Biomaterials Science
·
2020
·Vol. 9
·期 3
·1000-1007
·
IF 6.183
Bi Lin,Jun Wu,Yanxing Wang,Song Sun,Ying Yuan,Xiaofeng Tao,Ruichan Lv
Early diagnosis is critical and challenging for tongue squamous cell carcinoma (TSCC), which is a kind of tumor with high malignancy, poor prognosis, and a high incidence of invasion and metastasis. In this research, dual-modal optical imaging rare earth nanoparticle (RENP) probes with peptide functionalization are designed for targeted TSCC imaging and therapy. RENP@C@Au (UCA) with enhanced red upconversion luminescence (UCL) and near infrared II (NIR II) imaging intensity is designed by metal and codopant modulation, and the two peaks at about 650 nm and 1064 nm of Nd ions are relatively stable with less quenching and suitable for luminescence bioimaging. Then, the cMBP peptide targeted to Cal 27 TSCC cells with highly expressed c-MET proteins is combined with UCA. Compared with human's normal cells of MCF-10A, other tumor cell lines such as A549 and HeLa, together with mice tumor cells of 4T1, the designed probe has targeted imaging and therapy to Cal 27. The final in vivo experiment shows that the probe with high NIR II luminescence signals is not easy to retain when injected into the tail vein, indicating its potential precise clinical application for the diagnosis and therapy of TSCC.
研究领域:
生物医学工程
·
肿瘤学
·
纳米医学
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DOI
PubMed
高影响因子
International Journal of Nanomedicine
·
2020
·
IF 5.115
Li He,Fangzhen Qing,Maode Li,Daitian Lan
Purpose The aim of this study was to develop an “all-in-one” nanoplatform that integrates at the second near-infrared (NIR-II) region dye IR1061 and anticancer drug paclitaxel (PTX) into an apoferritin (AFN) nanocage (IR-AFN@PTX). Simultaneously, folic acid (FA), tumor target molecule, was conjugated onto IR-AFN@PTX to be IR-AFN@PTX-FA for tumor-targeted and pH/NIR-II-triggered synergistic photothermal-chemotherapy.Methods IR1061 was firstly reacted with PEG and then conjugated with AFN to be IR-AFN. Then, FA was conjugated onto the surface of IR-AFN to be IR-AFN-FA. At last, PTX was incorporated into IR-AFN-FA to fabricate a nanoplatform IR-AFN@PTX-FA. The NIR-II photothermal properties and pH/NIR-II triggered drug release were evaluated. The ability of IR-AFN@PTX-FA to target tumors was estimated using optical bioluminescence. In vitro and in vivo synergistic therapeutic effects of pH/NIR-II-triggered and tumor-targeted photothermal-chemotherapy were investigated in 4T1 tumor model.Results IR-AFN@PTX-FA showed excellent water solubility and physiological stability, which significantly enhanced the solubility of both IR1061 and PTX. After 5 min of laser irradiation at 1064 nm, IR-AFN@PTX-FA exhibited an effective photothermal effect compared with laser irradiation at 808 nm, even when blocked with 0.6 cm thick chicken breast. Cellular uptake experiments showed IR-AFN@PTX-FA utilized clathrin-mediated and caveolae-mediated endocytosis pathways to enter 4T1 cells, and was then delivered by the endosome to the lysosome. NIR-II laser irradiation and pH could synergistically trigger PTX release, inducing significant tumor inhibition in vitro and in vivo.Conclusion As a novel “all-in-one” nanoplatform, IR-AFN@PTX-FA was found to selectively target tumors and showed very efficient NIR-II photothermal effects and pH/NIR-II triggered drug release effects, showing a remarkable, synergistic photothermal-chemotherapy effect.
