ACS Applied Energy Materials
·
2021
·
IF 6.024
Zheng Jiang,Jun Wang,Enyi Hu,Jingjing Liu,Lei Yu,Faze Wang
The p-i-n junction structure has garnered great interest from researchers due to its increased photoactive area and wider space charger region compared with that of the p-n junction. Herein the ultrawide bandgap (∼6.7 eV) semiconductor alumina (Al2O3) has been introduced to construct a p-i-n junction with ZnO and NiO. ZnO–Al2O3–NiO powders are suitable for electrolyte membrane material of low-temperature solid oxide fuel cells (LT-SOFCs). The insulating Al2O3 brings a doubled depletion region and more effective charge separation compared with the p-n junction consisting of ZnO and NiO. The fuel cell based on the p-i-n junction membrane material delivers an enhanced maximum power density (MPD) of 917 mW cm–2 along with a high open-circuit voltage (OCV) of 1.013 V at 550 °C. An analysis based on the space charge region and energy band alignment in the p-i-n junction is proposed to account for the appreciable cell performance and ionic conductivity, as well as the electron blocking and charge separation ability. This study presents a practical p-i-n junction design based on ZnO–Al2O3–NiO via a solution process for LT-SOFC electrolyte material and sheds light on the extensive exploration of p-i-n junctions applied in LT-SOFCs.
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高影响因子
TETRAHEDRON
·
2019
·
IF 2.379
Jingyuan Li,Qingwen Song,Hengxuan Zhang,Ping Liu,Kan Zhang,Junwen Wang,Dengsong Zhang
Chemical fixation of carbon dioxide under mild reaction conditions e.g. atmospheric pressure and low temperature depends upon the ability of catalyst. Herein, a synergistic catalytic scheme of silver sulfadiazine/ n Bu 4 NBr was described for the three-component reaction of propargylic alcohols, CO 2 , and monohydric alcohols. This catalytic system was demonstrated effectively to provide β-oxopropyl carbonates in excellent yields (up to 99% yield with 5 mol% catalyst). The method tolerated a wide scope of propargylic alcohols and monohydric alcohols under atmospheric CO 2 pressure and solvent-free conditions. The excellent catalytic performance was attributed to the synergistic catalysis confirmed by the careful experiments.
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BIOORGANIC & MEDICINAL CHEMISTRY
·
2023
·
IF 3.5
Guiying Wu,Hui Zhong,Ying Wang,Li Chen,Jianbo Sun
A number of NO-releasing quinoline derivatives have been designed and synthesized by introducing NO donor to quinoline carboxylic acid fragment. The anti-proliferation of all target compounds was evaluated against human cancer cell lines (HCT-116, MCF-7, and A549), MCF-7/ADR and normal cell (MCF-10A). Most compounds showed cytotoxic activity on cancer cells and drug-resistant cells with IC 50 values in the range of 0.62–5.51 μM. Importantly, these compounds showed low toxicity to normal cells (4.21–34.08 μM). Further mechanism studies showed that the most potent compound 9 could release high concentration of NO and inhibit the activity of topoisomerase I. In addition, 9 regulated apoptosis-related proteins, generated ROS and blocked MCF-7 cells in G2/M phase to induce cell apoptosis. Furthermore, the P-gp-mediated transport was also influenced by 9 . And 9 could significantly inhibit the growth of tumor in vivo without observable organ-related toxicities. Overall, as a novel NO-releasing quinoline derivative, 9 was worthy for further in-depth study.
