ACS Applied Nano Materials
·
2025
·
IF 5.5
Lingling Li,Zihao Lv,Hao Jiang,Xiaoxian Zhao,Lan Wu,Xiuming Cao,Helan Xu,Qufu Wei,Qingqing Wang
A pH-responsive bacterial cellulose (BC)-based composite nanofiber membrane functionalized with rose bengal (RB)-encapsulated ZIF-8 (BC/RB@ZIF-8) was developed via in situ growth for the targeted therapy of bacterial stomatitis. The BC film enhanced the photodynamic effect, addressing the challenges of photosensitizer aggregation-induced quenching and its reuse. The BC/RB@ZIF-8 nanofiber membrane demonstrated sustained photodynamic activity, maintaining a stable singlet oxygen (1O2) quantum yield under continuous 130 min irradiation. The nanofiber membrane exhibited robust mechanical properties, including a tensile strength greater than 33 MPa, high water absorption capacity (916.61 ± 4.7%), and optimal moisture vapor transmission rate (40.56 ± 1.37 g/m2·h), meeting the key requirements for oral wound dressings. In acidic infection microenvironments, ZIF-8 degradation facilitated the synchronized release of Zn2+ and RB, leading to dual-mode antibacterial action: (1) the continuous release of Zn2+ from ZIF-8 disrupts bacterial cell membranes through electrostatic interactions; and (2) ROS generation via Type I (•OH) and Type II (1O2) pathways, resulting in irreversible damage to bacterial cell membranes and components. This synergistic mechanism led to a 99.99% eradication of S. aureus and MRSA under acidic conditions, outperforming conventional therapies. Cytocompatibility and hemocompatibility were confirmed in accordance with ISO 10993 standards. The BC/RB@ZIF-8 nanofiber membrane represents a significant advancement in pH-responsive antibacterial materials, offering a promising alternative to antibiotic-based treatments for biofilm-infected oral wounds.
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高影响因子
CHEMICAL ENGINEERING SCIENCE
·
2025
·
IF 4.3
Xiaoting Feng,Chenlu Liu,Kunkun Ren,Xinglei Zhao,Longjie Liu,Keming Zhang,Xiaohe Tian,Qingnan Wang,Xiangyu Liu,Yueyangchao Yu,Tianhe Gu,Shaofei Wang
The urgent need for efficient CO 2 capture technologies to mitigate climate change has driven the advancement of membrane-based separation systems. We report a mixed matrix membrane design through the in-situ growth of a ZIF-8 gel network within a Pebax-1657 matrix. By tuning the solvent ratio and concentration of modulator, ZIF-8 gel rather than particles are formed within the polymer, establishing a three-dimensional interconnected MOF network that ensures homogeneous filler dispersion and creates continuous gas transport nanochannels. The optimized membrane achieves a remarkable CO 2 permeability of 183.9 Barrer and a CO 2 /N 2 selectivity of 73.3, surpassing the 2008 Robeson upper bound. These values represent 190.4 % and 34.9 % enhancements in permeability and selectivity, compared to the pristine polymer. The membrane also demonstrates robust operational stability and maintains > 95 % of its initial performance over 60 days. This work offers a promising solution to creating continuous channels in CO 2 separation membranes.
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高影响因子
POLYMER DEGRADATION AND STABILITY
·
2025
·
IF 7.4
Yanyan Liu,Hongzhan Huang,Xin Wei,Panpan Gui,Guobin Li,Zhenbang Han,Changhai Xu
Polyethylene terephthalate (PET) fabrics are highly flammable and generate substantial smoke emissions, necessitating effective flame-retardant treatments. In this study, we developed an environmentally friendly strategy to construct a metal-organic framework (MOF)-assisted phosphorus-nitrogen synergistic flame-retardant system on PET fabric. This was achieved through in situ growth of ZIF-8 via a solvent-saving hot-pressing method, followed by 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide (DOPO) incorporation using a water-saving supercritical CO 2 technique. Comprehensive characterizations and density functional theory (DFT) calculations demonstrated that ZIF-8 enhances the immobilization and stabilization of DOPO on PET through chemical interactions, resulting in a durable flame-retardant material. The treated fabric demonstrated significantly improved fire safety compared to pristine PET, with a higher limiting oxygen index (LOI, from 21% to 31.6%), reduced peak heat release (20.2%), suppressed peak smoke production (54.1%), and lower average CO yield (79.6% reduction). A dual-phase flame-retardant mechanism (condensed and gas phases) was proposed based on systematic analyses. Importantly, the modified fabric retained its mechanical properties and breathability while acquiring additional functionalities including UV resistance and antibacterial properties. This work presents a sustainable and efficient strategy for designing high-performance, fire-safe textiles via MOF assisted synergistic engineering.
