COLLOIDS AND SURFACES B-BIOINTERFACES
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2015
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IF 4.152
Fanfei Meng,Sajid Asghar,Shiya Gao,Zhigui Su,Jue Song,Meirong Huo,Weidong Meng,Qineng Ping,Yanyu Xiao
In this study, a novel low density lipoprotein (LDL)-mimic nanostructured lipid carrier (NLC) modified with lactoferrin (Lf) and loaded with curcumin (Cur) was designed for brain-targeted delivery, and its effect on controlling the progression of Alzheimer's disease (AD) in rats was evaluated. NLC with the composition resembling the lipid portion of LDL was prepared by using solvent evaporation method. Lf was adsorbed onto the surface of NLC via electrostatic interaction to yield Lf modified-NLC (Lf-mNLC) as the LDL-mimic nanocarrier. In order to make sure more Lf was adsorbed on the surface of NLC, negatively charged carboxylated polyethylene glycol (100) monostearate (S100-COOH) was synthesized and anchored into NLC. Different levels of S100-COOH (0–0.02 mmol) and Lf modified NLC (0.5–2.5 mg/mL of Lf solution) were prepared and characterized. The uptake and potential cytotoxicities of different preparations were investigated in the brain capillary endothelial cells (BCECs). An AD model of rats was employed to evaluate the therapeutic effects of Lf-mNLC. The results indicate that Lf-mNLC with a high level of Lf showed the maximum uptake in BCECs (1.39 folds greater than NLC) as cellular uptake of Lf-mNLC by BCECs was found to be mediated by the Lf receptor. FRET studies showed Cur still wrapped inside NLC after uptake by BCECs, demonstrating stability of the carrier as it moved across the BBB. Ex vivo imaging studies exposed Lf-mNLC could effectively permeate BBB and preferentially accumulate in the brain (2.78 times greater than NLC). Histopathological evaluation confirmed superior efficacy of Lf-mNLC in controlling the damage associated with AD. In conclusion, Lf-mNLC is a promising drug delivery system for targeting therapy of brain disease.
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Foods
·
2024
·Vol. 13
·期 13
·2007
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IF 4.7
Huimin Xiao,Lin Wang,Nitong Bu,Jie Duan,Jie Pang
Due to the growing concerns surrounding microbial contamination and food safety, there has been a surge of interest in fabricating novel food packaging with highly efficient antibacterial activity. Herein, we describe novel photodynamic antibacterial konjac glucomannan (KGM)/polyvinylpyrrolidone (PVP) nanofibers incorporated with lignin-zinc oxide composite nanoparticles (L-ZnONPs) and curcumin (Cur) via electrospinning technology. The resulting KGM/PVP/Cur/L-ZnONPs nanofibers exhibited favorable hydrophobic properties (water contact angle: 118.1°), thermal stability, and flexibility (elongation at break: 241.9%). Notably, the inclusion of L-ZnONPs and Cur endowed the nanofibers with remarkable antioxidant (ABTS radical scavenging activity: 98.1%) and photodynamic antimicrobial properties, demonstrating enhanced inhibitory effect against bothStaphylococcus aureus(inhibition: 12.4 mm) andEscherichia coli(12.1 mm). As a proof-of-concept study, we evaluated the feasibility of applying nanofibers to fresh strawberries, and the findings demonstrated that our nanofibers could delay strawberry spoilage and inhibit microbial growth. This photodynamic antimicrobial approach holds promise for design of highly efficient antibacterial food packaging, thereby contributing to enhanced food safety and quality assurance.
