MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Helei Yang,Pei Li,Jinfu Zhang,Zhiguo Zhu,Hua Zhou,Zhenhe Wang,Xia Sun
A portable, low-cost, and efficient sensing strategy is developed for real-time, non-destructive monitoring ammonia (NH 3 ) released to evaluate the shrimp spoilage. In this study, a colorimetric sensing hydrogel with ammonia-responsive properties is prepared by incorporating Cu 2+ into sodium alginate hydrogel. The sensor exhibits a detection limit of 1.19 ppm for NH 3 and a response time of approximately 10 min, demonstrating good sensitivity. The color changes of the colorimetric ammonia sensor are captured with a smartphone and its response values are analyzed via software. When monitoring NH 3 accumulation in shrimp stored at 4 °C, the colorimetric hydrogel shows a color change from light green to dark blue, with results indicating a positive correlation between color variation and TVB-N value changes in shrimp meat. This study demonstrates the great potential of colorimetric hydrogel gas sensors in the field of food safety supervision.
✓ 已验证
产品关联
DOI
高影响因子
ANALYST
·
2019
·Vol. 144
·期 23
·6962-6967
·
IF 4.019
Guoxing Yin,Jingfeng Yao,Sai Hong,Yinuo Zhang,Zhaohua Xiao,Ting Yu,Haitao Li,Peng Yin
The monitoring of heavy transition metals has increasingly attracted great attention because they pollute the environment and have unique physiological functions. Chemosensors are useful tools for monitoring heavy transition metals due to their simple visualization, excellent sensitivity and high selectivity. Herein, we have developed a novel chemosensor for the detection of water-soluble Cu2+ and Ni2+ species with different mechanisms, and low detection limits of 2.1 nM for Cu2+ and 1.2 nM for Ni2+ were obtained. The colorimetric probe CPH has been applied to qualitative and quantitative detection of Cu2+ and Ni2+ species in real samples.
✓ 已验证
DOI
PubMed
高影响因子
Biomicrofluidics
·
2015
·Vol. 9
·期 2
·
IF 3.357
Li Yinbao,Yang Xiujuan,Chen Zuanguang,Zhang Beibei,Pan Jianbin,Li Xinchun,Yang Fan,Sun Duanping
Investigations were conducted to determine acute effects of Pb 2+ and Cu 2+ presented individually and collectively on zebrafish embryos. Aquatic safety testing requires a cheap, fast, and highly efficient platform for real-time evaluation of single and mixture of metal toxicity. In this study, we have developed a microfluidic system for phenotype-based evaluation of toxic effects of Pb 2+ and Cu 2+ using zebrafish ( Danio rerio ) embryos. The microfluidic chip is composed of a disc-shaped concentration gradient generator and 24 culture chambers, which can generate one blank solution, seven mixture concentrations, and eight single concentrations for each metal solution, thus enabling the assessment of zebrafish embryos. To test the accuracy of this new chip platform, we have examined the toxicity and teratogenicity of Pb 2+ and Cu 2+ on embryos. The individual and combined impact of Pb 2+ and Cu 2+ on zebrafish embryonic development was quantitatively assessed by recording a series of physiological indicators, such as spontaneous motion at 22 hours post fertilization (hpf), mortality at 24 hpf, heartbeat and body length at 96 hpf, etc. It was found that Pb 2+ or Cu 2+ could induce deformity and cardiovascular toxicity in zebrafish embryos and the mixture could induce more severe toxicity. This chip is a multiplexed testing apparatus that allows for the examination of toxicity and teratogenicity for substances and it also can be used as a potentially cost-effective and rapid aquatic safety assessment tool.
✓ 已验证
DOI
PubMed
高影响因子
Analytical Methods
·
2015
·Vol. 7
·期 20
·8925-8930
·
IF 1.821
Xiangyang Zhang,Youming Shen,Hui Zhang,Junling Jin,Shibiao Zhou
A new bifunctional fluorescent sensor for Cu2+ based on naphthalimide-functionalized silica nanoparticles (NF-SiO2) was designed and synthesized. NF-SiO2 exhibits excellent fluorescence sensitivity and selectivity towards Cu2+ over other metal ions in aqueous media, and it also shows a good adsorption capacity for Cu2+. Moreover, the detection limit of NF-SiO2 for Cu2+ is 1.5 × 10−7 M (S/N = 3) and it can be easily recovered by treatment of a solution of EDTA. These results indicate that this fluorescent sensor may find potential and favorable applications for simple detection and efficient removal of Cu2+ in toxicological and environmental fields.