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高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2025
·
IF 3.9
Fang Qi,Luo Chongwen,Guo Xiaohuan,Cai Bingbing,Zhou Yuzhu,Hu Kun,Wen Changchun
Chemodynamic therapy (CDT) uses the Fenton reaction to generate highly toxic hydroxyl radicals (∙OH) to achieve efficient treatment strategies for tumors. However, the high concentration of glutathione (GSH) in the tumor microenvironment (TME) can scavenge these radicals, thereby diminishing the efficacy of CDT. In this study, we propose a programmable synergistic therapeutic strategy that depletes GSH during chemotherapy (CT) and subsequently increases the production of reactive oxygen species (ROS) to achieve high-potency CDT. We constructed a Cu-Q@Co/ZIF-8 (CQZ) composite nanoplatform by encapsulating cobalt-doped ZIF-8 (Co/ZIF-8) with copper-quercetin (Cu-Q, CQ). The construction of nanoplatform significantly enhanced the water solubility of Co/ZIF-8 and CQ. When the nanoplatform reached the tumor site, the TME triggered the release of quercetin and Cu 2+ from CQ, thus enabling quercetin-based chemotherapy and Cu 2+ -mediated GSH depletion while generating Cu + . Subsequently, the Co 2+ released from Co/ZIF-8 acted with Cu + to catalyze a Fenton-like reaction with endogenous H 2 O 2 , efficiently producing toxic ∙OH radicals for CDT. Throughout the treatment process, Cu 2+ was preferentially released in response to the TME to consume GSH, not only generating Fenton-active Cu + but also preventing the GSH-mediated scavenging of ∙OH. This procedural mechanism has substantially enhanced the therapeutic efficacy of CDT following CT.
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高影响因子
Surfaces and Interfaces
·
2025
·
IF 6.3
Aminov Nail,Huan Liu,Decheng Meng,Liran Zhu,Xiaohan Guo,Cong Li,Hao Yu,Zilian Yu,Huanjun Li
In the frontier of drug delivery research, the amalgamation of nanotechnology with 3D printing presents a transformative avenue for patient-centric therapies. This study presents the development of insulin/GOx-loaded Zeolitic Imidazolate Framework-8 (ZIF-8) microneedles, utilizing the unique properties of Metal-Organic Frameworks (MOFs) and advanced 3D printing techniques to enhance transdermal drug delivery systems. A key innovation lies in the use of a Polymerizable Deep Eutectic Solvent (PDES)-based ink for digital light processing (DLP) 3D printing, enabling accelerated photopolymerization and precise fabrication of microneedles. The PDES formulation, consisting of Betaine, Methacrylic Acid (MAA), 2-Hydroxyethyl Methacrylate (HEMA), Polyethylene Glycol Diacrylate (PEGDA), and the photoinitiator trimethylolpropane triacrylate (T-POL), was specifically designed to exploit hydrogen bonding interactions, thereby enhancing polymerization efficiency and structural integrity. The insulin/GOx-loaded ZIF-8 microneedles demonstrated responsive and controlled drug release, with notable sensitivity to glucose and pH changes, making them particularly suitable for diabetic applications. In vitro and in vivo results confirmed the superior drug encapsulation, stability, and release kinetics of the microneedles, showcasing their potential for effective and sustained transdermal delivery of insulin. This work establishes a new paradigm in the synthesis of multifunctional microneedles through the integration of MOFs and PDES for DLP 3D printing. The findings highlight the capability of this approach to address current challenges in drug delivery, offering a scalable, biocompatible, and responsive platform for advanced therapeutic applications.
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高影响因子
Discover Applied Sciences
·
2025
·Vol. 7
·期 7
·728
·
IF 0
Lan Tian,Ding Xiaofan,Xiao Songtao,Yuan Zhongwei,Yan Taihong,Chen Qi,Li Tianchi,Zheng Weifang
Developing effective iodine capture technologies is critical for both nuclear safety and environmental protection. This study investigates the iodine adsorption properties of ZIF-8, a metal–organic framework (MOF). ZIF-8 samples with varying particle sizes (∼50 nm, 90 nm, 150 nm, and 8 μm) were synthesized and tested for iodine vapor adsorption at 80 °C. Iodine uptake continuously increased with time, reaching ~ 3500 mg/g after 24 h without reaching equilibrium, with no significant dependence on particle size. Structural changes in ZIF-8 were observed, as iodine accumulation led to the breakdown of the framework into an amorphous gel-like substance, representing a previously unreported phase transformation. SEM and XRD characterization confirmed the collapse of the crystalline structure after iodine loading. These results indicate that iodine adsorption in ZIF-8 involves strong chemisorption in addition to physical uptake, causing irreversible framework transformations. This work highlights the influence of particle size and provides important insights for using ZIF-8 in effective radioactive iodine capture.
