Acta Biomaterialia
·
2026
·
IF 10.4
Hao Zhang,Yining Wang,Tian Deng,Jiahui Peng,Xiaxin Ye,Xing Zeng,Jingjing Zhu,Linzhe Huang,Xiaoming Zheng,Yun Li,Yang Kang
Sepsis is a serious syndrome characterized by acute dysfunction of multiple organs, and there is a notable lack of effective preventive strategies and interventions. As a natural anti-inflammatory and antioxidant feedback regulator in the body, itaconic acid can precisely and synergistically modulate anti-inflammatory and antioxidant effects through various mechanisms, providing a metabolic regulation strategy for inflammatory diseases and diseases related to oxidative damage. Previous studies primarily utilized small molecule derivatives of itaconate, such as dimethyl itaconate (DMI) and itaconate 4-octyl ester. However, their in vivo stability and tissue targeting capabilities are often suboptimal, significantly reducing their anti-inflammatory and antioxidant efficacy in disease treatment. Poly itaconic acid (pIA) was synthesized through a one-step polymerization method, and pIA NPs were prepared using nanoprecipitation, effectively addressing the current challenges associated with itaconic acid delivery. Through comprehensive in vitro and in vivo evaluations, the nanoparticles have demonstrated good biocompatibility in the inflammatory microenvironment and can specifically release, thereby enhancing its targeting at the sites of inflammation. In contrast to dimethyl itaconate, pIA NPs exhibited enhanced anti-inflammatory and antioxidant properties, which more effectively safeguard against multi-organ dysfunction caused by sepsis and increase the survival rate in mice. Mechanistic investigations demonstrated that these therapeutic benefits mainly occurred through the facilitation of nuclear factor erythroid 2-related factor 2 nuclear translocation and the reprogramming of macrophages by pIA NPs. Furthermore, the preparation process of the nanoparticles are simple and cost-effective, providing a foundation for the clinical translational application of itaconic acid. Statement of significance This work innovatively developed a simple, safe esterase-responsive polymer delivery system for itaconic acid, solving defects of complex preparation, poor stability and targeting of conventional systems. It advanced sepsis therapy and macrophage metabolic regulation research. For journal readers, it links nanomedicine, immunometabolism and sepsis treatment, providing valuable insights for researchers in inflammatory diseases and drug delivery. Download: Download high-res image (236KB) Download: Download full-size image
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高影响因子
JOURNAL OF POLYMER RESEARCH
·
2026
·Vol. 33
·期 9
·379
·
IF 3.5
Li Hao,Ma Xinyi,Chen Jian,Li Xiaohong,Vishneuski Kanstantsin,Wang Shun,Wu Yadong,Jin Huile
This study synthesizes dendritic mesoporous silica nanoparticles (DMSN) via an anion-assisted templating method, utilizing sheet-like micelles formed from anion-cation complexes to direct silica condensation, followed by calcination. The obtained high-surface-area DMSN were incorporated as a filler into fluororubber (FKM) to fabricate FKM/DMSN composites. The extensive interface and mesoporous structure of DMSN provide sufficient areas for polymer chain adsorption, enhancing mechanical interlocking with the FKM matrix, significantly improving the composite’s properties. At an optimal loading of 10 phr, the composite demonstrates a tensile strength of 15.7 MPa, elongation at break of 300%, modulus at 100% strain of 3.8 MPa, and Shore A hardness of 68, representing increases of 292%, 36%, 217%, and 28%, respectively, over pure FKM. Additionally, the composite exhibits enhanced thermal stability with an initial decomposition temperature of 440 ℃, improved accelerated thermal transport, and retained electrical insulation alongside stable vulcanization characteristics. These superior mechanical and thermal properties make the DMSN-reinforced FKM composite a promising material for advanced sealing applications in aerospace, automotive, and energy sectors.
