RSC Advances
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2021
·Vol. 11
·期 28
·17431-17436
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IF 3.361
Ting Yu,Zheng-hua Qian,Lin Li,Xiao-ling Wu,Hui He,Yan-bo Qiao,Guo-an Ye
Three new thorium-based MOFs based on 1,2,4,5-tetrakis(4-carboxyphenyl)benzene (H4TCPB) were obtained under a similar reaction system (metal salt, ligand, solvent, and acid are the same). Th(IV) forms the central unit of the MOFs in mononuclear and binuclear clusters, respectively. All the MOFs show blue ligand-based luminescence under an ultraviolet environment. This is the first time that multiple thorium-based MOFs with luminescence have been found with the same ligand.
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MATERIALS CHEMISTRY AND PHYSICS
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2021
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IF 4.094
Hanxue Li,Haoliang Huang,Xianguang Yan,Chuanxiang Liu,Liang Li
Dyes are indispensable in the textile industry and are very difficult to degrade due to the presence of two or more benzene rings in their structures. However, the purification of water resources is currently an urgent issue. In this study, a trichlorotriazine-derived calix[4]arene and 1,3,5-tris(4-aminophenyl) benzene were crosslinked to generate a calix[4]arene crosslinked polymer that can serve as a highly efficient adsorbent for separating cationic dyes from water. This research provides evidence for the efficiency of the polymer to adsorb various organic micropollutants in water via batch adsorption experiments. In particular, this polymer exhibited a removal efficiency over 99.6% and 99.4% for methylene blue and toluidine blue within 5 min, respectively. The kinetic results showed that the adsorption process of this polymer for organic dyes could be described with quasi-second-order models, and Langmuir isotherm adsorption models demonstrated that the maximum equilibrium adsorption capacity for methylene blue and toluidine blue was reached to 1806.82 and 2161.32 mg g −1 , respectively. These observations suggest that the adsorption is mainly dependent on the electrostatic interactions, π−π interactions, and hydrogen bonding between the polymer and the organic dyes. Furthermore, the adsorption capacities of the adsorbent were maintained at high levels after five cycles. Its excellent adsorption capability and recyclability make this polymer a promising candidate for potential applications in water purification.
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MOLECULAR IMMUNOLOGY
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2020
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IF 3.641
Keyan Wu,Guanghuai Yao,Xiaolei Shi,Huan Zhang,Qingtian Zhu,Xinnong Liu,Guotao Lu,Lianghao Hu,Weijuan Gong,Qi Yang,Yanbing Ding
Acinar cell necrosis is one of the most prominent pathophysiological changes of acute pancreatitis (AP). Asiaticoside (AS) is a triterpene compound with confirmed apoptosis-and necrosis-related activities. However, the specific effects of AS on AP have not been determined. In this study, we aimed to investigate the protective effect of AS on AP using two mouse models. In the caerulein-induced mild acute pancreatitis (MAP) model, We found that AS administration reduced serum amylase levels and alleviated the histopathological manifestations of pancreatic tissue in a dose-dependent manner. And the levels of toll-like receptor 4 (TLR4) and necrotic related proteins (RIP3 and p-MLKL) of pancreatic tissue were reduced after AS administration. In addition, TLR4 deficiency eliminated the protective effect of AS on AP induced by caerulein in mice. Correspondingly, we elucidated the effect of AS in vitro and found that AS protected against pancreatic acinar cells necrosis and TAK-242 counteracted this protective effect. Meanwhile, we found that AS ameliorated the severity of pancreatic tissue injury and pancreatitis-associated lung injury in a severe acute pancreatitis model induced by l -arginine. Furthermore, Molecular docking results revealed interaction between AS and TLR4. Taken together, our data for the first time confirmed the protective effects of AS on AP in mice via TLR4 pathway.
