JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
·
2025
·
IF 14.3
Jianfeng Ma,Xin Zhou,Zenqi Ye,Xian Tong,Zhaoping Chen,Qianshu Xia,Tianran Wang,Yangshuai Jin,Yuncang Li,Jixing Lin,Zhe Zhao,Cuie Wen,Li Zhu
Lithium disilicate glass-ceramics (LDGCs) are widely employed in dental aesthetic restorations; however, their application is constrained by insufficient fracture toughness and the inefficiencies inherent in conventional milling processes. This study investigated the additive manufacturing of LDGCs doped with β-spodumene to address these limitations. LDGCs doped with 0, 2.5, 5, 10, and 20 wt% β-spodumene were prepared via additive manufacturing followed by heat treatments, and their thermal behavior, density, phase composition, microstructure, mechanical properties, and molding accuracy were evaluated. The results indicate that as the doping level of β-spodumene increased, the porosity, crystallinity, strength, and toughness initially improved and then decreased, with the most significant enhancement observed at 2.5 wt%. The size of lithium disilicate crystals decreased as the doping of β-spodumene increased. Notably, the 2.5 wt% doped composites demonstrated a toughness of 3.4±0.2 MPa m 1/2 , attributed to the secondary phase toughening mechanism of β-spodumene. Additionally, these β-spodumene-doped LDGCs exhibit excellent molding accuracy. These findings suggest that β-spodumene-doped LDGCs possess good mechanical properties and machinability, showing promising potential for dental restorative applications.
✓ 已验证
产品关联
DOI
高影响因子
Synthetic and Systems Biotechnology
·
2025
·
IF 4.4
Mingyu Dai,Qingyi Cao,Shuanglong Jia,Jiang Chen,Hui-Ying Xu,Bang-Ce Ye,Wei-Bing Liu,Ying Zhou
β-Elemene, a pharmacologically active sesquiterpene derived from the traditional Chinese medicinal herb Curcuma wenyujin, exhibits broad-spectrum antitumor and anti-inflammatory activities. Currently, its commercial production relies heavily on plant extraction, a process associated with high costs and environmental burdens, limiting industrial scalability. To address these challenges, we developed a metabolically engineered Yarrowia lipolytica strain as an efficient microbial cell factory for de novo Germacrene A biosynthesis, the direct precursor of β-elemene. Through combinatorial optimization strategies—including (1) mevalonate (MVA) pathway enhancement, (2) copy number amplification of germacrene A synthase (GAS), (3) β-oxidation pathway reinforcement, and (4) introduction of the isopentenyl utilization pathway (IUP)—we significantly improved β-elemene production. The engineered strain achieved a titer of 3.08 ± 0.05 g/L in shake-flask cultures, with a yield of 51.27 ± 0.75 mg/g glucose, representing a 3.5-fold increase over the parental strain. Our work highlights the potential of Y. lipolytica as a sustainable and scalable platform for high-value sesquiterpene production, offering a viable alternative to plant-derived extraction.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CARBOHYDRATE RESEARCH
·
2025
·
IF 2.5
Hongmian Jiang,Jinzhuai Li,Shuying Luo,Chenxi Cui,Lifeng Luo,Yingying Li,Zhijie Liang
Oat β-glucan, a natural polysaccharide extracted from Avena sativa (oats), possesses significant biological activity and various health benefits. In recent years, it has been widely used in the field of skin health management. The molecular weight of oat β-glucan varies depending on the plant source and extraction method, which can affect its absorption and utilization by the skin. Drawing on strategies from other polysaccharide materials, β-glucan can be converted into smaller oligosaccharides which may exhibit better solubility and bioavailability, through enzymatic hydrolysis or other degradation methods. In this study, we optimized the enzymatic hydrolysis and purification conditions to successfully obtain oat β-glucan oligosaccharides(β-GOS), which have an average molecular weight of 1 kDa and a narrow molecular weight distribution. Compared to the original high-molecular-weight β-glucan, these oligosaccharides showed significantly improved solubility. Furthermore, β-GOS was demonstrated to exhibit superior skin permeability and the enhancement of fibroblast activity. Additionally, bioinformatics analysis revealed that skin photodamage is closely associated with biological processes such as oxidative stress, immune imbalance, apoptosis, and aging. Our in vitro study showed that oat β-GOS can modulate these biological processes. Furthermore, we identified potential gene targets of β-GOS, including VEGFA, LGALS-3, and CDK1, linked to angiogenesis, aging, and apoptosis, respectively. Finally, using a UVB-induced acute skin injury mouse model, we also confirmed that β-GOS promotes skin repair. These findings highlight the potential value of oat β-GOS in skincare management and its promising application in the repairing UVB-induced skin damage.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Applied Biomaterials & Functional Materials
·
2026
·
IF 2.9
Chen Zhang,Yi Qi,Binying Dai,Runyi Lin,Jinchao You,Yaomei Wang,Shunxue Xing,Yuansong Ye,De-Jing Li
Poly(ε-caprolactone) (PCL) and β-tricalcium phosphate (β-TCP) are promising materials for bone tissue engineering due to their complementary biodegradability and osteoconductivity. However, their individual limitations hinder clinical application. In this study, PCL@β-TCP composite scaffolds containing 5%, 10%, and 20% β-TCP were fabricated via fused deposition modeling (FDM). The effects of β-TCP content on the physicochemical, mechanical, and antibacterial properties of the scaffolds were systematically investigated. Results showed that increasing β-TCP content enhanced hydrophilicity (contact angle reduced from 89.1° to 66.9°), accelerated biodegradation (higher weight loss after 103 days in PBS), and improved antibacterial activity, as evidenced by larger inhibition zones against E. coli and S. aureus. These findings demonstrate that β-TCP incorporation effectively enhances the bioactivity and antibacterial performance of PCL scaffolds, highlighting their potential for bone tissue engineering applications, particularly in non-load-bearing contexts.
