JOURNAL OF MEMBRANE SCIENCE
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2025
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IF 9
Jinwei Zhang,Yujun Zhang,Ning Li,Shilin Nie,Leixin Yang,Yihao Luan,Yuchao Ma,Ge Wang,Kaihua Li,Long Jiao,Bowen Cheng
Physical aging presents a significant challenge that hinders the practical application of high-permeability polymer-based membranes. Herein, we have designed a polymer network membrane (PI–CO@Trip-TB (1:10)) featuring H-bonding interactions by regulating the ratio of the carboxyl-containing copolymer PI-CO (6FDA-FDA-DABA) to Trip-TB (Tröger's base), which significantly improved the anti-aging performance without compromising the high permeability. The introduction of PI-CO not only generates H-bonding interactions to enhance compatibility, but also the introduction of its linear chain segments effectively hinders the relaxation of the chain of the Trip-TB spatial structure. Which synergistically stabilizes the free volume elements and mitigates the rate of their temporal collapse. Compared to Trip-TB, the PI-CO@Trip-TB (1:10) polymer network membrane demonstrates outstanding anti-aging performance, in which the permeability of CO 2 and O 2 is maintained at approximately 60 % even after 90 days. Notably, the performance of both fresh and aged PI-CO@Trip-TB (1:10) membranes surpasses the 2008 Robeson upper bound (CO 2 /CH 4 ) and the 2015 Robeson upper bound (O 2 /N 2 ). Overall, this study establishes an effective strategy for designing high-permeability polymers with anti-aging properties for practical applications in separation membranes.
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高影响因子
Pharmaceuticals
·
2025
·Vol. 18
·期 11
·1699
·
IF 4.8
Zheng Ye,Chao Hong,Min Jiang,Wenkui Zou,Yaning Ren,Mingfang Li,Xinyue Xue,Xiaoting Xie,Tong Zhang,Yue Ding
Background/Objectives: Breast cancer is the most prevalent malignancy among women, and paclitaxel (PTX) is a first-line chemotherapeutic, but chemoresistance driven by ATP-binding cassette (ABC) transporters limits its efficacy. Single-target ABC inhibitors fail due to toxicity and cooperative transporter activity, creating an urgent need for safe multi-target strategies. Membrane cholesterol-rich lipid rafts support ABC transporter function, making cholesterol a key chemoresistance target. This study explored a cholesterol-targeted approach for overcoming PTX resistance.Methods: A PTX-resistant breast cancer line (MCF-7/PTX) showing ABCB1/ABCC3 co-upregulation and enriched cholesterol rafts was established. The effects of Polyphyllin H (PPH), a steroidal saponin fromParis polyphylla, were compared with lovastatin, a biosynthetic cholesterol inhibitor. In vitro and in vivo assays investigated Polyphyllin H’s cholesterol binding and effects on transporters, PTX accumulation, and tumor growth.Results: PPH directly binds membrane cholesterol, disrupting lipid rafts, downregulating ABCB1/ABCC3, reducing drug efflux, and increasing intracellular PTX to restore sensitivity. PPH showed superior cholesterol-binding and resistance-reversal efficacy than lovastatin, with faster, stronger PTX-enhanced cytotoxicity and tumor suppression.Conclusions: PPH reverses PTX resistance by targeting cholesterol-lipid rafts to inhibit multiple ABC transporters. This offers a safer adjuvant for PTX-based breast cancer therapy and a translational framework for other drug-resistant malignancies.
