ACS Applied Materials & Interfaces
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2021
·
IF 9.229
Li Lin,Liangen Shen,Junfeng Zhang,Yiyan Xu,Zheng Fang,Peter Müller-Buschbaum,Qi Zhong
Wearable solar radiation sensors based on ionic hydrogels are facilely prepared to simultaneously monitor the radiation dose for the production of vitamin D and the prevention of sunburn. Tetramethylethylenediamine (TEMED) is neutralized with acrylic acid (AA) to obtain tetramethylethylenediamine acrylate (TEMEDA), which is further polymerized with acrylamide by a free radical reaction. By simply adding MB or NR during the polymerization, the final obtained ionic hydrogels can indicate solar radiation. Due to the extent of discoloration, the discoloration speed of MB and NR is correlated to the radiation dose. This wearable sensor can indicate the solar radiation dose required by the human body to synthesize vitamin D through the discoloration of the ionized hydrogel of MB, whereas those with NR are able to illustrate the threshold of radiation dose that causes potential skin hurt. Therefore, the benefit and drawback of solar radiation can be well balanced by optimizing the exposure time to solar irradiation. In addition, polyurethane cross-linked with a thermoresponsive coating is used as band for this wearable sensor. Due to the hydrophilicity below its transition temperature, the cross-linked band possesses the easy cleaning capability of stains after the daily wear. Such type of wearable sensor can be broadly used for monitoring the solar radiation, especially in outdoor activities.
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高影响因子
Advanced Composites and Hybrid Materials
·
2021
·Vol. 5
·期 3
·2193-2205
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IF 5.693
Huang Yajing,Chen Songlin,Ma Ruitong,Cheng Yalin,Jin Lun,Chen Guohua
A novel method has been developed to synthesize fine coal-based carbon composite particles containing rich nitrogen-doped microcrystalline structure with superior electromagnetic-shielding (EMI) performances using anthracite as raw material for the first time. Carbon composite was observed after reacting with furanmethylamine (FMA), followed by ball-milling and a high-temperature (1000 °C) thermal anneal. Carbon structure was assessed before and after reacting FMA with X-ray diffraction (XRD), Raman, Fourier transform infrared spectroscopy (FT-IR), temperature-programmed oxidation (TPO), and X-ray photoelectron spectroscopy (XPS). All data are consistent with the occurrence of Diels–Alder (D-A) reaction, providing D-A reaction occurred between coal and FMA for the first time. Because the D-A reaction changes the three-dimensional structure of coal and weakens the cross-linking of the coal structure, ball-milling modified coal reduces the size of coal particles without deepening the disorder of coal, and heat treatment caused the reverse reaction of D-A reaction, which improved the structural integrity of the carbon networks. The final product called “Coal-FBT” shows a maximum attenuation of 62.2 dB, which qualifies as excellent electromagnetic shielding as 50wt% mixed with paraffin. Graphical abstract The modified coal (Coal-FBT) showed a max SE T of 62.2 dB, which is much higher than the pristine coal (8.81 dB).
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JOURNAL OF FOOD SCIENCE
·
2021
·Vol. 86
·期 6
·2434-2444
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IF 3.167
Rehebati Nuerxiati,Paiheerding Mutailipu,Aytursun Abuduwaili,Jun Dou,Haji Akber Aisa,Abulimiti Yili
In this study, an enzyme-assisted extraction method was used to extract Orchis chusua D. Don (Salep) polysaccharide (SP), which was then modified by sulfation, acetylation, phosphorylation, and carboxymethylation to obtain modified polysaccharides. Furthermore, their degree of substitution, chemical composition, and molecular weight were evaluated. The primary structural features were characterized by UV spectra, FT-IR spectra, Congo-red test, and scanning electron microscope. The phosphorylated polysaccharide (SP-P) was demonstrated the highest scavenging ability on hydroxyl radical and growth-promoting activity on Lactobacillus Bulgaricus . The carboxymethylated polysaccharide (SP-C) was exhibited the strongest DPPH and ABTS radical scavenging effects. The acetylated polysaccharide (SP-A) displayed the best proliferation effects on Bifidobacterium adolescentis , whereas the sulfated polysaccharide (SP-S) maintained moderately stable antioxidant and probiotic ability. These findings indicate that the modified polysaccharides had their potential significance as new antioxidants and probiotics for the food industry. Practical Application This article provides a new source for the development of polysaccharide derivatives as new antioxidants and probiotics for the food industry.