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JOURNAL OF MATERIALS SCIENCE
·
2026
·Vol. 61
·期 38
·29087-29101
·
IF 4.4
Wu Zhengyang,Zhang Jiarui,Wang Meiqi,Yang Rui,Zhang Wenqi,Fan Sidi,Yao Cheng,Yu Xiang
Poly(m-phenylene isophthalamide) (PMIA)-based insulating paper exhibits excellent electrical insulation and mechanica l properties, including higher breakdown strength ( E b ) than conventional cellulose insulating paper. However, its intrinsically low thermal conductivity limits heat dissipation in oil-paper insulation systems, causing Joule heat accumulation, insulation degradation, and thermal breakdown. Herein, we report PMIA-based composite papers prepared by binary multidimensional doping the small-size 0D sphere-like aluminum nitride (AlN) filler with large-size 3D sphere-like, 2D lamellar-like, and 1D wire-like AlN fillers, respectively. At the same total filler volume fraction, large-size fillers with different morphologies show distinct advantages. For electrical insulation, the 2D lamellar-like filler most effectively enhances E b by optimizing trap characteristics and mitigating electric field distortion, reaching 284.3 kV/mm, 29.5% higher than that of the 0D-only doped sample (N15). For thermal conduction, 3D sphere-like filler is most effective in enhancing the out-of-plane thermal conductivity ( k ⊥ ) by reducing thermal resistance, reaching 0.282 W/(m·K) and representing a 14.5% improvement over N15. In contrast, 1D wire-like and 2D lamellar-like fillers are more favorable for constructing in-plane heat transfer pathways, yielding in-plane thermal conductivity ( k // ) values of 0.546 W/(m·K) and 0.386 W/(m·K), respectively. Moreover, finite element analysis further reveals the morphology-dependent electric and thermal field distributions in the composites.
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CHINESE JOURNAL OF POLYMER SCIENCE
·
2026
·
IF 4.6
Liu Guan-Jun,Yan Mei-Ling,Tian Zhen,Wang Lu,Yang Fan,Wang Rong-Guo
Hot pressing is widely used to tailor the structures and properties of polymer composites. However, how it drives structural evolution and thereby affects barrier, mechanical, and thermal properties remains insufficiently understood. In this work, graphene oxide-grafted carbon nanotube/polyamide 6 (GO- g -CNT/PA6) composites were subjected to hot pressing at different radial expansion ratios ( ε =0, 2, and 4) to investigate the flow-induced structural evolution and the resulting property changes. Scanning electron microscopy and transmission electron microscopy observations revealed that hot pressing promoted the rearrangement and preferential alignment of the hybrid nanofillers, while two-dimensional wide-angle X-ray diffraction confirmed the enhanced crystalline orientation after hot pressing. Differential scanning calorimetry showed increased crystallinity in both the neat PA6 and GO- g -CNT/PA6 composites. Representative positron annihilation lifetime spectroscopy analysis further indicated a reduction in the fractional free volume, whereas the characteristic size of individual free-volume holes remained nearly unchanged. The results indicate that the optimal hot-pressing condition is property-dependent. A moderate deformation at ε =2 is more favorable for improving the hydrogen barrier and tensile properties, whereas a stronger deformation at ε =4 is more effective in promoting in-plane heat transport. These findings establish a correlation between the processing, structural evolution, and multifunctional properties of GO- g -CNT/PA6 composites, providing guidance for the design of PA6-based liner materials for Type IV hydrogen storage vessels.
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Nature Communications
·
2026
·
IF 18.1
Chen Haojie,Gao Rui-Ting,Wang Lei,Wu Limin
Photoelectrochemical bipolar systems enable bias-free H 2 O 2 synthesis by integrating light harvesting, water oxidation and oxygen reduction. However, poor selectivity due to competing 4e - pathways, slow charge transfer, and inferior stability severely limit their practical application. Herein, we present a bias-free photoelectrochemical bipolar system for H 2 O 2 production, which integrates a Zn-TiO 2 /BVO/WO 3 photoanode for the 2e - water oxidation reaction and a Ru:CuO/Nb-CBO photocathode for the 2e - oxygen reduction reaction. The photoanode suppresses *OOH intermediates to favor H 2 O 2 formation, achieving a Faradaic efficiency (FE) of 90.2% at 0.6 V RHE . The photocathode stabilizes *OOH intermediates and delivers an FE of 91.9% under the same conditions while maintaining performance for over 50 h. Practical testing under natural sunlight with 36 cm 2 electrodes achieves an FE of 163.37% and a yield of 11.44 mmol L −1 . In situ generated H 2 O 2 achieves over 99% bacterial inactivation within 60 min. This work provides an adaptive platform for solar-driven H 2 O 2 synthesis and energy conversion.
