Materials Today Bio
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2026
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IF 11
Yanan Xue,Ying Lu,Yiran Lin,Junping Zhou,Kan Zhan,Cheng Chen,Huiling Zhang,Bailin Chen,Xue Cai,Qiuping Zhou,Lei Pan,Yi Sun,Sufan Wu,Zhiqiang Liu,Liqun Jin,Yuguo Zheng
Chronic diabetic wounds heal poorly due to a persistently imbalanced microenvironment involving inflammation and bacterial infection. Notably, oxidative stress, driven by mitochondrial damage, perpetuates inflammation and hinders repair. Existing therapeutic materials struggle to simultaneously address infection, inflammation, and oxidative stress through combined drug delivery and targeted activation of mitophagy. To tackle these intertwined challenges, we designed a bee ovum-inspired hydrogel (BOV) that mimics the parasitic wasp egg strategy, firm host adhesion and staged bioactive secretion, to programmatically remodel the wound microenvironment. The BOV consists of a borate-ester-crosslinked hyaluronic acid network providing robust wet adhesion and self-healing properties. It encapsulates gelatin-coated ZIF-8@Myricetin (Myr) nanoparticles and polyhexamethylene biguanide (PHMB), which are released sequentially in response to the wound’s acidic, high-reactive oxygen species (ROS), and high-matrix metalloproteinase-9 (MMP-9) microenvironment: PHMB first exerts antibacterial action to control infection, followed by Myricetin release to scavenge ROS and suppress inflammation. Beyond antioxidant effects, BOV further activates the SIRT1/FOXO3a/BNIP3 pathway to promote mitophagy, clearing damaged mitochondria and thereby mitigating oxidative stress at its source. In vivo , BOV reduced bacterial burden, alleviated inflammatory response, and enhanced collagen deposition, and re-epithelialization. This study translates a natural parasitic strategy into a programmable drug-delivery platform, offering a promising approach for refractory diabetic wound therapy through microenvironment-responsive sequential treatment and upstream mitochondrial homeostasis restoration.
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高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2026
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IF 9.6
Tancheng Dong,Yang Xiao,Wei Guo,Baojun Liu,Jincheng Mu
Biochar-induced interfacial defects modulate electronic structure of Mn Co spinel. • Complete IBU was removed in 5 min with an apparent reaction rate of 1.08 min −1 . • Interfacial structural defects accelerated redox cycles for boosted 1 O 2 generation. • The micropollutant was removed through a 1 O 2 dominated non-radical pathway. Spinel-based transition metal oxides are potential activators for peroxymonosulfate-based advanced oxidation processes (PMS-AOPs) in water purification, yet their sluggish redox cycling, stemming from poor conductivity, remains a critical limitation. In this work, a distiller's grain-derived porous biochar (BC)-decorated Mn Co spinel nanosheet catalyst (MnCoO x @BC) is developed and applied for PMS activation. The catalyst exhibits high efficacy in degrading ibuprofen (IBU), achieving complete removal within 5 min with an apparent reaction rate constant of 1.08 min −1 ([IBU] = 10 mg L −1 , [catalyst] = 200 mg L −1 , [PMS] = 200 mg L −1 ), which is 18 and 15 times for pristine BC and unsupported MnCoO x , respectively. Characterization and DFT calculation results indicate that the introduction of biochar could improve the conductivity and induce the formation of abundant oxygen defects, which accelerate the redox cycles of Co (III)/Co (II) and Mn (IV)/Mn (III) catalytic centers. This interfacial configuration facilitates the conversion of PMS into peroxysulfate radical (SO 5 • − ) and superoxide radical (O 2 • − ) species, and finally towards singlet oxygen ( 1 O 2 ), establishing a non-radical dominant pathway where 1 O 2 accounts for over 95% of the reactive species contribution. This work presents an effective strategy for developing defect-controlled catalytic interfaces to modulate the d-band center of metal sites and steer the interfacial electron transfer pathway, offering profound insights into non-radical-dominated mechanisms for the degradation of emerging micropollutants. Download: Download high-res image (312KB) Download: Download full-size image