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PubMed
高影响因子
JOURNAL OF CATALYSIS
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2025
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IF 6.5
Ajibola T. Ogunbiyi,Wenzhi Li,Amir Hamza,Chenchen Gui,Liqun Wang
Despite significant advances in lignin depolymerization studies, the specific combination of Mo and W in bimetallic catalysts and their impact on hydrogen activation and Lewis acidity in lignin conversion remains poorly understood, particularly in terms of the synergistic effects that enhance efficiency and selectivity. A bimetallic Mo x W y /H-Beta catalyst was synthesized via incipient wetness impregnation with the catalyst characterized using XPS, H 2 -TPR, NH 3 -TPD, and other methods. The catalyst demonstrated high activity for selective kraft lignin depolymerization due to the synergy between Lewis acid sites, hydrogen activation sites, and the Mo-W interaction on the support. The proximity of metal and acid sites facilitated effective diffusion of intermediates, leading to enhanced synergy and the eventual cleavage of etheric C–O bonds. A Liquid fuel (LF) yield of 84.3 % and 71.6 % kraft lignin conversion at 300 °C without external hydrogen. The higher heating value (HHV) increased from 25.45 MJ/kg in the original kraft lignin feed to 35.9 MJ/kg in the LF. XPS analysis showed a predominant amount of Mo 6+ on the fresh catalyst surface, with complete conversion to lower oxidation states during the reaction. This study provides insights into the structure–activity relationships of Mo-based bimetallic catalysts, highlighting the importance of hydrogen activation sites and acidic sites in kraft lignin depolymerization.
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高影响因子
CARBON
·
2025
·
IF 11.6
Junzhu Yang,Junchen Liu,Yi Zhang,Wei Pei,Qi Xia,Sanyang Han,Yuan Lu
Efficient regeneration of the coenzymes NADH and NADPH is crucial for sustaining biocatalytic processes, particularly in driving the biocatalysis reaction. In this study, the photocatalytic properties of alkali-doped graphitic carbon nitrates were explored to achieve efficient NAD(P)H regeneration. g-C 3 N 4 doped with potassium (KOH), sodium (NaOH), and calcium (Ca(OH) 2 ) was synthesized and characterized, showing significant enhancements in light absorption, charge separation, and photogenerated electron transport. Among the synthesized photocatalysts, KOH-doped g-C 3 N 4 (KCN) exhibited the best photocatalytic performance, regenerating 95 % NADH and 92 % NADPH within 30 min. This result compares favorably with those reported in previous studies. Based on this superior performance, K-0.2 was further applied to the in vitro CO 2 reduction to formate as a proof of concept. To clarify the mechanistic insights of the improved photocatalytic performance of KCN, the chemical model of g-C 3 N 4 and KCN was established, and DFT calculations were performed to reveal the electronic structure modifications responsible for the enhanced photocatalytic activity. Furthermore, to expand the light utilization capability of the system, upconversion nanoparticles (UCNPs) were incorporated into the system to utilize near-infrared light (980 nm), which successfully achieved NADH regeneration under near-infrared excitation and extended the light absorption range of the photocatalytic system. Overall, this study demonstrated that alkali-doped g-C 3 N 4 offered a highly efficient platform for NAD(P)H regeneration, and the integration of UCNPs further enriched the coenzyme regeneration scenario, suggesting a promising strategy for advancing sustainable coenzyme regeneration technologies.
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高影响因子
INORGANIC CHEMISTRY
·
2020
·
IF 4.825
Ji Wu,Ke Cao,Cai-Yan Zhang,Tao-Tao Xu,Xin-Yu Wen,Bo Li,Junxiao Yang
A palladium catalyzed selective B(3)–H activation/oxidative dehydrogenative coupling for the synthesis of bis(o-carborane)s connected with B(3)–B(3′) and B(3)–B(6′) bonds has been developed for the first time. A plausible mechanism involving stepwise activation of B(3)–H and B(3′/6′)–H bonds by PdII and PdIV was proposed. This work is the first example and the most efficient protocol for synthesis of bis(o-carborane)s connected with B(3)–B(3′) and B(3)–B(6′) bonds, which has important reference for design, synthesis, and application of bis(o-carborane)s in related fields.