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FOOD CHEMISTRY
·
2021
·
IF 7.514
Jing Li,Kunpeng Gao,Francesco Secundo,Xiangzhao Mao
Chitin, one of the most abundant renewable biopolymers on Earth, is commercially available from crustacean wastes. One critical step in converting chitin to high-value products is its degradation by chitinolytic enzymes to N -acetyl- d -glucosamine (GlcNAc), which plays a significant role in functional food and pharmaceutical industries. Here, we cloned and biochemically characterized two novel β - N -acetylglucosaminidases named SvNag2557 (family-84) and SvNag4755 (family-3) from Streptomyces violascens ATCC 27968. Both SvNag2557 and SvNag4755 exhibited strict substrate specificity toward N -acetyl chitooligosaccharides with GlcNAc as the sole product. Thus, a one-pot production for pure GlcNAc from chitin by an enzyme cocktail reaction was further developed. Under the co-action of an endo-type chitinase SaChiA4 and SvNag2557 (mass ratio 1:2), the final conversion rates of colloidal chitin and ionic liquid pretreated chitin to GlcNAc were 80.2% and 73.8% with GlcNAc purities of 99.7% and 96.8%, respectively.
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JOURNAL OF FOOD PROCESSING AND PRESERVATION
·
2021
·Vol. 45
·期 7
·e15604
·
IF 2.19
Cheng Peng,Rui Li,Hui Ni,Li Jun Li,Qing Biao Li
The naringinase, a desirable candidate for citrus juice debittering, consists of α-L-rhamnosidase and β-D-glucosidase. This study aimed to elucidate the effects of α-L-rhamnosidase, β-D-glucosidase, and their combination on naringin, polyphenols, antioxidant activity, and aroma quality. The α-L-rhamnosidase and the two enzymes combination reduced the naringin concentration from 356.33 to 10.52 and 4.17 mg/L, respectively. The α-L-rhamnosidase, β-D-glucosidase, and their combination significantly increased the antioxidant activity. The unpleasant cooking note was significantly weakened and the floral note was increased after three treatments. The combinational treatment increased the sweet note greatly. The substrate competition between α-L-rhamnosidase and β-D-glucosidase may help to explain the inconsistencies of the polyphenols, antioxidant activity, and aroma quality after single enzyme or combined enzymes treatments. The results indicated that taste, antioxidant activity, and aromatic quality were well improved by the combined treatment than either α-L-rhamnosidase or β-D-glucosidase treatment, providing an attractive reference for debittering orange juice. Practical applications The work showed that the combined treatment of α-L-rhamnosidase and β-D-glucosidase was better to remove the bitter taste of citrus juice than the solo treatment with α-L-rhamnosidase or β-D-glucosidase in regarding with taste, antioxidant activity, and aromatic quality. It helps to better the quality of citrus juice with enzymatic treatment.
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Acta Biomaterialia
·
2021
·
IF 8.947
Ri-Tong Lan,Yue Ren,Xin Wei,Li-Zhi Tang,Nouman Ali Shah,Lu Xu,Shi-Shu Huang,Rizwan M. Gul,Jia-Zhuang Xu,Zhong-Ming Li
Oxidative stability of radiation crosslinked ultrahigh molecular weight polyethylene (UHMWPE) artificial joints is significantly improved by vitamin E (VE), but there is a dilemma that VE hinders crosslinking and thus jeopardizes the wear of UHMWPE. In this effort, we proposed an efficient strategy to stabilize UHMWPE under limited antioxidant contents, where VE and D-sorbitol (DS) were used as the primary antioxidant and the secondary antioxidant respectively. For non-irradiated blends with fixed antioxidant contents, oxidative stability accessed by oxidation induction time (OIT) of VE/DS/UHMWPE blends was superior to that of VE/UHMWPE blends, while DS/UHMWPE blends showed no increase in OIT. The cooperation between DS and VE exhibited a synergistic effect on enhancing the oxidative stability of UHMWPE. Interestingly, the irradiated VE/DS/UHMWPE blends showed comparable OIT but a significantly higher crosslink density than the irradiated VE/UHMWPE blends. The crystallinity, melting point, and in vitro biocompatibility of the blends were not affected by VE and DS. The quantitative relationships of mechanical properties , oxidation stability, crystallinity and crosslink density were established to unveil the correlation of these key factors. The overall properties of VE/UHMWPE and VE/DS/UHMWPE blends were compared to elucidate the superiority of the antioxidant compounding strategy. These findings provide a paradigm to break the trade-off between oxidative stability, crosslink density and mechanical properties, which is constructive to develop UHMWPE bearings with upgraded performance for total joint replacements. Statement of significance VE-stabilized UHMWPE is the most commonly