研究领域:
生物医学工程
·
药学
·
肿瘤学
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DOI
高影响因子
Small
·
2024
·
IF 13
Muhammad Hassan,Yi Tan Su,Sania Zafar Iqbal,Raziq Nawaz,Yucai Wang,Wei Jiang
Near-infrared-II (NIR-II) fluorescence imaging-guided photothermal therapy (PTT) represents a cutting-edge approach for precise tumor diagnosis and treatment, providing real-time therapeutic efficacy evaluation. However, a significant challenge lies in the creation of phototheranostic agents that provide robust imaging and efficient photothermal conversion. To address this, a donor- π -acceptor (D- π -A) structure heptamethine cyanine derivative, IR1116, that confers a strong intramolecular charge transfer effect is developed. To enhance its applicability, IR1116 is formulated with DSPE-PEG to create a water-dispersible NIR-II phototheranostic nanoheater, NP IR1116 . This nanoheater benefits from the incorporation of an electron-withdrawing group, leading to reduced photooxidation activity and significantly improved photostability. NP IR1116 exhibits strong NIR-II absorption and fluorescence, peaking at 1004 and 1116 nm, respectively, as well as a photothermal conversion efficiency of 79% under 1064 nm lasers. In vitro and in vivo studies showed the efficacy of NP IR1116 in tumor imaging via NIR-II fluorescence and its ability to effectively induce tumor cell apoptosis under 1064 nm laser irradiation. These findings underscore the potential of NP IR1116 in NIR-II fluorescence imaging-guided PTT for tumor treatment, paving the way for further advancements in NIR-II dye development and bioimaging technologies.
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DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2021
·Vol. 9
·期 35
·7216-7228
·
IF 6.331
Kaimin Du,Shuang Zhao,Jing Feng,Xuan Gao,Kai Liu,Xiaozhen Wang,Manli Zhang,Yao Li,Yu Lu,Hongjie Zhang
The integration of chemodynamic therapy (CDT) and photothermal therapy (PTT) has played a huge role in improved anticancer treatments. Here, a novel multifunctional nanoplatform based on Cu2−xS conjugated NaYF4:Yb/Er@NaYF4:Yb upconversion nanoparticles (UCNPs) was proposed and designed. In the UCNPs–Cu2−xS nanocomposites, UCNPs with excellent luminescent properties and a high X-ray attenuation coefficient can serve as an upconversion luminescence (UCL) and computer tomography (CT) imaging contrast agent; meanwhile, Cu(II) in the Cu2−xS nanodots enables the nanocomposites to have a magnetic resonance imaging (MRI) ability owing to the presence of unpaired electrons. Moreover, the Cu2−xS nanodots with a strong absorbance in the NIR II biowindow not only could be employed as a stable photothermal agent under NIR laser irradiation, but also could be used as a photothermal-enhanced Fenton nanocatalyst to respond to over-expressed H2O2 in the tumor microenvironment (TME) and generate toxic hydroxyl radicals (˙OH) to effectively kill cancer cells. Furthermore, the UCNPs–Cu2−xS nanocomposites possess negligible cytotoxicity and a high photothermal conversion efficiency (43.8%) in the NIR-II biowindow (1064 nm), indicating that they possess great potential for the UCL/CT/MR multi-modal imaging guided synergistic enhanced CDT/PTT of cancer.
研究领域:
生物医学工程
·
肿瘤治疗学
·
材料科学
✓ 已验证
DOI
高影响因子
Fundamental Research
·
2022
·
IF 0
Hongguang Liao,Yanji Chu,Shenglong Liao,Yonglin He,Yingchao Ma,Yapei Wang
Photothermal therapy has aroused great attention and showed promising potential in minimally invasive tumor ablation, but the clinical translation is still stifled by the concerns of unwanted injury to normal tissues. The safety concerns might be completely solved only when the two security obstacles of “material-toxicity” and “photo-toxicity” were overcome simultaneously. Herein, a completely non-toxic food-grade photothermal transduction agent (PTA) with double safety guarantees was invented, which shows an absolute transformation of the photothermal effect from “0” to “1” after being triggered by an acidic tumor microenvironment. Inspired by the classical starch-iodine test, a preprogrammed [starch-KI-KIO 3 ] complex was prepared in large quantities through a modified wet-milling procedure. It's demonstrated that a macroscopic consecutive reaction could be triggered by low pH to produce the starch-iodine complex which can generate lethal temperature under the near-infrared light irradiation. Meanwhile, the PTA shows excellent biocompatibility with no “material-toxicity” owing to the raw materials drawn from our daily food. Animal experiments reveal that the tumor microenvironment can activate the switch of photothermal effect from “0” to “1” successfully, which is thus responsible for the discriminative photo-damage to the tumor region while no “photo-toxicity” to normal tissue. The good treatment efficacy confirms the feasibility of such photothermal transduction agents with double safety guarantees in clinical applications.