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JOURNAL OF NANOBIOTECHNOLOGY
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2024
·Vol. 22
·期 1
·1-21
·
IF 10.6
Chen Tianjun,Wan Li,Xiao Yongchun,Wang Ke,Wu Ping,Li Can,Huang Caiqiang,Liu Xiangge,Xue Wei,Sun Guodong,Ji Xin,Lin Hongsheng,Ji Zhisheng
Spinal cord injury (SCI) often accompanies impairment of motor function, yet there is currently no highly effective treatment method specifically for this condition. Oxidative stress and inflammation are pivotal factors contributing to severe neurological deficits after SCI. In this study, a type of curcumin (Cur) nanoparticle (HA-CurNPs) was developed to address this challenge by alleviating oxidative stress and inflammation. Through non-covalent interactions, curcumin (Cur) and poly (-)-epigallocatechin-3-gallate (pEGCG) are co-encapsulated within hyaluronic acid (HA), resulting in nanoparticles termed HA-CurNPs. These nanoparticles gradually release curcumin and pEGCG at the SCI site. The released pEGCG and curcumin not only scavenge reactive oxygen species (ROS) and prevents apoptosis, thereby improving the neuronal microenvironment, but also regulate CD74 to promote microglial polarization toward an M2 phenotype, and inhibits M1 polarization, thereby suppressing the inflammatory response and fostering neuronal regeneration. Moreover, in vivo experiments on SCI mice demonstrate that HA-CurNPs effectively protect neuronal cells and myelin, reduce glial scar formation, thereby facilitating the repair of damaged spinal cord tissues, restoring electrical signaling at the injury site, and improving motor functions. Overall, this study demonstrates that HA-CurNPs significantly reduce oxidative stress and inflammation following SCI, markedly improving motor function in SCI mice. This provides a promising therapeutic approach for the treatment of SCI.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Xiquan Li,Xinhua Zhang,Jiale Lv,Xiuling Zhang,Yingying Li,Xiaofeng Han,Wentao Zhang
In current study, curcumin-loaded bioactive nanocomplexes (Cur NCs) (2 %, 5 %, 8 %, and 11 %) were used to prepare corn starch (CS)-based composite films (CS-Cur NCs). Fourier-transform infrared spectroscopy, X-ray diffraction and scanning electron microscopy revealed that Cur NCs were uniformly dispersed in the polymer matrix via physical interaction. Moreover, the mechanical, gas barrier, hydrophobicity, optical, and thermal properties and the antioxidant activity of composite films were potentially improved with the addition of Cur NCs. Subsequently, CS-based film with 11 % Cur NCs exhibited high antioxidant activity (the scavenging rates of DPPH and ABTS are 50.07 % ± 0.82 % and 65.26 % ± 1.60 %, respectively) and was used for packaging blueberries. Compared with the control, the CS-Cur NCs packaging treatment effectively improved the appearance and nutrition of blueberries, and maintained the high activity of several antioxidant enzymes. Furthermore, CS-Cur NCs packaging treatment significantly improved the ascorbic acid (AsA) and glutathione (GSH) levels, thus regulating the AsA-GSH cycle system and suppressing the accumulation of reactive oxygen species (ROS). In summary, the CS-Cur NCs packaging could effectively conserve the postharvest quality of blueberries by improving antioxidant enzyme activity and suppressing excessive accumulation of ROS, which contributes to the development of bioactive packaging and provides novel insights into the preservation of blueberries. This work demonstrates that the development of active packaging is promising to absorb the oxidative radicals from food, and protect the food from inherent and external factors, thus enhancing the quality, security, and shelf-life of the food during storage.
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DIAMOND AND RELATED MATERIALS
·
2025
·
IF 5.1
Jinyan Du,Shiji Liu,Jinrui Hou,Xinyue Wu,Haojie Si,Xingya Guo,Shujuan Zhuo
Due to the abuse of traditional antibiotics, the increasing prevalence of antibiotic resistance poses a significant challenge to the finding of novel antimicrobial materials. Curcumin, a natural polyphenolic compound, exhibits broad-spectrum antibacterial, anti-inflammatory, and antioxidant properties. However, its therapeutic utility is limited by its bioavailability. To improve the biological activity of curcumin, the highly water-soluble carbon dots ( E -CDs) were synthesized by a one-step hydrothermal method using curcumin and ethylenediaminetetraacetic acid disodium salt (Na 2 EDTA) as precursors. It was shown that the surfaces of E -CDs still remain the structural and functional groups of their precursors. The as-obtained E -CDs exhibited a higher antimicrobial efficacy against Staphylococcus aureus ( S. aureus ) and Escherichia coli ( E. coli ) with the minimum inhibitory concentration (MIC) of only 40 and 150 ppm, respectively. Strikingly, the E -CDs did not induce significant bacterial resistance while exhibiting excellent biocompatibility. In a mouse model of bacterial-induced wound infection, the wound closure had approached 60 % within just four days, highlighting their significant potential for accelerating wound healing. Our experimental results convincingly demonstrated that the E -CDs are a promising candidate for clinical applications in treating infected wounds and combating drug-resistant bacterial infections.