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高影响因子
MICROCHEMICAL JOURNAL
·
2026
·
IF 5.2
Li Wang,Liwei Wang,Yuhang Que,Ling Xin,Fugang Xu
Donut-like Cu-Zn-MOF@CuNPs were synthesized via facile two-step approaches. • Cl − amplifies Cu signal via formation of highly electroactive CuCl. • Ag + inhibits the signal by competitive binding with Cl − to form AgCl. • The sensor detects Ag + with a low LOD of 1.4 nM and wide linear range. • It shows good selectivity, stability, and real water sample recovery. Silver ions (Ag + ) are highly toxic heavy metal pollutants. Conventional electrochemical methods for Ag + detection typically involve complex ionophore preparation, long preconcentration/stripping steps, or costly biorecognition agent. Here, we report a Cu-Zn-MOF supported CuNPs composite (Cu-Zn-MOF/CuNPs) for Ag + detection. The composite is prepared via a two-step room temperature mixing process. The nest-like Cu-Zn-MOF, composed of stacked two-dimensional nanosheets, provides a high specific surface area and accessible active sites for CuNPs deposition, which improves conductivity and generates a detectable redox signal. The presence of Cl − enhances the Cu redox signal due to the formation of electroactive CuCl. In the presence of Ag + , this signal enhancement is suppressed due to the competitive binding that forms AgCl precipitates. Leveraging this “amplification-inhibition” response, the Cu-Zn-MOF/CuNPs modified electrode allows for Ag + detection with two linear ranges (5 nM–100 nM and 100 nM–1100 nM), a detection limit of 1.4 nM, and recoveries ranging from 96.5% to 104.5% in spiked real water samples. The preparation procedure and detection protocol are relatively straightforward, and the sensing mechanism offers an alternative pathway for heavy metal ion detection. A donut-like Cu-Zn-MOF/CuNPs composite enables sensitive and selective electrochemical detection of Ag + via a novel amplification-inhibition mechanism: Cl − enhances the Cu redox signal through CuCl formation, while Ag + competitively binds Cl − to suppress the signal. The sensor achieves a low detection limit of 1.4 nM and good performance in real water samples. Download: Download high-res image (121KB) Download: Download full-size image
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2026
·Vol. 65
·期 28
·14910-14919
·
IF 3.9
Yang Qiqi,Hu Minglv,Zhang Wenkang,Zhou Ke,Liang Zheng,Gu Qilin,Zhong Zhaoxiang,Xing Weihong
Janus
ceramic membranes with asymmetric wettability have
proven
highly effective for preparing water-in-diesel (W/D) emulsions. Therefore,
the fabrication of such tubular membranes for continuous emulsification
processes is of significant interest. In this study, tetraethyl orthosilicate
(TEOS) and methyltriethoxysilane (MTES) were used as precursors, with
ammonia serving as the catalyst, to achieve the controlled synthesis
of hydrophobic silica (SiO 2 ) particles. Subsequently, these
hydrophobic SiO 2 particles were coated onto the inner walls
of tubular silicon carbide (SiC) membranes (mean pore size = 1.2 μm)
via a simple dip-coating process. Results indicate that controlling
the ammonia concentration allows for the synthesis of SiO 2 particles with sizes that appropriately match the pore dimensions
of the tubular SiC membranes. As the SiO 2 solid content
was increased from 0.10 to 2.00 wt %, the average pore size of the
tubular SiC membranes decreased from 1.2 to 0.52 μm. Concurrently,
the apparent water contact angle on the inner walls increased significantly
from 15 ° to 142 ° , while the outer surface remained hydrophilic.