研究领域:
医学
·
生物材料科学
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DOI
Nanoscale
·
2019
·Vol. 11
·期 40
·18874-18880
·
IF 6.97
Guanying Chen,Mingjuan Sun,Juan Li,Mingshan Zhu,Zaizhu Lou,Baojun Li
Anisotropic plasmonic metals have attracted significant attention in enhancing the catalytic performance of catalysts due to their broad light-harnessing capabilities and active hot electrons; however, limited investigations have been dedicated towards improving their electrochemical reaction performance in the visible and near infrared (NIR) regions. Herein, anisotropic Pt-edged Au nanodisks (NDs) were synthesized by controlling the preferential loading of Pt and used as catalysts for plasmon-enhanced electrochemical methanol oxidation reactions (MORs) under visible-NIR light irradiation by, and the light-enhanced electric current over the Pt-edged Au NDs was found to be 3-fold higher than that under dark conditions. Wavelength-dependent electric current over the Pt-edged Au NDs for the MOR in the visible-NIR light region demonstrates that the light-induced enhancement of the electric current is due to surface plasmon resonance (SPR) of the Au NDs. Furthermore, plasmonic hot electron transfer was studied by the single-particle photoluminescence images and spectra of Au NDs and Pt–Au NDs, and the dipole surface plasmon resonance (DSPR) mode was proved to be the main channel for hot electron transfer. During the electrochemical reaction under visible-NIR light irradiation, a plasmonic hot electron is transferred to the electrode, and a “hot hole” is left on the surface, boosting the MOR.
研究领域:
材料科学
·
催化化学
·
纳米技术
·
物理化学
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DOI
PubMed
高影响因子
NANOTECHNOLOGY
·
2022
·Vol. 33
·期 22
·225101
·
IF 3.953
Yaqun Ma,Yanxing Wang,Xin Hui,Bi Lin,Ying Yuan,Xiaofeng Tao,Ruichan Lv
In this research, a fluorescent probe of 7-(diethylamine) coumarin derivatives with multiple binding sites to detect biothiols in tumor cell with strong NIR II luminescence in vivo was synthesized. The biothiols include cysteine (Cys) and glutathione (GSH) in tumor cells, and the tumor-response luminescence was proved by the cell experiment. Importantly, the monolayer functional phospholipid (DSPE-PEG) coating and aggregation induced emission (AIE) dye of TPE modification made the probe have good stability and biocompatibility with little luminescence quenching in aqueous phase, which was proved by in vitro and in vivo experiments. The final aqueous NIR II probe combined with bevacizumab (for VEGF recognition in the cancer cells) and Capmatinib (for Met protein recognition in the cancer cells) has stronger targeted imaging on head and neck squamous cell carcinoma (HNSCC) cancer with intravenous injection. This GSH/Cys detection in the tumor cell and strong dual-molecular NIR II bioimaging in vivo may provide new strategy to tumor detection.