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JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
·
2025
·
IF 4.9
Wenjing Ren,Huiru Zhu,Dongshuai Shang,Xinyu Zhou,Hua Zhang,Juan Zhang,Guangpu Liu,Yunbo Wei,Kaiming Wang,Chengshi Jiang,Ping Sun
In this article, folic acid (FA) modified biodegradable poly (ethylene glycol) (PEG 2K ) was chosen as the polymeric skeleton to conjugate with curcumin (CUR) via a disulfide bond to construct a reduction-responsive drug delivery system (FA-PEG 2K -SS-CUR), aiming at improving the solubility of CUR and providing a targeted, efficient, and low side-effect anti-cancer nano-preparation. The polymers were synthesized through three steps to develop FA-PEG 2K -SS-CUR micelles, with a drug loading capacity of up to 10.9% and good stability. The particle of FA-PEG 2K -SS-CUR micelles determined by Malvern Mastersizer was 79.14±2.2 nm, and a hemolysis assay confirmed their good biocompatibility. The reduction sensitivity of FA-PEG 2K -SS-CUR micelles was verified by adding dithiothreitol (DTT) to the release medium, showing a programmed drug release mode with 60.41% released within 72 h, indicating a certain sustained-release capability. In vitro cytotoxicity assays showed that the FA-PEG 2K -SS-CUR micelles were more cytotoxic than free CUR. Additionally, FA-PEG 2K -SS-CUR micelles exhibited a higher cellular uptake rate than micelles without FA. Hence, the prepared multifunctional FA-PEG 2K -SS-CUR micelles is a promising anti-tumor nano-preparation.
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FOOD CHEMISTRY
·
2025
·
IF 9.8
Shumin Wang,Shengnan Wang,Xiuzhi Cao,Lina Yang,He Liu
To enhance the selective release of curcumin (Cur), a novel metal organic framework (Cys-γ-CD-MOF) was designed to achieve glutathione (GSH)-triggered Cur release. Soy hull polysaccharide (SHP) was used as a coating on the surface of Cys-γ-CD-MOF, to reduce potential side effects and improve intestine bioavailability. Crystal structure analysis confirmed that the SHP coating did not disrupt the inherent crystallinity of Cys-γ-CD-MOF. Scanning electron microscope (SEM) revealed a regular cubic morphology for Cys-γ-CD-MOF. Cur was incorporated in an amorphous form in the carrier, achieving maximum loading and encapsulation efficiencies of 51.99 % at a 1:3 Cur-to-carrier ratio after soaking 24 h at 35 °C. Cys-γ-CD-MOF@SHP loaded with Cur exhibits selective release in GSH solution, with a cumulative release of 56.39 % after 24 h in a 10 mM GSH solution. These findings indicate that Cys-γ-CD-MOF@SHP can serve as a promising novel carrier for the delivery of Cur or other hydrophobic bioactive compounds.
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FOOD CHEMISTRY
·
2024
·
IF 8.5
Jin Feng,Zhen Wang,Wuyang Huang,Xingyu Zhao,Lujing Xu,Cong Teng,Ying Li
This study aimed to investigate how hyaluronic acid interfacial decoration affects the stability, cellular absorption, and anti-inflammatory effects of curcumin-loaded nanostructured lipid carriers. Nanocarriers were synthesized with an ovalbumin single layer and ovalbumin/hyaluronic acid double, mixed, or conjugated layers. All nanocarriers were spherical (200–300 nm diameter), and their encapsulation efficiency exceeded 95 %. Among the layers, the conjugated one exhibited the highest elastic surface dilatational modulus of approximately 40 mN/m, and the longest curcumin half-life of 186.07 days at 4 °C. Spearman's correlation analysis showed a negative correlation ( r = −0.6698) between the recrystallization index and curcumin stability. The layer's mechanical strength improved curcumin stability by preventing crystal transition. Hyaluronic acid decoration enhanced the curcumin uptake of Caco-2 cells by 1.96–2.48 folds. Among the layers, the conjugate one was the most effective because of its strong binding constant with the receptor. Hyaluronic acid decoration improved the anti-inflammatory effects of curcumin.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Yajuan Li,Jingbo Liu,Xiaoxia Shi,Shanglin Li,Hui Zhang,Leiyi Zhang,Xinyi Huang,Shuaiyan Liu,Weiyi Wang,Longjiang Tian,Ting Zhang,Zhiyang Du
Soft assembly of peptide and curcumin (Cur) molecules enables functional integration by finding dynamic equilibrium states through non-covalent interactions. Herein, we developed two soft assembly systems, curcumin-egg white peptides (Cur-EWP) aggregations (AGs) and Cur-EWP-casein-quaternary chitosan (Cur-EWP-CA-QC) nanoparticles (NPs) to comparatively investigate their therapeutic effects on ulcerative colitis in mice and elucidate their underlying mechanism. Results revealed that Cur-EWP AGs, despite gastrointestinal tract instability, exhibited a propensity for swift accumulation within the colorectal region, enriching mucus-associated and short-chain fatty acid (SCAF)-producing bacteria, restoring the intestinal barrier damage. Whereas, Cur-EWP-CA-QC NPs, benefiting from their remarkable stability and exceptional mucosal adsorption properties, not only enhanced permeability of Cur and EWP in the small intestine to activate the immune response and boost tight junction protein expression but also, in their unabsorbed state, regulated the intestinal flora, exerting potent anti-inflammatory activity. Soft assembly of peptides and hydrophobic nutraceuticals could synergize biological activities to modulate chronic diseases.
