-κB signaling pathways by stimulating the p65 protein both inside and outside the cell membrane. Additionally, in vivo strudy further confirmed CPS0.2B had an immune-enhancing effect on CTX-induced immune suppression model in mice. This study confirmed the immune-enhancing activity and related mechanisms of the inulin-type fructan CPS0.2B and, more importantly, demonstrated the significant role of the advanced structure of the polysaccharides in immunomodulatory effects.
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DESALINATION
·
2025
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IF 9.8
Hailin Chang,Shilei Fu,Ziao Zhang,Yating Hu,Zijian Cui,Jun Ma,Kexin Hou,Xiaobin Tang,Guibai Li,Heng Liang
Nanofiltration (NF) membranes with efficient selectivity are critical for addressing water source pollution from toxic heavy metals and emerging micropollutants. Herein, we engineered a polyamide (PA) NF membrane with ambidextrous selectivity by leveraging the concentration-driven effect of piperazine (PIP) during interfacial polymerization (IP). This PIP concentration-driven effect was verified by modulating the PIP concentration gradient from low to high, which enhanced IP efficiency via both an intensified alkaline reaction environment and concentration-driven diffusion. The optimized NF membrane features an ultrafine pore size distribution and reduced electronegativity, exhibiting a remarkable shift from sole SO 4 2− /Cl − selectivity to impressive ambidextrous selectivity, encompassing both SO 4 2− /Cl − (α ≈ 48, 98.3 % for Na 2 SO 4 ) and Mg 2+ /Na + (α ≈ 37, 98.2 % for MgCl 2 ). Moreover, it membrane also achieved exceptional removal efficiencies of 94.8–98.9 % for heavy metals and 77.6–99.3 % for antibiotics, while maintaining a water permeability of 19.3 L/m 2 h bar and mitigating the perm-selectivity trade-off. When purifying surface water containing heavy metals and antibiotics, the optimized NF membrane exhibited superior multi-pollutant removal and improved water production quality compared to the NF270 and NF90 membranes, and especially with its water permeance increased by ~27 % to 179 %. Our work uncovers a fundamental correlation between the PIP concentration, IP reaction, PA nanostructures and NF performance, providing valuable insights into customizing high-performance NF membranes to address complex water pollution challenges.
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JOURNAL OF ENVIRONMENTAL MANAGEMENT
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2025
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IF 8.4
Ke Li,Kun Wang,Tong Xu,Chencong Lyu,Xuejiao Yang,Hongjin Lin,Shiwen Xu
With the widespread application of the brominated flame retardant tetrabromobisphenol A (TBBPA), it poses a threat to human health, especially intestinal health. Quercetin (Que) is a flavonol compound with anti-inflammatory and antioxidant properties. However, whether Que can prevent TBBPA-induced intestinal toxicity remains unknown. Therefore, in this study, a TBBPA (75 μM) exposure model and a Que (0.1 μM) treatment model were established using mouse colon epithelial cells (MCEC). The p38 pathway, pyroptosis, and intestinal barrier function-related indicators were analyzed using an oxidative stress reagent kit, immunofluorescence staining, western blotting, and qRT-PCR. The results showed that TBBPA exposure dose-dependently reduced cell viability, impaired the antioxidant function of cells, promoted ROS accumulation, activated the p38 signalling pathway, induced pyroptosis, and decreased the expression levels of ZO-1, Occludin, and Claudin-1. Notably, Que treatment significantly restored the antioxidant enzyme activity in MCEC cells, reduced the ROS level, inhibited the p38 axis, alleviated MCEC cell pyroptosis, and recovered the intestinal barrier function. Further studies found that using LX-3 (a p38 activator) treatment disrupted the therapeutic effect of Que. In summary, Que can exert a protective effect by inhibiting the ROS-mediated p38 pathway, thereby alleviating the damage of TBBPA to MCEC cells.
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INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
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2024
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IF 8.1
Cengceng Du,Zhenyu Wang,Xin Chen,Yiming Wang,Chen Chen,Xinyu Liu,Yuqiu Huo,Hongbin Sun,Guangwen Xu
The efficient and high-quality production for hydrogen through water electrolysis at high current densities is crucial for commercial utilization. However, the performance of existing hydrogen evolution reaction (HER) electrocatalysts is far from satisfactory. In this regard, we proposed a method to prepare Rh–Ni(OH) 2 catalyst based on Nickel foam (NF). The hydrolysis galvanic replacement of nickel boride with RhCl 3 led to produce a lattice contraction in Ni(OH) 2 due to the rigid pressure generated, resulting in outstanding HER performance at high current densities. It achieves an industrial current density of 500 mA cm −2 with an overpotential of 130 mV. Furthermore, at the industrially prefer temperature of 80 °C, only 67 mV overpotential is required. The catalyst also demonstrated exceptional stability, maintaining excellent performance even after a stability test of 100 days with a current density of 200 mA cm −2 . Through Density-functional theory (DFT) calculations, Rh series reduced the hydrogen adsorption free energy.
