EUROPEAN POLYMER JOURNAL
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2019
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IF 3.621
Jie Wu,Ximing Tian,Yihua Yin,Meng He,Weiquan Cai,Guanghua He,Wenjin Xu,Yue Dai,Jiahao Mai,Mengqi Gan,Fengxinjia Zhang
To improve hydrolytic stability and biological half-life and anticancer efficacy of the anti-cancer drug melphalan (Mel), a novel esterification strategy was developed to fabricate a pH/enzyme dual-responsive polymer prodrug (mPEG-Mel) via the formation of an ion bond between the carboxyl group in Mel and diazotized p-aminobenzoate-terminated poly(ethylene glycol) monomethyl ether (mPEG-N 2 + ) followed by light-induced conversion of the ionic bond to an ester bond. The prodrug could self-assemble into nanoparticles. Under physiological conditions (pH 7.4), the nanoparticles exhibited a regular core-shell structure with about 100 nm, which could effectively inhibit the hydrolysis of pharmacophores in Mel structure and showed the long-circulation ability. While pH dropped to 5.0, an obvious increase in the nanoparticle size was observed and enhanced by different concentrations of cathepsin B (CTB), reaching a diameter of 675 nm or more in the presence of 2.0 µg/mL CTB. The nanoparticles showed minimal drug release at pH 7.4 (less than 10% in 24 h); however, drug release could be significantly accelerated in a CTB-containing medium at pH 5.0. Cell experiments showed that the half-inhibitory concentration (IC50) of nanoparticles was 1.00 µg/mL, which was about 5 times lower than that of free Mel (5.00 µg/mL), and indicating that the nanoparticles were more cytotoxic to cancer cells (4T1 cells). However, significantly reduced cytostatic effects were observed for normal cells (3T3 cells). In addition, cell uptake observation further supported the above experimental results, a stronger red fluorescence in 4T1 cells was observed for NR-loaded nanoparticles, which meant that the nanoparticles could release drug in response to pH/enzyme stimulation. Thus, mPEG-Mel based pH/enzyme double-response polymer prodrug nanoparticles could effectively enhance drug stability and anticancer efficacy.
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JOURNAL OF HAZARDOUS MATERIALS
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2019
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IF 7.65
Qin Zhu,Jiaorong Yan,Qiguang Dai,Qingqing Wu,Yuanpu Cai,Jinyan Wu,Xingyi Wang,Wangcheng Zhan
A unique zeolite catalyst, Fe doped ZSM-5 microsphere assembled by uniform nanorod-like crystals with hierarchical pore structure, was successfully synthesized and applied for the adsorption and degradation of trace chlorobenzene (CB) in the presence of H 2 O 2 . The organic ferric salts as the precursors, ethylene glycol as a chelating/reducing agent and the dynamic two-stage temperature-varied hydrothermal technique, together made the synthesized hierarchical Fe-ZSM-5 nanorods assembled microspheres (FZ-CA-5EG) to be characterized by abundant highly dispersed and valency-controlled framework Fe 3+/2+ species. As a result of these features, the FZ-CA-5EG showed excellent ability of adsorption and degradation efficiency of CB, and enhanced durability due to negligible leaching of framework Fe species. Moreover, the hydroxyl radicals were determined as the main the reactive oxygen species of CB oxidation degradation, and a possible adsorption-oxidation degradation pathway was proposed.
