Foods
·
2024
·Vol. 13
·期 24
·4127
·
IF 4.7
Jianguo Huang,Rashid Khan,Chunhui Zhai,Xianting Ding,Li-Sha Zhang,Jin-Ming Wu,Zhizhen Ye
Developing and implementing technologies that can significantly reduce food loss during storage and transport are of paramount importance. Ozone synergistic catalytic oxidation (OSCO) technology has been developed, which sterilizes bacteria and viruses on the surface of food and degrades ethylene released during fruit storage through the active oxygen produced by the catalytic decomposition of ozone. Herein, we report the hydrothermal synthesis of MnO2with distinct phase compositions and nanostructures through simply varying the reaction temperatures. Optimized copper-doped α-MnO2nanorods exhibited remarkable efficacy in activating ozone at a concentration of 40 ppb, and this activation resulted in the complete eradication of indicator bacteria on food surfaces within a 24 h period. Moreover, these nanorods demonstrated high effectiveness in decomposing more than 80% of the ethylene molecules emitted by apples and bananas during the preservation period. The high concentration of surface oxygen vacancies is believed to contribute to the enhanced catalytic activity of the Cu-doped α-MnO2catalyst in the OSCO procedure by reducing ethylene production and maintaining the fruit quality during the preservation period.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Small
·
2025
·
IF 12.1
Huihui Chen,Xiao Hu,Bingying Hou,Liying Qin,Eve-Graciella M.E.K. Kuete,Levinus Hendrik Koole
Bacterial keratitis (BK) is a critical and sight-threatening corneal infection that significantly impairs the quality of life. Due to the widespread antibiotic-resistant microbes and the slow development in antibiotics, there is an increasingly growing demand to create new antimicrobial agents for the treatment of BK. Herein, copper-intercalated molybdenum disulfide (Cu-MoS 2 ) nanosheets are constructed by intercalating Cu into the interlayer structure of MoS 2 via intercalation chemistry, which not only introduces the Fenton reaction but also modulates the electronic structure of MoS 2 . Cu-MoS 2 can convert H 2 O 2 into more toxic reactive oxygen species (ROS), thereby exhibiting excellent bactericidal performance against Staphylococcus aureus (S. aureus) , methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli (E. coli) at room temperature in the dark. Animal experiments indicated that Cu-MoS 2 can effectively treat BK caused by MRSA. This work demonstrates that intercalation chemistry as a novel and effective strategy to tune MoS 2 as the antibacterial agent with no reliance on light that has great potential therapeutic effects on clinical drug-resistant BK.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF ENVIRONMENTAL MANAGEMENT
·
2025
·
IF 8.4
Yang Yu,Na Jiang,Yuanbo Zhou,Fei Huang,Yide He,Yongjun Zhang
Ofloxacin (OFX), commonly employed in the treatment of infectious diseases, is frequently detected in aquatic environments and poses potential ecological risks. UV/H 2 O 2 oxidation has been recognized as an efficient approach for removing antibiotics. In this study, Cu-doped waste-tire carbon was prepared and used as a UV/H 2 O 2 catalyst for the degradation of OFX. The results showed that the OFX removal was 89.3% within 90 min under the optimal reaction conditions. It was found that ZnO, used in the tire manufacturing to promote rubber vulcanization for enhanced stability and durability, played an important role in UV/H₂O₂ oxidation for OFX degradation. Toxicity experiments conducted with a microbial degradation respirometer demonstrated that the treated water exhibited low toxicity. This study introduces a sustainable catalyst derived from waste tires, and facilitating the development of metal-carbon catalysts for the effective removal of antibiotics from wastewater.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Environmental Science-Processes & Impacts
·
2024
·
IF 4.3
Chang Xu,Bo Gong,Shan Zhao,Xiao-Min Sun,Shu-Guang Wang,Chao Song
