Frontiers in Veterinary Science
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2025
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IF 2.9
Mengjuan Chen,Hui Han,Mengke Qin,Huixin Li,Qiqi Lu,Xin Huang,Qingda Meng,Shanshan Xie
Introduction: Current management of canine mammary tumors (CMTs) remains reliant on surgical resection and chemotherapy. However, these strategies are often limited by high recurrence rates and systemic toxicity. Addressing these limitations requires urgent development of safer and more effective therapeutics. Pseudolaric acid B (PAB), a bioactive compound extracted from the roots of the Pseudolarix kaempferi Gord., has garnered attention for its broad-spectrum antitumor activity and favorable pharmacokinetic profile, and it has shown promise in inhibiting the growth of a variety of tumors, including breast cancer. The aim of this study was to investigate the anticancer effects of PAB on canine mammary tumor U27 cells and its underlying mechanisms.Methods and results: In vitro analyses demonstrated that PAB dose dependently reduced cell viability, suppressed cell proliferation, and triggered caspase-mediated apoptosis. Transcriptomic profiling of PAB-treated tumor cells revealed significant enrichment of differentially expressed genes in pathways such as gap junction, cell cycle, and cellular senescence. Mechanistically, CDK1 suppression by PAB, achieved through binding that diminishes its expression and stability, induced G2/M phase arrest and halted mitotic progression. While these findings suggest the potential of PAB as a candidate for canine mammary tumor treatment, further investigations are warranted to delineate its precise in vivo targeting specificity and pharmacodynamic interactions.Discussion: These findings not only expand the translational applicability of PAB in veterinary oncology but also identify CDK1 as a potential therapeutic vulnerability for combinatorial treatment strategies in CMTs.
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ACS Applied Polymer Materials
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2025
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IF 4.7
Xida Zhang,Chunlei He,Zhongwei Chen,Tingting Chen,Zhiquan Chen,Lei Ni,Yuan Yu,Juncheng Jiang
A ubiquitous challenge exists in the pursuit of high-efficiency flame retardancy for flame retardants, which is the inability of these agents to effectively maintain the mechanical stability of epoxy resin (EP). To address this issue, a phosphate-imidazoline-boron ester flame retardant (PDDBS) was designed and synthesized. The hydroxyl groups within PDDBS were capable of participating in the curing reaction of EP. At a 1 wt % addition level, the Tg of EP/1PDDBS was increased to 148.2 °C. Mechanical property tests from bending and tension experiments indicated that the addition of PDDBS enhanced the mechanical performance of EP. When 5 wt % PDDBS was added, the tensile and flexural strength reached 69.9 and 123.5 MPa, respectively. Furthermore, PDDBS exhibited certain flame-retardant capabilities: compared with neat EP, the peak heat release rate, total heat release, and total smoke production of EP/5PDDBS were decreased by 48.6, 15.4, and 28.4%, respectively. Analysis of residual carbon revealed that thermal decomposition of boron-based groups triggers the formation of boron oxide, which facilitates the construction of a carbonaceous layer and thereby enhances the thermal stability of EP composites. Developing PDDBS through synthesis offers an approach to reconciling the compromise between flame-retardant capability and structural strength.
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ACS Applied Materials & Interfaces
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2026
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IF 7.8
Renjie Liu,Yongjun Zhang,Zhenli Zhang,Hongjing Han,Haiying Wang,Yuting Guan,Yanan Zhang,Bolong Jiang,Xuzhong Gong,Enhao Sun,Yanguang Chen
Coke deposition is a key obstructive problem to be solved in the production of ethylene via steam cracking; moreover, the removal of graphitic carbon in coke is particularly difficult. A strategy integrating Fe–Mn bimetallic synergy at the B-site with oxygen vacancy engineering in perovskites was proposed to accelerate the catalytic conversion of coke/graphitic carbon via steam. DFT simulations and experimental results revealed that Mn incorporation induces dynamic lattice reconstruction of SrFeO3, generating abundant oxygen vacancies that enhance oxygen ion mobility and H2O adsorption. The interaction between Fe and Mn atoms has been observed to narrow the band gap, strengthen the hybridization of the O-2p and Fe-3d orbitals, induce electron delocalization, regulate the transfer of electrons from surrounding atoms to the adsorbed oxygen species, and thus accelerate the desorption and activation of *OH and the transfer of *O2–, which provides the possible reaction pathway for the transformation of graphitic carbon into CO or CO2. At 900 °C, the conversion of graphitic carbon and coke with steam catalyzed by SrFe0.1Mn0.9O3 reached 60.61% and 99.87%, respectively. This study provides an active material that facilitates the in situ online decoking strategy for catalytic coatings on steam cracking furnace tubes along with theoretical insights into the underlying reaction mechanism.