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SOLAR ENERGY MATERIALS AND SOLAR CELLS
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2019
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IF 6.019
Xinquan Zou,Weidong Zhou,Junfeng Shi,Yongming Ye,Yunhe Zhao,Hong Zhang,Yuanfa Liu,Yue Yu,Jing Guo
The cross-linked poly (N-methylol acrylamide)/polyethylene glycol (PN-MA/PEG) with an interpenetrating polymer network (IPN) was prepared by emulsion polymerization as composite phase change material (CPCM). N, N′-methylene bisacrylamide (MBA) was used for crosslinking agent. The prepared CPCM was characterized by Fourier Transform Infrared (FT-IR) spectroscopy, X-ray Diffraction (XRD), Differential Scanning Calorimetry (DSC), Thermogravimetric Analysis (TGA), thermal cycle test, Scanning Electron Microscope (SEM) and Transmission Electron Microscope (TEM). FT-IR results stated that there is no chemical interaction between PEG and PN-MA. XRD results indicated that the introduction of PN-MA did not change the crystal type of PEG. PEG still exhibits crystallization behavior under the constraints of cross-linked PN-MA. The DSC results indicated that CPCM melts at 26.24 °C with a latent heat of 106.5 J/g and solidifies at 32.56 °C with a latent heat of 104.9 J/g. The TGA results indicated that the CPCM has good thermal stability and is suitable for thermal energy storage application. The results of thermal cycle test indicated that the macroscopic morphology and latent heat of CPCM were almost unchanged after 40 thermal cycles. SEM and TEM results indicated that the microscopic morphology of CPCM was spherical and the particle size distribution was around 145 nm.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
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2019
·
IF 3.375
Xingang Li,Rui Wang,Yutao Yan,Runnan Zhao,Hong Li,Xin Gao
EG is an important industrial raw material, and the hydrolysis of 2-ethyl-1,3-dioxolane (2ED) to re-obtain EG is a very important step to recover EG from an EG and 1,2-BDO azeotropic mixture via a reversible-reaction-assisted intensification process. The applicability of reactive distillation for 2ED hydrolysis in the presence of KRD-002 ion exchange is studied by experiments and simulations. The reaction kinetics were investigated, and the kinetic parameters were derived. Thermodynamic aspects of the reaction system were discussed, and the NRTL model was built. Pilot-plant reactive distillation experiments were performed using the structured catalytic packing unit (SCPI) with several operating condition variations (reflux ratio (RR), feed mole ratio (FMR), and feed-in style). The experimental results are in good agreement with the simulation results, which prove that the equilibrium stage model can describe the hydrolysis experiments quantitatively. The simulation was subsequently used to determine the influence of important design factors and laid the foundation for industrial application.
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COLLOIDS AND SURFACES B-BIOINTERFACES
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2019
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IF 3.973
Lifen Wang,Pengpeng Xue,Mengqi Tong,Rui Chen,Waigeng Yang,Deli ZhuGe,Jiandong Yuan,Qing Yao,Yingzheng Zhao,Helin Xu
Inflammatory bowel diseases (IBDs) are chronic relapsing disorders of the gastrointestinal tract characterized pathologically by intestinal inflammation and epithelial injury. Laquinimod (LAQ), a poorly water-soluble compound, was proved to be effective for colitis remission at low dose of 0.5 mg/kg in patients with Crohn’s disease. Due to its extremely low solubility in water, it was difficult to develop an injectable liquid dosage form. Herein, D-α-Tocopheryl polyethylene glycol-1000 succinate (TPGS) polymeric micelles were developed as a delivery vehicle of LAQ for the management of inflammatory bowel disease. Using the LAQ/TPGS ratio of 1:100, LAQ-loaded micelles were successfully prepared by thin-film dispersion method. The solubility of LAQ in water was significantly increased from 10.5 μg/mL in pure water to 500 μg/mL in TPGS micelles. LAQ-loaded micelles of TPGS exhibited the fine particle size of 34.6 nm and Zeta potential of -0.67 mV. Moreover, the good stability of LAQ-loaded micelles in physiology-mimicking medium was confirmed by detecting their particle size, zeta potential and leakage of the loading drug. Therapeutic effect of LAQ-loaded micelles on DSS-induced mice was proved by detecting DAI score, colon length and loss of body weight. Moreover, the morphology and colonic mucosal barrier of the injured colon of DSS-induced mice was largely recovered after treatment with LAQ-loaded micelles. Meanwhile, the inflammation of colitis colon was also obviously alleviated by LAQ-loaded micelles. Conclusively, polymeric micelles of TPGS may be a promising delivery vehicle of LAQ for the management of inflammatory bowel disease.
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POLYMER COMPOSITES
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2023
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IF 5.2
Yao Peng,Yao Wang,Yingdi Dan,Zengkun Li,Quankai Sun,Yanxin Wang,Wei Wang,Zhonglin Du,Linjun Huang,Matt J. Kipper,Laurence A. Belfiore,Jianguo Tang
In this work, innovative hybrid poly(ethylene terephthalate) (PET) materials with strong luminescence were successfully synthesized by doping PET with silicon-linked poly(ethylene glycol)-PET copolymer nanostructures either with (Si-PEG-PET) or with (ETP@Si-PEG-PET) luminescent Eu 3+ -complexes. The chemical properties and nanostructures of the hybrid materials were characterized by Fourier-transform infrared spectroscopy, nuclear magnetic resonance spectroscopy, x-ray photoelectron spectroscopy, and high-resolution transmission electron microscopy. PET composites ranging from 0.25 to 4 wt% silicon additive were prepared by the melt blending method. The crystal properties, mechanical properties, and fluorescence properties of the composites were systematically studied by differential scanning calorimetry, x-ray diffractometry, tensile testing, and fluorescence spectrometry. When the addition of Si-PEG-PET or ETP@Si-PEG-PET was 0.75 wt%, the relative crystallinity and maximum tensile strength increase substantially. Moreover, the fluorescence intensity of hybrid luminescent PET materials is the strongest at 0.75 wt% loading. ETP@Si-PEG-PET not only endows PET polyester with stronger fluorescence properties and mechanical properties but also acts as an effective nucleation additive for PET. Highlights Silicon-linked poly(ethylene glycol)-poly(ethylene terephthalate) (PEG-PET) nanostructures generate hybrid luminescent PET materials. ETP@Si-PEG-PET improves the crystallization rate and crystallinity of PET. The composite with 0.75% addition showed the best fluorescence performance. Three-dimensional-grid structure of ETP@Si-PEG-PET enhances the mechanical property of PET.