Tetracycline (TC) and Cu(II) coexist commonly in various waters, which may infiltrate into the subterranean environment through runoff and leaching, resulting in substantial ecological risks. However, the underlying mechanisms why Cu(II) affects the transport of TC in porous media remain to be further explored and supported by more evidence, especially the role of complexation. In this study, the transport of TC with coexisting Cu(II) was comprehensively explored with column experiments and density functional theory (DFT) calculation. At natural environmental concentrations, Cu(II) significantly inhibited the transport of TC in the quartz sand column. Cu(II) augmented the retention of TC in the column mainly via electrostatic force and complexation. The interaction between TC and TC–Cu complexes on the surface of SiO2 was investigated with first-principles calculations for the first time. There were strong van der Waals forces and coordination bonds on the surface of complexes and SiO2, leading to higher adsorption energy than that of TC and inhibiting its penetration. This study offers novel insights and theoretical framework for the transport of antibiotics in the presence of metal ions to better understand the fate of antibiotics in nature.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Xiaohong Zhu,Tiantian Feng,Yidan Chen,Yao Xiao,Wei Wen,Xiuhua Zhang,Dong Wang,Shengfu Wang,Jichao Liang,Huayu Xiong
Skin wound healing, particularly diabetic wound healing, is a common clinical challenge. Reducing bacterial infection and promoting angiogenesis are key strategies for diabetic wound healing. In this study, we construct the porphyrin-based Cu-covalent organic frameworks (Cu-COF) through a Schiff base condensation reaction, and then functionalize Cu-COF with 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)] (mPEG-DSPE), denoted as PEG/Cu-COF, for enhancing diabetic wound healing. PEG/Cu-COF exhibits dual enzymatic properties (glutathione (GSH) oxidase-like and peroxidase (POD)-like nanozymes), facilitating the depletion of GSH and the generation of reactive oxygen species (ROS) through a self-cascading enzymatic reaction, thereby leading to chemodynamic therapy (CDT). Density functional theory (DFT) calculations are employed to investigate the catalytic mechanism and the results reveal that Cu-COF exhibits higher catalytic activity for POD. Moreover, porphyrin-based COF generates singlet oxygen and localize heating under white light and near-infrared irradiation, respectively. Both in vitro and in vivo experiments demonstrate that PEG/Cu-COF exhibits multimodal synergistic sterilization and promotes angiogenesis, collagen deposition, and re-epithelialization during diabetic wound healing. This work highlights the potential utilization of PEG/Cu-COF for self-supplying hydrogen peroxide (H 2 O 2 ) and amplifying self-cascade reactions to address the limitations of enzymatic treatment, while the synergistic effect of phototherapy improves sterilization and minimizes side effects in vivo .
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2025
·Vol. 15
·期 6
·4443-4457
·
IF 4.6
Junqi Zhang,Yongwang Li,Zhiwei Zhang,Zheng Wang,Jiaxing Zhang,Shuai Liu,Yang Qin,Bingxin Zhu,Tongxue Zhang,Hongyu Wang,Fumin Wang,Xubin Zhang
The development of simple, efficient and economical catalysts for the hydrogenation of biomass to produce high value-added chemicals is of great significance in solving the energy crisis. In this work, a series of non-precious metal catalysts (Cu–Al2O3–ZnO) with different defect sites were prepared by etching Devarda's alloy. Under optimized mild reaction conditions, the furfural conversion and furfuryl alcohol selectivity are both greater than 99.0%, and the catalyst has good reusability. Characterisation and experiments were used to investigate the activate species for hydrogenation reaction. It can be proved that the low-valent Cu species in the Cu–Al2O3–ZnO catalysts play an important role as adsorption and dissociation sites for H2. Different etching degrees and sample reduction temperatures of the alloy can be used to adjust the content of acidic sites such as Al2O3 and CuO, which have appropriate adsorption properties for furfural. ZnO promotes the dispersion of the Cu species and enhances the accessibility of the active sites. The etching method achieves the interaction between species to further enhance the stability and activity of the catalyst. The catalytic performance of the catalyst is very competitive and this study provides a new method for the efficient hydrogenation of furfural to furfuryl alcohol.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Biomedical Materials