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高影响因子
Materials
·
2026
·Vol. 19
·期 3
·554
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IF 3.2
Naveed Karim,Tin Kyawoo,Saeed Ahmed,Weiliang Tian,Huiyu Li,Yongjun Feng
A carbon-modified attapulgite composite (C-AATP@CTAB) was synthesized via the hydrothermal method using citric acid as the carbon source and cetyltrimethylammonium bromide (CTAB) as a surface modifier for efficient rhodamine B (Rh-B) removal. Carbon modification elevated the composite’s specific surface area (212 m2/g) and negative surface charge (−38.21 mV), significantly enhancing dye adsorption capacity to 666.66 mg/g—nearly double that of unmodified ATP variants (360.4–386.8 mg/g). Kinetic studies confirmed pseudo-second-order adsorption kinetics, attributed to hydrogen bonding and van der Waals interactions between Rh-B and the composite. Under photo-Fenton conditions, C-AATP@CTAB achieved 99.8% Rh-B degradation within 20 min, demonstrating superior catalytic performance in heterogeneous Fenton/photo-Fenton systems. This work establishes a low-cost, high-efficiency adsorbent-catalyst hybrid derived from low-grade attapulgite, offering promising avenues for sustainable wastewater treatment.
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LANGMUIR
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2026
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IF 4.4
Ziwei Wu,Xinpeng Chen,Jingqi Cao,Yifeng Wang,Yongxuan Xiang,Yixiao Li,Haoyu Wang,Hongmei Cao,Tieling Xing
Photocatalysis and piezocatalysis rely on light energy and mechanical energy (via the piezoelectric effect) as driving forces, respectively. Both have been successfully applied to pollutant degradation and wastewater treatment as advanced oxidation processes. However, in this study, BiFeO3 nanoparticles derived from MIL-101 were solidified in a flexible polyvinylidene fluoride (PVDF) porous structure, forming a dynamic synergistic effect between the piezoelectrically polarized electric field induced by mechanical agitation and the photogenerated carriers. Additionally, the hydrolytic inactivation of the material was inhibited by the chemical barrier effect of PVDF, while the charge separation at the heterojunction interface was directionally driven by the built-in electric field generated by the piezoelectric effect. The BiFeO3/PVDF composite membrane degraded 97.1% of RhB after 60 min of treatment under the synergistic effect of stirring and light. Free radical trapping and electron spin resonance (ESR) analysis confirmed that •O2– and •OH were the key active species (contributing over 60%). Piezoresponse Force Microscopy (PFM) test revealed the mechanism behind the enhancement of the built-in electric field, and density functional theory (DFT) calculations combined with Fukui’s function elucidated that the N4, N5, and C6 sites in the RhB molecule were the preferred targets for free radical attack. Plant growth experiments verified the environmental safety of the system. The BiFeO3/PVDF porous composites with piezoelectric photocatalytic properties proposed in this study provide a promising solution for developing novel materials for efficient catalysis of organic pollutants in water.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2026
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IF 8.7
Juan Zhou,Hao Li,Mingting Lv,Yumeng Bao,Jinghua Chen
To overcome the clinical limitations of amphotericin B (AmB), such as poor aqueous solubility, significant systemic toxicity, and dose-dependent nephrotoxicity, we developed a pH-responsive nanodelivery system (HH18@AmB) based on engineered human serum albumin (HSA) fused with 18 histidine residues (HH18). The histidine-rich design enables HH18 to undergo hydrophobicity-driven self-assembly, encapsulating AmB within uniform nanoparticles with an average size of ~150 nm and a high drug-loading capacity of 23.08 ± 2.93%. In vitro release studies confirmed a sustained, pH-dependent drug release profile under acidic conditions mimicking the microenvironment of fungal infections. Notably, the encapsulated AmB remains predominantly in the monomeric state, which is associated with reduced toxicity. Cytotoxicity assays demonstrated that HH18@AmB exhibited significantly enhanced biocompatibility against RAW 264.7 macrophages and HEK 293 T renal cells, maintaining cell viability above 65%, while retaining potent antifungal activity. The minimum inhibitory concentration against Candida albicans was determined to be 4 μg/mL, and at this concentration, HH18@AmB inhibited biofilm formation by 55%. In vivo pharmacokinetic evaluation revealed a prolonged circulation time, with the half-life (t₁/₂) extended by 2.12-fold and the area under the curve (AUC 0-t ) increased by 9.39-fold compared to free AmB. Moreover, HH18@AmB exhibited reduced renal accumulation, indicating alleviated nephrotoxicity. By integrating pH-responsive drug release, HSA-mediated stability, and markedly improved safety profile, HH18@AmB represents a promising nanotherapeutic strategy to enhance the clinical utility of AmB, particularly for the treatment of drug-resistant fungal infections.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
