INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
·
IF 8.5
Danyang Wang,Yuming Zhou,Xiaoting Wang,Xiaopu Ji,Yiying Wei,Shengdi Tong,Jinghui Hu,Haiqing Song,Zonglei Mou,Guofeng Zhang,Bo Cong,Wan Ru Sun,Pingyu Wang,Yuqiang Zhang,Shuyang Xie,Ranran Wang
Natural conductive hydrogels are regarded as desirable materials for motion monitoring owing to their outstanding biocompatibility and degradability. It has been reported that the occurrence rate of injuries in the final 30 % of the activity is closely associated with fatigue-induced changes in neuromuscular control. However, most hydrogels are designed solely for motion state and electromyography (EMG) detection and do not provide the capability to alleviate muscle fatigue. The development of conductive hydrogels that integrate motion monitoring with fatigue alleviation could enable simultaneous fatigue detection and on-demand fatigue relief, thereby reducing the risk of sports-related injuries. Photothermal therapy has been proven to be an effective method for relieving muscle fatigue. In this study, a double-network hydrogel composed of chitosan and sodium alginate was prepared, which incorporates lignin‑silver nanoparticles (NPs) and melanin NPs to achieve effective motion monitoring and photothermal therapy. A physical cross-linking network formed via electrostatic interactions between chitosan and sodium alginate was reinforced with a Genipin-mediated chemical cross-linking network. The addition of lignin‑silver NPs enhanced the hydrogel's conductivity and mechanical integrity, whereas melanin NPs improved adhesion and conferred photothermal responsiveness. The resulting hydrogel enabled reliable motion monitoring and real-time identification of exercise-induced fatigue through EMG. Upon fatigue detection, the photothermal properties of the hydrogel facilitated rapid fatigue alleviation.
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ACS Applied Bio Materials
·
2025
·
IF 4.7
Yuanhong Zhou,Ziyuan Zong,Xiaofang Liu,Xiang Chen,Zhifeng Hao,Mohamed S. Selim,Jian Yu
Hydrogels have received significant attention in the biomedical field, but traditional antibacterial hydrogels have certain limitations in terms of antibacterial activity, resistance, and functionality. In this study, we present a multifunctional hydrogel synthesized through a one-step process using carboxymethyl chitosan (CMCS) as the matrix, tannic acid (TA) as the cross-linking agent, and penicillin (PG)-loaded MXene as the drug additive, for antibacterial therapy. In this system, the composite hydrogel is physically cross-linked through ionic bonds and hydrogen bonds between CMCS and TA, exhibiting good injectability, self-healing properties, and tissue adhesiveness. The incorporation of MXene drug-loaded with penicillin imparts photothermal properties to the hydrogel, thereby enabling a synergistic antibacterial effect between the components, resulting in stable antibacterial activity. In addition, the hydrogel exhibits favorable biocompatibility, as well as the capacity to scavenge reactive oxygen species (ROS) and rapidly arrest hemorrhaging, showing promising applications in wound care.
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ChemistrySelect
·
2024
·Vol. 9
·期 42
·e202404909
·
IF 1.9
Shephrah Olubusola Ogungbesan,Eduardo Buxaderas,Rosemary Anwuli Adedokun,Yanina Moglie,Santiago Grijalvo,María Teresa García,Cui Bingbing,David Díaz Díaz,Guodong Fu
Graphical The reduction of silver ion by chitosan slurry leads to the green synthesis of well-characterized silver nanoparticles (10 nm) stabilized within the chitosan–silver nanocomposite film with enhanced antibacterial activities. This study is aimed at the in situ preparation and antibacterial study of silver nanoparticles within the matrix of an eco-friendly, biocompatible, biodegradable, and bioavailable biopolymer (chitosan) to form Chi–AgNP film via multiple noncovalent interactions between the organic polymer and the nanoparticles. The film is fully characterized by infrared and ultraviolet spectroscopy, scanning electron microscopy, transmission electron microscopy, X-ray photoelectron spectroscopy, and thermogravimetric analysis. The characterization confirms the successful incorporation of silver nanoparticles into the polymeric network. Infrared spectroscopy reveals peaks corresponding to the vibration of functional groups present in chitosan with enhanced intensity and blueshifts caused by the presence of silver nanoparticles. Well-monodispersed spherical silver nanoparticles with an average size of 10 nm are observed in the Chi–AgNP film. The surface plasmon resonance at 447 nm is consistent with a typical silver plasmon. Furthermore, the antibacterial effects on E. coli and S. aureus were determined and attributed to the release of AgNPs observed by UV absorption.
