IRANIAN POLYMER JOURNAL
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2025
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IF 2.8
Yang Yi,Sun Yawen,Yang Xin,Zhang Chenchen,Gao Huajie,Zhang Haorong,Wang Jianfeng,Yang Yanyu,Wang Wanjie,Cao Yanxia
This study investigates the shape memory and reconfigurability behaviors of recycled polyvinyl butyral (RPVB) with partially extracted plasticizer, which is crosslinked using hexamethylene diisocyanate (HDI) and a catalyst, dibutyltin dilaurate (DBTDL). The use of RPVB, a recycled plastic, is significant as it contributes to sustainability by reducing waste and promoting the reuse of plastic materials. The effect of HDI content on the shape memory performance of RPVB was explored, with emphasis on the catalyst's role in enhancing its reconfigurability. RPVB-20, with 20% plasticizer extraction, exhibits excellent shape fixation at room temperature, with a shape recovery rate (R r ) of 81.2%, which increases to over 95% after HDI crosslinking. The addition of DBTDL further improves the material's reconfigurability, enabling it to adopt new permanent shapes through dynamic covalent bond exchange at 160 °C. The material demonstrates good shape memory performance with an R f of 99.4% and an R r of 96.9% when 0.2 phr HDI is added. Stress relaxation and creep tests show that the catalyst accelerates urethane exchange, providing plasticity at elevated temperatures. Furthermore, RPVB-20-0.2-DL exhibits excellent reprocessing properties, with stable mechanical properties after reprocessing, making it suitable for manufacturing permanent three-dimensional shapes and for potential recycling applications. The results suggest that dynamic covalent bonds in RPVB shape memory polymers offer both high reconfigurability and stable mechanical properties, providing a promising approach for sustainable material design in smart applications while promoting the recycling and reusing of plastic materials in line with environmental objectives. Graphical
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Tungsten
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2025
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IF 11.2
Chang Si-Jie,Zhang Xin,Wang Rui-Ge,Wang Jun-Kai,Wang Chao-Fan,Zhang Long-Fei,Yu Zhi-Peng,Hu Qian-Ku,Zhou Ai-Guo
The methanol oxidation reaction is a critical half-reaction in direct methanol fuel cells (DMFCs), but its efficiency is limited by the low activity and poor stability of traditional electrocatalysts. This study reports the development of a high-performance PtCo/Mo 2 CT x catalyst for methanol oxidation in DMFCs. Synthesized by depositing PtCo alloy nanoparticles on Mo 2 CT x sheets prepared via cetyltrimethylammonium bromide-assisted etching of Mo 2 Ga 2 C, the PtCo/Mo 2 CT x catalyst achieved enhanced interlayer spacing and excellent dispersion of active sites. The optimized PtCo/Mo 2 CT x catalyst exhibited remarkable catalytic activity, reaching a mass activity of 2296 mA·mg Pt −1 —6.5 times that of commercial Pt/C. Electrochemical studies confirmed the catalyst’s low charge transfer resistance, high electrochemical surface area, and strong CO anti-poisoning ability. Stability tests showed that the catalyst retained 62.26% activity after 1000 cycles. These improvements are attributed to the synergistic effects between Pt and Co, the conductive and layered structure of Mo 2 CT x , making PtCo/Mo 2 CT x a promising, durable anode material for DMFCs in sustainable energy applications. Graphical abstract
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npj Science of Food
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2025
·Vol. 9
·期 1
·1-12
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IF 7.8
Zhang Hongyi,Ma Qiaoling,Wang Weichao,Wang Bin,Liu Jiawen,Wang Fu,Hu Yuan,Chen Lin,Liu Youping,Wang Qi,Chen Hongping
Oysters are recognized for flavor and health benefits, but their shells are regarded as waste, contributing to resource inefficiency. This study investigates the chemical composition and pharmacological activity of oyster shells, using a fraction partitioning approach to separate the oyster shells water extract (WE) into two fractions: WE of extra-membranous (WEE, <1000 kDa) and intra-membranous (WEI, >1000 kDa). Using UPLC-Q-Exactive MS, 231 components were identified such as organic acids, amino acids. ELISA analysis revealed that high-dose WEE significantly increased serum T3, T4, FT3, and FT4 levels while reducing TSH, and improved thyroid tissue lesions. Network pharmacology identified 291 drug-disease intersection targets enriched in the PI3K/AKT pathway. Furthermore, the RT-qPCR and WB results showed that high-dose WEE protected against propylthiouracil-induced goitre by inhibiting the PI3K/AKT/Bcl-2 pathway. This study evaluated the anti-goitre potential properties of WE and provided a theoretical basis for further development of oyster shells as a functional food source.