研究领域:
生物医学工程
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分子生物学
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癌症研究
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纳米技术
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药学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF NANOPARTICLE RESEARCH
·
2020
·Vol. 22
·期 9
·1-14
·
IF 2.132
Zhang Jun-Zheng,Tang Huan,Chen Xing-Zhu,Su Qianqian,Xi Wen-Song,Liu Yuan-Yuan,Liu Yuanfang,Cao Aoneng,Wang Haifang
Narrow bandgap Ag 2 Te quantum dot (QDs) hold great promise in the fields of bioimaging, chemo-/bio-detection, and thermoelectric materials, but their biosafety has not been well estimated yet. In this study, we studied the biodistribution and toxicity of polyethylene glycol–coated Ag 2 Te QDs (Ag 2 Te QDs-PEG) in mice after a single intravenous injection. After entering the mice, Ag 2 Te QDs-PEG displayed a short circulation time in the blood (half-life was less than 2 h), and mainly accumulated in the liver and spleen. The stability of Ag 2 Te QDs-PEG in the mice depended on accumulation organ and time. Ag 2 Te QDs-PEG were stable in the spleen within 28 days but decomposed in the liver after 7 days. The decomposed Ag 2 Te QDs-PEG were eliminated from the body via different routes, as Ag was detected only in feces while Te was found only in urine. Meanwhile, Ag 2 Te QDs-PEG did not show obvious adverse effects on the body weights, organ indices, biochemical parameters, the levels of essential metal Cu and Zn in organs, and organ pathological investigations during 28 days. In addition, the important effects of anion to the fates of silver chalcogenide QDs in vivo was demonstrated by comparing the distributions of the Ag 2 Te QDs and other two silver chalcogenide QDs (Ag 2 S and Ag 2 Se). Our findings indicate Ag 2 Te QDs have good biocompatibility in mice, which is a guarantee for their safe applications in the future.
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DOI
高影响因子
Small
·
2023
·Vol. 19
·期 19
·2300203
·
IF 13.3
Jun Guan,Chang Liu,Chendong Ji,Wenchao Zhang,Zongyang Fan,Penggang He,Qiuhong Ouyang,Meng Qin,Meizhen Yin
Extensive efforts have been devoted to the design of organic photothermal agents (PTAs) that absorb in the second near-infrared (NIR-II) bio-window, which can provide deeper tissue penetration that is significant for phototheranostics of lethal brain tumors. Herein, the first example of NIR-II-absorbing small organic molecule (N1) derived from perylene monoamide (PMI) and its bio-application after nano-encapsulation of N1 to function as a nano-agent for phototheranostics of deep orthotopic glioblastoma (GBM) is reported. By adopting a dual modification strategy of introducing a donor-acceptor unit and extending π-conjugation, the obtained N1 can absorb in 1000–1400 nm region and exhibit high photothermal conversation due to the apparent intramolecular charge transfer (ICT). A choline analogue, 2-methacryloyloxyethyl phosphorylcholine, capable of interacting specifically with receptors on the surface of the blood-brain barrier (BBB), is used to fabricate the amphiphilic copolymer for the nano-encapsulation of N1. The obtained nanoparticles demonstrate efficient BBB-crossing due to the receptor-mediated transcytosis as well as the small nanoparticle size of approximately 26 nm. The prepared nanoparticles exhibit excellent photoacoustic imaging and significant growth inhibition of deep orthotopic GBM. The current study demonstrates the enormous potential of PMI-based NIR-II PTAs and provides an efficient phototheranostic paradigm for deep orthotopic GBM.
研究领域:
生物医学工程
·
药学
·
癌症研究
·
纳米技术
·
神经科学
✓ 已验证
DOI
PubMed
高影响因子
Biosensors-Basel
·
2021
·Vol. 11
·期 5
·148
·
IF 5.519
Tingting Peng,Rui Pu,Baoju Wang,Zhimin Zhu,Kai Liu,Fan Wang,Wei Wei,Haichun Liu,Qiuqiang Zhan
