INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2020
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IF 5.162
Ye He,Xingxian Wu,Guanglin Zhang,Xingwen Huang,Wenrui Zhang,Mei Tu,Rong Zeng
A zwitterionic phosphoryldiserine (PDS)- chitosan conjugate was synthesized via Atherton-Todd reaction, and its degree of substitution of PDS and structure were characterized by 1 H and 31 P NMR spectra, ICP, FTIR and XRD. Thermal analysis confirmed that there existed the freezing bound water surrounding PDS-chitosan due to the introduction of zwitterionic PDS groups onto chitosan backbone. In vitro cytotoxicity and hemolysis assay demonstrated that PDS-chitosan had excellent cell compatibility. UV adsorption and fluorescence spectra revealed that the model protein, bovine serum albumin (BSA) tended to keep its native conformation and showed better thermal stability in aqueous media in the presence of PDS-chitosan. We also found that the esterase-like activity of BSA could be enhanced by low concentration of PDS-chitosan (C BSA = 0.33 mg/mL, C PDS-chitosan = 0.0625 and 0.125 mg/mL, pH = 7.4, T = 25 °C). The results indicated that zwitterionic PDS-chitosan showed great potential for maintaining protein function in biomedical applications.
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ACS Biomaterials Science & Engineering
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2024
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IF 5.4
Xin Wang,Zheng Wei,Zuoyao Wu,Yanping Li,Chenjiao Miao,Zheng Cao
Endometritis, a prevalent obstetric condition primarily caused by Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), significantly threatens the reproductive performance of female animals. In this study, thermosensitive injectable chitosan (CS)/β-glycerophosphate (β-GP) hydrogels loaded with berberine (BBR) and carvacrol (CAR) were prepared for endometritis treatment. In vitro, BBR/CAR-CS/β-GP hydrogels exhibited rapid gelation within 5 min at 37 °C, excellent injectability, and more than 90% degradation within 30 days under enzymatic action. The dual drug-loaded system also exhibited controlled release of BBR and CAR and demonstrated the antimicrobial activity against E. coli and S. aureus. In vivo, uterine injection of BBR/CAR-CS/β-GP hydrogels alleviated infection-induced injuries and reduced the bacterial load in infected uterine tissues. In summary, these findings highlight the potential of BBR/CAR-CS/β-GP hydrogels as innovative carriers for drug delivery targeting endometritis.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Youjing Shi,Lijie Wang,Wei Wei,Sheng Ding,Wen Zhang,Fan Li,Zhaoming Li,Xin Meng
Rapid and effective hemostasis can immediately control blood loss and prevent fatal complications. Chitosan sponge loaded with carbon nanospheres PC-800 for rapid hemostasis was first reported here. Preparation process is simple, green and low-cost. Specifically, microporous carbon nanospheres (PC-800) were synthesized by hydrothermal method and followed by calcination in high yield. Afterwards, PC-800 was homogeneously dispersed in the chitosan solution and lyophilized to obtain the composite sponge. The aim of this study is to explore the synergistic hemostatic effect of chitosan and PC-800 and validate its feasibility in trauma therapy. The composite sponges exhibited porous structure, suitable mechanical properties, strong water absorption capacity (49.2 ± 0.8 g/g), good hemocompatibility (hemolysis rate<5 %) and low cytotoxicity. However, cytotoxicity occurs with excessive PC-800 loads. The blood coagulation index of CS-1.0 with 9.5 % was significantly lower than the commercially available Celox Rapid. Upon application to a wound, CS-1.0 sponge rapidly forms a wound seal, achieving effective hemostasis through the synergistic action of chitosan and PC-800. Compared to Celox Rapid, tail hemorrhage and hepatic hemorrhage time in rats decreased to 73 s and 34 s, respectively. The composite sponges were expected to be a safe and fast hemostatic dressing for uncontrolled bleeding during emergencies.