·
2025
·Vol. 20
·期 2
·025042
·
IF 3.7
Hongchao Zhao,Hengcheng Zhu,Yang Du,Mu He,Mao Ding,Fan Cheng
Photodynamic therapy (PDT) holds promise for cancer treatment by generating reactive oxygen species via photosensitizers (PSs) activated by specific wavelengths of light. However, the poor water solubility of PSs and the tumor microenvironment, characterized by high glutathione (GSH) levels and hypoxia, limit its efficacy against hypoxic tumors. To overcome these challenges, we developed a novel nano-reactor, Zr(Cu)-MOF@Au@DHA, to augment PDT-ferroptosis therapy. By incorporating Cu2+ into the porphyrin ring of PCN-224 and decorating it with gold nanoparticles, we enhanced the photocatalytic efficiency of the metal–organic framework (MOF). Additionally, dihydroartemisinin (DHA) was loaded onto the nano-reactor to boost the ferroptosis sensitivity of bladder cancer cells. Both in vitro and in vivo studies confirm that under laser irradiation, Zr(Cu)-MOF@Au@DHA significantly elevates oxidative stress, depletes GSH, and triggers DHA release, sensitizing tumor cells to ferroptosis and enhancing PDT-ferroptosis therapy for bladder cancer. This innovative nano-platform integrates near-infrared light-triggered PDT with chemotherapy to induce ferroptosis, addressing critical limitations in bladder cancer treatment.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Biomedical Materials
·
2024
·Vol. 19
·期 6
·065025
·
IF 3.9
Xiaohuan Guo,Qi Fang,Nan Leng,Yuan Liu,Bingbing Cai,Yuzhu Zhou,Changchun Wen
Chemodynamic therapy (CDT) is a new method for cancer treatment that produces highly toxic reactive oxygen species (ROS) in the tumor microenvironment to induce cancer cell apoptosis or necrosis. However, the therapeutic effect of CDT is often hindered by intracellular H2O2 deficiency and the activity of antioxidants such as glutathione (GSH). In this study, a nano-catalyst HCM was developed using a self-assembled Cu/Mn-doped metal-organic framework, and its surface was modified with hyaluronic acid to construct a tumor-targeting CDT therapeutic agent with improved the efficiency and specificity. Three substances HHTP (2, 3, 6, 7, 10, 11-hexahydroxybenzophenanthrene), Cu2+, and Mn2+ were shown to be decomposed and released under weakly acidic conditions in tumor cells. HHTP produces exogenous H2O2 in the presence of oxygen to increase the H2O2 content in tumors, Cu2+ reduces GSH content and generates Cu+ in the tumor, and Cu+ and Mn2+ catalyze H2O2 to produce OH in a Fenton-like reaction. Together, these three factors change the tumor microenvironment and improve the efficiency of ROS production. HCM showed selective and efficient cytotoxicity to cancer cells, and could effectively inhibit tumor growth in vivo, indicating a good CDT effect.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ChemCatChem
·
2024
·
IF 3.8
Libin Liu,Yuxi Si,Wenjie Zhao,Qingqin Zhu,Zhaoran Yang,Jing He,Yangqiang Huang,Youwei Cheng
Cyclopentanone (CPO) and cyclopentanol (CPL), derived from renewable biomass resource hemicellulose, are considered sustainable chemicals that can substitute fossil-based products, which could be obtained through the hydrogenation-rearrangement reaction of furfural (FFA). However, the inevitable condensation reactions of FFA and furfuryl alcohol (FA) in aqueous solutions generate humins and result in carbon loss, limiting the industrial application of this process. Herein, a series of Cu-based catalysts were synthesized using the reverse co-precipitation method with various metal promoters and applied in the FFA hydrogenation-rearrangement reaction. The highest yield of 97.1% CPO/CPL achieved in a typical reaction condition at 200 °C, 4 MPa, in 20 wt% isopropanol-water mixed solvent over CuZnZr catalyst and the recyclability test confirmed that the catalyst had excellent stability. Experimental studies and characterizations showed that the enhanced performance could be attributed to the adequate Lewis acid sites, regulated through the synergistic interaction between Cu, Zn, and Zr compounds. The simultaneous introduction of Zn and Zr promotes the Cu reduction, and results in more dispersed Cu0 and Cu+, providing an ample and reliable active site. This study outlines a viable method for the catalyst designing and valorizing biomass into high-value-added products.