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高影响因子
INORGANICA CHIMICA ACTA
·
2021
·
IF 2.545
Dan Zheng,Ting-Hong Huang,Cheng Luo,Jing Tang
Three dinuclear Cu(I) complexes, [Cu 2 (pnd)(PPh 3 ) 4 ](BF 4 ) 2 (1) , [Cu 2 (pnd)(dppp) 2 ] (BF 4 ) 2 (2) , and [Cu 2 (pnd)(DPEphos) 2 ](BF 4 ) 2 (3) (PPh 3 = triphenylphosphine , dppp = 1, 3-bis (diphenylphosphino)propane, DPEphos = bis(2-diphenylphosphinophenyl)ether, pnd = N , N ’-bis (pyridin-2-ylmethylene)naphthyl-1, 5-diimine), have been prepared and characterized by IR, 1 H NMR, 31 P NMR, 13 C NMR, XRD , elemental analysis and X-ray crystal structure analysis. The structural analysis reveals that the flexible pnd in 1 – 3 acts in a trans bridging coordination mode to connect two Cu + ions, forming a S-shape conformation, while each of Cu (I) ion is four-coordinate N2P2, adopting a distorted-tetrahedral geometry. DFT calculations show that the HOMOs of complexes 1 – 3 are primarily located on the copper d -orbital and the phosphine ligand, together with a specific contribution of pnd, while LUMOs are mostly composed of pnd with admixed Cu(I) d-orbital character. Corresponding calculations of atomic charges indicate that the charge of the copper atom in complexes 1 – 3 is below + 1, while the total charges of the coordinated atoms are 0.743–0.786. Moreover, the solid-state emission spectra of complexes 1 – 3 show the existence of broad emission bands at 350–550 nm.
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高影响因子
SYNLETT
·
2021
·Vol. 32
·期 14
·1437-1446
·
IF 2.454
Haifei Wang,Chuliang Gong,Chen Zhang,Xiaojun Zheng,Qinglin Hou,Qingxia Zhou,Guiyin Zhou,Yao Chen
In this work, we introduced a multifunctional Ag(I)/CAAA-amidphos complex catalyzed asymmetric 1,3-dipolar cycloaddition of acrylates with α-imino esters, affording a series of 2,4,5-trisubstituted endo-pyrrolidines in good yields (up to 97%) with high enantioselectivities (up to 98% ee). Meanwhile, the catalytic system was also applied in the three-component one-pot reaction of α-imino esters formed in situ under the action of N,N′-diisopropylcarbodiimide. In addition, the gram-scale reaction was realized for the formal synthesis of (+)-ibophyllidine in eight steps.
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高影响因子
BIOORGANIC CHEMISTRY
·
2019
·
IF 3.926
Wen-Jin Zhang,Peng-Hui Li,Min-Cong Zhao,Yao-Hao Gu,Chang-Zhi Dong,Hui-Xiong Chen,Zhi-Yun Du
Psoriasis is a chronic inflammatory and immune-mediated skin disease. Although certain agents have shown clinical success in treating psoriasis, development of safe and effective strategies for the treatment of this condition remains important. Research suggests that DNA topoisomerase I (Topo I) inhibitors may have potent psoriasis-ameliorating effects. Here, 25 quinoline derivatives were synthesized and identified as Topo I inhibitors. These compounds inhibited the 12– O –tetradecanoylphorbol-13-acetate-induced mouse ear inflammation. The most potent analogs, 5i and 5l , suppressed the expression of inflammatory cytokines in lipopolysaccharide-stimulated HaCaT cells. Additionally, the lead compounds significantly improved imiquimod-induced psoriasis-like inflammation in mice. Moreover, the expression levels of cytokines and inflammatory mediators, such as interleukin (IL)-17A, IL-22, IL-23, nuclear factor-κB subunit p65, tumor necrosis factor-α, and interferon-γ, were dramatically inhibited in the dorsal skin of 5i - and 5l -treated mice. These findings indicate that the inhibition of Topo I activity may potentially be an effective strategy for psoriasis treatment.
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高影响因子
PROGRESS IN ORGANIC COATINGS
·
2025
·
IF 7.3
Yuan Jing,Fandi Meng,Fuhui Wang,Li Liu
Slippery liquid-infused porous surface (SLIPS) has garnered significant attention in marine anticorrosion and antifouling applications due to their slippery attributes. Nevertheless, it remains challenging to fulfill the protection requirements by relying exclusively on the barrier and anti-adhesion mechanisms of surface lubricating layer. In this work, a dual-functional slippery organogel coating was meticulously synthesized by introducing Ag(Ӏ)-imine coordination bonds into organosilicon networks, thereby endowing the coating with self-healing and antibacterial properties. A surface scratch with a width of 50 μm can be effectively repaired within 6 h at 60 °C, and the repair efficiency exceeds 85 %. In addition, the coating exhibits a dual antibacterial mechanism, which functions through both sterilization via the release of Ag + and antiadhesion due to its slippery properties. Following a 7-day cocultivation period with PAO1 bacteria, the coating retained 100 % bactericidal activity and 99.8 % resistance to bacterial adhesion. Moreover, the antialgal efficacy of the AP-TA 0.2 -Ag 1 @Oil coating against Chlorella and P. tricornutum increased by 99.9 % and 99.7 %, respectively. Furthermore, the combination of Ag(Ӏ)-imine coordination bonds and silicone oil effectively preserves the corrosion resistance of the coating. The EIS results demonstrated that the | Z | 0.01 Hz value of the slippery organogel coating was maintained at 1.07 × 10 7 Ω·cm 2 after immersion in 3.5 wt% NaCl solution for 14 days, suggesting excellent anticorrosion performance of the coating. This study provides a novel perspective for the development of marine protective coatings that possess antifouling, self-healing, and anticorrosive properties.