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Molecular Catalysis
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2023
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IF 4.6
Xiaozhong Wang,Jiali Hu,Cai Xu,Yingqi Chen,Liyan Dai
Herein, a series of NiCu/Al 2 O 3 catalysts were prepared by impregnation method and subsequent thermal treatment under different reduction temperatures. The catalysts exhibited excellent catalytic activity for the amination of diethylene glycol (DEG), and satisfactory yield of tertiarybutylaminoethoxyethanol (TBEE) could be obtained. XRD, N 2 adsorption-desorption, SEM, TEM, XPS, and H 2 -TPR were employed to characterize the catalysts, the interaction between Ni and Cu on the catalytic activity was studied. It was found that NiCu alloy was formed after catalyst reduction, which strengthened the reduction ability of NiO and increased the number of Ni 0 active center, contributing to the enhanced catalytic activity. Moreover, the effects of reaction parameters on catalytic activity were explored. There was no need for a solvent, only 3 molar equivalents of tert‑butylamine (TBA) and 1 wt.% catalyst was required. After 7 h of reaction at 220 °C, satisfactory conversion (89.6%) and selectivity (84.6%) were obtained over the prepared catalyst. Cycle experiment demonstrated that the prepared catalyst retained excellent stability and reusability after six runs without significant loss of catalytic activity. This work provided an efficient catalyst for the catalytic amination of diethylene glycol with tert‑butylamine to TBEE.
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Peptide Science
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2023
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IF 2.4
Qianyu Zhang,Hongjing Chen,Huali Chen
PASylation has been recently reported as a feasible alternative to PEGylation, which in essence is using polypeptides constituted of a combination of proline, alanine and serine for the hydrophilic modification of pharmaceuticals. In this work, we focused on the biocompatibility evaluation of two PAS peptides, (PAS) 8 and (PA 3 ) 7 as well as the more frequently used polymers polyethylene glycol (PEG) and polyglycerol (PG). It has been verified in this study that (PAS) 8 and (PA 3 ) 7 both exhibited low cell toxicity against HUVEC and RAW 264.7 cell lines. They also showed negligible RBC hemolysis and agglutination, which demonstrated adequate hemocompatibility. Their potential interactions with bovine serum albumin have also been investigated, and the results indicated little hydrophobic interactions between the polymers and protein. In conclusion, (PAS) 8 and (PA 3 ) 7 as well as PEG and PG all showed considerable compatibility and safety in these studies, suggesting that (PAS) 8 and (PA 3 ) 7 could be considered as potential candidates for PEG replacement in future studies. Graphical
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WOOD SCIENCE AND TECHNOLOGY
·
2023
·Vol. 57
·期 3
·717-739
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IF 3.4
Li Yanchen,Zhang Weiye,Sun Jingmeng,Fang Xiaoyang,Wang Beibei,Li Fangzhou,Zhang Daihui,Guo Hongwu,Liu Yi
Wood is a great natural material with good energy storage and temperature adjustment for the energy crisis. In this study, wood was delignified, and the PEG-based eutectic polymer (PGMA) was impregnated into the delignified wood, and styrene (SM) grafted AlN was selected as thermal conductive filler to synthesize a stable phase change heat storage wood. The result shows that the styrene (SM) polymerized on the surface of AlN to form polystyrene (PS), and the dispersion of AlN was enhanced. The thermal stability and loss resistance of PCES-Wood are improved for the penetration of PS-AlN into the cavities, which is attributed to the PS-AlN playing a “limiting” role in the crystallization of PGMA. When the content of PS-AlN is 6%, the thermal conductivity of PCES-Wood reaches 0.5148 W/(m·K). 4% PS-AlN-PCES@Balsa has the lowest undercooling and heat loss rate, and the melting enthalpy and solidification enthalpy reach 125.60 J/g and 120.30 J/g, respectively. The phase change temperature range is between 19.59 and 33.87 °C, which is in the comfortable temperature range for humans. Under the illumination of the simulated solar light source, the surface temperature of PS-AlN-PCES@Balsa rises rapidly and shows a lasting heat storage capacity at low temperatures compared with the original wood. After 200 cold and hot cycle tests, the phase change enthalpy of PS-AlN-PCES@Balsa is still high, and there is a slight leakage phenomenon. The phase change wood prepared in this study shows that it is a potential material to store and release solar energy in practical applications.