✓ 已验证
DOI
PubMed
高影响因子
Materials
·
2026
·Vol. 19
·期 11
·2417
·
IF 3.7
Boyang Chen,Xinyu Liu,Yiyuan Liu,Zeliang Gao,Zhitai Jia,Wenxiang Mu
HighlightsFor the first time, a high-quality Ti3+-dopedβ-Ga2O3single crystal was successfully grown via the EFG method.The photoelectric properties ofβ-Ga2O3were effectively modulated via Ti3+doping, achieving a moderate semi-insulating state and a reduced bandgap.Ti3+-dopedβ-Ga2O3crystal was fabricated into X-ray detectors with a metal–semiconductor–metal (MSM) structure, demonstrating superior detection performance.Gallium oxide (Ga2O3) is emerging as a promising material for X-ray detectors due to its high sensitivity, high melting point, and stable physicochemical properties. However, intrinsic background shallow donors in raw materials hinder the preparation of high-resistance intrinsic crystals, making doping essential to tailor electrical properties. This study grew Ti3+-dopedβ-Ga2O3single crystals via the Edge-defined Film-fed Growth (EFG) method using Ti2O3as a dopant, achieving high resistivity and a moderate reduction in bandgap. High-resolution X-ray diffraction (HRXRD) showed a rocking curve full width at half maximum (FWHM) of 96.50 arcsec. Compared with the unintentionally doped (UID) crystal, the bandgap exhibited a slight reduction, decreasing from 4.76 eV to 4.59 eV. In the infrared transmission spectra, the onset wavelength of the decrease in transmittance for the Ti3+:β-Ga2O3crystal showed a distinct redshift relative to that of the UID crystal, indicating effective suppression of free electrons within the crystal. X-ray photoelectron spectroscopy (XPS) revealed that Ti3+incorporation minimally affected the valence states of Ga and O or the Ga/O ratio, with no significant shift in valence band maximum (EVBM). A metal–semiconductor–metal (MSM) structured X-ray detector fabricated on polished Ti3+:β-Ga2O3(100) substrate with Ti/Au electrodes exhibited a peak sensitivity of 943.16 μC/(Gy·cm2) at 40 V bias and 2.944 μGy/s dose rate, surpassing the upper sensitivity limit reported for semi-insulating doping bulkβ-Ga2O3detectors. The rise and fall times were 0.23 s and 0.30 s, respectively, with a minimum detectable limit (MDL) of 164.26 nGy/s, demonstrating its potential for high-performance X-ray detection applications.
✓ 已验证
DOI
PubMed
高影响因子
RUSSIAN JOURNAL OF INORGANIC CHEMISTRY
·
2026
·
IF 1.5
Genxing Zhu,Qi Liu
Silver nanoparticle/β-tricalcium phosphate (Ag/β-TCP) composites were facilely prepared through in situ reduction deposition of Ag nanoparticles onto β-TCP porous nanoparticles and characterized by SEM, TEM, HRTEM, X-ray powder diffraction, XPS and UV-visible spectroscopy, which demonstrated that both the β-TCP porous nanoparticle carriers and the anchored Ag nanoparticles had a narrow size distribution range with their average particle sizes being 120 and 30 nm, respectively. Moreover, the plasmon coupling effects between adjacent Ag nanoparticles intensified as the loading amount of Ag nanoparticles increased, resulting in a significant red-shift and broadening of their UV-vis absorption peak. The as prepared Ag/β-TCP nanocomposites show excellent catalytic activity and stability during the reduction of 4-nitrophenol in the presence of NaBH 4 . Moreover, they can be used as a nanoprobe for highly sensitive and selective detection of hydrogen sulfide and a surface-enhanced Raman scattering (SERS) substrate with a detection limit of 10 –8 M for crystal violet. In light of these characteristics, the as prepared Ag/β-TCP nanocomposites show promising and great potential for multifunctional applications in catalysis, chemical sensing and SERS.