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CARBOHYDRATE POLYMERS
·
2024
·
IF 10.7
Nian Xiang,Yuming Lin,Zuzeng Qin,Tongming Su,Xinling Xie,Hongbing Ji
Polysaccharides-based smart fertilizers are essential for promoting plant growth, yet significant challenges exist in achieving stable structures and synchronizing nutrient release and plant growth. This study developed a temperature-responsive gating chitosan-based microcapsule (CTSMC-g-PNIPAM) by grafting N-isopropyl acrylamide (NIPAM) onto chitosan microcapsules (CTSMC) via atom transfer radical polymerization (ATRP). The interfacial crosslinking of chitosan (CTS) and terephthalendehyde (TPA) formed the CTSMC matrix with a hollow chamber structure and ensured stability. CTSMC-g-PNIPAM exhibited reversible temperature-responsive gating properties and sustained release behavior, and the PNIPAM chains acted like gating switches. Below the low critical solution temperature (LCST) (25 °C), the PNIPAM chains stretched and the gating switch closed, slowing down the release rate. Above the LCST (40 °C), the PNIPAM chains contracted and the gating switch opened, accelerating the release rate. The release behaviors of CTSMC-g-PNIPAM in soil indicated that the gating microcapsule effectively prolonged the release of urea. Moreover, the cumulative release of CTSMC-g-PNIPAM at 40 °C was significantly higher than at 25 °C. The first-order kinetic and Korsmeyer-Peppas model indicate that the urea release involves concentration gradient diffusion and skeleton dissolution. Compared with pure urea, urea@(CTSMC-g-PNIPAM) increased the growth status of maize, suggesting a promising strategy for smart fertilizers.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Hui Wang,Chen Chen,Kun Dai,Houle Xiang,Jingwei Kou,Han Guo,Hanjie Ying,Xiaochun Chen,Jinglan Wu
Dyes pollution is well known for their hazardous impacts on human health and the environment. The removal of dyes from wastewater has become an important issue. In this study, magnetic micrometer-sized particles AL-CTS@MNPs were synthesized from alkaline lignin (AL) and chitosan (CTS) by “one-pot method”. The adsorbent presented higher selectivity adsorption effect on anionic dyes than amphoteric and cationic dyes, and even no adsorption effect on cationic methylene blue (MB), which showed that the anionic dyes could be better separated from the other two types of dyes. The adsorption isotherms of the dyes were highly consistent with the Langmuir model, and the maximum adsorption capacity was 329.50 mg/g for methyl orange (MO) and 20.00 mg/g for rhodamine B (RhB). AL-CTS@MNPs showed good adsorption of anionic dyes (MO) in the pH range of 3–9. Meanwhile, the adsorbent AL-CTS@MNPs were also characterized, showing rough surface with specific surface areas of 37.38 m 2 /g, pore diameter of 95.8 nm and porosity of 17.62 %. The particle sizes were ranged from 800 μm to 1300 μm. The electrostatic attraction and π-π* electron donor-acceptor interactions were the main forces between the adsorbent and anionic dyes. While the electrostatic repulsive force between the adsorbent and the cationic dyes resulted in the non-absorption of MB by AL-CTS@MNPs. Subsequently, the adsorbent maintained a removal rate of >95 % after five adsorption-desorption cycles, demonstrating its excellent stability and recoverability. Ultimately, the prepared AL-CTS@MNPs illuminated good prospect on complex components dyes wastewater treatment.
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MINERALS ENGINEERING
·
2024
·
IF 4.9
Longxia Jiang,Bo Feng,Tao Wang,Ziming Wang
Fluorite and barite share similar physicochemical properties, making them challenging to separate efficiently using flotation. To address this problem, sodium oleate (NaOL) was used as a collector to study the separation effect of carboxylated chitosan (CCS) as a depressant for fluorite and barite. Infrared Spectroscopy (FTIR) test, X-ray photoelectron spectroscopy (XPS), Zeta potential test, contact angle test and adsorption test were investigate the selective depression mechanism of CCS. The test results showed that CCS, acting as the depressant, effectively depressed fluorite and separated fluorite and barite. According to mechanistic analysis, CCS developed stable chemisorption by bonding the carboxyl group (–COOH) in its molecule and the calcium sites of fluorite. In contrast, CCS adsorption on barite was a hydrogen bonding interaction, making CCS easily fall off the barite surface. As a result, NaOL can be stably adsorbed on the barite surface, whereas CCS present on the fluorite surface consumes a high number of Ca sites and reduces Ca sites available for NaOL adsorption, resulting in distinct hydrophobicity and floatability differences between fluorite and barite. Consequently, barite and fluorite were successfully separated.