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高影响因子
MICROPOROUS AND MESOPOROUS MATERIALS
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2024
·
IF 4.8
Tianyu Bai,Jinquan Tao,Yijing Jia,Wenbin Huang,Rongpeng Yao,Xinan Xue,Yasong Zhou,Qiang Wei
In the research of directly synthesizing H-form ZSM-5, ammonium hydroxide is commonly used as an alkali source instead of NaOH to avoid multiple ion exchange steps. However, the volatile nature and the lack of structure-directing effect of ammonium hydroxide limit its application in practical. In this study, n -butylamine (NBA) was used as the main alkali source to directly prepare HZSM-5 zeolites with SiO 2 /Al 2 O 3 ratios ranging from 40 to 300 under traditional hydrothermal conditions. The influence of the amount of NBA, ethanol, seed, and pre-crystallization on the synthesis products was investigated under the condition of SiO 2 /Al 2 O 3 = 80. Theoretical simulation suggested that n -butylamine cations (NBA + ) play the most potent directing role in the formation of the MFI structure but could lead to difficulties in removal during calcination. The addition of ethanol as the zeolite growth modifier (ZGM) could decrease the usage of NBA and reduce the difficulties in calcination, and the addition of seed provided the conditions for initiating crystallization in the system that could not spontaneously nucleate. HZSM-5 with different SiO 2 /Al 2 O 3 ratios were prepared under the optimal crystallization conditions, and the as-synthesized samples exhibited superior textural and acid properties compared to commercial zeolite. Finally, the 1 L scale-up synthesis and MTP reaction were conducted to demonstrate the practicality of this economically and environmentally-friendly synthesis strategy.
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高影响因子
Energetic Materials Frontiers
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2022
·
IF 0
Zhi-qiang Wang,Zhen-qi Zhang,Shan-hu Sun,Mi Yan,Shi-liang Huang,Shuang-qi Hu,Jin-jiang Xu,Li-shuang Hu
Polymorphs of energetic materials generally exhibit distinct features, such as density, thermal stability, sensitivity, and detonation performance. These features are important in determining the appropriate applications of a given polymorph. To understand the thermal stability of new high explosive 4,4′,5,5′-tetranitro-1H,1′H- [2,2′-biimidazole]-1,1′-diamine (DATNBI), we systematically investigated its polymorphic transition (PT) under thermal stimulation and discovered a novel stable γ form of DATNBI. The results showed that the solid-solid PT path was β → α → γ . In this study, the three polymorphs of DATNBI were prepared through solvent recrystallization, and their PT processes in solution were explored. Crystal structure analysis of γ -DATNBI suggested that its special cross-cross grid crystal packing may be the main reason for its stable existence at room temperature and its lack of PT process before chemical decomposition, which starts at 240 °C. To further explore the PT process of DATNBI, the solid phase transition mechanism of DATNBI was analyzed using non-isothermal kinetics. The results demonstrated that the two high-temperature PT processes— β → α and α → γ —were not single-step reactions but complex multi-step reactions. The PT activation energy of the β → α process was slightly higher than that of the α → γ process. In addition, the influences of different polymorphs on the performance of DATNBI were explored. The results revealed that safety and detonation performance should decrease as a result of the incorporation of γ -DATNBI. This study contributes to understanding the PT behavior and the crystal structure evolutionary mechanism of DATNBI. This study provides practical support for formula design, process condition selection, and thermal stability evaluation of DATNBI explosives.