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高影响因子
JOURNAL OF STRUCTURAL CHEMISTRY
·
2018
·Vol. 59
·期 3
·744-747
·
IF 0.521
Sun S.-W.,Wang G.-F.
The synthesis of a novel Cu(I) complex with V-shaped bidentate ligands {[Cu(BIPMO)]×[CuBr 2 ]} n where BIPMO = bis(4-(1 H -imidazol-1-yl)phenyl)methanone is reported. It is characterized by IR spectroscopy, elemental analysis, and single crystal X-ray diffraction. Copper(I) ions in the complex are in a distorted environment in which donor atoms are provided by the bromide anion and nitrogen atoms of BIPMO ligands, respectively. Infinite anion chains formed by CuX 4 (X = Br or N) polyhedra are linked by BIPMO ligands to give rise to layers. Furthermore, the layers are linked into 3D networks through weak intermolecular interactions.
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高影响因子
JOURNAL OF MEDICINAL CHEMISTRY
·
2025
·
IF 6.8
Quan Wang,Lili Yang,Xiaoyu Xing,Wenjie Liang,Renzhi Wu,Chen Xiong,Meng Wu,Cheng Zhong,Haoke Zhang,Shixuan Wang,Fan Xia,Xiaoding Lou,Dugang Chen,Jun Dai
Phototherapy, renowned for its noninvasiveness, is widely employed in tumor treatment. However, the tumor microenvironment is usually hypoxic, with insufficient reactive oxygen species (ROS) production, severely limiting its application. Herein, we introduce a regio-isomerization optimization strategy and have synthesized four regio-isomeric photosensitizers featuring a donor–acceptor (D–A) configuration by tactically varying the linkage sites between D and A. Among them, TAF-3 with excellent photostability has an ultrahigh type I ROS production efficiency (4.79 times that of methylene blue) and a photothermal conversion efficiency of 41.7%. TAF-3 improves the conjugation degree; produces an appropriate intramolecular charge transfer effect, which enhances its optical properties and phototherapeutic efficiency; and promotes a stronger immune cell death effect, reducing postoperative melanoma recurrence by 60%. Overall, the optical attributes of D–A type photosensitizers can be tailored through the precision modulation of regio-isomerization, offering a promising avenue for the advancement of clinical photosensitizers suitable for phototherapy.
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PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2024
·
IF 10.7
Xueping Wang,Chengying Zhao,Jirong Wang,Xingmiao Lu,Yuming Bao,Deli Zhang,Jinkai Zheng
To facilitate the application of rhamnogalacturonan-I (RG-I)-enriched pectins (RGPs) as novel, healthy, and gelling food additives, this study compared the structural characteristics and gelling properties of RGPs extracted from citrus peel via four methods (alkali: AK, high-temperature/pressure: TP, citric acid: CA, and enzyme-assisted: EA extractions). AK and CA yielded pectins with the highest RG-I proportions (54.8 % and 51.9 %, respectively) by disrupting the homogalacturonan region; TP and EA increased the RG-I proportions by ~10 %. Among the four methods, AK induced the lowest degree of esterification (DE) (6.7 %) and longer side chains that form strong entanglement, contributing to its highest gel hardness. The relatively low DE (18.5 %) of CA RGP facilitated stable gel formation. Notably, its highly branched RG-I region afforded more intramolecular hydrophobic interactions, making a more highly cross-linked gel network of better gel resilience. In contrast, TP induced the highest DE (57 %) and curved molecular chains; it inhibited Ca 2+ binding, entanglement, and intramolecular hydrophobic interactions, and thus no gel formed. EA RGP was associated with the lowest molecular size, rendering it more difficult for Ca 2+ to form links, which resulted no gel. These findings offer insights into the relationship among the extraction methods, molecular structures, and gelling properties of RGPs.
