Nature Communications
·
2026
·
IF 18.1
Jianping Xu,Jian Zhang,Xiaotong Wang,Tengfei Zhao,Qingsheng Qi,Qian Wang
Lignin-related aromatics are promising renewable feedstocks, but their microbial conversion into useful compounds is fundamentally constrained by substrate toxicity and metabolic flux imbalance. Here, we report an autonomous microbial system in Corynebacterium glutamicum , which integrates evolutionary engineering with multiplexed dynamic control to overcome these constraints. This system features a robust, evolved chassis with reinforced cellular defenses and upgraded aromatic efflux machinery. We engineer a layered, multi-input regulatory network that enables real-time, substrate-responsive and precise control of metabolic pathways. This system achieves 99.89% conversion of diverse lignin-related aromatics to protocatechuic acid and subsequently achieves a titer of 53.40 g L⁻¹. This further supports high-titer production of value-added downstream chemicals, including cis,cis -muconic acid and β-ketoadipic acid with titers of 51.90 g L⁻¹ and 38.33 g L⁻¹, respectively. This work establishes a versatile and scalable paradigm for the autonomous bioprocessing of lignin feedstocks into sustainable value-added products. Biological valorization of lignin is hindered by substrate toxicity and metabolism inefficiency. Here, the authors established a platform for lignin-derived aromatics tolerance engineering and multi-node dynamic pathway control in Corynebacterium glutamicum .
✓ 已验证
DOI
PubMed
高影响因子
EUROPEAN POLYMER JOURNAL
·
2026
·
IF 6.8
Anjia Zheng,Zitao Yang,Zhongte Pei,Jiaming Zhang,Chuanxi Wang,Qianyu Wang,Cancan Zhang,Rui Hu,Bin Zhang,Qiaoling Liu,Feng Jiang
As the most abundant aromatic biomass resource in nature, lignin exhibits excellent ultraviolet (UV) absorption, photothermal conversion, and antioxidant properties. However, its complex structure and poor processability limit its application in flexible functional materials. In this work, a series of lignin- graft -poly(acrylamide- co - n -butyl acrylate) (Lignin- g -P(AM- co -BA)) copolymers was designed and synthesized by homogeneous reversible addition-fragmentation chain transfer (RAFT) polymerization. These Lignin- g -P(AM- co -BA) copolymers show tunable glass transition temperatures ranging from −21.9 to 51.2 °C and adjustable tensile strength values from 0.24 to 20.2 MPa by manipulating the PAM and lignin contents. Benefiting from the efficient light absorption and non-radiative relaxation processes of the aromatic conjugated structure of lignin, the lignin-based elastomers possess outstanding UV-shielding performance and extraordinary photothermal conversion ability. Furthermore, these Lignin- g -P(AM- co -BA) copolymer films can be integrated as a photothermal layer into thermoelectric power generation (TEG) devices to construct a flexible photothermal power generation system. Overall, this study provides a new strategy for the high-value utilization of lignin, and the developed lignin graft copolymers show great application potential in smart devices.
✓ 已验证
产品关联
DOI
高影响因子
Theranostics
·
2025
·Vol. 15
·期 15
·7425
·
IF 13.3
Yi Yu,Jiaxin Pan,Jianbo Zhang,Zhengdong Zhang,Chenghao Qiu,Yiming Xiang,Yizhou Zhu,Zhanjun Wu,Peng Yu,Tong Li,Lei Tan
Rationale: Clinically, patients experience severe pain, frequent bleeding, and delayed wound healing after hemorrhoidectomy due to recurrent fecal contamination during postoperative dressing changes and bowel movements, which exacerbate wound irritation. Methods : In this study, we developed a strain-programmed lignin-based multifunctional Janus patch (S-SFR@AGL) to accelerate rectal wound repair. This patch features a pre-stretched fluorinated silicone rubber side with robust anti-biofouling and strain-programmed properties, paired with a lignin-based hydrogel side offering potent antibacterial, antioxidant, bioadhesive, and hemostatic capabilities. Results : By modulating the wound's mechanical microenvironment and combating infection-induced inflammation, the patch healed infected rat rectal wounds within one week via effective bacterial clearance, attenuated inflammatory responses, and promoted muscle contraction and epithelial cell differentiation. Conclusions : This Janus patch could shorten intestinal wound healing time, potentially optimizing postoperative management after intestinal lesion resection.