✓ 已验证
DOI
高影响因子
DIAMOND AND RELATED MATERIALS
·
2025
·
IF 5.1
Jinpu Fang,Youliang Cheng,Xinyi Cheng,Changqing Fang,Jing Chen,Xin Zhang,Yuzhen Wang,Yanli Du,Xingbo Yao
Cu 2+ -containing wastewater causes serious risks to environmental and human health, necessitating efficient Cu 2+ removal. The electrosorption has present a promising alternative pattern in the field of wastewater treatment containing metal ions, however, it is still a challenge to develop appropriate electrode materials to efficiently remove Cu 2+ in wastewater. Thus, the Ti 3 C 2 T x /cellulose acetate composite films were prepared by incorporating less-layered Ti 3 C 2 T x into cellulose acetate matrix via a casting method in this work. Their morphology, microstructure, electrochemical performances and adsorption mechanism were investigated by scanning electron microscopy, X-ray diffraction, X-ray photoelectron spectroscopy, Brunauer–Emmett–Teller method, electrochemical workstation, Lagergren and pseudo-second order kinetic models, Freundlich and Langmuir adsorption models. These results showed that less-layered Ti 3 C 2 T x nanosheets were stacked orderly in the composite films where cellulose acetate filled the interlayer space and then expanded this spacing. The sample of CT-1 had the highest specific surface area of 3.83 m 2 /g with the average pore size of 16.86 nm. Additionally, the sample of CT-3 had the highest specific capacitance. Interestingly, the sample of CT-2 with moderate specific surface area, average pore size and specific capacitance exhibited the maximum electrosorption capacity of 3.39 mg/g at an applied voltage of 1.0 V in a 10 mg/L CuSO 4 solution, corresponding to a removal efficiency of 21.55 %. The adsorption process followed pseudo-first-order kinetics and Langmuir isotherm model, indicating that it was dominated by monolayer chemisorption. Therefore, these findings demonstrate the successful development of Ti 3 C 2 T x /cellulose acetate composite films as novel electrosorption materials, providing a viable strategy for wastewater treatment containing Cu 2+ that aligns with environmental sustainability objectives.
✓ 已验证
产品关联
DOI
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2024
·
IF 4.3
Wenbo Lv,Yafang Song,Ruibin Guo,Nijuan Liu,Zunli Mo
Residual heavy metal ions in water pose a major hazard to ecology as well as human health, and Cu 2+ , as the most common heavy metal ion in water bodies, can cause a variety of diseases in human beings with prolonged exposure, therefore, a rational sensing platform is needed for the specific detection of Cu 2+ . In this work, based on the solvothermal method, we successfully prepared the composite UIO-66@FS by encapsulating the dye fluorescein sodium molecule (FS) with a metal–organic framework material (UIO-66). The composite material has bright fluorescence emission properties with a fluorescence quantum yield of 62.03 %, and the composite material has been used to construct a fluorescence sensing platform for detecting the heavy metal Cu 2+ in the aqueous environment. The fluorescence of UIO-66@FS can be greatly quenched by Cu 2+ , which is visible to the naked eye under UV lamp. The sensing platform is able to withstand environmental interference and has the advantages of high selectivity, excellent sensitivity, fast response, wide linear range (2.5 µM−500 µM), and low detection limit (0.246 µM) in the fluorescence quenching detection of Cu 2+ . In addition, the sensor has been used to detect Cu 2+ in real water samples with satisfactory recoveries. Therefore, this sensing probe can be an excellent candidate for Cu 2+ detection and has wonderful potential for real water sample detection.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Jiaying Chang,Man Wang,Junrong Wang,Guoqing Zhu,Yulin Xie,Yanrong Qian,Qianqian Sun,Chunxia Li