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PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
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2026
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IF 8.3
Ziqiang Liu,Fujian Tang,Yufang He,Jie Huang
Liquefied petroleum gas (LPG) is a highly flammable fuel widely used for cooking, heating and transportation, making real-time leak detection essential for preventing fire, explosion, and suffocation hazards. In this study, a room-temperature no-core fiber (NCF) sensor coated with CoFe 1.96 La 0.04 O 4 /LaFeO 3 heterostructures was developed for LPG detection. The heterostructures were characterized using XRD, Raman spectroscopy, SEM, TEM, XPS, PL spectroscopy, and UV–vis spectroscopy. Experimental results showed that La incorporation and heterostructure formation refined the particles size, improved surface accessibility, and modulated the electronic structure and band gap, thereby enhancing LPG adsorption, carrier redistribution, and the refractive-index response of the sensing film. Among the investigated compositions, the 1:1 CoFe 1.96 La 0.04 O 4 /LaFeO 3 heterostructure exhibited the best performance, achieving a sensitivity of −2.87 pm/ppm, a response/recovery time of 36/69 s, and a limit of detection of 39.7 ppm, together with excellent selectivity and stability. The effects of temperature and relative humidity were also quantified and compensated to improve detection accuracy. These results demonstrate that the proposed sensor is a promising, low-cost platform for LPG leak detection in domestic and industrial applications.
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CHEMICAL ENGINEERING JOURNAL
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2026
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IF 12.5
Qi Liu,Wenrou Yu,Anping Liu,Lianjie Zhou,Wen Tang,Yingzhou Huang
Multiple Synergistic SERS Enhancement of 3D micro-nano Ni-foam@MoS₂ • Overcomes EBC matrix interference for ultrasensitive 2.95 nM lactate detection • AI algorithms decode complex SERS spectra for non-invasive health monitoring. To address the critical demand for highly sensitive sensing interfaces in non-invasive exhaled breath condensate (EBC) analysis, this study develops a high-performance SERS substrate featuring interlaced, needle-like MoS₂ nanoclusters grown in situ on a 3D nickel foam scaffold (Ni-foam@MoS₂). This architecture effectively overcomes the severe signal heterogeneity and poor wearable compatibility that typically plague traditional plasmonic metal substrates. The system synergizes multiple coupled SERS enhancement mechanisms: the 3D porous scaffold and interwoven needle-like arrays form abundant optical microcavities. These microcavities effectively confine incident light and significantly enhance light-matter interactions, thereby inducing electromagnetic enhancement. Concurrently, the interlaced MoS₂ arrays not only efficiently concentrate trace analytes but also induce substantial chemical mechanism via vigorous charge transfer. Consequently, the substrate achieves an outstanding average enhancement factor of 1.88 × 10 9 , alongside superb signal reproducibility and long-term environmental stability. By deploying this Ni-foam@MoS₂ substrate for the rapid off-line analysis of simulated exhaled breath condensate (EBC), we achieved the ultrasensitive detection of lactate (LA), a critical metabolic biomarker, with a limit of detection as low as 2.95 nM. Furthermore, coupling these complex spectral datasets with advanced artificial intelligence algorithms enabled the highly accurate classification of concentration-dependent LA spectral variations, demonstrating significant proof-of-concept potential for mask-integrated biomolecular sensing and non-invasive physiological monitoring.