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Jiawei Zhang,Kang Sun,Gaoyue Zhang,Xinchen Lu,Jian Zhao,Ruizhen Wang,Haihong Xia,Kui Wang,Kaili Zhang,Jianchun Jiang
Lignin possesses intrinsic ultraviolet (UV) shielding properties, making it one of the most promising natural materials for eco-friendly sunscreen development. However, the wide molecular weight distribution, complex structure, dark color, and poor dispersibility of industrial sulfonated lignin (LS) have hindered its commercial application in cosmetic formulations. In this study, a green and efficient antisolvent approach using ethanol was developed to simultaneously fractionate LS and fabricate lignin nanoflowers (LSNFs). The results revealed that the low-molecular-weight fraction, LSNF 3 , exhibited a high density of oxygen-containing functional groups (phenolic hydroxyl content = 2.12 mmol/g), superior antioxidant activity (RSI = 6.45), and a significantly lighter appearance—with brightness and whiteness values increased by 253.5 % and 286.2 %, respectively, compared to LS. Molecular dynamics simulations further elucidated the self-assembly mechanism of nanoflower formation. Finally, LSNFs were incorporated into cream and SPF15 sunscreen formulations. The SPF value of 10 % LSNF 3 /Sunscreen reached as high as 67.8, demonstrating a green and cost-effective pathway for the application of lignin in the field of sun protection.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
REACTIVE & FUNCTIONAL POLYMERS
·
2025
·
IF 5.1
Yuntong Li,Long Li,Caiying Bo,Lihong Hu,Xiaohui Yang,Yonghong Zhou
Phenolic foam (PF) has gained extensive applications in architectural insulation, petrochemical industries, and aerospace engineering due to its exceptional thermal resistance. However, its practical implementation was hindered by inadequate mechanical strength, pronounced brittleness, and reliance on non-renewable petroleum-derived precursors. The substitution of lignin and its derivatives for phenol represented a sustainable innovation that synergistically enhanced foam performance and cost-effectiveness, while significantly minimizing environmental pollution and fostering the high-value conversion of renewable biomass resources. In this study, enzymatic hydrolysis lignin was functionalized by introducing nitrogen (N), phosphorus (P), and silicon (Si) moieties into its side chains, yielding an intrinsic lignin-based flame retardant (NPSi-L). Subsequent partial replacement of phenol with NPSi-L enabled the fabrication of NPSiLPFX composites. The modified lignin exhibited elemental compositions of 4.26 % N, 4.25 % P, and 6.65 % Si, with its char residue rate increasing to 69.18 %. The comparative study demonstrated that NPSiLPFX exhibited significantly enhanced fire resistance, with its LOI reaching up to 58.5 % and compressive strength attaining 0.22 MPa. Furthermore, peak heat release rate (PHRR) and total heat release (THR) were reduced by 28.68 % and 51.54 %, respectively, while fire growth index (FIGRA) and total smoke production (TSP) decreased by 55.14 % and 99.26 %, respectively. The composite exhibited remarkable improvements in fire safety. Analytical characterization of char residues through morphological and elemental composition studies elucidated the cooperative flame-retardant mechanism of the N-P-Si ternary system. This study established an eco-friendly paradigm for developing high-performance phenolic foams that synergistically addressed fire hazards and structural deficiencies in engineering applications.