Autologous tumor cells demonstrate considerable promise as individualized therapeutic vaccines owing to their endogenous neoantigen repertoire. Nevertheless, their suboptimal immunogenicity substantially impedes clinical translation. Herein, we engineered an innovative whole tumor cell vaccine platform utilizing photothermal Cu 2- x Se nanoparticles, which encapsulate comprehensive tumor-associated antigens and intrinsic immunostimulatory molecules to elicit a polyvalent antitumor immune response. In this work, Cu 2-x Se was applied to prepare the whole tumor cell vaccine for the first time. As a pyroptosis inducer, Cu 2-x Se triggered the expression of damage-associated molecular patterns (DAMPs) as endogenous adjuvants in 4T1 cells (mouse breast cancer cells) under near-infrared (NIR) irradiation. Repeated freeze-thaw cycles inactivated and lysed Cu 2-x Se-loaded 4T1 cells, releasing DAMPs for laser-activated Cu 2-x Se-based whole tumor cell vaccine (LC-TCV) preparation. Mild photothermal therapy (PTT) at the vaccination site by NIR irradiation effectively suppressed tumor growth. This efficacy was primarily attributed to the synergistic effects of multiple natural antigens and adjuvants in LC-TCV, which promoted dendritic cells (DCs) maturation and subsequent immune activation. Consequently, it potentiates the recruitment of cytotoxic T lymphocytes, elicits immunogenic cell death (ICD), and consequently initiates a potent antigen-specific immune cascade. Collectively, this study presents an innovative approach to unleash the potential of personalized whole tumor cell vaccines in cancer therapy.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Hui Zhang,Jingqi Wang,Dejin Lin,Linfan Wang,Jiale Chen,Junjie Pan,Xiaofei Wang,Da Chen
The increasing persistence of harmful ions and pesticide residues has been a matter of concern due to their pernicious and ubiquitous impact on environmental processes. Herein, we design a ratiometric fluorescent platform for the cascade identification of Cu 2+ and glyphosate, which is devised by grafting rhodamine 6G onto F, N-doped carbon dots (F, N-CDs@Rh6G). The formation of F, N-CDs@Rh6G/Cu 2+ chelation complex induces fluorescence quenching at 438 nm, attributed to static complex formation and photoinduced energy transfer. Subsequently, the introduction of glyphosate reverses the binding priority of the chelated complex and results in the recovery of fluorescence signal at 438 nm, while the reference peak (558 nm) remains relatively stable. Under optimal conditions, the fluorescent probe exhibits the low detection limits (LODs) for Cu 2+ (61 nM) and glyphosate (53 nM). Additionally, a portable microcavity sensing platform combining with smartphone is devised for visual and on-site quantification of Cu 2+ and glyphosate with the exceptional LODs. Therefore, this newly microcavity with F, N-CDs@Rh6G provides a reliable cascade sensing platform for Cu 2+ and glyphosate determination, showcasing potential applications.
✓ 已验证
产品关联
DOI
高影响因子
EUROPEAN POLYMER JOURNAL
·
2025
·
IF 6.3
Junqi Zhao,Zicheng Chen,Aijian Cao,Jiahao Huang,Suiping Deng,Jingxian Zhang,Langhuan Huang,Shaozao Tan
Bacterial infections pose a significant threat to the healing of human skin wounds, as the reactive oxygen species (ROS) they produce can significantly delay the wound healing process, ultimately leading to the formation of chronic wounds and even endangering human life. Therefore, this study successfully constructed a dynamically reversible hydrogel network through dual crosslinking of Schiff base bonds and hydrogen bonds using oxidized hyaluronic acid (OHA), carboxymethyl chitosan (CMCS), and tannic acid (TA). By loading Cu@PDA, the OCTC2 hydrogel wound dressing was prepared, exhibiting synergistic antibacterial and antioxidant properties through TA/Cu 2+ release and NIR-II photothermal effects. We used FTIR, XRD, SEM, and TEM to thoroughly analyse the specific composition and morphology of the Cu@PDA and hydrogel. We measured the injectability, adhesion, NIR-II photothermal, and antibacterial properties of each group of hydrogels. The results showed that TA and Cu@PDA endowed the hydrogel with excellent antioxidant properties, enabling effective scavenging of various free radicals. Additionally, OCTC2, which possesses sustained-release TA/Cu 2+ capability, achieves antibacterial rates of over 94 % against S. aureus and E. coli . Under the combined effect of NIR-II photothermal therapy, it can achieve highly efficient bacterial killing (99.8 %), effectively promoting the healing of bacterial infection wounds. OCTC2 holds promise as a potential ideal hydrogel dressing for treating bacterial-infected wounds.