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高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
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2026
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IF 5.9
Guorui Zhang,Changping Wang,Hongjie Ding,Yingfan Guo,Jianfeng Wu,Huali Nie,Cong Wang
Facile one-step fabrication of a multifunctional coating on Zn implants under mild conditions. • Gradient coating controls Zn 2 ⁺ release and prevents excessive ion cytotoxicity. • Zn/Ca/Sr synergy enhances dual osteogenic and antibacterial activities. Biodegradable zinc (Zn)-based implants are emerging as one of the leading candidate materials for orthopedic applications owing to their favorable degradation behavior and mechanical properties; however, their clinical translation is delayed by insufficient surface bioactivity. In this study, a multifunctional composite coating incorporating strontium (Sr) and calcium (Ca) was fabricated on Zn implants via a redox-assisted co-deposition strategy. This method harnesses the strong oxidizing power of permanganate to controllably dissolve the Zn substrate, facilitating the gradient incorporation of Ca 2 ⁺ and Sr 2 ⁺ through hydroxyl-mediated cross-linking and resulting in a composite structure with a concentration gradient. The process is completed within 30 min under mild temperature and atmospheric pressure without the need for specialized equipment. The coating operates through a dual mechanism: it regulates the degradation behavior of the Zn substrate and modulates Zn 2 ⁺ release kinetics to mitigate cytotoxicity from excessive local ion concentrations, while simultaneously leveraging the synergistic effects of Ca 2 ⁺ and Sr 2 ⁺ to enhance hemocompatibility and long-term cytocompatibility. Moreover, the coating promotes osteogenic activity by activating osteogenesis-related signaling pathways and stimulating cell adhesion, spreading, migration, and differentiation, alongside conferring antibacterial properties, thus achieving a balanced osteogenic–antimicrobial functionality. This surface modification strategy offers a novel and scalable approach for engineering biodegradable Zn-based implants, demonstrating strong potential for clinical translation in orthopedics.
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APPLIED CATALYSIS B-ENVIRONMENTAL
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2026
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IF 19.7
Xinding Lv,Longling Ruan,Xinman Tu,Junjie Cheng,Xinhui Jiang,Jiaxin Qiu,Qian Jin,Jianping Zou
A hierarchical porous S-doped g-C 3 N 4 nanotube with crystalline-amorphous interfaces is successfully constructed. • The catalyst achieves simultaneous H 2 evolution (7796 μmol g −1 ) and nearly 100% tetracycline removal within 60 min. • Directional charge transport pathways are established to efficiently suppress electron–hole recombination. • Crystalline-amorphous interface induces electron spin polarization, boosting reactive oxygen species generation. • The system exhibits excellent stability and promising potential for real wastewater treatment. Photocatalytic hydrogen evolution and environmental remediation are hindered by sluggish reaction kinetics and rapid charge recombination. Herein, we construct hierarchical porous S-doped g-C 3 N 4 nanotubes featuring abundant crystalline-amorphous interfaces (CA-SCN). The porous nanotube architecture provides more active sites and facilitates reactant diffusion. Notably, the crystalline poly(heptazine imide) phase at the interface acts as an electron donor, directionally injecting unpaired electrons into the amorphous melon domain, creating a charge transport pathway and inducing electron spin polarization, which effectively stabilizes charge separation. As a result, CA-SCN simultaneously achieves nearly 100% tetracycline removal and a high hydrogen yield (7796 μmol g −1 ) within 60 min under visible light, along with excellent stability and broad applicability in real water matrices. Mechanistic studies identify photogenerated holes as key reactive species for pollutant removal, with •O 2 - and •OH also involved. Furthermore, interface-induced electron spin polarization is accompanied by an upshift of the p-band center, optimizing H* adsorption free energy to accelerate hydrogen evolution kinetics, promoting the accumulation of photogenerated holes and the formation of •O 2 - and •OH to enhance contaminant degradation. This study underscores the critical role of interface-induced spin polarization in achieving efficient dual-functional photocatalysis. Download: Download high-res image (179KB) Download: Download full-size image
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ACS Nano
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2026
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IF 17.3
Zhuo Xiqian,Li Yunfeng,Qiu Ling,Aishajiang Reyida,Lei Pengpeng,Wang Tiejun,Yu Duo
Radiotherapy plays a pivotal role in the management of
nonsmall-cell
lung cancer (NSCLC), particularly for patients who are not candidates
for surgical intervention. Despite its significance, the issue of
radioresistance remains a substantial challenge in the treatment of
the NSCLC. Therefore, it is crucial to uncover new targets to enhance
radiotherapy and investigate the mechanisms underlying radioresistance.