✓ 已验证
产品关联
DOI
高影响因子
BIORESOURCE TECHNOLOGY
·
2026
·
IF 9
Rui Gao,Zekai Jin,Lidong Li,Chenhuan Lai,Xueni Sun,Fuxiang Chu,Yupeng Liu,Shishuai Gao,Daihui Zhang
The use of non-degradable polymer films has raised urgent environmental concerns, prompting the development of biodegradable alternatives with robust mechanical performance; however, the heterogeneous structure and poor interfacial compatibility of lignin often limit its reinforcing efficiency in polymer matrices. Herein, a green γ-valerolactone–gallic acid solvent system was developed for in situ lignin modification during pretreatment, enabling controlled structural reorganization and interfacial engineering within the polyvinyl alcohol (PVA) matrix. GA incorporation increased the density of polar functional groups and enhanced hydrogen bonding interactions with PVA chains, leading to improved interfacial compatibility and a more uniform polymer network. The resulting film demonstrated improved mechanical properties—tensile strength (∼46 MPa), Young’s modulus (0.22 GPa), and toughness (70 MJ·m −3 ). Lignin integration enhanced water resistance and imparted efficient photothermal conversion, enabling stable cyclic heating under solar irradiation. This strategy provides a viable approach for developing biodegradable films that combine mechanical integrity with multifunctionality.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nanoscale
·
2026
·
IF 5.1
Lingjuan Luo,Ya Ma,Dingfu Wang,Fangfang Wang,Zhicheng Jiang,Bi Shi
Lignin structure significantly affects the self-assembly ability into lignin nanoparticles (LNPs) and their properties for the specific applications. Herein, several lignin oligomers with distinctive chemical structures were extracted from the typical biomasses and self-assembled into LNPs, which were further used to stabilize Pickering emulsion. The linearly arranged catechyl unit and the abundant phenolic hydroxyl groups in the castor seed coats-derived lignin oligomers would promote their π-π stacking and hydrogen bonding interactions for the self-assembly. Associating with further fractionation of the catechyl lignin, the hydrophilic part with large molecular weight were separated, and self-assembled into small and uniform LNPs. The catechyl unit in the catechyl lignin self-assembled LNPs endowed high hydrophilicity of the LNPs surface with rich negative charge. The uniform LNPs could stabilize Pickering emulsion with smaller vacuoles, which showed high stability maintaining at least 15 days. Subsequently, the LNPs-stabilized Pickering emulsion was applied for curcumin encapsulation, improving its storage and controllable release. This study may contribute to the application of curcumin in food and drug formulations, increase the utilization efficiency of pharmaceutical molecules and reduce their usages, creating economic and alleviating environmental issue.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2026
·
IF 10.4
Xin Chen,Guangyi Kan,Jingqi Zhang,Xinyue Li,Ting Zhang,Xichang Wang,Jian Zhong
The gelatin-anionic polysaccharide complex coacervation system represents a promising platform for developing oil powders. Herein, the complex coacervation of dealkaline lignin (DAL) with three types of skin gelatins (Bovine skin gelatin, BSG; porcine skin gelatin, PSG; cold water fish skin gelatin, CFSG) was explored for fish oil encapsulation. At optimal pH conditions, the particle sizes of the fish oil@gelatin-DAL complex coacervates were comparable (100-μm scale) across all three gelatin types. The resulting oil powders exhibited production yields of 58.7%–75.1%, loading capacities of 35.5%–44.5%, encapsulation efficiencies of 5.08%–8.66%, maximum peroxide values of 130.0–212.3 mmol/kg oil under 63 °C, and accumulative free fatty acid released percentages (49.3%–85.8%) in the in vitro digestion process. The differences were associated with the molecular interaction of gelatins with fish oil/DAL. All results suggested that DAL is a promising material to prepare oil powders in functional foods if low encapsulation efficiency is solved.
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Huiqing Wei,Kunhua Chen,Minting Liang,Xueqing Qiu,Liheng Chen
Solvent-free synthesis of lignin-derived carbon nanomaterials. • Confined reaction environment regulates carbonization pathways. • Simultaneous improvement in product yield and fluorescence efficiency. • Sensitive detection of copper ions in real water samples. The synthesis of biomass-derived carbon dots (CDs) often suffers from solvent dependency, poor control over reaction pathways, and limited mechanistic understanding of structure formation. Herein, we present a solvent-free self-foaming confined-condensation strategy in which the coordinated thermal reactions of alkali lignin, amino acids, and oxalic acid generate in situ confined microenvironments during thermal treatment. This engineered multiphase system leverages bubble confinement to influence nucleation and carbonization behavior, suppress over‑carbonization, and promote effective nitrogen incorporation from basic amino acids. The process eliminates reaction solvents and avoids pressurized reactors, thereby simplifying the synthetic procedure and reducing solvent-related post-treatment requirements. Rather than claiming a fundamentally new solvent-free concept, this work highlights a self-foaming confined-condensation strategy that integrates low-cost lignin, readily available amino acids, and oxalic acid to regulate lignin carbonization under ambient pressure. The resulting OKLCDs function as a sensitive and selective fluorescent probe for Cu 2+ detection, achieving a detection limit of 1.35 μM and recoveries exceeding 92% in real water samples. This work provides a practical solvent-free confinement-regulation approach for lignin valorization and the preparation of functional carbon nanomaterials. This figure depicts a green, self-foaming strategy to transform waste alkali lignin into fluorescent carbon dots for sustainable copper ion sensing. Download: Download high-res image (265KB) Download: Download full-size image