✓ 已验证
DOI
高影响因子
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
·
2023
·Vol. 332
·期 1
·23-32
·
IF 1.6
Ou Minrui,Li Wanying,Zhang Zihui,Xu Xiaoping
In this work, we synthesized a novel β -cyclodextrin/poly(2-acrylamide-2-methylpropionic acid)/attapulgite (CAMA) hydrogel for uranium(VI) adsorption. Various instrumental techniques such as FTIR, SEM, EDX, and TGA were utilized for characterization of the CAMA. Simultaneously, different important parameters, in specific pH, time, initial uranyl ion concentration and temperature were investigated to evaluate the optimal conditions of the adsorption process. The experiments proofs that the adsorption follows the pseudo-second-order kinetic model so as the Langmuir model, and revealed the maximum adsorption capacity of 434.78 mg g −1 at 298.15 K. Regeneration studies further sighted out the good reusability of the synthesized CAMA hydrogel.
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2023
·Vol. 13
·期 9
·5667-5673
·
IF 3.9
Bin Li,Haibo Qin,Ming Ma,Xiaojia Xu,Mengjing Zhou,Wenrui Hao,Zhigang Hu
In this paper, betaine (Bet) was used as a hydrogen bond acceptor (HBA), and acrylic acid (AA) and acrylamide (AM) were used as hydrogen bond donors (HBD) and mixed to form a deep eutectic solvent (DES). Different concentrations of β-cyclodextrin (β-CD) were dispersed in the DES, and a novel β-CD/P(AA-co-AM) hydrogel was prepared by frontal polymerization (FP). The characteristic structure and morphology of the hydrogels were analyzed using Fourier transform infrared (FTIR) spectroscopy and scanning electron microscopy (SEM), and the properties of the hydrogels were investigated. The results show that the mechanical properties of the hydrogel were improved by β-CD acting as a second cross-linking agent in the polymerization process, thus increasing the cross-link density of the hydrogel. Because the carboxyl groups contained in the acrylic acid dissociate under alkaline conditions, the composite hydrogel shows excellent pH responsiveness under alkaline conditions. Tetracycline hydrochloride was used as a drug model to test the drug loading and drug release performance of the hydrogels. With the increase of β-CD content, the loading capacity of the hydrogels for tetracycline hydrochloride gradually increased. The data of drug release indicated that the hydrogel has good drug delivery performance and has promising applications in drug delivery systems and other areas.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2022
·
IF 8.025
Mengting Lin,Yuqing Li,Haiyue Long,Yueling Lin,Zhuo Zhang,Fengyun Zhan,Manmei Li,Chaoxi Wu,Zhong Liu
Biomimetics plays an important role in cancer treatment since it can prolong the circulation of nanoparticles, enhance their delivery and retention in target tissues, and reduce the systemic toxicity of drugs and their carriers. In this study, we developed a biomimetic nanosystem consisting of chemotherapeutic and immunotherapeutic agents wrapped in cell membranes. Specifically, the anti-tumor drug doxorubicin (DOX) was loaded into a bacterial-derived immunomodulatory agent (low molecular weight curdlan, lCUR), and the lCUR-DOX was further wrapped in the red blood cell membrane for camouflage and prolonged circulation. The successful preparation of the [email protected] nanosystem was supported by various optical and morphological characterizations. In vitro studies indicated that the nanosystem can escape uptake by macrophages, inhibit the invasion of tumor cells, and reprogram M2 macrophages with an immunosuppressive phenotype into M1 macrophages with an immunopromoting phenotype via the MAPK signaling pathway while promoting the phagocytosis of macrophages. In vivo studies showed that the nanosystem effectively inhibits tumor growth in the A-375 tumor-bearing mouse model. Taken together, the above results support further development of the [email protected] platform for cancer immunochemotherapy in clinical applications.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
EUROPEAN POLYMER JOURNAL
·
2022
·
IF 5.546
Mi Wu,Yunen Liu,Peifang Cong,Shun Mao,Rufei Zou,Jianhua Lv,Huaqin Tian,Yan Zhao
Developing natural polymer-based hydrogel with excellent injectability, suitable mechanical properties, and the ability to facilitate full-thickness skin wound healing is highly desirable in clinical application. Herein injectable hydrogels made of polydopamine (PDA) modified β-chitin nanofibers (β-ChNFs) were successfully prepared and applied for irregular wound healing. Compared with β-ChNFs hydrogels which were too weak to be used, the surface coating of PDA helped concentrate the β-ChNFs, and hydrogels with much higher strength were obtained and could be conveniently applied to the wound. The incorporation of chitosan oligosaccharide (COS) remarkably increased the hydrogels’ bioactivity. Shown as the biocompatibility measurement, ChNFs-PDA-COS hydrogels significantly promoted the proliferation of L929 cells. Demonstrated by the in vivo study in a rat full-thickness skin defect model, ChNFs-PDA-COS hydrogels with 1 % of COS significantly reduced inflammatory cell infiltration, improved the maturation of granulation tissue and well-organized collagen deposition, and regenerated thick dermis and epidermis with some cutaneous appendages at 9th post-operative day. All these contributed to the acceleration of wound closure and a better healing outcome as compared to the control group, indicating that the COS-incorporated ChNFs-PDA hydrogels are promising wound dressing for full-thickness skin tissue repair.