Cuproptosis, as an emerging form of cell death dependent on intracellular
copper (Cu) ions, remains unclear in its role in radioresistant NSCLCs.
This study investigates the development of radioresistant NSCLC models,
focusing on the role of the FOS-like antigen 1 (FOSL1) as a significant
factor in mediating radioresistance. The FOSL1 gene is downregulated
in radioresistant cells. Overexpression of FOSL1 induces mitochondrial
damage and dysfunction, causing cuproptosis in radioresistant cells.
To tackle the challenge of radioresistance in NSCLC, we propose an
innovative nanostrategy focused on cuproptosis, aiming to enhance
the efficacy of radiotherapy specifically in radioresistant NSCLC.
This intervention could significantly enhance an increase in intracellular
Cu 2+ concentration and glutathione depletion while also
increasing irradiation (IR)-induced oxidative stress and mitochondrial
damage. The resulting mitochondrial dysfunction leads to tricarboxylic
acid cycle disruption and Fe–S cluster protein destabilization.
These cumulative effects ultimately induced cuproptosis and enhanced
the response of radioresistant NSCLC cells to IR. Our findings highlight
the potential of combining cuproptosis targeting with nanotechnology
to enhance the efficacy of radiotherapy, presenting a promising strategy
to address radioresistance in clinical contexts.
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FOOD CHEMISTRY
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2026
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IF 10.4
Zhiyuan Lin,Han Yan,Longyu Guo,Jiakun Peng,Ying Wang,Jianjian Gao,Jiatong Wang,Huimin Jiang,Ying Wang,Liang Zeng,Yin Zhu,Zhi Lin,Weidong Dai
The aging process reshapes the aromatic profile of white tea, yet the associated volatile transformation pathways remain poorly understood. In this study, Shoumei white tea samples sourced from distinct production years (2001, 2006, 2010, 2014, and 2017) were stored and collected annually from 2018 to 2022. A decrease in grassy and floral notes and an increase in woody and stale scents were observed in aroma profile during storage. In total, 125 volatile compounds were identified by gas chromatography–mass spectrometry. Dihydroactinidiolide (woody), cedrol (woody), and 1,2,3-trimethoxybenzene (musty) were identified as key volatile compounds responsible for the characteristic aroma of aged Shoumei by gas chromatography–olfactometry and odor activity value measurement. Aroma precursors and microbial community structure analyses suggested that the degradation of carotenoids and the microbial transformation of farnesyl diphosphate and gallic acid may contribute to the aroma evolution of Shoumei white tea during storage.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
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2026
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IF 12.5
Wenzhuo Lv,Xuefeng Zhang,Xingong Li,Xin Guo,Yiqiang Wu
Bridge–Gel Co-Path reactor couples polarization with nanoplastic enrichment. • Ti–O–P–O–Zr bridges enhance interfacial piezoresponse to ~145 pm V −1 . • Hydrogel enrichment gives a PS NPs adsorption capacity of 312.4 mg g −1 . • UTPCH achieves 68.4% apparent PS NPs removal without light or oxidants. • Reactor-level design improves charge use and substrate delivery. Piezocatalytic treatment of polystyrene nanoplastics (PS NPs) is limited by inefficient conversion of mechanical input into interfacial charge and by poor delivery of dilute particles to reactive sites. Here, we constructed a Bridge–Gel Co-Path (BGCP) reactor that coupled a Ti-O-P-O-Zr-bridged UiO-66-NH 2 /C,N-TiO 2 heterointerface with a polyethyleneimine-modified cellulose nanofibril hydrogel. The phosphate-mediated covalent–ionic bridge integrated the two components into a strongly coupled heterointerface with enhanced interfacial polarization and charge redistribution. Bader charge analysis indicated pronounced interfacial charge redistribution around the phosphate bridge, with ca. 1.20 |e| localized in the bridged region, while piezoresponse force microscopy yielded an apparent local piezoresponse