used material in total joint replacements at present. However, oxidation and wear resistance of VE/UHMWPE implants cannot be unified since VE reduces the efficiency of radiation crosslinking. It limits the use of VE. Herein, we proposed a compounding stabilization by the synergy between VE and DS. The antioxidation capability of VE was revived by DS, thus enhancing the oxidation stability of unirradiated UHMWPE. The irradiated VE/DS/UHMWPE exhibited similar oxidation stability but higher crosslink density than irradiated VE/UHMWPE, which is beneficial to combat wear of UHMWPE and to inhibit the occurrence of osteolysis . This synergistic antioxidation strategy endows the UHMWPE joint material with good overall performance, which is of clinical significance.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2020
·
IF 4.192
Xiaofeng Zhang,Xinqi Xu,Xuemei Yao,Rong Wang,Hengtao Tang,Xin Ju,Liangzhi Li
Ribose-5-phosphate isomerase B is of great importance for biocatalysis and biosynthesis, but the multifunctional residues in active sites hinder the research efforts. This study employed rational design strategies to locate the key residues of RpiB from Ochrobactrum sp. CSL1 (OsRpiB). A single-mutant S9T of a noncontact residue showed 80% activity improvement toward d-allose. A double-mutant S98H/S134H further increased the activity to 3.6-fold. The mutations were analyzed by kinetics and molecular dynamics analyses, indicating that S9T might enhance the substrate binding and catalysis by inducing a steric effect, and S98H/S134H could strengthen both ring opening and binding of d-allose. Though S98H/S134H showed low temperature stability, its potential was explored by isomerizing d-allose to d-psicose with higher conversion and in less reaction time. The findings of this study were beneficial for illustrating the complex functions of key residues in RpiBs and applying OsRpiB in preparing rare sugars.
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POLYMER BULLETIN
·
2020
·Vol. 78
·期 1
·147-163
·
IF 2.014
Shao Jun,Xu Lanli,Pu Shouzhi,Hou Haoqing
Blending of poly( l -lactide) and poly( d -lactide) (PLLA, PDLA) results in the formation of poly(lactide) stereocomplex crystallites (SC). For the preparation method, numerous reports employed solution mixing and stirring to receive a product with uniform performance. However, the effect of stirring time during solution mixing on the subsequent crystallization behavior did not clear yet, and which is important for solution crystallization, casting and spinning. In this paper, linear PLLA and PDLA with various molecular weights were synthesized. The PLLA and PDLA solutions were mixed together and stirred for different times before casting. Results revealed that the structures of PLA SC and homochiral crystallites (HC) did not vary with change in the stirring time. More amount of content of SC with uniform structure and less amount of content of HC were produced in the specimens stirred for longer time. When the specimens crystallized either from the melt or from the melt-quenching, less amount of content of crystallites (total crystallinity of SC and HC) was produced and the melting temperature of SC and HC depressed in the specimens that were stirred for longer time. With the increase in molecular weights, the effect of stirring time on the crystallization behaviors declined. This investigation provides a route to tailor the crystallization behavior of PLLA/PDLA specimens.
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International Journal of Medical Sciences
·
2020
·
IF 2.523
Zhao Qu,Yushan Lin,Daniel Kam-Wah Mok,Qingya Bian,William Chi-Shing Tai,Sibao Chen
Triple-Negative Breast Cancer (TNBC) is a most dangerous breast cancer subtype. The naturally occurring sesquiterpene lactone, arnicolide D (AD), has proven effective against a variety of tumors, however, the inhibitory effects of AD against TNBC and the underlying mechanisms remain unclear. In the present study, two TNBC cell lines (MDA-MB-231 and MDA-MB-468) and an MDA-MB-231 xenograft mouse model were employed to investigate the anti-TNBC effects of AD in vitro and in vivo . Cell viability was assessed by MTT assay. Cell cycle arrest and apoptosis were analyzed by flow cytometry. Protein levels were determined by immunoblotting. In vitro studies demonstrated that AD significantly decreased cell viability, and induced G2/M cell cycle arrest and apoptosis. In vivo assays showed that oral administration of 25 or 50 mg/kg AD for 22 days led to a reduction of tumor weights by 24.7% or 41.0%, without appreciable side effects. Mechanistically, AD inhibited the activation of Akt/mTOR and STAT3 signaling pathways. Based on our findings, AD is a promising candidate for development as an adjunctive therapeutic drug for TNBC.