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ACS Applied Polymer Materials
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2025
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IF 4.7
Jinyu Shan,Jie Zhang,Xinru Wang,Kaili Yang,Dong Yang,Guangming Tian,Yunzhi Dang,Jianhua Ma
Inhibiting bacterial growth on wound surfaces is crucial for accelerating wound healing. Although antibiotics are commonly used to address the antibacterial needs of inflammatory wounds, their use can lead to bacterial resistance. To avoid the prolonged use of antibiotics while meeting the antibacterial requirements during the wound healing process, the combination of natural antibacterial materials with inorganic antibacterial agents to create efficient antimicrobial medical composites has shown promising potential. In this work, we first prepared a spinning solution by combining zinc oxide (ZnO) with chitosan (CS). Using a wet spinning process, CS/ZnO fibers were fabricated. Subsequently, a layer of zinc alginate (Alg-Zn) was coated on the surface of the CS/ZnO fibers through an in situ impregnation technique, resulting in the formation of composite fibers with high-efficiency and sustained antibacterial properties. Due to the inherent cationic antibacterial activity of CS and the zinc ion release from both Alg-Zn and ZnO, the composite fibers exhibited excellent antibacterial performance. The maximum inhibition zones against Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa were 6.7, 4.3, and 2.5 mm, respectively. Benefiting from the Schiff base reaction between CS and Alg-Zn, the composite fibers maintained good mechanical properties, with a tensile strength of 170 ± 2 MPa. Additionally, the composite fibers demonstrated favorable biocompatibility, moisture absorption, and breathability. This work provides valuable data for the design and preparation of antibacterial functional fibers and offers an approach for the development of high-efficiency antibacterial medical composites.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
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IF 7.7
Zhicheng Zhang,Wei Zou,Hong Wang,Zhongjie Du,Chen Zhang
A high-performance biomass-based adsorption materials could be the promising trend for CO 2 capture and storage technology. However, the direct application of biomass-based porous materials as a CO 2 adsorbent with enhanced performance is an emerging issue. Herein, a facile synthesis and a biomimetic strategy were combined to prepare amine-functionalized chitosan foam for CO 2 capture, and then a porous biomass is achieved for the application on the environment protection field. Firstly, the chitosan foam was synthesized by the emulsion-templating method at room temperature. Depended on stabilizing n-octane in the chitosan hydrogel with Span 80, a tunable three-dimensional network porous structure was obtained. Subsequently, co -deposition with dopamine (DA) and polyethyleneimine (PEI) was applied to load abundant amine content on the surface of chitosan foam and thereby improving CO 2 adsorption capacity. Finally, the as-prepared amine-functionalized chitosan foam exhibited the impressive adsorption capacity of 3.59 mmol/g at 333 K and atmospheric pressure, and the better adsorption selectivity and stability. The results extend the preparation approach of biomass porous materials, and also its application in CO 2 adsorption technology.
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CELLULOSE
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2025
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IF 4.8
Bai Xiaoyu,Wan Mengyu,Fan Wuhou,Kang Jianping,Xia Zhaoxia,Li Jiangtao,Lan Jingying,Xiao Lan,Zuo Song,Jiang Yuanzhang,Tan Lin,Zhang Yong
Electrostatic spinning technology can prepare nanofiber materials with high specific surface area and unique microstructure. Cellulose acetate (CA) has excellent membrane formation and processability, while chitosan (CS) is positively charged due to the abundance of amino groups and has certain biological activities. In this paper, CA/CS nanofiber membranes with different CS contents were prepared by solution blending and electrostatic spinning techniques and used in hemoperfusion (HP) for targeted removal of endotoxins. The CA/CS nanofibrous membranes were systematically characterized using infrared spectroscopy, scanning electron microscopy, etc., and the clearance ability of CA/CS nanofibrous membranes for endotoxin was tested under static and dynamic simulated HP conditions. The results showed that the addition of CS changed the structure of CA nanofibers, significantly increased the specific surface area of CA/CS nanofiber membrane, and provided more adsorption sites for the membrane material. The positive charge of CS interacted with the negatively charged endotoxin in the blood through electrostatic attraction, which enabled the CA/CS nanofiber membranes to adsorb endotoxin efficiently and exhibit higher endotoxin clearance ability. In the static adsorption experiment, when the CS content was 3.75%, the endotoxin adsorption and clearance rate could reach 580.0 ± 32.2 EU/g and 65.1 ± 3.6%, respectively. In the dynamic adsorption experiment, when the CS content was 2.50%, the CA/CS nanofiber membrane had a good effect on the adsorption of endotoxin. Meanwhile, CA/CS nanofiber membrane also has good blood compatibility. Therefore, the CA/CS nanofiber membrane is potentially valuable in blood purification.