coefficient (d 33 , eff ) of ca. 145 pm V −1 . The hydrogel network provided both strain relay and substrate enrichment, with a Langmuir maximum adsorption capacity of 312.4 mg g −1 toward PS NPs. Under 40 kHz ultrasonic excitation, the BGCP reactor achieved 68.4% overall apparent removal of PS NPs after 75 min of adsorption pre-equilibration followed by 105 min of mechanical excitation, retained 87.6% of its initial activity after ten cycles, and kept the individual leached concentrations of Ti, P, and Zr below 10 ppb in the effluents collected during cycling. Calorimetry-derived apparent energy metrics were provided to contextualize the energy scale of the present laboratory configuration. These results established the integration of a bridged polarization interface with a transport-active hydrogel network as an effective reactor-design strategy for intensifying mechanically driven interfacial oxidation of dilute colloidal pollutants. Download: Download high-res image (183KB) Download: Download full-size image
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CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Xingkai Hao,Chi Gao,Peiji Yang,Yuhao Wen,Wen Chen,Yuanjie Wu,Shenye Qian,Yibin Ying,Lizhou Xu
Compact MFMV-SCC integrates staining, antifouling channels, and vision counting. • G6.5-COOH channels reduce fouling and visible bubbles during raw-milk flow. • MV-FCC-PCM mitigates high-SCC undercounting from connected cell contours. • SCC is quantified in 2 min over 39–1106 × 10 3 cells/mL, with an LOD of 51 × 10 3 cells/mL. • Validation supports portable, low-cost, field-oriented SCC screening. Somatic cell count (SCC) is a key indicator of milk quality and udder health, with elevated SCC levels linked to mastitis and economic losses in the dairy industry. However, rapid SCC analysis in raw cow milk remains challenging because staining efficiency, microchannel fouling, bubble-induced imaging interference, and undercounting of clustered cells can affect analytical performance. Here, we report a miniaturized microfluidics-fluorescence machine-vision platform for rapid, high-accuracy SCC analysis in raw cow milk. The platform integrates an optimized SYBR GOLD-based rapid staining protocol, G6.5-COOH-modified microchannels that reduced protein adsorption, somatic-cell adhesion, and visible bubble interference, and a rule-based cluster-aware image-analysis algorithm, termed the Machine Vision-based Fluorescent Cell-Cluster Precise Counting Method (MV-FCC-PCM), for quantifying connected fluorescent cell contours. Under the optimized image-processing conditions, MV-FCC-PCM achieved a counting accuracy of 98.11% ± 0.80% against manual counting for high-density fluorescent cell images. The system enables frame-based fluorescence detection and automated SCC quantification within 2 min per sample. It provides a quantification range from 39 × 10 3 to 1106 × 10 3 cells/mL and achieves a limit of detection (LOD) of 51 × 10 3 cells/mL. Validation using certified reference materials and 58 field-collected individual Holstein cow milk samples showed close agreement with reference methods, good reproducibility, and robust performance against selected milk-matrix interferents. Overall, this integrated platform provides a compact workflow for rapid raw cow milk SCC screening and supports further validation for on-site milk-quality monitoring.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
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IF 12.5
Naseer Ahmad,Muhammad Jamshed,Mansoor Ahmad,Neha,Bei Wang,Siew Ling Lee,Wei Sun