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Journal of Materials Chemistry B
·
2019
·Vol. 7
·期 16
·2634-2642
·
IF 5.047
Yulin Jiang,Yi Deng,Ying Tu,Birol Ay,Xiaodong Sun,Yubao Li,Xiaohong Wang,Xianchun Chen,Li Zhang
Chitosan-based guided tissue regeneration (GTR) membranes are extensively used in orthopedic/stomatological regenerative medicine since chitosan shares many chemical and structural similarities with glycosaminoglycans (GAGs) in the extracellular matrix. However, the available chitosan-based GTR membranes mostly lack topological features of natural tissues, resulting in unsatisfactory biocompatibility. To address this limitation, we developed a novel biologically-inspired asymmetric topological chitosan (ATCS) membrane supported by a nanoporous anodic aluminum oxide (AAO) template. We, thereafter, investigated the mechanical properties, degradation, and cytocompatibility of the ATCS membranes and compared them with those of the symmetric chitosan (SyCS) membranes, produced with a smooth Al template. The asymmetric topological structure significantly increased the tensile strength but decreased the extent of degradation of the ATCS membranes compared to those of SyCS. In the in vitro studies, the ATCS membranes outperformed the SyCS membranes in cytocompatibility due to their cell-like features. In addition to the ATCS membranes, the ethylene vinyl acetate (EVA) membranes with a similar cell-like structure were successfully fabricated using the AAO template to verify the universality of the AAO template-assisted technique. Accordingly, the AAO template-assisted strategy, defined in this study, is an innovative, universal, and facile way to fabricate polymeric asymmetric membranes with cell-like features. The bioengineered ATCS membranes with tunable degradability, prominent mechanical properties and biocompatibility are promising candidates for orthopedic healthcare applications.
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Analytical Methods
·
2013
·Vol. 5
·期 20
·5471-5477
·
IF 1.855
Shan Yang,Yuzhi Wang,Minli Xu,Meizhi He,Min Zhang,Dan Ran,Xiaopin Jia
A simple molecularly imprinted polymer (MIP) was prepared to recognize the template lysozyme (Lys). Chitosan (CS) was selected as the functional biopolymer to enhance the adsorption capacity. The aldehyde group was introduced to CS, so that the template protein could be immobilized onto the modified CS beads. After the template protein was successfully immobilized, two kinds of organic siloxane, tetraethoxysiloxane (TEOS) and 3-aminopropyl triethoxysilane (APTES), were added and polymerized via a sol–gel process in aqueous solution at 25 °C. After template removal, adsorption experiments were performed to study the properties of the synthesized MIP. The results showed that the MIP exhibited much higher adsorption capacity for Lys than the non-imprinted polymer (NIP). The theoretical maximum adsorption capacity (Qmax) and equilibrium constant (KL) were determined by the Langmuir model, which turned out to be 15.89 mg g−1 and 6.78. The selectivity of the MIP was verified by direct adsorption of a single reference protein and mixed protein. The UV measurement and sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) analysis results showed the MIP had a relatively high adsorption capacity and excellent selectivity, which made it possible to remove the template protein from different sample solutions.
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Journal of Biomedical Nanotechnology
·
2018
·Vol. 14
·期 8
·1486-1495
·
IF 5.068
Wang Yonghong,Wen Baofang,Yu Hongli,Ding Dejun,Zhang JingJing,Zhang Yunxiang,Zhao Limin,Zhang Weifen
Nasopharyngeal carcinoma (NPC) is a common epithelial malignancy that occurs in the nasopharynx and it is one of the high incidences of malignant tumors in China. As previous reports, berberine hydrochloride (BH) possesses a repressive effect on the proliferation of various cancer types.
But the application of BH was hampered for a long time due to its hydrophobic properties, along with poor stability and bioavailability. In this study, folate acid modified chitosan nanoparticles loaded berberine hydrochloride (BH/FA-CTS NPs) were prepared by the ionic cross-linking technique,
the physicochemical properties and the influence of BH/FA-CTS NPs on proliferation, migration and apoptosis in human nasopharyngeal carcinoma CNE-1 cells were studied in vitro and in vivo. Results of scanning electron microscopy (SEM) images showed that BH/FA-CTS NPs were sphere
and the diameter was 258.2±9.1 nm. The drug loading and encapsulation efficiency were 8.17±1.12% and 87.73±4.21%, respectively. The drug release kinetics exhibited a slower and sustained release over a period of 48 h. Moreover, results of MTT assay and scratch assay displayed
that BH/FA-CTS NPs inhibited proliferation and migration of CNE-1 cells remarkably. BH/FA-CTS NPs promoted apoptosis and necrosis of CNE-1 cells. And BH/FA-CTS NPs displayed distinguished higher tumor inhibition than control group, free BH and BH/CTS NPs in vivo. Therefore, as a nanocomposite,
BH/FA-CTS NPs provide a new method and option for the treatment of nasopharyngeal carcinoma patients.