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF POLYMER RESEARCH
·
2026
·Vol. 33
·期 7
·273
·
IF 3.5
Yan Xilai,Tang Yuqing,Huang Guangying,Han Han,Mondal Ajoy Kanti,Lin Weijie,Huang Fang
The use of renewable Kraft lignin (KL) as a partial substitute for petroleum-based polyols has attracted significant interest in polyurethane foam (PUF) development. However, the effect of unmodified KL content on the balance among cellular structure, mechanical stability, cyclic compression behavior, and thermal properties of flexible polyurethane foam (FPUF) still requires further clarification. In this study, a series of lignin-based flexible polyurethane foams (LFPUF) with different KL contents were prepared via a one-shot method using polyethylene glycol 400 (PEG400) and hexamethylene diisocyanate (HDI). The proposed interactions between KL and PEG400, together with the reaction between hydroxyl groups and –NCO groups, contributed to the formation of lignin-containing polyurethane networks. With 15 wt% KL addition, L 15% FPUF exhibited the most favorable cellular structure, with the smallest average cell size (843.5 μm) and pore diameter (249.3 μm). Its rebound resilience and elastic recovery rate reached 20.36% and 98.24%, respectively, which were higher than those of KL-free FPUF (13.45% and 96.97%). After 300 compression cycles at 75% strain, L 15% FPUF maintained a high elastic recovery rate of 93.53% and a stable hysteresis loss of 32.71%, demonstrating good cyclic compression stability. Thermal analysis further showed that KL incorporation improved high-temperature residue retention while affecting the initial degradation behavior. This study identifies 15 wt% KL as a balanced substitution ratio for preparing LFPUF with improved cellular structure, mechanical stability, cyclic compression stability, and thermal performance, supporting its potential application in flexible cushioning materials.
✓ 已验证
DOI
高影响因子
GLOBAL CHANGE BIOLOGY
·
2026
·Vol. 32
·期 8
·e71059
·
IF 12.5
Leilei Xiao,Chuancheng Fu,Isaac R. Santos,Carlos M. Duarte,Jian Liu,Lifeng Zhou,Meng Zhou,Run Dang,Jinkuo Lin,Kai Xiao,Yongming Luo,Guangxuan Han
CH 4 emissions from mangrove, saltmarsh, and seagrass ecosystems partially offset carbon sequestration, potentially diminishing the climate mitigation capacity of these blue carbon habitats. However, a mechanistic understanding of the processes governing CH 4 production potential across large spatial scales remains limited. By integrating incubation-based measurements from 116 sites, we reveal significant ecosystem-specific differences in CH 4 production potential, with saltmarshes emerging as CH 4 production hotspot relative to mangroves and seagrass meadows. Using an integrated analytical approach encompassing more than 30 environmental, biogeochemical, and microbial parameters, we demonstrate that CH 4 production potential converges on sediment organic carbon availability, particularly plant-derived carbon, as a key regulatory axis. Additionally, metagenome-assembled genomes (MAGs) recovered from saltmarshes show a functional bias toward lignin degradation, thereby fueling downstream CH 4 production via methylotrophic pathways. Lignin-addition and stable carbon isotope experiments further provide supportive evidence that lignin decomposition enhances Chinese saltmarsh CH 4 production potential, revealing a pathway that may reduce net blue carbon benefit. Together, these findings underscore that saltmarsh plant-derived lignin is less stable than conventionally assumed, as microbial processing redirects stored carbon toward CH 4 production, challenging current blue carbon accounting frameworks at a continental scale within China.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Wenxuan Wang,Feihan Yu,Ming He,Shengkai Liu,Huiling Li,Junreng Liu,Xi Li,Jing Wang,Guihua Yang,Daxin Liang
Wood, as a renewable resource, is mainly composed of cellulose, lignin, and hemicellulose. Lignin is spatially confined within the rigid cage-like structure formed by cellulose and hemicellulose, which restricts its rotation and thereby enhances the phosphorescence emission of lignin. To investigate the effect of the phosphorescence emission properties of lignin on photocatalysts, this study employed a demethylation reaction to perform in-situ modification of lignin in wood. Through the chelating effect of demethylated lignin, cuprous oxide (Cu 2 O) photocatalysts were anchored on the wood surface via an in-situ synthesis method, forming a stable heterostructure. The design of lignin-sensitized catalysts with lignin spatially confined in wood was verified using the catalytic reduction reaction of 4-aminophenol (4-AP). The results show that the loading of the stable heterostructure and the sensitization effect of spatially confined lignin can increase the photocatalytic efficiency of Cu 2 O by 23.08 times, which provides an effective approach for the high-value application of wood.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）