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DESALINATION
·
2025
·
IF 9.8
Jialu Li,Zhonghao Xu,Yangdong He,Sheng Shi,Sihan Ye,Liyun Zhang,Lan Ma,Jian Zhen Ou,Hao Yu
Integrating metal-organic-frameworks (MOFs) into graphene oxide (GO) membranes offers a pathway toward stable and highly selective nanofiltration, yet conventional blending or precursor-diffusion-driven in situ growth compromise structural integrity and is prohibitively slow (∼36 h). Here, we report an electric-field-driven strategy that induces electrophoretic migration of Zn 2+ and 2-methylimidazole precursors, enabling ultrafast (<60 s) synthesis of ZIF-8 within the internal pores of ethylenediamine (EDA)-crosslinked GO-based membranes intercalated by arched graphene (WG). Growth is directed preferentially into high-permeability channels, sequentially plugging dominant and subdominant pores at a rate 2160 times faster than diffusion. This selective pore filling suppresses ZIF-8 overgrowth and minimizes structural disruption, while enhancing rejection performance. The resulting membrane exhibits exceptional dye rejection of 87.11 % (MB), 99.45 % (EBT), 97.39 % (CV), 99.21 % (CR), and 99.37 % (TB), surpassing pristine GO (36.90–91.07 %) and slightly outperforming diffusion-grown counterparts. Meanwhile, the intrinsic 0.7 nm pores of ZIF-8 permit nearly complete salt permeation (rejection <2.73 %), yielding practical dye/salt selectivity >8. Amine-functionalized ZIF-8 further promotes crosslinking, imparting remarkable stability: wet/dry interlayer spacing variation <1 Å and strong resistance to acid/base exposure, hydraulic flushing, and ultrasonication. This electric-field-guided, sub-nanopore engineering strategy thus establishes a generalizable platform for precision separation membranes using diverse substrates and porous framework.
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高影响因子
SENSORS
·
2025
·Vol. 25
·期 24
·7462
·
IF 3.5
Yuanyue Lu,Yong Mei,Yingying Gu,Ye Tao,Yuhan Yang,Jiao Yu,Yang Zhang,Lin Liu,Xin Li
An electrochemical immunosensor was fabricated to identify CA15-3, a biomarker for breast cancer (BC). A composite sensor substrate made of “zeolitic imidazolate framework-8” (ZIF-8) and “reduced graphene oxide” (rGO) was chosen and its conductivity was further improved by the addition of chitosan (CS)-doped gold nanoparticles (AuNPs). The CS@AuNPs are able to conjugate with antibodies via the strong Au-S interaction, which offers multiple active sites for antibody immobilization and enhances the sensor performance. This immunosensor is capable of ultrasensitive detection of CA15-3 by specific antigen–antibody –interactions. In healthy people, normal serum CA15-3 is up to 25 U/mL. Under optimized experimental conditions, the alteration in the signal intensity measured by the sensor was related to the CA15-3 activity. The quantitative relationship was linear over 0.001–400 U/mL with a limit of detection (LOD) of 0.0031 U/mL at a “signal-to-noise ratio” (S/N) of 3 and a “correlation coefficient” (r2) of 0.9983. The developed immunosensor showed great accuracy, stability, and selectivity, and was able to detect CA15-3 in human serum samples. These results validate its potential as a reliable analytical platform for BC diagnosis and early clinical screening.
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PubMed
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2019
·
IF 3.375
Huajiao Liu,Yingjie Du,Jing Gao,Liya Zhou,Ying He,Li Ma,Guanhua Liu,Zhihong Huang,Yanjun Jiang
Based on glucose oxidase (GOx) and horseradish peroxidase (HRP), compartmentalization of a bienzyme system was successfully carried out by immobilizing them in hollow metal–organic frameworks via a protein-induced soft-templating pathway. The morphology, structure, and properties of the obtained HRP@H-ZIF-8-GOx (GOx and HRP were immobilized in the shell and cavity of hollow ZIF-8, respectively) were investigated by powder X-ray diffraction, scanning transmission electron microscopy (STEM), and so forth. HRP@H-ZIF-8-GOx showed excellent catalytic activity for the cascade reaction with glucose and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) diammonium salt as the substrates. The temperature adaptability, thermal stability, mechanical stability, and long-term storage stability of HRP@H-ZIF-8-GOx are better than that of HRP-GOx@H-ZIF-8 (GOx and HRP were coimmobilized in the cavity of hollow ZIF-8). HRP@H-ZIF-8-GOx was used for the detection of glucose and phenol, which showed excellent detection performance. This proposed platform provides a facile strategy for constructing a compartmental multienzyme system and expands the application potential of multienzyme in biosensor construction, biocatalysis, and environmental field.