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2026
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IF 3.8
Bo Chunmiao,Han Xiaoyu,Tang Xiaofan,Zhao Weilong
Efficient adsorption and sensitive detection of baicalin (BAI) are essential for maximizing its medical value. In this work, a rhodamine B (Rb)-encapsulated metal–organic framework (MOF)@boric acid–modified covalent organic framework (COF) composite material (Rb-MOF@COF-BA) was designed for high-capacity adsorption and high-sensitivity detection of BAI. Specifically, the Zr-based MOF of UiO-66 was prepared with Zr 4+ and 2-aminoterephthalic acid, during which Rb was encapsulated, resulting in strong red fluorescence. The –NH 2 group on the Rb-MOF surface then reacted with 2,5-dimethoxyterephthalaldehyde and coupled with the ligand 1,3,5-tris(4-aminophenyl)benzene to integrate the COF. Subsequently, to enhance the recognition of cis -diol-containing BAI through boron affinity, Rb-MOF@COF was functionalized with (4-ethynylphenyl)boronic acid via aza-Diels–Alder cyclization, obtaining the Rb-MOF@COF-BA composite with blue fluorescence. For BAI, Rb-MOF@COF-BA demonstrated a high adsorption capacity of 114.2 mg g −1 and reached equilibrium within 200 min. Additionally, the Rb-MOF@COF-BA composite displayed dual emissions at 440 and 580 nm, enabling its use as a ratiometric fluorescence sensor for BAI detection, accompanied by a visible blue-to-red spectral transition. The resulting radiometric fluorescence method demonstrated linear ranges of 0.2−3.0 and 3.0−20.0 μmol L −1 with a low detection limit of 0.0173 μmol L −1 for BAI. This analytical method was employed to identify and quantify BAI in Yinhuang oral solution, yielding favorable results that confirmed the potential of this ratiometric detection for practical applications. Graphical
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JOURNAL OF LUMINESCENCE
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2026
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IF 3.6
Yuhong Xie,Yiying Wang,Yourong Zhao,Jiali Yang,Yangchun Fan,Hongda Li,Daojiang Gao,Zhanglei Ning
In this study, a dual-emission ratiometric fluorescent materials, rhodamine B-functionalized terbium-based metal-organic frameworks (RhB@Tb-MOFs), were synthesized through an ultrasonic immersion approach. The resulting RhB@Tb-MOFs demonstrate a distinct red-green dual emission, generating an easily distinguishable orange-red luminescence with excellent stability across a wide pH range and aqueous environments. This novel probe demonstrates excellent selectivity along with outstanding anti-interference capability, achieving a detection limit as low as 0.219 μM for S 2− . Moreover, the sensing mechanism was studied in detail, which is attributed to a dynamic quenching mechanism. This study highlights a versatile and generalizable approach for enhancing luminescence-based sensing performance through the encapsulation of fluorescent dyes in Ln-MOFs, presenting significant potential for environmental monitoring and bioanalytical applications.
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JOURNAL OF MEMBRANE SCIENCE
·
2026
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IF 9
Jingtai Wang,Wenliang Wang,Niamat Ullah,Ming Qi,Ningxin Zhou,Yunxia Hu
A novel high-flux polyethersulfone- block -polyethylene glycol (PES- b -PEG) microfiltration (MF) membrane was developed via the vapor-assisted non-solvent-induced phase separation (V-NIPS) method using a 10-s humid air bath. Compared to control PES membranes, the PES- b -PEG membranes exhibit a looser, hourglass-like structure with higher porosity, larger pore diameters, and enhanced water flux and filtration capacity. The onset position of the hourglass-like pores can be finely tuned by adjusting the humid air bath time, enabling significant control over pore diameter and water permeance. Incorporation of PEG into the block copolymer, along with the low viscosity of the casting solution, accelerates water uptake and improves compatibility with water during V-NIPS, promoting efficient vapor-induced phase separation (VIPS) and the formation of a looser, highly permeable structure. With a 10-s air bath, the PES- b -PEG membrane achieves water flux of 45,712 L m −2 h −1 bar −1 , a pore diameter of 0.8 μm, 99.5 % rejection of 1.0 μm polystyrene microspheres, and a filtration capacity of 1,233 L m −2 (at 10 % flux decline). This study highlights the advantages of PES- b -PEG block copolymers for producing high-performance MF membranes with a tailorable hourglass-like architecture via ultrashort humid air exposure.