✓ 已验证
产品关联
DOI
高影响因子
Journal of Building Engineering
·
2024
·
IF 6.7
Tianxiao Li,Huabing Zhang,Xiang Tan,Rui Zhang,Fasi Wu,Qinglin Ma,Bingjian Zhang,Bomin Su
Nanomaterials, such as TiO 2 , ZnO, and Cu, have become popular materials for controlling the growth of microorganisms that cause the deterioration of stone monuments, but it is not clear which material is best. In this study, the dominant strains from two stone monuments, the Klippe Statue and Lingyan Temple, were used to compare the antimicrobial activities of the three materials. The minimum inhibitory concentrations (MICs) of the three materials were obtained using the microdilution and macrodilution methods, a linear regression model of the relationship between the addition of the nanomaterial and the color change of the stone was constructed, and the antimicrobial effect of the screened nanomaterial applied to the stone samples was also evaluated. Among the three materials, only the Cu nanoparticles exhibited a broad antimicrobial activity, and its MIC was 0.5 %. There was a linear relationship between the addition of Cu nanoparticles and the color change of the stone, the maximum addition without significant effect on the aesthetic appearance was 67 μg/cm 2 , and there was no difference between the limestone and sandstone. However, the antimicrobial activity of the Cu nanoparticles was only observed in limestone due to the low concentration of the material that could be retained on the sandstone surface. In addition, the adsorption between the Cu nanoparticles and limestone was weak and easily removed by various factors, indicating that the microorganisms could re-colonize the Cu-treated limestone after the limestone was exposed to environmental influences such as rainfall. In this paper, we propose a candidate biocide, Cu nanoparticles, to inhibit the growth of microorganisms on stone monuments, the Klippe Statue and Lingyan Temple, and our results provide a reference for the application of nanomaterials in stone monuments.
✓ 已验证
产品关联
DOI
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2024
·
IF 10.7
Lin Fan,Lijun Kong,Hao Liu,Jiawei Zhang,Mengdi Hu,Li Fan,Hongliang Zhu,Shancheng Yan
Ag and Cu based nanostructures serve as advanced functional materials for biomedical applications , due to their unique properties. Here, we proposed a novel neurotransmitter biosensing method based on Ag–Cu composite nanozyme , synthesized through the soft film plate method. Supported by the soft film template , the Ag–Cu nanozymes were stably kept to an ultrafine 2D structure with high monodispersity, which provided a large specific surface area and sufficient binding sites , leading to controllable and improved dual-nanozyme activities over similar-sized mono-Ag and mono-Cu, and up to 4.95 times of natural enzyme-level. The multi-path enzymatic reaction processes catalyzed by Ag–Cu composite nanozymes were firstly theoretically discussed in detail, according to the theoretical redox potential of redox couples in the reaction systems. On this basis, the Ag–Cu filled nanonets based neurotransmitter biosensing is successfully applied in rapid detection for glutathione and dopamine, possessing a linear range of 10∼100 μM and 1–10 μM, and a detection limit of 3.01 μM and 0.29 μM, respectively, which exhibited superior performance for biomedical purposes over most commercially available products in speed and precision.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SOLAR ENERGY MATERIALS AND SOLAR CELLS
·
2024
·
IF 6.3
Le Huy Thai,Le Thi Thanh Nhi,Nguyen Minh Hiep,Dinh Thanh Khan,Trinh Ngoc Dat,Le Vu Truong Son,Truong Quang Trung,Le Hoang Sinh
A novel all-in-one electrochromic device from viologen-based Cu-MOF was demonstrated successfully for the first time. The viologen-based Cu-MOF was dispersed in a photochemical eutectic solvent and directly used as an electrochromic material with the outstanding advantage of good modulation ability in a wide range of visible light. The electrochromic device's (ECD) color changed from transparent and light lime green to blue during the change of potential from 0 V to −3.5 V. The bistability of the ECD was demonstrated by the transmittance degradation of less than 10 % over 1.79 h when the power was turned off. This showed that the ECD could maintain its optical state long without a continuous power supply.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）