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APOPTOSIS
·
2025
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IF 8.1
Huang Xiangyang,Liu Yi,Fu Hangling,Rong Xia,Zhao Yiheng
Systemic sclerosis (SSc) is a life-threatening autoimmune disease characterized by progressive skin and organ fibrosis. Although interferon signaling is dysregulated in SSc, the role of interferon-induced proteins like IFIT3 in the skin fibrosis of SSC remains unclear. Here, we demonstrate that IFIT3 expression is significantly elevated ( p < 0.01) in SSc fibroblasts and promotes fibrosis via SOCS1-dependent activation of the EGFR/VEGF axis. Silencing IFIT3 upregulated SOCS1 ( p < 0.05), suppressed EGFR/VEGF ( p < 0.01), and inhibited fibroblast proliferation/migration ( p < 0.01). In a bleomycin-induced SSc model, IFIT3 knockdown ameliorated skin/lung collagen deposition and fibrosis ( p < 0.05). Our findings reveal a novel mechanism whereby IFIT3 regulates EGFR and VEGF through down-regulating SOCS1 in SSc fibrosis, identifying IFIT3 as a novel therapeutic target for SSc.
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Chinese Journal of Integrative Medicine
·
2025
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IF 2.5
Liu Shu-yan,Zhang Xiao-wei,Gao Gai,Liu Chang-xin,Chen Hui,Fu Zhong-xue,Xu Jiang-yan,Wang Zhen-zhen,Zhang Zhen-qiang,Xie Zhi-shen
Objective To investigate the therapeutic potential of pseudolaric acid B (PAB) on non-alcoholic fatty liver disease (NAFLD) and its underlying molecular mechanism in vitro and in vivo . Methods Eight-week-old male C57BL/6J mice ( n =32) were fed either a normal chow diet (NCD) or a high-fat diet (HFD) for 8 weeks. The HFD mice were divided into 3 groups according to a simple random method, including HFD, PAB low-dose [10 mg/(kg·d), PAB-L], and PAB high-dose [20 mg/(kg·d), PAB-H] groups. After 8 weeks of treatment, glucose metabolism and insulin resistance were assessed by oral glucose tolerance test (OGTT) and insulin tolerance test (ITT). Biochemical assays were used to measure the serum and cellular levels of total cholesterol (TC), triglycerides (TG), aspartate aminotransferase (AST), alanine aminotransferase (ALT), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C). White adipose tissue (WAT), brown adipose tissue (BAT) and liver tissue were subjected to hematoxylin and eosin (H&E) staining or Oil Red O staining to observe the alterations in adipose tissue and liver injury. PharmMapper and DisGeNet were used to predict the NAFLD-related PAB targets. Peroxisome proliferator-activated receptor alpha (PPARα) pathway involvement was suggested by Kyoto Encyclopedia of Genes and Genomes (KEGG) and search tool Retrieval of Interacting Genes (STRING) analyses. Luciferase reporter assay, cellular thermal shift assay (CETSA), and drug affinity responsive target stability assay (DARTS) were conducted to confirm direct binding of PAB with PPARα. Molecular dynamics simulations were applied to further validate target engagement. RT-qPCR and Western blot were performed to assess the downstream genes and proteins expression, and validated by PPARα inhibitor MK886. Results PAB significantly reduced serum TC, TG, LDL-C, AST, and ALT levels, and increased HDL-C level in HFD mice ( P <0.01). Target prediction analysis indicated a significant correlation between PAB and PPARα pathway. PAB direct target binding with PPARα was confirmed through luciferase reporter assay, CETSA, and DARTS ( P <0.05 or P <0.01). The target engagement between PAB and PPARα protein was further confirmed by molecular dynamics simulations and the top 3 amino acid residues, LEU321, MET355, and PHE273 showed the most significant changes in mutational energy. Subsequently, PAB upregulated the genes expressions involved in lipid metabolism and mitochondrial biogenesis downstream of PPARα ( P <0.05 or P <0.01). Significantly, the PPARα inhibitor MK886 effectively reversed the lipid-lowering and PPARα activation properties of PAB ( P <0.05 or P <0.01). Conclusion PAB mitigates lipid accumulation, ameliorates liver damage, and improves mitochondrial biogenesis by binding with PPARα, thus presenting a potential candidate for pharmaceutical development in the treatment of NAFLD.