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Journal of Environmental Chemical Engineering
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2025
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IF 7.2
Jun Tu,Qiuru Chen,Siyu Ke,Xiaohui Yi,Yiquan Qiu,Ziyi Lin,Shuxiang Yang,Xinzhi Wang,Xiaotong Bai,Mingzhi Huang
In this study, corn stover biochar was prepared and modified with manganese (II) chloride (MnCl 2 ) and phosphoric acid (H 3 PO 4 ) to investigate the adsorption performance and mechanism of neonicotinoids represented by clothianidin (CLO). MnCl 2 promotes pore formation in biomass and enhances activation efficiency, while H 3 PO 4 boosts the specific surface area and adsorption capacity of the product. These properties make them widely used in biomass activation. The modified biochar (Mn-P-BC) exhibited an adsorption capacity of 11.5 mg·L -1 for CLO, representing a 2.8-fold enhancement compared to unmodified biochar (BC). In materials characterization, SEM and BET analysis results show that Mn-P-BC has a developed porous structure, and the surface area increases by 13.7 times compared with BC, which can provide more adsorption sites. According to the electrochemical properties, kinetics, and isotherm analyses, the adsorption mechanism for CLO was identified as involving physicochemical processes. Furthermore, density functional theory (DFT) calculations indicated that Mn-P-BC was more efficient in removing CLO compared to thiamethoxam (THM) and imidacloprid (IMI). It is shown that the mechanism of interaction between Mn-P-BC and CLO mainly involves pore filling, π-π interactions, and hydrogen bonding. In summary, the co-modification of biochar with MnCl 2 and H₃PO₄ significantly improved the adsorption performance of biochar, which provided new insights into the development of adsorbents for neonicotinoid insecticide removal.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Yu-Xuan Fu,Shu-Yi Huang,Ming-Shuai Sun,Yan Zhou,Dan-Dan Cai,Wen-Shuai Zhu,Wei Hui,Duan-Jian Tao
Current industrial catalysts for α-pinene hydrogenation suffer from harsh reaction conditions and poor selectivity to cis -pinane, primarily due to their inability to effectively adsorb α-pinene in a specific favorable configuration on the catalyst surface. In this study, a high-specific-surface-area, rod-shaped CeO 2 -supported ultra-fine Ru nanoparticle (average particle size of 4 nm) catalyst was synthesized via hydrothermal method for the highly stereoselective hydrogenation of α-pinene to cis -pinane. The resulting Ru/CeO 2 -H catalyst achieved an α-pinene conversion of 99.3 % and an impressive cis -pinane selectivity of up to 99.6 % under exceptionally low temperature (30°C), 0.6 MPa H 2 and 0.5 h with high TOF (1236 h −1 ). Density functional theory (DFT) calculations indicated that α-pinene preferentially adsorbs onto the Ru surface via the backside of its intramolecular dimethyl bridge. This particular adsorption mode lowers the energy barriers for further hydrogenation to generate cis -pinane. The oriented dimethyl-up configuration of α-pinene and ultra-low activation energy (12.04 kJ/mol obtained from kinetic tests) enable the highly selective production of cis -pinane at ambient temperature. Furthermore, the strong interaction between the CeO 2 -H support and highly dispersed Ru, combined with the ambient-temperature reaction conditions, effectively prevents metal nanoparticle agglomeration and coking, imparting the catalyst with exceptional stability. Notably, the catalyst was reused at least 15 times without observing any significant deactivation, demonstrating its significant potential for practical applications.
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高影响因子
Journal of Environmental Chemical Engineering
·
2023
·
IF 7.7
Jing Wang,Jia-Wei Fang,Zhi-Yong Ji,Zhi-Yuan Guo,Xin-Wei Li,Jie Liu,Ying-Ying Zhao,Zhong Liu,Feng-Feng Gao,Yuan Zhong,Jun-Sheng Yuan
Lithium extraction from the solution in low Li + concentration by an energy-saving and high-efficiency method is still a challenge. Herein, a novel hollow porous LiMn 2 O 4 (H-LMO) with highly active site was proposed to enhance the extraction performance of Li + . Based on the established hollow porous structure, the H-LMO film electrode (H-LMOE) exhibits excellent lithium electrosorption performance and stability. Under the current density of 0.5 C, the electrosorption capacity of Li + could reach 31.52 mg/g, the separation coefficient of Li + /Mg 2+ was 581.67, and the energy consumption was as low as 0.49 Wh/mol Li. This unique structural strengthening mechanism made H-LMOE maintain a good Li + extraction performance even in a solution of low Li + concentration. The Li + electrosorption capacity of H-LMOE was 2.13 times that of T-LMOE in a 60 mg/L Li + solution, while the specific energy consumption of the H-LMOE was 15.78% lower than that of the traditional-LiMn 2 O 4 film electrode (T-LMOE). Even in a 10 mg/L Li + solution, the electrosorption capacity of H-LMOE was 21.48 mg/g, which was 10.0% higher than that of T-LMOE. Moreover, after 50 recycling processes, the final electrosorption capacity of the H-LMOE was about 25.0% higher than that of the T-LMOE.