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YONSEI MEDICAL JOURNAL
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2021
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IF 2.759
Chunting Hu,Chen Li,Qiaoya Ma,Ruili Wang,Ya He,Hui Wang,Guogang Luo
Purpose Ischemic brain injury results in high mortality and serious neurologic morbidity. Here, we explored the role of SNHG15 in modulating neuronal damage and microglial inflammation after ischemia stroke. Materials and Methods The hypoxia/ischemia models were induced by middle cerebral artery occlusion in mice and oxygen-glucose deprivation/reoxygenation (OGD/R) in vitro. Quantitative real-time PCR (qRT-PCR) and Western blot were conducted to determine the levels of SNHG15, miR-302a-3p, and STAT1/NF-κB. Moreover, gain- or loss-of functional assays of SNHG15 and miR-302a-3p were conducted. MTT assay was used to evaluate the viability of HT22 cells, and the apoptotic level was determined by flow cytometry. Furthermore, enzyme-linked immunosorbent assay was performed to detect oxidative stress and inflammatory mediators in the ischemia cortex and OGD/R-treated BV2 microglia. Results The SNHG15 and STAT1/NF-κB pathways were both distinctly up-regulated, while miR-302a-3p was notably down-regulated in the ischemia cortex. Additionally, overexpressing SNHG15 dramatically enhanced OGD/R-mediated neuronal apoptosis as well as the expression of oxidative stress and inflammation factors from microglia. In contrast, knocking down SNHG15 or overexpressing miR-302a-3p relieved OGD/R-mediated neuronal apoptosis and microglial activation. Moreover, the rescue experiment testified that overexpressing miR-302a-3p also attenuated SNHG15 up-regulation-induced effects. In terms of the mechanisms, SNHG15 sponged miR-302a-3p and activated STAT1/NF-κB as a competitive endogenous RNA, while miR-302a-3p targeted STAT1 and negatively regulated the STAT1/NF-κB pathway. Conclusion SNHG15 was up-regulated in the hypoxia/ischemia mouse or cell model. The inhibition of SNHG15 ameliorates ischemia/hypoxia-induced neuronal damage and microglial inflammation by regulating the miR-302a-3p/STAT1/NF-κB pathway.
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ACTA BIOCHIMICA ET BIOPHYSICA SINICA
·
2026
·Vol. 58
·期 9
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IF 4.5
Jingjing Chen,Lu Zhou,Xiguang Liu,Mengxin Li,Sijie Zhao,Jun Wang,Qian Dong,Xinran Li,Zibo Dong,Huizhen Chen
Chronic intermittent hypoxia (CIH) is an alternating state of recurrent hypoxia and reoxygenation triggered by disorders such as sleep apnea, leading to systemic oxidative stress and organ damage. In this study, we investigate the protective effect and mechanism of atraric acid (AA), a secondary metabolite produced by lichens, against CIH-induced liver injury. By establishing a CIH mouse model (10 h/d, oxygen cycling 5%-21% for 4 weeks) and an in vitro model of AML-12 cell hypoxia/reoxygenation (H/R), we perform H&E staining, biochemical assays (ALT/AST/MDA/CAT/T-AOC/GSH-Px), qPCR, western blotting, immunofluorescence and flow cytometry (JC-1 detection of the mitochondrial membrane potential) analyses. The results show that AA significantly reduces alanine aminotransferase (ALT)/aspartate aminotransferase (AST) levels, inhibits the elevation of hepatic malondialdehyde (MDA), restores the activities of catalase (CAT), total antioxidant capacity (T-AOC), and glutathione peroxidase (GSH-Px) in CIH mice, ameliorates mitochondrial dysfunction, activates autophagy, and reduces the expression levels of inflammatory factors. Mechanistically, AA reduces the release of downstream proinflammatory factors by blocking NF-κB nuclear translocation through the inhibition of IκBα phosphorylation. The activation of autophagic flow by AA is accompanied by a significant increase in LC3BII/I protein expression. Furthermore, autophagy blockade impedes the role of AA in alleviating inflammatory oxidative stress and mitochondrial dysfunction in the CIH-induced injury model, confirming that autophagy activation is necessary for the protective effect of AA. In conclusion, the present study reveals that AA alleviates oxidative stress and mitochondrial dysfunction, as well as NF-κB signaling, through the activation of autophagy, providing a novel therapeutic strategy for CIH-associated liver injury.
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