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Pharmaceutics
·
2020
·Vol. 12
·期 3
·202
·
IF 4.421
Lan Zhang,Min Yan,Kun Chen,Qikang Tian,Junying Song,Zijuan Zhang,Zhishen Xie,Yong Yuan,Yaquan Jia,Xin Zhu,Zhenqiang Zhang,Xiangxiang Wu,Huahui Zeng
A new platform for triptolide (TP) delivery was prepared by conjugating TP to a carboxylmethyl chitosan (CMCS). Compared with the natural TP, the TP-conjugate (TP-CMCS) containing TP of ~5 wt% exhibited excellent aqueous solubility (>5 mg/mL). Results of in vitro experiments showed that TP-CMCS could relieve TP-induced inhibition on RAW264.7 cells and apoptosis, respectively. Compared with the TP group, TP-CMCS could effectively alleviate the toxicity injury of TP and decreased the mortality rate of the mice (p< 0.05). TP-CMCS did not cause much damage to the liver (AST and ALT) and kidney (BUN and CRE) (p< 0.05). After administration, the levels of IL-6, IL-1β, and TNF-α decreased, and the arthritis detumescence percentages increased significantly, and the bony erosion degree was distinctly decreased in the TP-CMCS groups and TP group. Our results suggested that TP-CMCS was a useful carrier for the treatment of RA, which enhanced aqueous solubility of free TP and reduced drug toxicity in vitro and in vivo.Keywords:triptolide;toxicity;water solubility;carboxylmethyl chitosan;drug carrier system
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Huixiang Wu,Yujun Zhang,Hao Chen,Jing Liu,Lili Xiu,Jianying Huang
In this work, we synthesized cryptate copper(II) followed by complexed with sulfonate chitosan (SCS). After characterization, the evaluation of the antioxidant properties of resulting complexes were carried out by 1,1-Diphenyl-2-picrylhydrazyl radical (DPPH•), hydroxyl radical (•OH), and 2,2′-Azinobis-(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS •+ ), while the antibacterial and biofilm inhibitory activity against Pseudomonas aeruginosa PAO1 ( P. aeruginosa PAO1) were also investigated. According to the results, cryptate copper(II) exhibited the best antioxidant activity followed by cryptate copper(II)/SCS complexes, and SCS. Significant antibacterial activity of cryptate copper(II) against P. aeruginosa PAO1 was observed with the minimum inhibitory concentration of MIC value 12.50 μg/mL and minimum bactericidal concentration of MBC value 100.00 μg/mL, followed by cryptate copper(II)/SCS complexes and SCS. Cryptate copper(II) and cryptate copper(II)/SCS exhibited antibacterial activity which copper ions might enter the interior of cells, and the intracellular ions made the killed bacteria serve as an antibacterial agent showing a zombie effect. The copper ions complexed with cryptate and SCS rendering potential unlimited biological activities, might become one of the most popular research areas because of their unique coordination chemistry and their long-term biological activities.
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MATERIALS & DESIGN
·
2021
·
IF 7.991
Pengfei Ma,Wenjing Wu,Yu Wei,Le Ren,Shuxian Lin,Junhua Wu
Multi-component bone tissue engineering scaffolds are the dominant trend to address complex requirements of bone defect repair. In this study, to mimic component and microstructure of natural bone, polymers (natural and synthetic) and nano-hydroxyapatite (nHAp) were fabricated to form a porous composite scaffold. Gelatin (Gel), chitosan (CS) and polyvinyl alcohol (PVA) were first assembled to simulate extracellular matrix. The simulated matrix exhibited tunable pore size, porosity, swelling, pH, degradation and mechanical strength. After the incorporation of nHAp, the composite scaffolds showed improved compression resistance, pH adaptability, improved surface bioactivity and biomimetic structure. In addition, the composite scaffolds can effectively promote cell proliferation and adhesion, of which, scaffolds containing 12.5% of nHAp were demonstrated to have high osteogenic differentiation ability. Hence, these results suggest that Gel/CS/PVA/nHAp composite scaffolds could be a promising biomimetic scaffold for bone tissue engineering.
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