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高影响因子
Journal of Materials Chemistry B
·
2017
·Vol. 5
·期 17
·3111-3121
·
IF 4.543
Yan-Ling Luo,Xue-Yin Zhang,Yuan Wang,Fang-Jie Han,Feng Xu,Ya-Shao Chen
pH-Sensitive H-type multiblock copolymers, namely, poly(methacrylic acid)2-block-epoxidized hydroxyl-terminated polybutadiene-block-poly(methacrylic acid)2 (PMAA2-b-epoHTPB-b-PMAA2), were synthesized by atom-transfer radical polymerization and subsequent in situ epoxidation by peracetic acid and characterized by 1H NMR, FT-IR and SEC techniques. The impact of epoxidation on the physicochemical and biomedical properties of copolymer self-assembly micelle nanoparticles was investigated by fluorescence spectrometry, DLS, TEM and an MTT assay. The experimental results indicated that epoxidation resulted in the formation of more stable copolymer micelle nanoparticles with a lower critical micelle concentration, smaller micelle size, and higher loading capacity and encapsulation efficiency of drugs than those without epoxidation. In particular, epoxidized copolymer micelle nanoparticles exhibited reasonable pH sensitivity at a pH of 5.3–5.6. The hydrophobic anticancer drug paclitaxel (PTX) displayed faster release rates from epoxidized nanomicelles than from unepoxidized nanomicelles in a PBS solution of a pH of 4.8–6.6, whereas in PBS of a pH of 7.4 smaller amounts of PTX were released from epoxidized nanomicelles than from unepoxidized nanomicelles. Epoxidized copolymer nanomicelles were reasonably biodegradable after the drug was released, and their degradation rate was faster than that of their unepoxidized counterparts. An MTT assay was performed to determine the biocompatibility of epoxidized copolymer micelle nanoparticles and the anticancer activities of PTX-loaded nanomicelles, which were important for applications in the therapy of cancers as a controlled-release drug carrier.
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PubMed
高影响因子
FUEL
·
2020
·
IF 5.578
Jing-Pei Cao,Tao Xie,Xiao-Yan Zhao,Chen Zhu,Wei Jiang,Ming Zhao,Yun-Peng Zhao,Xian-Yong Wei
Selective hydrogenolysis, the aromatic ether C-O bonds under mild conditions, is crucial for the valorization of lignin. In this context, the effects of H 2 and solvent on the hydrogenolysis of lignin model compounds over Ru catalysts were explored. With H 2 as hydrogen donor, the Ru/AC exhibited the highest activity for converting lignin model compounds into monomeric compounds, whereas H 2 led to low selectivity of aromatics. However, isopropanol was the good H-donor solvent, which could provide a large amount of active hydrogen to promote the cleavage of C-O bonds. Additionally, the yield of aromatics in isopropanol was higher than that under H 2 atmosphere. It could be ascribed to the fact that isopropanol is the protic solvent which displays Lewis basicity, and is a good H-bond donor and a good H-bond acceptor. The higher electron-releasing inductive effect of isopropanol made it easier to provide active hydrogen. Based on the experiments, the mechanism of benzyl phenyl ether hydrogenolysis in H 2 and isopropanol system was presented.
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高影响因子
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