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高影响因子
ANALYTICAL CHEMISTRY
·
2024
·
IF 6.7
Qianru Zhang,Anqi Liu,Xin Song,Shihao Xu,Liangguo Da,Dan Lin,Changlong Jiang
Organophosphate pesticides (OPs) are widely utilized in agricultural production, and the residues threaten public health and environmental safety due to their toxicity. Herein, a novel and simple DNA aptamer-based sensor has been fabricated for the rapid, visual, and quantitative detection of profenofos and isocarbophos. The proposed DNA aptamers with a G-quadruplex spatial structure could be recognized by SYBR Green I (SG-I), resulting in strong green fluorescence emitted by SG-I. The DNA aptamers exhibit a higher specific binding ability to target OP molecules through aromatic ring stacking, disrupting the interaction between SG-I and DNA aptamers to induce green fluorescence quenching. Meanwhile, the fluorescence wavelength of G-quadruplex fluorescence emission peaks changes, accompanied by an obvious fluorescence variation from green to blue. SG-I-modified aptasensor without any additive reference fluorescence units for use in multicolor fluorescence assay for selective monitoring of OPs was first developed. The developed aptasensor provides a favorable linear range from 0 to 200 nM, with a low detection limit of 2.48 and 3.01 nM for profenofos and isocarbophos, respectively. Moreover, it offers high selectivity and stability in real sample detection with high recoveries. Then, a self-designed portable smartphone sensing platform was successfully used for quantitative result outputs, demonstrating experience in designing a neotype sensing strategy for point-of-care pesticide monitoring.
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高影响因子
ANALYTICA CHIMICA ACTA
·
2024
·
IF 5.7
Jiahao Ni,Lichao Yu,Yixuan Wang,Tong Yang,Yueqi Bai,Bowen Zheng,Manshan Liang,Xiaoxia Ye,Yun-Yun Quan,Feifei Lin,Zu-Sheng Huang
Background Photodynamic therapy (PDT) is a pioneering and effective anticancer modality with low adverse effects and high selectivity. Hypochlorous acid or hypochlorite (HClO/ClO − ) is a type of inflammatory cytokine. The abnormal increase of ClO − in tumor cells is related to tumor pathogenesis and may be a “friend” for the design and synthesis of responsive phototherapy agents. However, preparing responsive phototherapy agents for all-in-one noninvasive diagnosis and simultaneous in situ therapy in a complex tumor environment is highly desirable but still remains an enormously demanding task. Results An acceptor-π bridge-donor-π bridge-acceptor (A-π-D-π-A) type photosensitizer TPTPy was designed and synthesized based on the phenothiazine structure which was used as the donor moiety as well as a ClO − responsive group. TPTPy was a multifunctional mitochondria targeted aggregation-induced emission (AIE) photosensitizer which could quickly and sensitively respond to ClO − with fluorescence “turn on” performance (19-fold fluorescence enhancement) and enhanced type I reactive oxygen species (ROS) generation to effectively ablate hypoxic tumor cells. The detection limit of TPTPy to ClO − was calculated to be 185.38 nM. The well-tailored TPTPy anchoring to mitochondria and producing ROS in situ could disrupt mitochondria and promote cell apoptosis. TPTPy was able to image inflammatory cells and tumor cells through ClO − response. In vivo results revealed that TPTPy was successfully utilized for PDT in tumor bearing nude mice and exhibited excellent biological safety for major organs. Significance and novelty A win-win integration strategy was proposed to design a tumor intracellular ClO − responsive photosensitizer TPTPy capable of both type I and type II ROS production to achieve photodynamic therapy of tumor. This work sheds light on the win-win integration design by taking full advantage of the characteristics of tumor microenvironment to build up responsive photosensitizer for in situ PDT of tumor.
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