BIOMATERIALS
·
2019
·
IF 10.273
Tao Sun,Guangping Zhang,Qingbing Wang,Zhongyuan Guo,Qinjun Chen,Xinli Chen,Yifei Lu,Yu Zhang,Yujie Zhang,Qin Guo,Xiang Gao,Yongzhong Cheng,Chen Jiang
Real-time monitor of drug-release from drug formulations in a noninvasive way can provide spatio-temporal information for drug activation and guide further clinical rational administration. In this work, a molecular shuttle, as a typical nanosized artificial molecular machine, was managed to act as a conceptually-new nanotheranostics for oxaliplatin. A post-recognition strategy was utilized, where a default supramolecular-dye couple was pre-blocked. The rational design, synthesis, characterization and proof-of-concept of this strategy were described in detail. The drug-release upon reducing environment can be translated into near-infrared (NIR) fluorescence signal (OFF-to-ON), allowing to track the drug-release procedure by multi-modal images including IVIS, FLECT and photoacoustic imaging. The versatile nanotheranostics system can target to triple negative breast tumor via conjugated F3 peptide, and show an improved anti-tumor efficacy with much lower side effect. The intelligent nanotheranostics system based on molecular shuttle provides new reference for precision medicine in preclinical trial and postclinical evaluation.
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DOI
PubMed
高影响因子
ACS Omega
·
2020
·
IF 2.87
Xinming Feng,Jing Guo,Rubing Zhang,Wei Liu,Yujin Cao,Mo Xian,Huizhou Liu
An aminotransferase ω-TAEn was identified from Enhydrobacter aerosaccus. The ω-TAEn was successfully expressed in Escherichia coli and the obtained enzyme showed activity toward β-phenylalanine (β-phe) at optimal conditions. For optically pure (R)-β-phe, 50% yield was observed by kinetic resolution of racemic amino with pyruvate as the amino acceptor. To obtain (S)-β-phe, the lipase/ω-TAEn catalytic system was adopted. The ω-TAEn showed strict stereoselectivity to the amino donor. The formation of (S)-β-phe was observed using 3-aminobutyric acid as the amino donor, and (S)-β-phe was obtained by asymmetric synthesis with a yield of 82%.
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DOI
PubMed
高影响因子
MOLECULAR PHARMACEUTICS
·
2018
·
IF 4.556
Hui Liu,Yuxiang Han,Jiyuan Li,Ming Qin,Qunfeng Fu,Chunhong Wang,Zhibo Liu
Amino acids derivative are well established molecular probes for diagnosis of a variety of cancer using positron emission tomography (PET). Recently, boramino acid (BAAs) was found as a prospective molecular platform for developing PET tracer. The objective of this study was to develop a 18F-labeled alanine derivative through displacing its carboxylate by trifluoroborate as a selective ASCT2 marker for cancer imaging. 18F-Ala-BF3 was first evaluated in healthy FVB/N mice in vivo, exhibiting rapid renal clearance with almost negligible uptake in stomach (1.53 ± 0.31%ID/g). Notable uptake was observed in thyroid (3.71 ± 0.49%ID/g, 40 min post injection), of which the uptake was significantly inhibited by co-injection with natural L-alanine. In addition, we further established 18F-Ala-BF3 on a human gastric cancer cell (BGC-823) xenografts bearing mouse model. Dynamic PET-CT scan revealed the optimal time window for tumor imaging, it was between 40 and 60 min post injection, when the BGC-823 xenografts uptake was 5.49 ± 1.47%ID/g (n = 4), and the tumor-to-stomach, tumor-to-blood, tumor-to-muscle, and tumor-to-brain ratios were 3.27 ± 1.53, 3.80 ± 1.48, 3.47 ± 1.48, and 6.20 ± 1.47, respectively.
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DOI
PubMed
高影响因子
JOURNAL OF COASTAL RESEARCH
·
2020
·
IF 0.793
Gao Nan,Kong Xiangfeng,Lv Hongmin,Sun Zhongliang,Liu Yan
Gao, N.; Kong, X.; Lv, H.; Sun, Z., and Liu, Y., 2020. An effective fluorescent probe method applied in the analysis of microplastics. In: Liu, X. and Zhao, L. (eds.), Today's Modern Coastal Society: Technical and Sociological Aspects of Coastal Research. Journal of Coastal Research , Special Issue No. 111, pp. 70–77. Coconut Creek (Florida), ISSN 0749-0208. Microplastic pollution has received global attention because of the durable hazards it brings to the environment. Methods used to analyze microplastics are mainly limited by laboratory conditions, instruments, and labor. This study investigated a method to analyze microplastics, and in situ verification was carried out to prove the feasibility of the technique. The method employed the fluorescent probe Nile red, followed by identification with Raman spectroscopy. Six kinds of common polymers were tested to verify the optimal operating condition of the technique. Possible fluorescence interference that obscured the Raman signal was excluded through verification of the Laman spectrum. Using this method, four kinds of polymers were found in Qingdao coastal waters, and the size of microplastics was confirmed. The results demonstrate that the fluorescent probe technique may offer considerable application in further monitoring studies to obtain reliable microplastic data.