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高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2019
·
IF 5.107
Zhihao Si,Di Cai,Shufeng Li,Guozhen Li,Ze Wang,Peiyong Qin
The diffusion process is the rate-limiting step for n -butanol recovery from diluted aqueous solution, which can be improved by incorporating hydrophobic nanoparticle into the polymer matrix. However, the micropore structure of zeolitic imidazolate framework-8 (ZIF-8) in the commonly applied ZIF-8-based mixed matrix membrane (MMM) could hardly meet the diffusion demand of the penetrant molecules. Herein, ZIF-8-derived nanoporous carbon (ZNC) with larger pore diameter and pore volume was prepared to replace ZIF-8 in conventional MMM in order to improve the diffusion process. An increase of 68.7% in n -butanol permeability of ZNC/PDMS MMM with 3 wt% of particle loading was obtained compared with ZIF-8/PDMS MMM. Coupled with the good compatibility between ZNC and PDMS , ZNC was homogeneously dispersed in PDMS matrix. As a result, a n -butanol permeability of 109,583 Barrer and a n -butanol/water selectivity of 4.47 were obtained for n -butanol recovery from 1.5 wt% n -butanol/water solution at 55 °C, which were increased by 145.4% and 17.6%, respectively, compared with the pure PDMS membrane. Overall, the ZNC-filled PDMS membrane shows promising in effective separation of n -butanol in realistic applications.
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高影响因子
POLYMER TESTING
·
2021
·
IF 4.282
Xuanhe Yang,Shaoping Li,Yanqing Yao,Jia Zhao,Zhiguo Zhu,Chunpeng Chai
A Polypropylene non-woven fabric/ZIF-8 composite film was prepared by in-situ grown method. The loading amount of ZIF-8 of PP non-woven fabric/ZIF-8 composite film increases as the volume of reaction solution and the aging time go up. Scanning electron microscopy (SEM) was used to characterize the microstructure of PP non-woven fabric/ZIF-8 composite film. The results show that ZIF-8 nanoparticles were evenly distributed on the PP fiber. The hydrophobicity of PP non-woven fabric/ZIF-8 composite was characterized by water contact angle. The contact angle was up to 137.45°, when ZIF-8 loading amount was 0.85 g·g −1 . The material can quickly adsorb floating oil and underwater heavy oil without absorbing water, and the gasoline adsorption capacity of the composite was up to 3612% of its mass and maintains a high oil absorption capacity after it was reused 43 times, which proves that PP non-woven fabric/ZIF-8 composite film is a well recyclable oil/water separation material.
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高影响因子
NANOTECHNOLOGY
·
2020
·Vol. 31
·期 12
·125601
·
IF 3.551
Qianyun Bin,Min Wang,Lishi Wang
In this work, silver nanoparticles (Ag NPs) were decorated into the cavities of ZIF-8 to fabricate a novel Ag NPs/ZIF-8 modified glassy carbon electrode (GCE) for electrochemical sensing of chloride ion. Benefiting from the synergistic properties of ZIF-8 and Ag NPs, the Ag NPs/ZIF-8/GCE showed favorable performance towards chloride ion. For comparison, the electrochemical activity of Ag NPs wrapped by ZIF-8 (Ag NPs@ZIF-8) and Ag NPs coating on ZIF-8 (Ag NPs-on-ZIF-8) were also investigated and it was found that Ag NPs/ZIF-8 possessed the best performance. Some experimental parameters including pH of the supporting electrolyte and scan rate were also investigated. Under optimal conditions, the proposed sensor exhibited excellent stability, reproducibility and selectivity for the determination of chloride ion with a wide linear detection range from 5 to 4000 μmol dm−3 and a low detection limit of 0.61 μmol dm−3 (S/N = 3). The proposed sensor was successfully applied to the determination of chloride ion spiked in human serum. All these results indicated that the developed Ag NPs/ZIF-8/GCE sensor was superior.
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高影响因子
危险品化学品经营许可证（带存储）