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BIOCHEMICAL GENETICS
·
2025
·
IF 1.6
Li Qiaoxia,Zhang Yongyan,Shen Haoyu,Wang Ziqian,Huang Jiezhuang,Tang Shuli,Chen Peiyue,Zhi Zhifu
Intrauterine adhesions (IUA) is one of the most prevalent gynecological conditions affecting women of childbearing age. The active ingredient curcumin (CUR), derived from turmeric, is a promising candidate for the treatment of IUA. Nevertheless, the mechanism of action remains undetermined. This study investigates the role and mechanism of CUR in the treatment of IUA through network pharmacology, molecular docking, and molecular biology experiments. IUA-related targets were sourced from the GeneCards database. CUR-related targets were obtained from Herb and SwissTarget Prediction. Cytoscape version 3.10.2 was employed to construct PPI networks and to identify core targets. GO and KEGG enrichment analyses were conducted using the DAVID database. Additionally, molecular docking was employed to evaluate the interaction between CUR and core targets. Finally, the mechanism and targets of CUR in IUA were validated through animal experiments. A total of 122 common target points for CUR and IUA were identified. Topological analysis and KEGG analysis identified 20 core target points, encompassing multiple pathways, including inflammation and the PI3K/AKT signaling pathway. Molecular docking results demonstrated that CUR exhibits a strong binding affinity for the core target points. In vivo experiments indicate that CUR significantly alleviates the fibrosis and epithelial-mesenchymal transition (EMT) processes of the endometrium in IUA rats while inhibiting the overexpression of TGF-β1 in the uterine tissue of IUA rats and the activation of the PI3K/AKT and TLR4/NLRP3 signaling pathways. CUR can inhibit fibrosis and the EMT process in the endometrium of IUA rats, and its mechanism may be associated with the inhibition of the PI3K/AKT and TLR4/NLRP3 signaling pathways.
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LANGMUIR
·
2024
·
IF 3.7
Xue Yang,Lu Li,Guoshuo Shang,Meng Zhuo,Huiqing Zhu,Suyue Xu,Jingya Zhao,Xueyan Hou,Yongli Shi
Antioxidant play a crucial role in the prevention and treatment of diseases associated with oxidative stress. Curcumin (CUR), as a natural antioxidant, exhibits numerous therapeutic properties, including antioxidant, anti-inflammatory, antibacterial, and antitumor activities. However, its limited bioavailability and poor water solubility hinder its application as an effective antioxidant. In this study, a series of mesoporous silica nanomaterials with distinct morphologies, i.e., mesoporous silica nanoparticles (MSN) and mesoporous silica nanorods (MSR) were synthesized by a template–sediment–etching method. CUR was selected as a model drug and encapsulated into these nanomaterials to improve its bioavailability in vivo. The morphology and size distribution of MSN and MSR were determined through transmission electron microscopy (TEM) imaging and Zetasizer analysis. Fourier transform infrared spectroscopy (FTIR) spectra confirmed the successful encapsulation of CUR within these nanomaterials. Furthermore, these CUR-loaded silica nanomaterials, denoted as CUR@MSN and CUR@MSR, exhibited excellent DPPH and ABTS free radical scavenging activity in vitro. Furthermore, CUR@MSN and CUR@MSR also exhibited obvious in vivo antioxidant activity. This study opens up new avenues for the development of enhanced antioxidants through the utilization of mesoporous silica nanomaterials.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Yuan Wang,Jinfang Liu,Like Mao,Fang Yuan,Yanxiang Gao
In this study, the structural design and physicochemical property enhancement of undenatured type II collagen (UC-II) nanofibrils with sodium alginate (SA) coating induced by calcium ions (Ca 2+ ) were investigated. The research aimed to elucidate the impact of Ca 2+ concentration on the morphology, thermal stability , and digestive resistance, as well as to assess the potential of UC-II/SA nanofibrils as a delivery system for curcumin (Cur). A series of Ca 2+ concentrations (1–9 mM) were methodically applied to optimize the condition that maintains the triple-helical structure of UC-II, thereby enhancing its functional properties. It was found that the Ca 2+ level up to 5 mM effectively preserved the structural integrity and improved thermal stability of UC-II, with the added benefit of ensuring the substantial delivery of active fragment to small intestine (70.7 %), which was 3.43 times greater than that of uncoated UC-II. Moreover, incorporating Cur into the UC-II/SA nanofibrils resulted in a 300 times increase in Cur solubility and showcased the superior dispersion stability, antioxidant activity , and sustained release profile during simulated digestion. These findings underscored the dual functionality of the UC-II/SA system as both a stabilizing agent for UC-II nanofibrils and an efficient carrier for Cur delivery.
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