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NANO
·
2020
·
IF 1.566
Heng Chen,Mengbing Cui,Cuilan Miao,Gairong Chen,Yongchun Zhang
In this work, the function of 4-nitroimidazole (4-NIm) in the formation of Cr-MIL-101 was confirmed. It was found that 4-NIm is an effective additive in the formation of Cr-MIL-101 synthesized at lower temperature. The investigation of crystallization time showed that 4-NIm can prevent Cr-MIL-101 phase converting into Cr-MIL-53 phase. The effect of concentration of 4-NIm on the morphology and the yield of Cr-MIL-101 may therefore be explained by increasing the nucleation rate. The investigation of crystallization temperature revealed that 4-NIm changes the synthesis temperature range of Cr-MIL-101 into 423–463 K. The assistant function of 4-NIm was played through interaction with H + and NO 3 − in the synthesis system, which may lead to enhancement of the deprotonation of H 2 BDC.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2020
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IF 3.232
Na Li,Xing Hu,Junhui Pan,Ying Zhang,Deming Gong,Guowen Zhang
4–Octylphenol is an endocrine disruptor , belonging to environmental estrogens. It can be enriched in the human body through the food chain and may harm human health. Herein, we used a variety of spectroscopic techniques, molecular docking, and gel electrophoresis to study the interaction of 4–octylphenol and ctDNA . It was found that the mechanism of ctDNA quenching the endogenous fluorescence of 4–octylphenol was static quenching, and formed a complex. The negative enthalpy change (Δ H °), entropy change (Δ S °) and Gibbs free energy (Δ G °) have shown that 4–octylphenol and ctDNA spontaneously bind together under the action of hydrogen bonds and van der Waal's force . Viscosity, melting temperature and iodide quenching experiments showed that 4–octylphenol acted on the groove of ctDNA. Insignificant change in circular dichromism spectra further confirmed this binding mode. The binding sites and groups for 4–octylphenol and ctDNA interaction were identified by molecular docking. Gel electrophoresis found that 4–octylphenol at high concentrations caused DNA cleavage. Above findings may lay a theoretical foundation for understanding the toxicity mechanism of 4–octylphenol.
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PEST MANAGEMENT SCIENCE
·
2020
·Vol. 76
·期 9
·2978-2985
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IF 3.75
Xianfei Zhang,Jiuyong Xu,Solange Muhayimana,Hui Xiong,Xuefeng Liu,Qingchun Huang
BACKGROUND Sclerotinia stem rot (SSR) caused by Sclerotinia sclerotiorum threatens oilseed rape cultivation, and the emergence of fungicide-resistant strains has led to control failures worldwide. Identifying novel chemical alternatives with different modes of action and high antifungal activities is thus crucial. Herein we evaluated the antifungal effects of 3-(2-pyridyl)methyl-2-(4-chlorphenyl)imino- thiazolidine (PMAS) on S. sclerotiorum to determine its efficacy for SSR management. RESULTS PMAS had an inhibitory effect on mycelial growth; the EC 50 values were 17.83 and 21.15 μg mL −1 for the carbendazim-susceptible strain Ss01 and carbendazim-resistant strain Hm25, respectively. PMAS treatment changed the color of inhibited mycelia to green, and the hyphae were sustained in the undifferentiated stage. Cysteine supplementation made this green color disappear, whereas methionine enhanced the color. Moreover, PMAS treatment markedly inhibited oxalic acid biogenesis, increased free thiol content in mycelia, and weakened the activities of oxaloacetase and malate dehydrogenase, but had little effect on the activity of glyoxylate dehydrogenase. Cysteine could reverse the inhibitory effects of PMAS on mycelial morphogenesis and biochemical constituents, except thiol production. In the pot-culture experiment, PMAS showed a good protective effect, with the control efficacy being >91% on SSR. CONCLUSION PMAS appears to be an effective fungicide for SSR management. © 2020 Society of Chemical Industry
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MOLECULES
·
2020
·Vol. 25
·期 4
·946
·
IF 3.267
Mengling Zhang,Rui Zhang,Jian Liu,Hongliang Wang,Zhen Wang,Juan Liu,Yang Shan,Huanling Yu