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高影响因子
Plasma Processes and Polymers
·
2017
·Vol. 15
·期 4
·1700176
·
IF 2.846
Lei Wang,Jinxiu Wang,Junxin Lin,Songlin Zhang,Yongjun Liu
Degradation of metronidazole (MNZ) by radio frequency discharge in water was examined. Results showed that • OH, H • , and • O were produced. Decay of MNZ followed pseudo-first order kinetics, where the apparent rate constant was independent of its initial concentration in the range 0–0.5 mM, decreased in the range 0.5–1.0 mM, and leveled off in the range higher than 1.0 mM. pH had no effects on MNZ degradation. • OH scavengers enhanced the MNZ removal. Formic acid, nitrite ion, oxalic acid, nitrate ion, and acetic acid were determined as the primary intermediate byproducts. The eventual products were ammonia and inorganic carbon. Both • OH and H • participated in the MNZ degradation. H • played more efficient role than • OH in the early stage.
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DOI
高影响因子
Frontiers of Physics
·
2015
·Vol. 11
·期 2
·1-5
·
IF 2.086
Zhang Xin-Fang,Zhang Zheng-Wei,He Yan-Lan,Liu Yi-Xing,Li Shuang,Fang Jing-Yue,Zhang Xue-Ao,Peng Gang
Decane is one of the volatile organic compounds (VOCs) in human breath. Successful detection of decane in human breath has vast prospects for early lung cancer diagnosis. In this paper, a novel detecting device based on a filter surface acoustic wave (SAW) gas sensor is presented. SAW sensors coated with a thin oxidized graphene film were used to detect decane in parts per million (ppm) concentrations. Control and signal detection circuits were designed using a vector network analyzer with a detection resolution of insertion loss down to 0.0001 dB. The results showed that the SAW sensor could respond quickly with great sensitivity when exposed to 0.2 ppm decane. This device shows tremendous potential in medical diagnosis and environmental assessment.
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高影响因子
ANALYTICAL SCIENCES
·
2017
·Vol. 33
·期 1
·105-110
·
IF 1.228
Li Yan,Guo Ran,Liu Shengnan,He Anqi,Bao Yanan,Weng Shifu,Huang Yaping,Xu Yizhuang,Ozaki Yukihiro,Noda Isao,Wu Jinguang
In this study, the feasibility of using copper oxide (CuO) as an interface for the coupling of liquid chromatography (LC) and Fourier-transform infrared (FTIR) spectroscopy was investigated. CuO exhibits low absorption in the 4000 to 1000 cm −1 FTIR spectral region. In addition, LC-FTIR using CuO as the interface was extended to the analysis of sample mixtures containing benzamide and dioctyl sebacate; both analytes were successfully separated. After complete removal of (he mobile phase, benzamide and dioctyl sebacate were successfully identified from the FTIR spectrum. Surprisingly, the interference from adsorbed water or conventionally used LC solvents in the FTIR spectrum was completely eliminated by using CuO particles as the interface in the off-line hyphenation of LC-FTIR. Based on these results. CuO demonstrates potential as an ideal interface for LC-FTIR analysis.
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DOI
PubMed
高影响因子
TRANSITION METAL CHEMISTRY
·
2019
·Vol. 44
·期 8
·689-697
·
IF 1.016
Jin Di,Wang Bowei,Wu Xingchun,Li Jiayi,Mu Manman,Chen Ligong
Functionalization of covalent organic frameworks (COFs) with specific groups will endow them special characteristics, and further complexation with transition metals may improve their catalytic performance and widen their applications. Herein, we constructed an amino-functionalized covalent organic framework TpPa–NH 2 by the facile reduction in TpPa–NO 2 and took it as a carrier for transition metal ion Cu(II) to yield a hybrid Cu–COF. All characterizations verified that the crystallinity and porosity of original COF were retained after functionalization. Subsequent evaluation of their catalytic performance indicated that the framework TpPa–NH 2 has potential application in alkali-catalyzed reactions, while the hybrid Cu–COF displayed satisfactory catalytic performance both in selective oxidation of styrene and the reduction in 4-nitrophenol to 4-aminophenol. The above results demonstrated that TpPa–NH 2 is a promising platform with diverse applications, and the introduction of Cu(II) will endow the material with more potential applications in oxidation and reduction reactions.