CoO/g-C 3 N 4 shows marginal improvement in PLA microplastic degradation. • CoO modification narrows the distribution of low-molecular-weight oxygenated products. • A lactate/lactic-acid-type product is tentatively identified as a key intermediate. • O 2 • ˉ is confirmed as the dominant reactive species during photocatalysis. Polylactic acid (PLA) microplastic endures in the environment despite the biodegradable nature of PLA, requiring effective methods for conversion under mild conditions. In this work, a CoO/g-C 3 N 4 composite was synthesized by a wet impregnation-calcination method and evaluated for UV-driven photocatalytic conversion of PLA microplastics. A loading-screening study identified the nominal 0.53 wt% CoO/g-C 3 N 4 composite as the best-performing composition among the tested loadings, and ICP analysis confirmed an elemental Co content of 0.4170 wt%, close to the theoretical value of 0.4168 wt%. Replicated photocatalytic tests showed apparent conversions of 14.50 ± 0.06%, 56.07 ± 0.72%, 65.46 ± 0.27%, and 69.68 ± 0.65%, after 100 min for UV only, CoO, g-C 3 N 4 , and CoO/g-C 3 N 4 , respectively. The corresponding apparent pseudo-first-order rate constant for CoO/g-C 3 N 4 was 0.01153 ± 0.00021 min −1 . The recyclability experiment showed that the catalyst retained 92.02% of its initial apparent conversion after four cycles, and ICP-MS analysis of the final-cycle filtrate showed a trace Co concentration of 0.083 μg/L. Radical-trapping and electron paramagnetic resonance analysis suggested that O 2 • ˉ was the dominant reactive species, whereas • OH and h + provided secondary contributions. Product analysis by total organic carbon, high-performance liquid chromatography, liquid chromatography-mass spectrometry, and pyrolysis-gas chromatography/mass spectrometry suggested that CoO/g-C 3 N 4 composite promoted a narrower distribution of low-molecular-weight oxygenated products compared with pristine g-C 3 N 4 . Additional LC/MS analysis using an authentic lactic acid standard and a lactic acid-spiked PLA sample supported the assignment of the m / z 89.02 product signal to lactic-acid/lactate-type species. These results indicate that CoO modification influences both the apparent conversion and the product distribution during UV-driven photocatalytic PLA transformation. Download: Download high-res image (156KB) Download: Download full-size image
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Zhicheng Wang,Xin Shi,Zizhen Peng,Wenzhong Ma,Yakai Lin,Hideto Matsuyama,Qiuyan Bi
A SISAIP strategy was developed to regulate interfacial PA formation. • SDS/NaCl regulation produced ultrathin PA layers with sub-nanometer pathways. • The membrane achieved S Li, Mg of 90.9 and permeance of 9.5 L m −2 h −1 bar −1 . • Stable operation and strong flux recovery were obtained under brine-relevant tests. The rapidly increasing global demand for lithium has stimulated the development of advanced membrane technologies for lithium extraction from salt-lake brines. Nanofiltration (NF) membranes with precisely regulated subnanometer transport pathways are highly attractive for Li + /Mg 2+ separation; however, the rational construction of selective layers that simultaneously deliver high ion selectivity and fast water transport remains challenging. Herein, we report a scalable surfactant–inorganic salt–assisted interfacial polymerization (IP) strategy, termed SISAIP, to fabricate high-performance polyamide NF membranes. Interfacial tension, dynamic light scattering, and UV–vis analyses indicated that sodium dodecyl sulfate enriched at the water/oil interface and regulated PEI transport across the interface, whereas NaCl modified the aqueous-phase microenvironment, moderated PEI diffusion toward the interface, and helped confine the interfacial reaction zone. This coordinated regulation produced an ultrathin PA selective layer with an apparent thickness of 11.2 ± 0.6 nm and compact subnanometer transport pathways. The optimized membrane achieved a water permeance of 9.5 L·m −2 ·h −1 ·bar −1 , an S Li,Mg of 90.9, and Mg 2+ rejection above 99.5%, corresponding to 578.6% and 437.9% increases in water permeance and S Li,Mg over the control T-IP membrane, respectively. The membrane also maintained stable performance during 120 h of continuous filtration and exhibited favorable fouling/scaling resistance, with a flux recovery ratio of 100% under organic-conditioned CaSO 4 scaling conditions. This SISAIP strategy provides a promising and scalable route for designing advanced NF membranes toward efficient lithium recovery from salt-lake brines.
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高影响因子
危险品化学品经营许可证（带存储）