5,6,7,8,3,4′-Hexamethoxyflavone, also called nobiletin (NOB), widely found in the citrus peel, is one of the main byproducts in citrus processing. NOB is considered safe, but its safety for women during pregnancy is unknown. Therefore, the effect of NOB on apoptosis in human choriocarcinoma trophoblast cells (BeWo cells) was evaluated. Cells were divided into four groups and cultured with different concentrations of NOB (0, 10, 33, and 100 μM) for 12, 24, 36, and 48 h respectively. Cell viability was detected by CCK-8 assay, cell morphology was detected by a Cell Imaging Multi-Mode Reader, and cell cycle and apoptosis were detected by flow cytometry. Cleaved PARP level, the expressions of B cell lymphoma 2 (BCL2) family proteins, and p53 pathway proteins were detected by Western blot. The results showed that after 48 h of cell culture, the cell viability was decreased significantly, but apoptosis was significantly increased. Compared to the cells without NOB treatment, the cells treated with NOB at 10 or 33 μΜ showed no significant differences in the number of suspended cells or late apoptosis rate, except the increase of cell viability. Treatment of NOB at the concentration of 100 μM improved cell viability, attenuated apoptosis, decreased suspended cells, and did not alter the G1 phase arrest, compared with the non-NOB-treated group after 48 h of culturing. The 100 μΜ NOB treatment increased the levels of BCL2 and BCLXL, and decreased p53 accumulation in BeWo cells at 48 h, but had no effect on the expression of BAX, BAK, BAD, p21, and G1 phase arrest. These findings provide evidence that NOB (10, 33, and 100 μΜ) was safe for BeWo cells. NOB at the concentration of 100 μΜ could attenuate apoptosis in BeWo cells, which might be helpful to prevent pregnancy-related diseases caused by apoptosis.Keywords:nobiletin;safety;trophoblast;BeWo cells;apoptosis
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JOURNAL OF ELECTRONIC MATERIALS
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2021
·Vol. 50
·期 11
·6228-6236
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IF 1.938
Liang Yue,Weng Ling,Zhang Wenlong
Polypropylene (PP) is considered a promising material for eco-friendly high-voltage direct current (HVDC) cable insulation. However, PP is prone to space charge accumulation under direct current (DC) electric stress, which limits its applications. In this study, 4-allyloxy-2-hydroxybenzophenone (AHB) with polar functional groups and a conjugated structure was grafted onto PP via melt grafting to improve its electrical properties. The effects of several reaction variables, specifically initiator and monomer content, reaction temperature, rotor speed, and grafting yield time were studied, and the optimal grafting conditions were determined. Evidence of grafting was examined by Fourier transform infrared (FTIR) spectroscopy. Moreover, the space charge characteristics, volume resistivity, and DC breakdown strength of the grafted PP were also studied. The FTIR results demonstrated that the AHB monomer was successfully grafted onto PP, and the maximum grafting yield obtained under the optimal grafting conditions was 0.94%. Furthermore, when the grafting yield was 0.73%, the grafted PP effectively inhibited space charge accumulation and exhibited the highest volume resistivity and DC breakdown strength. Thus, this work provides useful ideas for the design and development of environmentally friendly polymer insulating materials for HVDC applications.
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LANGMUIR
·
2021
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IF 3.882
Chuncai Kong,Weijie Lei,Bosen Lei,Fangzhao Pu,Ge Wang,Xiaojing Zhang,Cheng Zhou,Zhimao Yang
High-performance, nonprecious metal catalysts with special morphologies and easy-to-recycle properties are essential for the treatment of environmental pollutants. Herein, CoFe nanoparticle-decorated reduced graphene oxide (RGO) catalysts were designed and successfully fabricated, and the catalyst was then used to reduce 4-nitrophenol into 4-aminophenol. Outstanding catalytic properties with a reduction rate constant of 4.613 min–1 were achieved due to the synergistic properties of the CoFe metal alloy and the high-conductivity RGO components in the catalysts. In addition, the catalyst was conveniently recovered via magnets due to its inherent magnetic properties. The facile preparation, outstanding catalytic performance, structural stability, and low material costs make the CoFe/RGO nanocatalyst a promising candidate for potential applications in catalysis.