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Xiaoyi Zhang,Rongqing Chen,Xiaoying Gao,Jinlan Weng,Yunjia Liu,Tian Gui,Shenghong Yang,Dunqing Wang,Xiangshu Chen,Jian Liu
Cyclodextrin-based porous polymers have become a kind of promising adsorbents for the remediation of wastewater by virtue of their sustainability and economic potential. The acquisition of aforementioned adsorbents commonly requires elaborate preparation procedures which involve organic solvent, catalyst, inert atmosphere, or long reaction time. Herein, a facile and scalable solid-state mechanochemical approach was developed to afford reticular β-cyclodextrin polyurethanes (CDPUs) in a short time (2 h) without any organic solvents and catalysts at ambient conditions. Various diisocyanates can be used as coupling agents to link β-CD molecules into CDPUs relying on the driving force of ball milling. CDPUs-based composites can be also successfully synthesized via a “one-pot” mechanochemical reaction. The afforded CDPUs exhibit nearly the same physiochemical characteristics as those synthesized in solvents or with the assistance of catalyst. CDPUs have numerous accessible active adsorption sites, including β-CD cavities, bridging urethane groups, dangling amino groups, and aromatic rings. Owing to the accessible porosities and abundant adsorption sites, CDPUs exhibited rapid adsorption rate and high adsorption capacity towards phenolic micropollutants. CDPUs can maintain adsorption efficiency in a wide pH range, ionic strength, and humic acid. There is no significant decrease of adsorption efficiency for more than eight regeneration cycles, indicating their suitability for practical water treatment. This solid-state mechanochemical synthesis method for reticular CD-based polymers paves a new insight into green preparation of adsorbents and their sustainable use for the practical remediation of micropollutant wastewater.
✓ 已验证
产品关联
DOI
高影响因子
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
·
2023
·
IF 4.6
Qinghan Tang,Fei Xu,Xuchao Wei,Jingyue Gu,Pengli Qiao,Xuemin Zhu,Shaoping Yin,Defang Ouyang,Jie Dong,Junhong Yao,Yiwei Wang,Jun Chen
Terpenes are usually used as penetration enhancers (PE) for transdermal drug delivery (TDD) of various molecules. However, TDD of hydrophilic macromolecules is becoming an urgent challenge due to their potent activities. The aim of this study was to investigate the potential application of β-caryophyllene (β-CP), a sequiterpene, as PE for TDD of hydrophilic macromolecules for the first time. Commonly used PEs, namely azone and 1,8-cineole (1,8-CN), were applied as controls. Transepidermal water loss (TEWL) analysis revealed that the reduction of skin barrier function caused by β-CP was reversible. Transdermal experiments showed that when skin was treated with β-CP or azone, there was a significant permeation-enhancing effect on fluorescein isothiocyanate (FITC) and FITC-dextran with different molecular weight (MW) of 4k or 10k. CLSM analysis confirmed that β-CP and azone can facilitate the penetration of FD-4k through epidermis and dermis. However, the cytotoxicity of azone against epidermal keratinocytes was significantly higher than β-CP and 1,8-CN. Additionally, application of β-CP and 1,8-CN didn't increase erythema index ( EI ) but the EI values of azone group increased significantly and irreversibly, indicating the high biocompatibility of the natural terpenes. β-CP had better permeation-enhancing effect and higher stratum corneum (SC) retention than 1,8-CN due to its increased carbon chain length and lipophilicity, as further demonstrated by molecular dynamics (MD) simulation studies. Skin electrical resistance (SER) and attenuated total reflection fourier transform infrared spectroscopy (ATR-FTIR) studies revealed a significant interfering effect of β-CP on SC lipids. Taken together, β-CP exhibited significant penetration enhancement of hydrophilic macromolecules due to its SC retention and SC lipid fluidization ability.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）