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高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2019
·
IF 3.131
Jing Wang,Mingying Yu,Cheng Yang
Colloidal inorganic nanoparticles featured with ultrasmall sizes and near-neutral surface wettability are considered as efficient emulsifiers to stabilize Pickering emulsions . Herein, we demonstrated that colloidal TiO 2 nanoparticles synthesized by the well-established sol-gel approach using Ti(OC 4 H 9 ) 4 as precursor, could be directly used as an efficient Pickering emulsifier without any other additives. The sol-gel TiO 2 nanoparticles showed near-neutral wettability at the oil-water interface (θ ow ˜90°) derived from the surface residual butanol-related species as revealed by TGA/DTA and FT-IR analyses, which should be responsible for the formation of Pickering emulsion with ultrahigh stability. The Pickering emulsions stabilized by size-tunable TiO 2 nanoparticles under various emulsification conditions were characterized by photography, optical microscopy and rheology measurements. The results suggested that the droplet sizes and rheology properties of the emulsion could be adjusted by tuning the TiO 2 nanoparticle sizes. Moreover, as a potential application, we also demonstrated the simple fabrication of TiO 2 -coated silicone elastic hybrid microspheres through the Pickering emulsion templated polymerization. The present work demonstrated that sol-gel TiO 2 nanoparticles could serve as efficient particle emulsifiers for achieving stable emulsions, and may also extend the wide application of colloidal TiO 2 nanoparticles based on the Pickering emulsion platforms.
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高影响因子
Electrocatalysis
·
2021
·Vol. 12
·期 4
·456-468
·
IF 2.713
Huang Dihui,Huang Xiaozhou,Chen Jinyang,Ye Ruihong,Lin Qian,Chen Sheng
This work constructed a new-type bisphenol A (BPA) electrochemical sensor on the basis of self-assembled multi-layer strategy of Ce-Zn-metal organic framework/multiwall carbon nanotube (Ce-Zn-MOF/MWCNT)–modified glassy carbon electrodes (GCE). The novel bimetallic Ce-Zn-MOF are synthesized by 1,3,5-benzenetricarboxylic acid (H 3 BTC) as the ligand via a hydrothermal approach. Bimetallic Ce-Zn-MOF with multiple catalytic sites and ultra-high specific surface area introduces traditional electrode modification materials, which improves the conductivity and catalytic ability of MWCNTs. Field emission scanning electron microscopy, transmission electron microscope and Powder X-ray diffraction were performed to analyze the Ce-Zn-MOF/MWCNTs. The electrochemical property was researched utilize differential pulse voltammetry (DPV), cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). In the optimum conditions, the proposed sensor exhibited a wider dynamic linear range of BPA determination in 0.1 to 100 μmol·L −1 with a detection limit of 7.2 nmol·L −1 ( S / N = 3). This measurement of BPA was successfully used for drinking water with desirable recovery from 96.5 to 103.4%. Graphical Abstract
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高影响因子
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2013
·Vol. 161
·期 1
·B9
·
IF 2.588
Weimeng Si,Zhen Han,Wu Lei,Qiuju Wu,Yuehua Zhang,Mingzhu Xia,Qingli Hao
A fast and sensitive method for the determination of Imidacloprid (IMI) based on a simply pretreated glassy carbon electrode (GCE) has been developed. The easy activation at 2.0 V for only 30s of GCE leads to obvious catalytic property to IMI. The electrocatalytic properties and the electron-transfer kinetics of the activated GCE were investigated by cyclic voltammetry, differential pulse voltammetry and electrochemical impedance spectroscopy. The reduction mechanism of IMI was put forward and the limit of detection (LoD) was estimated to be about 0.61 μM.
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高影响因子
DALTON TRANSACTIONS
·
2021
·Vol. 50
·期 24
·8314-8321
·
IF 4.39
Qianqian Yang,Yijie Wang,Jianjian Yang,Jianbo Yin,Di Liu,Ning Liu,Rongming Wang,Daofeng Sun,Xiyou Li,Jianzhuang Jiang
Effective and selective removal of radioactive metal ions from aqueous solutions is of great importance due to their harmful effects on humans and other living species. However, it is a big challenge for researchers to develop effective adsorbents with high selectivity and a wide pH application range even if some progress has been achieved. Herein, we report an anionic potassium organic framework (UPC-K1) with protonated dimethylamine (Me2NH2+) residing inside the rhomboid channels. The unique 3D firm structure of UPC-K1 is constructed by the cross-linking of the 2D arrangement using weak K–O bonds (2.9270 Å) and strong hydrogen bonds (1.6498 Å), which endows it with excellent chemical stability in organic solvents, boiling water, and aqueous solution in the pH range 3–10. Based on the cation exchange, depending on pore size selectivity, UPC-K1 shows excellent adsorption performance towards UO22+ in aqueous solutions at 298 K with the following characteristics: (1) effective removal in the pH range 3–10; (2) high selectivity over other metal cations; (3) a high adsorption capacity of 551.4 mg g−1; (4) a rapid adsorption equilibrium within 3 hours under stirring; and (5) effective adsorption at low concentrations, with a residual concentration of 0.69 ppm even at an initial concentration of 10.3 ppm after stirring for 24 hours. These results indicate the great potential of UPC-K1 in the treatment of uranium-containing nuclear wastewater.
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高影响因子
危险品化学品经营许可证（带存储）