Among the membranes with various surface wettability, the configuration
featuring a hydrophobic inner wall and a hydrophilic outer surface
proved most effective for emulsion production, yielding W/D emulsions
with smaller average droplet diameter and uniform size distribution.
This work introduces an effective method for simultaneously tuning
the surface wettability and pore structure of tubular SiC ceramic
membranes, thereby establishing a foundation for the continuous membrane
emulsification of diesel fuel.
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Journal of Environmental Chemical Engineering
·
2026
·Vol. 14
·期 5
·124519
·
IF 7.5
Lin Zhou,Wei Zhang,Xiangyu Xi,Jiao Zhang,Mengyu Zhou,Gaofeng Wang,Jianxi Zhu,Faqin Dong
Uranium-contaminated sites are frequently characterized by high-intensity radiation, which poses a substantial challenge to traditional bioremediation technologies. While microbial interactions with uranium are extensively studied, their efficiency and mechanisms under radiation remain poorly understood. Here, we present a radiation-tolerant microbe, Kocuria rosea , and its removal mechanism for U(VI) in an irradiated system. We reveal remarkable tolerance of Kocuria rosea to radiation and uranium, showing 40.9% of cells survive after 6000 Gy irradiation (25 Gy/min) in 50 mg/L uranium stress. We demonstrate a radiation-dependent shift in the removal mechanism of U(VI)—from biosorption and biomineralization forming H 2 (UO 2 ) 2 (PO 4 ) 2 ⋅8 H 2 O and CaU(PO 4 ) 2 in non-irradiated systems to enhanced reduction and inhibited biomineralization under irradiation—responsible for 42% and 7.23% improvement in U(VI) immobilization and reduction capacities, reaching 238.12 mg/g removal capacity. This work advances our understanding of the removal mechanism of microorganisms for uranium under irradiation, offering a new, efficient microbial remediation strategy for radionuclides.
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ENERGY & FUELS
·
2026
·Vol. 40
·期 29
·15979-15989
·
IF 6
Ji Yun,Li Zhishan,Cheng Yi-Bing,Jiang San Ping
Carbon
deposition is a significant issue for hydrogen
(H 2 ) production from alcohol-based hydrogen carriers such
as methanol
(CH 3 OH) and ethanol (C 2 H 5 OH). In
this work, we propose an ammonia (NH 3 )-assisted decomposition
strategy for short-chain alcohols and investigate the catalytic performance
of a gadolinium-doped ceria-supported Ni–Fe catalyst (denoted
as Ni–Fe/GDC) for CH 3 OH or C 2 H 5 OH decomposition with NH 3 assistance. The results show
that the presence of NH 3 effectively suppresses the carbon
deposition typically associated with alcohol decomposition and increases
the H 2 production rate by 131% in CH 3 OH/NH 3 and 185% in C 2 H 5 OH/NH 3 feed
gases as compared to the individual CH 3 OH and C 2 H 5 OH decompositions at 800 ° C, respectively. There
exists a synergistic effect between the alcohol decomposition and
NH 3 decomposition reactions. This work demonstrates the
promising potential of H 2 production via the ammonia-assisted
decomposition of short-chain alcohols and provides a valuable reference
for other coking-prone scenarios.
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ENVIRONMENTAL SCIENCE & TECHNOLOGY
·
2026
·Vol. 60
·期 30
·21320-21331
·
IF 12.2
Ma Likun,Sun Peng-Fei,Deng Yuling,Zhu Zhiyang,Liang Huaxing,Yang Yi,Lu Xinglin
Achieving stringent boron compliance in seawater desalination
has
long depended on energy-intensive multipass reverse osmosis (RO) with
alkaline dosing, creating a trade-off between energy consumption and
water quality. This work breaks this bottleneck by developing a hybrid
single-pass multistage (HSPM) system with selectivity-optimized loose
RO membranes. Tailoring commercial RO membranes into high-flux variants
via a 5 h controlled chlorination achieves an optimal balance, whereas
an extended 20-h modification causes an impractical 24.1-fold increase
in boron passage. Mechanistic analysis reveals that the 4-fold increase
in apparent activation energy ( E a ) for
B(OH) 4 – transport at pH 11 fails to fully
offset the intrinsic loss of steric selectivity under neutral conditions.