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APPLIED CATALYSIS A-GENERAL
·
2019
·
IF 4.63
Xin Yuan,Panliang Zhang,Weifeng Xu,Kewen Tang
This paper reports the kinetics resolution of ( R , S )-4-methoxymandelic acid (4-MMA) by lipase AK-catalyzed transesterification reaction, using vinyl acetate (VA) as acyl donor in methyl tert-butyl ether (MTBE). Considering the Ping-Pong bi-bi mechanism with 4-methoxymandelic acid inhibition, the kinetic model was established. Kinetic parameters were obtained by fitting time-concentration curves for different initial 4-methoxymandelic acid concentrations. The average relative error below 3.0% indicated that the model predictions were in good agreement with the experimental data. Furthermore, the kinetic model was employed to predict the effects of enzyme loading, initial vinyl acetate concentration and reaction time on enantiomeric excess (ee s ) and conversion of substrate (c), and to optimize the conditions. The excellent results with high conversion of 4-MMA (50.2%) and large enantiomeric excess of substrate (98.6%) were achieved under the optimal conditions.
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INTERNATIONAL JOURNAL OF PHARMACEUTICS
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2019
·
IF 4.213
Jianle Zhou,Liang Li,Hailu Zhang,Jiangping Xu,Dandan Huang,Ningbo Gong,Weili Han,Xuemei Yang,Zhengzheng Zhou
Cocrystallization of chlorbipram (ChBP), a novel phosphodiesterase-4 (PDE) inhibitor with water insoluble property developed in our lab, was performed to improve the physicochemical properties and bioavailability in the present study. Three new cocrystals with fumaric aicd (FA), gentisic acid (GA) and salicylic acid (SA) as coformers were synthesized and fully characterized by using the combination of multi-techniques. The cocrystals are phase stable even under high humidity conditions. In vitro study indicates that the solubility of ChBP-GA and ChBP-SA cocrystals increase to 3724.4 ± 58.7, 2897.4 ± 81.9 μg/mL in comparison with ChBP (2561.3 ± 150.4 μg/mL), the intrinsic dissolution rates (IDRs) of ChBP-GA and ChBP-SA cocrystals (721.3 ± 8.0, 614.4 ± 13.2 μg/min/cm 2 ) are both higher than ChBP (537.9 ± 12.0 μg/min/cm 2 ). The blood concentration peak values of ChBP-GA and ChBP-SA cocrystals (165.8 ± 50.9, 105.3 ± 35.6 ng/mL) are both higher than ChBP (51.3 ± 15.1 ng/mL) in in vivo evaluation. It presents the same order in in vitro/vivo study: ChBP-GA > ChBP-SA > ChBP > ChBP-FA. ChBP-FA cocrystal presents a longer elimination half life ( t 1/2 = 10.0 ± 2.6 h), which makes it a potential candidate for prolonged controlled release formulation . ChBP-GA and ChBP-SA cocrystals both present enhanced solubility and bioavailability in comparison with ChBP, making them a better candidate for the solid dosage formulation development.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2019
·
IF 6.393
Yanling Shen,Hong Yan,Hua Guo,Yumei Long,Weifeng Li
A new electrochemical sensor has been developed for the simultaneous determination of 4-aminophenol (4-AP) and phenol (Ph) based on the defect-rich hexagonal boron nitride (D-h-BN). The D-h-BN was prepared via one-step calcination route using a single-source precursor. The obtained D-h-BN was structurally characterized by X-ray diffraction (XRD), fourier transform infrared (FTIR) spectroscopy and transmission electron microscopy (TEM). Photoluminescent (PL) result suggested that the as-synthesized h-BN was highly defective. More interestingly, such D-h-BN exhibited favorable electrocatalytic activity in the redox reaction of Ph and 4-AP, which was confirmed by cyclic voltammetry (CV) and differential pulse voltammetry (DPV) measurements. The enhanced electrocatalytic activity of D-h-BN was attributed to its large surface-active sites and fast electron transfer mediated by defect structure. Thus, D-h-BN was employed to modify glassy carbon electrode (GCE) without any binder agents and the as-fabricated sensor showed good electrochemical performances in the simultaneous determination of 4-AP and Ph. By using DPV method, the linear detection ranges between concentrations and current intensities for 4-AP and Ph were 0.01–30 and 0.1–30 μM, respectively, and their detection limits (S/N = 3) were estimated to be 0.003 and 0.035 μM. Moreover, the desirable selectivity and reproducibility make the proposed method successfully applied for real sample assay.
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