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ChemSusChem
·
2020
·Vol. 13
·期 14
·3662-3670
·
IF 7.962
Hefeng Yuan,Shiwei Wei,Bin Tang,Zizai Ma,Jinping Li,Manab Kundu,Xiaoguang Wang
Graphical Flakes make O 2 : Self-supported ultrathin CoNiB nanoflakes are prepared by a simple one-step solid-state boronation. The unique sheet-like structure, bimetallic boride components, and optimal hybrid crystalline nature enable a synergistic promotion for the catalysis of the oxygen evolution reaction with long-term stability. The development of highly active and efficient nonprecious-metal electrocatalysts for the oxygen evolution reaction is important for the design of renewable energy production and storage devices. In this work, highly dense, ultrathin Co–Ni boride nanoflakes supported on a 3 D CoNi skeleton are fabricated in situ by a simple one-step, high-temperature, solid-state boronation process. As a result of the induced high electroactive surface area and low charge transfer resistance, CoNiB-700 exhibits high catalytic activity at an overpotential of 262 ( η 10 ) and 284 mV ( η 20 ) to deliver current densities of 10 and 20 mA cm −2 , respectively, with a Tafel slope of 58 mV dec −1 in an alkaline medium towards the oxygen evolution reaction. DFT calculations show that the Ni-regulated Co–B compound has a lower rate-determining energy barrier for the *OOH intermediate than the mono-Co–B compound, which facilitates the production of more active catalytic sites for an accelerated surface charge-transfer process for the oxygen evolution reaction.
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INSTRUMENTATION SCIENCE & TECHNOLOGY
·
2020
·
IF 1.418
Li-Ye Niu,Qi Wang,Wan-Ming Zhao,Jian-Ying Jing
A D-type optical fiber surface plasmon resonance (SPR) sensor based on gold film and Au nanoshells is described. The sensor has a smaller full width at half maximum (FWHM) and a higher quality factor. The influence of the coupling effect between the Au nanoshells and gold film with different internal and external diameter ratios on the sensor was investigated by the finite element method. The simulation results show that the coupling effect between the SPR of the gold film and the localized surface plasmon resonance (LSPR) of the Au nanoshells effectively improved the electric field strength of the sensing region. The refractive index measurements show that the sensitivity of the D-type fiber/gold film/Au nanoshell (50/40 AuNS) SPR sensor is 3064 nm/RIU, which is 993 nm/RIU higher than for the D-type fiber/gold film SPR sensor. The D-type fiber/gold film/Au nanoshell (50/40 AuNS) SPR sensor also provides good linearity with a value of 99.4%. The sensor reported in this paper can be used for reference in the development of high performance biosensors.
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COLLOIDS AND SURFACES B-BIOINTERFACES
·
2019
·
IF 3.973
Lifen Wang,Pengpeng Xue,Mengqi Tong,Rui Chen,Waigeng Yang,Deli ZhuGe,Jiandong Yuan,Qing Yao,Yingzheng Zhao,Helin Xu
Inflammatory bowel diseases (IBDs) are chronic relapsing disorders of the gastrointestinal tract characterized pathologically by intestinal inflammation and epithelial injury. Laquinimod (LAQ), a poorly water-soluble compound, was proved to be effective for colitis remission at low dose of 0.5 mg/kg in patients with Crohn’s disease. Due to its extremely low solubility in water, it was difficult to develop an injectable liquid dosage form. Herein, D-α-Tocopheryl polyethylene glycol-1000 succinate (TPGS) polymeric micelles were developed as a delivery vehicle of LAQ for the management of inflammatory bowel disease. Using the LAQ/TPGS ratio of 1:100, LAQ-loaded micelles were successfully prepared by thin-film dispersion method. The solubility of LAQ in water was significantly increased from 10.5 μg/mL in pure water to 500 μg/mL in TPGS micelles. LAQ-loaded micelles of TPGS exhibited the fine particle size of 34.6 nm and Zeta potential of -0.67 mV. Moreover, the good stability of LAQ-loaded micelles in physiology-mimicking medium was confirmed by detecting their particle size, zeta potential and leakage of the loading drug. Therapeutic effect of LAQ-loaded micelles on DSS-induced mice was proved by detecting DAI score, colon length and loss of body weight. Moreover, the morphology and colonic mucosal barrier of the injured colon of DSS-induced mice was largely recovered after treatment with LAQ-loaded micelles. Meanwhile, the inflammation of colitis colon was also obviously alleviated by LAQ-loaded micelles. Conclusively, polymeric micelles of TPGS may be a promising delivery vehicle of LAQ for the management of inflammatory bowel disease.
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