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Journal of Materials Chemistry B
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2025
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IF 5.7
Zhiwen Hu,Fangjiu He,Anxiong Liu,Xuan Zhao,Shuangquan Wu,Jian You,Qifa Ye,Xiaowen Shi,Zibiao Zhong,Ruilong Shao
Liver failure, marked by a rapid or progressive decline in liver function, leads to complications such as hyperbilirubinemia and infections, contributing to approximately 2 million global deaths each year. Current hemoperfusion methods for hyperbilirubinemia treatment are limited by their low adsorption selectivity and inadequate biosafety, necessitating better treatments. In this study, a chitosan-based HKUST-1 aerogel (HC) was developed as a highly selective, biosafe, and antibacterial adsorbent. The integration of HKUST-1 with chitosan formed an aerogel that achieved high bilirubin adsorption in vitro along with significant biosafety, anticoagulant properties, and antibacterial activity against Staphylococcus aureus and Escherichia coli. In an animal model of hyperbilirubinemia, the HC aerogel demonstrated 53.8% bilirubin clearance from the whole blood. These findings suggest that the HKUST-1/chitosan aerogel is a promising candidate for liver failure treatment, effectively combining bilirubin adsorption with infection control in complex blood environments.
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CARBOHYDRATE POLYMERS
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2025
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IF 12.5
Ding Zhou,XinQing Li,Ying Zhu,Yaxin Hu,Siying Zhang,Zan Tong,Yingshan Zhou,Yun Chen
Persistent bacterial infections hinder wound healing by disrupting tissue repair and perpetuating inflammatory states. However, conventional therapies adopting antibiotics and passive dressings could only suppress pathogens temporarily and ignore antibiotic resistance or actively promote regenerative microenvironments. Herein, based on fungal-derived chitosan, guanidinium-functionalized chitosan (GCS) and aldehyde-modified chitosan (ACS) were synthesized, then chitosan hydrogels (SCgel) with self-healing capacity were prepared via the Schiff base reaction between GCS and ACS. Through a simple local injection through a dual-barrel syringe, a protective SCgel hydrogel barrier can be rapidly established on the wound. This hydrogel not only quickly eliminates bacteria in infected wounds but also reduces the level of wound inflammation, thereby promoting wound healing. In infected full-thickness rat wounds, SCgel achieved a 94.5 ± 1.1 % wound closure rate within 14 days, significantly superior to commercial silver-coated Aquacel™ Ag + . By integrating potent antimicrobial activity with inflammation control, this design reduces the reliance on systemic antibiotics and addresses the unmet need for microenvironment-responsive wound dressings.
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Current Research in Food Science
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2024
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IF 6.2
Jianfei Zhu,Tingting Huang,Xiaomei Chen,Dongling Tian
In this study, the effect of chitosan-vanillin Schiff base emulsions (CSVAEs) on dough and bread characteristics was investigated. The results revealed that CSVAEs were embedded in the gluten and that the viscoelasticity and mechanical strength of the dough gradually increased with increasing CSVAEs concentration, α-helical and β-fold content, and elastic structure in the dough increased with the same patterns. The basic properties of bread were measured, and it was found that low concentrations of CSVAEs were effective in improving the quality of bread and slowing the staling rate. As the storage time increased, CSVAEs had less effect on the rate of moisture loss, hardness and springiness of the bread and more effect on the inhibition of the acidity of the bread. The addition of CSVAEs slowed the increase in bacteria and molds and extended the shelf life of the bread.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2024
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IF 4.9
Yinggang Jia,Ronghao Man,Liannan Shang,Jian Chen