Lanthanide-doped upconversion nanoparticles (UCNPs) are promising bioimaging nanoprobes due to their excellent photostability. As one of the most commonly used lanthanide activators, Tm3+ions have perfect ladder-type electron configuration and can be directly excited by bio-friendly near-infrared-II (NIR-II) wavelengths. Here, the emission characteristics of Tm3+-doped nanoparticles under laser excitations of different near-infrared-II wavelengths were systematically investigated. The 1064 nm, 1150 nm, and 1208 nm lasers are proposed to be three excitation strategies with different response spectra of Tm3+ions. In particular, we found that 1150 nm laser excitation enables intense three-photon 475 nm emission, which is nearly 100 times stronger than that excited by 1064 nm excitation. We further optimized the luminescence brightness after investigating the luminescence quenching mechanism of bare NaYF4: Tm (1.75%) core. After growing an inert shell, a ten-fold increase of emission intensity was achieved. Combining the advantages of NIR-II wavelength and the higher-order nonlinear excitation, a promising facile excitation strategy was developed for the application of thulium-doped upconversion nanoparticles in nanoparticles imaging and cancer cell microscopic imaging.Keywords:upconversion nanoparticles;near-infrared-II;excitation mechanisms;luminescence quenching;microscopic imaging
研究领域:
材料科学
·
纳米技术
·
生物医学工程
·
光学
✓ 已验证
DOI
PubMed
高影响因子
CERAMICS INTERNATIONAL
·
2025
·Vol. 51
·期 25
·44694-44701
·
IF 5.6
Honglei Yuan,Huizhong Ma,Gaoliang Wang,Huanxia Jia,Liwei Wang
This study systematically investigates the structural and luminescent characteristics of LaSc 3 (BO 3 ) 4 :x %Cr 3+ and La (1-y) Gd y Sc 3 (BO 3 ) 4 :1.0 %Cr 3+ phosphors. X-ray diffraction confirms the formation of a pure hunter-type structure for all samples, with Cr 3+ occupying Sc 3+ sites and Gd 3+ substituting La 3+ , inducing lattice contraction. Luminescent analysis reveals that LaSc 3 (BO 3 ) 4 :Cr 3+ exhibits an emission at 980 nm under 430 nm excitation, attributed to the 4 T 2 → 4 A 2 transition of Cr 3+ in a weak crystal field. The substitution of Gd 3+ enhances photoluminescence intensity by 2.15-fold, and blue-shifts emission to 938 nm because of increased crystal field splitting and structural rigidity. The broadened full width at half maximum is also formed due to the enhanced degree of disorder in GdSc 3 (BO 3 ) 4 . Thermal stability studies show that GdSc 3 (BO 3 ) 4 :Cr 3+ retains 49 % intensity at 540 K, outperforming LaSc 3 (BO 3 ) 4 :Cr 3+ (41 %), supported by higher activation energy (ΔE = 0.338 eV vs. 0.296 eV). The improved thermal resistance is linked to lattice rigidity and reduced electron-phonon coupling. NIR-pc-LEDs fabricated with GdSc 3 (BO 3 ) 4 :Cr 3+ demonstrate superior radiant flux (68.7 mW at 200 mA) compared to La-based devices. These results highlight the critical role of host lattice engineering in optimizing Cr 3+ luminescence for high-power NIR applications.
研究领域:
材料科学
·
光学材料
·
固态化学
·
光子学
·
发光材料
✓ 已验证
产品关联
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2026
·
IF 6
Qi Chen,Rongyi Kuang,Yinyue Cao,Zezhong Yang,Siran Tao,Binchang Wu,Lin Huang,Bo-Mei Liu,Jing Wang
The second near-infrared window (NIR-II, 1000-1700 nm) phosphor-converted LEDs (pc-LEDs) show great potential for portable spectroscopic detection. However, high-performance long-wavelength (>1350 nm) NIR-II phosphors that combine broadband emission, high thermal stability, and efficient blue-light excitation, are still relatively scarce. Herein, a Lu 3 Ga 5 O 12 :Cr 3+ ,Ni 2+ phosphor was developed via a Cr 3+ sensitization strategy. Cr 3+ and Ni 2+ stably occupy the [GaO 6 ] octahedral sites, enabling efficient energy-transfer from Cr 3+ to Ni 2+ . The optimal sample exhibits broadband NIR-II emission at 1427 nm with an FWHM of 277 nm, an EQE of 23.1%, and excellent thermal stability (I 373K /I 293K = 81.5%). The pc-LED based on this NIR-II phosphor achieves penetration imaging and non-destructive identification of daily necessities. More notably, rapid spectral differentiation of common plastics (PA, PE, PP, PVC and PET) was successfully realized using the NIR-II luminescence of the as-prepared phosphor. This work provides guidance for constructing high-performance NIR-II phosphors and promotes the practical deployment of NIR spectroscopy in resource recycling.
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）