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ENVIRONMENTAL GEOCHEMISTRY AND HEALTH
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2025
·Vol. 47
·期 11
·1-13
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IF 3.8
Ji Runlai,Chen Wenming,Zuo Yanjun,Xin Yi,Zhang Jingjing,Wang Haibo,Kong Lingce,Wu Yufeng
Advanced oxidation processes (AOPs) utilizing sodium persulfate (PDS) have garnered significant attention in recent years. In this study, acetylguanidine (ACG) was discovered to effectively activate PDS for organic contaminants degradation. The system achieved a degradation rate of 98.5% for aniline in wastewater within 50 min and 95.0% for aniline in soil within 3 h. The reaction system showed remarkable resilience, with only a minimal impact from common inorganic ions and organic compounds. The ACG/PDS system displayed robust and efficient performance across a broad pH range of 7.5–12.5. ACG-activated PDS system also demonstrated significantly superior performance in soil remediation compared to humic acid and WQ-8476. EPR and scavenging experiments revealed that ·OH were the dominant active species in the ACG/PDS system. Degradation pathways were proposed based on the degradation products identified through GC–MS analysis. This research provides valuable insights into the practical application of ACG/PDS system for industrial wastewater treatment and soil remediation. Graphical abstract
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-12
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IF 15.7
Ma Ruiyu,Jia Lichuan,Guo Zhiguang,Lin Jie,Liu Mengxin,Wang Zhixing,Song Guilin,Yan Dingxiang,Li Zhongming
Producing high-concentration liquid metal (LM) inks is highly desirable for next-generation flexible electronics, and yet remains a dulling challenging due to the large surface tension and high density of LM droplets. Herein, a general finite-gel strategy is proposed to enable the fabrication of high-concentration liquid metal (LM) inks. In the LM-based inks, the LM droplets are confined in the relaxed finite-gel networks, which provide strong repulsive effects to avoid the reunition of the adjacent LM droplets. The unique structure imparts the LM-based inks with a good colloidal stability even at a very high LM concentration of 30,000.0 g/L. The LM-based inks also present tunable rheological behavior and are suitable for various processing technologies. Moreover, the proposed finite-gel strategy is scalable, and could be expanded to various cryogel systems (e.g., curdlan, gelatin, and gellan gum). This work takes a crucial step forward to producing highly concentrated LM-based inks for flexible electronics.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
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2025
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IF 3.8
Guo Hongyu,Hou Yumeng,Fang Xiaoting,Lin Liangbin,Yang Fafu
Carbendazim is widely used as a fungicide in various crops, but its residues might pose a threat to human health and environmental safety. It is significantly expected to develop a simple, sensitive, stable, and on-site method for detecting carbendazim. In this work, the first organic fluorescent sensor for carbendazim was designed and synthesized based on a crown ether-bridging tetra-cyanostilbene macrocycle. This macrocycle exhibited dark-blue fluorescence in THF–H 2 O (5:95) solution, which was transformed into bright-blue fluorescence after sensing carbendazim. High sensing selectivity for carbendazim was observed among 24 kinds of pesticides and ions. The detection limit was as low as 4.22 × 10 –8 M. The sensing mechanism was deduced as two carbendazim molecules being encapsulated in the macrocyclic cavity based on multiple hydrogen bonds, π–π stacking, and hydrophobic action, resulting in stronger rotation restriction of aromatic groups and then higher fluorescence emission. The sensing application on test paper, real samples, and simulated water samples indicated excellent qualitative and quantitative detecting capabilities for sensing carbendazim, implying a good application prospect for simple, sensitive, stable, and on-site detection of carbendazim in daily life.
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MICROCHIMICA ACTA
·
2025
·Vol. 192
·期 11
·1-14
·
IF 5.3
Li Minzhe,Zhou Yuzhu,Wei Guimei,Wang Wenyi,Liang Zhixing,Wen Changchun,Lin Xiang-Cheng
In practical applications, constructing bifunctional substrates with highly sensitive surface-enhanced Raman scattering (SERS) detection capabilities and environmentally friendly degradation technologies has significant importance in environmental remediation. Herein, Ag/CuO/CF (ACC) bifunctional composites were successfully fabricated via a two-step process. First, CuO nanowire arrays were grown in situ on a copper foam (CF) substrate using a facile thermal oxidation method. Subsequently, Ag nanoparticles were deposited uniformly onto the CuO nanowire surface via chemical reduction. As a SERS substrate, the ACC platform exhibited exceptional detection capabilities for methylene blue (MB) and malachite green (MG), achieving ultra-high sensitivity with remarkably high enhancement factors and extremely low detection limits for both target molecules. Moreover, the ACC substrates exhibited excellent uniformity, repeatability, and stability, as well as remarkable performance recovery in real sample testing. As a photocatalytic substrate, ACCs exhibited outstanding photocatalytic efficiency for degrading MB and MG, maintaining degradation of 91.97% after five cycles. Such a bifunctional design offers a novel approach for developing a new generation of intelligent environmental remediation technologies. It is particularly suitable for scenarios requiring on-site rapid analysis and immediate treatment, such as the monitoring and elimination of high-risk trace-level pollutants. Therefore, exploring integrated “detection-treatment” strategies holds significant importance for practical environmental applications. Graphical
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JOURNAL OF SOLID STATE ELECTROCHEMISTRY
·
2025
·
IF 2.6
Ma Chenxi,Li Yuhang,Zhao Peizhu,Chang Zenghua,Li Bin,Yang Man,Zhang Wei,Wang Bo
The pursuit of higher energy density in lithium-ion batteries (LIBs) often pushes safety limits, primarily due to the flammability of liquid electrolytes, which poses significant hazards. This study presents an in situ curing process for the fabrication of high-density pouch cells with gel electrolyte. The electrochemical performance of these pouch cells was evaluated using galvanostatic charge/discharge, electrochemical impedance spectroscopy (EIS), linear voltammetry, and hot box tests. The results show that the electrochemical performance of Ni-rich/silicon-graphite pouch cells with gel electrolyte is comparable to that of pouch cells with traditional liquid electrolyte. After 500 cycles, the pouch cells with gel electrolyte retained 87.59% residual capacity retention, outperforming the 85.40% retention observed in pouch cells with liquid electrolyte. Additionally, the gel electrolyte significantly enhanced the thermal stability of the pouch cells, delaying the thermal runaway by approximately 25 minutes during the 180 °C hot box test. These findings provide valuable insights for the further application and development of high specific energy batteries.