Developing an environmentally friendly adsorbent with high adsorption capacity and economic advantages is crucial for the treatment of cadmium (Cd)-contaminated wastewater. In this study, Bentonite (Bt), which is widely distributed in nature, was used to prepare a new type of chitosan (CS)-grafted polymerized aluminum-pillared bentonite (i.e., Al@Bt): CS@Al@Bt. This new material effectively addresses the issues of chitosan’s poor mechanical strength , limited load capacity, and the weak adsorption properties of raw bentonite for Cd. The effects of synthesis conditions on Cd adsorption by modified bentonite were investigated through batch experiments. The adsorption mechanism was revealed by characterization tests such as X-ray diffraction (XRD), N 2 adsorption-desorption experiments, Scanning and Transmission electron microscopy (SEM-TEM), Fourier transform infrared spectroscopy (FTIR), and X-ray photoelectron spectroscopy (XPS). The results showed that compared to raw Bt, when the ratio of Al in polymerized aluminum to the cation exchange capacity (CEC) of Bt was increased to 5 (i.e., Al/CEC=5), the specific surface area (SSA) of Bt increased from 78.46 m²/g to 195.99 m²/g. Additionally, the interlayer spacing and total pore volume increased by 1.22 and 1.13 times, respectively. After grafting chitosan onto Al@Bt, CS@Al@Bt reached adsorption equilibrium rapidly within 15 min, achieving a removal rate of up to 99.82% (initial concentration of Cd(II) was 20 mg/L, and the solid-liquid ratio was 1 g/L). Additionally, CS@Al@Bt showed good adsorption performance over a wide pH range. The rich pore structure of CS@Al@Bt and the complexation between amino (-NH 2 ) and hydroxyl (-OH) groups with Cd(II) were the main mechanisms for the removal of Cd(II) from the solution. The application showed that CS@Al@Bt effectively reduced Cd-containing mining wastewater from class V to class II quality, underscoring its significant potential for treating Cd(II)-contaminated wastewater.
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JOURNAL OF MOLECULAR STRUCTURE
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2022
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IF 3.841
Guo Yi,Junhong Ling,Yongjun Jiang,YuQing Lu,Li-Ye Yang,Xiao–kun Ouyang
In this study, we developed pH-sensitive chito-oligosaccharide nano-drug-loaded particles with good biocompatibility, biodegradation, and controlled drug delivery. Chitosan oligosaccharides (COS), Doxorubicin (DOX) amino groups, and aromatic aldehydes of benzaldehyde-terminated polyethylene glycol were used to spontaneously form pH-sensitive aniline bonds. We aimed to achieve site targeting under weak acidic tumor conditions, improve the efficacy, and reduce the toxic side effects of the drug. Particle size, drug encapsulation efficiency, loading efficiency, and zeta potential of nanoparticles were optimized by altering the ratios of aldehyde, amino groups, and sodium tripolyphosphate. The drug encapsulation efficiency and loading efficiency of COS-DOX1 were 5.55 ± 0.13% and 88.81 ± 2.00%, respectively, and the in vitro drug release process displayed a specific pH responsiveness. Co-culture of COS-DOX with HCT-116 human colon cancer cells showed that the nanoparticles exhibited dose-dependent cytotoxicity. At a low dose, COS-DOX1 can promote DOX uptake of tumor cells and exhibit higher cytotoxicity than DOX alone.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2023
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IF 8.2
Huixiang Wu,Yujun Zhang,Hao Chen,Jing Liu,Lili Xiu,Jianying Huang
In this work, we synthesized cryptate copper(II) followed by complexed with sulfonate chitosan (SCS). After characterization, the evaluation of the antioxidant properties of resulting complexes were carried out by 1,1-Diphenyl-2-picrylhydrazyl radical (DPPH•), hydroxyl radical (•OH), and 2,2′-Azinobis-(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS •+ ), while the antibacterial and biofilm inhibitory activity against Pseudomonas aeruginosa PAO1 ( P. aeruginosa PAO1) were also investigated. According to the results, cryptate copper(II) exhibited the best antioxidant activity followed by cryptate copper(II)/SCS complexes, and SCS. Significant antibacterial activity of cryptate copper(II) against P. aeruginosa PAO1 was observed with the minimum inhibitory concentration of MIC value 12.50 μg/mL and minimum bactericidal concentration of MBC value 100.00 μg/mL, followed by cryptate copper(II)/SCS complexes and SCS. Cryptate copper(II) and cryptate copper(II)/SCS exhibited antibacterial activity which copper ions might enter the interior of cells, and the intracellular ions made the killed bacteria serve as an antibacterial agent showing a zombie effect. The copper ions complexed with cryptate and SCS rendering potential unlimited biological activities, might become one of the most popular research areas because of their unique coordination chemistry and their long-term biological activities.
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