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JOURNAL OF MOLECULAR LIQUIDS
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2023
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IF 6
Fuliu Yang,Jixue Fan,Lingqiang Meng,Jian Wu,Jun Li,Zhuhong Yang,Yifeng Chen,Xiaoyan Ji
Deep eutectic solvents (DESs) are considered as the highly effective absorbents for sulfur dioxide (SO 2 ) capture. However, the high viscosity of DESs and the resulting slow absorption rate as well as low absorption capacity at low SO 2 concentration seriously hinder their industrial application. In this study, DES of N-methyldiethanolamine (MDEA) and imidazole (Im) is simply blended with ethylene glycol (EG) forming a hybrid absorbent, namely MDEA/Im-EG, which exhibits extremely high SO 2 capture capacity at low concentration. In particular, SO 2 capture capacity in MDEA/Im-EG (molar ratio = 1:1) reaches 0.446 g SO 2 /g absorbent at 293.2 K with SO 2 concentration of 2000 ppm. Moreover, the corresponding desorption enthalpy is only −40.67 kJ/mol. To well understand the results, thermodynamic analysis of SO 2 capture is performed and the SO 2 capture mechanism is speculated by nuclear magnetic resonance and Fourier transform infrared spectroscopy.
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APPLIED CATALYSIS A-GENERAL
·
2023
·
IF 5.5
Fengqin Guo,Liguo Wang,Yan Cao,Peng He,Huiquan Li
A series of Mg 3 Al 1−x Ce x O composite oxide catalysts were prepared by co-precipitation for the transesterification of ethylene glycol to ethylene carbonate. The characterization results revealed that the addition of cerium changed the acid-base properties of the catalyst and that the strong basic sites on the catalyst surface played an important role in the reaction. The Mg 3 Al 0.9 Ce 0.1 O catalyst showed the highest catalytic activity (ethylene carbonate yield 98.1%). Compared with pure Mg-Al oxide, the appropriate addition of Ce was conducive to improving the surface basicity and adsorbed oxygen content of the catalyst. Additionally, the reaction process of the formation of ethylene glycol hydroxyl group with the alkoxy anion formed by the catalyst attacking the carbonyl carbon of nucleophilic dimethyl carbonate to form an adsorption intermediate (HEMC) on the catalyst surface for further intramolecular rearrangement to form ethylene carbonate was confirmed by operando infrared spectroscopy. The reaction kinetics shows that the reaction conforms to the second-order kinetic equation, and the activation energy is 53.71 kJ·mol −1 . Catalytic stability in a fixed-bed reactor was studied. After a long cycle of use (150 h), the yield of ethylene carbonate was stabilized at about 89.0%.
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FOOD CHEMISTRY
·
2023
·
IF 8.8
Yimei Zheng,Chengang Zhao,Boyu Chen,Hui Teng,Chao Ai,Lei Chen
In the present study, D-α-Tocopherol polyethylene glycol 1000 succinate-based self-microemulsifying drug delivery systems (TPGS-SMEDDS) were introduced to enhance the solubility and stability of luteolin. The ternary phase diagrams were constructed to obtain the maximum area of microemulsion and suitable formulations of TPGS-SMEDDS. The particle size distribution and polydispersity index of selected TPGS-SMEDDS were analyzed to be less than 100 nm and 0.4, respectively. The thermodynamic stability results suggested that the TPGS-SMEDDS was stable during the heat-cool and freeze–thaw cycle. Moreover, the TPGS-SMEDDS exhibited excellent encapsulation capacity (51.21 ± 4.39 to 85.71 ± 2.40%) and loading efficiency (61.46 ± 5.27 to 102.86 ± 2.88 mg/g) to luteolin. In addition, the TPGS-SMEDDS showed an admirable vitro release ability with a ratio of more than 88.40 ± 1.14% for luteolin in 24 h. Therefore, TPGS-based SMEDDS might provide an effective role for the oral administration of luteolin and holds promise as a potential delivery for poorly soluble bioactive compounds.
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