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ANALYTICAL LETTERS
·
2014
·
IF 1.019
Qiong Cheng,Jun-Feng Li,Liqiu Zhang,Lichun Liu
This work reports an efficient method to quantify the Hepatitis B surface antigen and α-fetoprotein in human serum using a functional magnetic nanoparticle-assisted sandwich-type electrochemical immunoassay. The Fe
3
O
4 magnetic nanoparticles were first modified with carboxyl functional groups to permit stable bioconjugation to the amine groups of most biological targets. The primary antibodies were then covalently stained on the surface of the functional magnetic nanoparticles, followed by the analyte and secondary antibodies, resulting in a sandwich-type (antibody-antigen-antibody/enzyme) immune complex. The secondary antibodies were labeled with horseradish peroxidase for the catalytic oxidation of 2-aminophenol to yield electrochemically reducible molecules. The separation using an external magnetic field guaranteed fast and reliable purification and enrichment of analytes. Quantitative analysis was performed upon representative clinical targets: Hepatitis B surface antigen and α-fetoprotein in human serum. The detection limits were 0.06 ng/mL for the former and 0.5 ng/mL for the latter, which were about 10 times lower than values obtained by conventional enzyme-linked immunosorbent assays. The reported method may be adopted as a general strategy for the sensitive and selective determination of additional proteins and biological molecules.
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Journal of Physical Chemistry C
·
2010
·
IF 4.224
Shunwei Hu,Jia Zhu,Ling Wu,Xuxu Wang,Ping Liu,Yongfan Zhang,Zhaohui Li
Fluorinated In(OH)ySz solid solutions were synthesized via a hydrothermal method. The photocatalytic degradation of rhodamine B (RhB) over the fluorinated In(OH)ySz solid solutions revealed that the process of the de-ethylation of RhB was enhanced, while in the meantime, the rate of the mineralization of RhB was suppressed when In(OH)ySz was fluorinated. To elucidate the opposite effects of fluorination on the two processes of photocatalytic degradation of RhB (de-ethylation and mineralization) over In(OH)ySz, the adsorption of RhB over In(OH)ySz with and without fluorination, the active species involved in the de-ethylation and the mineralization of RhB, were investigated, and the electronic structure of fluorinated In(OH)ySz was studied. The results indicated that the major active species involved in the de-ethylation and the mineralization of RhB are different, that is, the hole direct oxidation leads to the de-ethylation of RhB, while the major active species responsible for the mineralization of RhB is the O2−• radical. The fluorination on In(OH)ySz solid solutions on one hand can enhance the adsorption of RhB on the catalyst surface, leading to a higher rate in the de-ethylation of RhB. On the other hand, fluorination lowers the conduction band of In(OH)ySz, which leads to a lower capability of the photogenerated electrons in the reduction of O2 to give O2−• radicals. Our results clearly show that the fluorine modifications can have ambilateral effects on the photocatalytic performance of semiconductor photocatalysts depending on the specific photocatalytic reactions.
研究领域:
材料科学
·
光催化
·
环境化学
·
半导体催化
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APPLIED SURFACE SCIENCE
·
2022
·
IF 7.392
Zuqin Duan,Xue Wang,Richu Wei,Qian Lei,Honglin Chen
A facile novel B, N co-doped carbon was fabricated by high-temperature pyrolysis of a mixture of ethylenediamine tetraacetic acid disodium salt and boric acid, on which Pd nanoparticles were loaded to synthesize highly efficient Pd/BNC catalyst for dehydrogenation of formic acid. The type and content of N are regulated by the doping of B elements in carbon materials. The high content of N and B doping provides more anchor sites for Pd and strengthens the interaction between the support and Pd nanoparticles, thus forming highly dispersed Pd nanoparticles and regulating the electronic property of Pd. Therefore, the obtained Pd/BNC catalyst displayed enhanced performance (TOF = 2760 h −1 ) and a lower activation barrier (31.84 kJ/mol). Furthermore, the catalyst also exhibited wonderful cycling stability for hydrogen evolution from formic acid.
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