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IONICS
·
2025
·
IF 2.6
Hu Kaihan,Cai Jiahui,Shi Zixu,Tan Xiaojun,Wang Li,Chen Jingbo,He Xiangming
Silicon dioxide (SiO₂), an anode material for lithium-ion batteries (LIBs), faces critical challenges such as irreversible phase transitions, severe volume expansion, and interfacial side reactions, leading to low initial Coulombic efficiency and poor cycling stability. To address these issues, this study proposes a novel design of SnO₂-based SiO₂ nanotubes composites (SiO₂/SnO₂) synthesized using ammonium tartrate as a water-soluble template. The hollow tubular structure effectively accommodates volume changes of SiO 2 during lithiation/delithiation, while SnO₂ component can contribute lithium storage capacity and improve the electrochemical reaction kinetics. The optimized SiO₂/SnO₂ composite exhibits a high discharge capacity of 778.07 mAh g⁻ 1 with a Coulombic efficiency exceeding 98% after 200 cycles at 1 A g⁻ 1 . Additionally, it demonstrates excellent rate capability, achieving 715.6 mAh g⁻ 1 at 1 A g⁻ 1 and recovering to 927.9 mAh g⁻ 1 when the current density returns to 0.1 A g⁻ 1 . The synergistic combination of structural engineering and SnO₂ functionality not only mitigates mechanical degradation but also enhances reaction kinetics. This work provides a scalable strategy for developing high-performance anode materials with improved energy density and long-term cyclability for advanced LIBs.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2025
·Vol. 23
·期 1
·1-26
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IF 12.6
Mu Zhenlong,Chen Yang,Hu Yunfeng,Wang Hui,Li Jin
Neuroinflammation, characterized by microglial overactivation and oxidative stress, plays a critical role in the initiation and progression of Alzheimer’s disease (AD). In this study, we focus on simulating the natural efferocytosis process to reprogram microglial and mitigate chronic neuroinflammation for combinational AD therapy. To achieve this goal, engineered apoptotic bodies derived from brain metastatic tumor cells (LAbs) are successfully developed. Specifically, LAbs-based nanocomposites were fabricated by hybridizing LAbs with liposomes co‐loaded with manganese dioxide nanoenzyme (BMn) and autophagy‐activating rapamycin (Rapa), referred to as LAbs@Lip@BMn/Rapa. LAbs@Lip@BMn/Rapa exhibits efficient BBB penetration via LAbs‐associated brain metastasis propensity of apoptotic bodies. Within the AD microenvironment, oxygen produced through BMn catalyzation in response to H 2 O 2 triggers the structural disintegration of LAbs‐camouflaged liposomes and their reassembly into ultra‐small vesicles, thereby significantly enhancing intracranial delivery efficiency. In vitro and in vivo experiments confirm that this multi‐target strategy effectively normalizes microglia toward anti-inflammatory M2 phenotype, scavenges reactive oxide species (ROS) accumulation, promotes β‐amyloid and phosphorylated tau clearance through synergistic intervention, restores the pathological microenvironment in the brain, and enhances cognitive functions in AD model mice. This study demonstrates a novel LAbs‐based biomimetic construction strategy that effectively penetrates the BBB and regulates microglia functions, offering a promising approach for AD treatment. Graphical abstract
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危险品化学品经营许可证（带存储）