✓ 已验证
产品关联
DOI
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2025
·
IF 4.6
Taiyi Chen,Xiaoping Lin,Peisong Li,Wei Liu,Lu Jiang,Leyuan Huang,Zhongliang Li,Ruirui Zhu,Zhi-Liang Chen,Rongying Zeng,Mengqin Liu,Wen Chen
The precise detection of metal ions is crucial in food safety, biomedical diagnostics, and environmental monitoring. Although traditional “on-off” fluorescence probes are frequently utilized, their anti-interference capability remains a limitation. This study synthesized three new copper-based fluorescent probes: PTA, PTP, and PTD. Among them, PTD exhibited unique aggregation-induced emission (AIE) properties. PTD's remarkable selectivity for Zn 2+ was due to the formation of Zn 2+ -induced J-aggregates, which resulted in a concentration-dependent fluorescence redshift from green to yellow and then to red. Additionally, PTD demonstrated a rapid and sensitive response to Cu 2+ , and it was successfully integrated into a smartphone-based platform for the semi-quantitative detection of Zn 2+ and Cu 2+ in real food samples. The effectiveness in biological applications was also validated through live-cell imaging tests. This work contributes to the creation of highly selective and interference-resistant ratiometric fluorescence sensors by leveraging the special process of target metal ion-induced J-aggregate production in AIE-based probes.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Digest Journal of Nanomaterials and Biostructures
·
2026
·Vol. 21
·期 1
·
IF 1.2
Miliang Zhang
Membrane fouling, especially the composite pollution caused by inorganic scaling and biological fouling, is a key challenge in the treatment of underground karst water with high salinity and high hardness. This study reports a polyethersulfone (PES) ultrafiltration (UF) membrane modified by molybdenum disulfide-tannic acid@copper ions (MoS2-TA@Cu2+) bionanomaterial. By blending MoS2-TA@Cu2+ nanoparticles into the PES matrix, the membrane's structure and comprehensive properties were systematically controlled. Scanning electron microscopy (SEM) and static water contact angle measurements were employed to characterize the morphology and surface properties of the membranes. Characterization analysis confirmed that the hydrophilicity of the modified membrane was enhanced (the water contact angle [WCA] was reduced from 69° to 56°), and it showed high antibacterial properties (the antibacterial rate against Escherichia coli [E. coli] reached 95%). The core contribution of this study is to systematically elucidate the tunable trade-off mechanism between key membrane properties dominated by nanoparticle loading. Specifically, a loading capacity of 10 g/m2 achieved optimal anti-fouling stability, with a flux recovery rate (FRR) as high as 81.5% (40.5% higher than that of the original membrane). In contrast, a loading capacity of 15 g/m2 showed the superior permeation and separation performance, with a turbidity removal rate of 92.9% in actual karst water and a silt density index (SDI) reduction value of 5.3, fully meeting the stringent requirements of reverse osmosis pretreatment. Both static and dynamic anti-fouling experiments confirmed its excellent performance, with the CaCO3 scaling amount reduced by up to 65.2%. This study provides an effective strategy for the development of multifunctional UF membranes that can cope with complex water quality challenges by revealing the inherent trade-off between separation efficiency and anti-fouling stability. This paper provides the key theoretical basis and practical guidance for the precise design of high-performance multifunctional membranes.
✓ 已验证
产品关联
DOI
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2026
·
IF 4.8
Mengjiao Pang,Yanjie Wang,Zengcheng Du,Qiqing Chen,Wenhao Liu,Miaoduo Deng,Yuanyuan Xie,Mingfang Zhu
In this study, a water-soluble perovskite quantum dot (PQDs) based on CsPbI 3 "on-off-on" fluorescent probe was successfully constructed. The probe exhibits red fluorescence emission at 660 nm under 465 nm excitation, and the response mechanism of Cu 2+ -induced fluorescence quenching (OFF) and D-penicillamine (D-PA) triggered fluorescence recovery (ON) is realized. In addition, the dual target detection platform of both copper ions (Cu 2+ ) and D-PA was established. Quantitative analysis showed that the detection linearity range was 0.5–15 μM (LOD = 0.21 μM) for Cu 2+ and 0.4–60 μM (LOD = 16.7 nM) for D-PA. Meanwhile, D-PA can be semi-quantitatively measured based on the change in solution color. The fluorescent probe provides a fast response time, high sensitivity, and convenient solution for real-time detection of Cu 2+ and D-PA. And it was applied in the determination of D-PA in serum samples with satisfactory results. It is particularly noteworthy that the synthesized perovskite quantum dots exhibit excellent stability in the aqueous environment, which provides a new strategy for expanding the application of perovskite materials in the field of biomedical analysis.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）