To overcome this material-level limitation, a multidimensional performance
map identifies the operational sweet spot of the HSPM system, enabling
membranes with moderate boron rejection and high water permeance to
meet the 1.0 mg L –1 threshold via multistage blending
and energy recovery. Coupling the 5 h chlorinated membrane with an
optimized 3-stage configuration theoretically yields a ∼42.5%
energy saving versus conventional two-pass RO. This research establishes
a novel paradigm for application-specific membrane selection and process
synergy, offering a scalable, low-carbon blueprint for desalination
and water reuse.
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PubMed
高影响因子
Food Bioscience
·
2026
·
IF 6.2
Xuecong Chen,Yan Wang,Wengang Zhang,Bin Dang,Xijuan Yang
Varietal differences play a crucial role in determining the quality of dried pepino slices. In this study, four varieties (Qingtianxiang, Qingcanxiang, Qingningxiang, and Qingyuxiang) were evaluated through sensory assessment, color analysis, and metabolomic profiling of both volatile and non-volatile compounds. A total of 1171 non-volatile metabolites and 6290 non-redundant, putatively annotated volatile features were detected across the four varieties; among the non-volatile metabolites, 115 showed significant differences and were mainly enriched in nucleotide metabolism, plant hormone signal transduction, and benzoxazinoid biosynthesis pathways. Based on relative odor activity value (ROAV) analysis, seven key aroma-active compounds (ROAV ≥1) were identified, with ( E )-2-nonenal, ( E )-2-octenal, heptanal, and 2-pentylfuran recognized as characteristic contributors. Integrated analysis indicated that Qingtianxiang exhibited the most favorable overall sensory quality with well-balanced metabolite profiles. This study provides the first systematic characterization of the key metabolites in dried pepino slices, offering a theoretical basis for the selection of processing-specific varieties, quality regulation, and deep processing of pepino.
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Advanced Healthcare Materials
·
2026
·
IF 11
Xin Liu,Zifan Zhao,Liujixiang Wang,Lei Tan,Fengxiao He,Gufeng Liu,Yang Xie,Bin Shi,Tao Wu,Haibin Xia
Infectious jawbone defects, arising from open fractures, surgical contamination, or hematogenous pathogen spread, represent severe orthopedic complications characterized by concurrent bone loss and chronic infection. Precise control of pathogen colonization, effective modulation of local immune microenvironment, and activation of osteogenesis are spatiotemporal phases that pose significant clinical challenges. Here, we construct a multifunctional platform of copper-zinc bimetallic metal–organic nanosheets encapsulated in a polyvinylpyrrolidone-polyvinyl alcohol hydrogel (CuZn-MON@gel). Upon ultrasound irradiation, CuZn-MON produces singlet oxygen, achieving antibacterial efficiencies of 99.93% against Staphylococcus aureus and 99.78% against Porphyromonas gingivalis . In the absence of ultrasound, the nanozyme switches to SOD- and CAT-like activities, scavenging excess reactive oxygen species and downregulating pro-inflammatory pathways, including chemokine and NF-κB signaling pathway. Simultaneously, controlled release of osteogenic Cu 2+ and Zn 2+ ions activates AMPK and PI3K/Akt pathways, enhancing the expression of osteogenic markers Runx2, ALP, OCN, and OPN. This system promotes osteogenic differentiation and accelerates bone regeneration in an infected rat model, achieving robust repair of jawbone defects. By dynamically balancing bactericidal ROS generation and antioxidant protection, CuZn-MON@gel offers a spatiotemporal therapeutic strategy for reconstructing infectious bone defects.
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