INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Sawsan Dacrory
3D multifunctional scaffold has been designed based on Cs/SA/NS/NPHA. Nanoparticles hydroxyapatite (NPHA) was prepared via precipitation method of sodium dihydrogen phosphate in presence calcium chloride . Different ratios of Chitosan (CS)/Sodium Alginate (SA) were used to prepare Cs/SA scaffolds in presence of CaCl 2 as a cross linker . NPHA was incorporated in CS/SA scaffold and neomycin sulfate (NS) was added as an antimicrobial agent. The structure and surface morphology of the scaffolds were investigated via infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscope (SEM) and thermal gravimetric analysis (TGA) techniques. Additionally, Antimicrobial activity of the scaffold has evaluated against Gram- negative and Gram- positive bacteria. The result showed promising antimicrobial activity against Bacillus subtilis , Staphylococcus aureus , Escherichia coli , Pseudomonas aeruginosa and Candida albicans . Furthermore, cytotoxicity against MG63 osteosarcoma cell and fibroblast normal cell line has investigated. The result showed anti-proliferative against MG63. DFT calculations and molecular docking were used to study the reactivity of the compounds. The results exhibited that Cs/SA/NS/NPHA is potent expected to be used in bone tissue regeneration .
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Gels
·
2024
·Vol. 10
·期 4
·258
·
IF 5
Mingyang Li,Yanen Wang,Qinghua Wei,Juan Zhang,Xiaohu Chen,Yalong An
Hydrogels with excellent flexibility, conductivity, and controllable mechanical properties are the current research hotspots in the field of biomaterial sensors. However, it is difficult for hydrogel sensors to regain their original function after being damaged, which limits their practical applications. Herein, a composite hydrogel (named SPBC) of poly(vinyl alcohol) (PVA)/sodium alginate (SA)/cellulose nanofibers (CNFs)/sodium borate tetrahydrate was synthesized, which has good self-healing, electrical conductivity, and excellent mechanical properties. The SPBC0.3 hydrogel demonstrates rapid self-healing (<30 s) and achieves mechanical properties of 33.92 kPa. Additionally, it exhibits high tensile strain performance (4000%). The abundant internal ions and functional groups of SPBC hydrogels provide support for the good electrical conductivity (0.62 S/cm) and electrical response properties. In addition, the SPBC hydrogel can be attached to surfaces such as fingers and wrists to monitor human movements in real time, and its good rheological property supports three-dimensional (3D) printing molding methods. In summary, this study successfully prepared a self-healing, conductive, printable, and mechanically superior SPBC hydrogel. Its suitability for 3D-printing personalized fabrication and outstanding sensor properties makes it a useful reference for hydrogels in wearable devices and human motion monitoring.
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CARBOHYDRATE POLYMERS
·
2025
·
IF 12.5
Xiang Zhao,Wei Xue,Weixiao Ding,Yalei Qiao,Xuehui Chu,Yudong Qiu,Min Tang,Dongping Sun,Xiao Fu
Type 1 diabetes mellitus (T1DM) are characterized by blood glucose elevation with pancreatic β cells deficiency. As a safe alternative to frequent subcutaneous insulin injection, pancreatic β cell transplantation provides a promising therapeutic option for blood glucose control in T1DM. However, pancreatic β cell transplantation faces intractable challenges of the poor viability and severe host immune rejection. Therefore, a novel approach capable of improving the poor oxygen/nutrients supply and severe host immune rejection is highly desired. Herein, a novel biohybrid artificial pancreas, presenting glucose-dependent insulin release behavior, is constructed via pancreatic β cells encapsulating in a hydrogel scaffold. The hydrogel scaffold is made of the commixture of sodium alginate (SA), chitosan (CS) and sulfated bacterial cellulose (SBC). The biocompatible three-dimensional (3D) hydrogels protected pancreatic β cells from immune response but also allowed the exchange of nutrients and insulin. As a result of the synergistic effect, the biohybrid artificial pancreas can reverse the hyperglycemia and achieve sustained glycemic control for at least 30 days in diabetic mice. Collectively, we consider that this biohybrid artificial pancreas with an elaborate structure could provide an effective option for the treatment of type 1 diabetes.
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CARBOHYDRATE POLYMERS
·
2024
·
IF 10.7
Yingge Shi,Xuyuan Yang,Yongqiang Zhang,Siyu Lu
Soft actuators for intelligent robots require further elaboration to improve their biomedical applicability, which has led to the development of a series of flexible stimulus-responsive materials. However, fabricating degradable soft actuators that exhibit synergistic color and shape changes in response to environmental stimuli remains challenging. Here, we developed a soft actuating gel based on carbon dots (CDs) that are chemically cross-linked with sodium alginate. The soft actuating gel exhibits rapid synergistic changes in color and shape in response to pH owing to CDs protonation and deprotonation. Soft actuators constructed using the gel and poly (lactic acid) tape not only perform actions, such as grasping and lifting, but also camouflage and warn through self-color changes. The combination of pH-responsive CDs and degradable polymers provides a simple strategy for fabricating degradable soft actuators that exhibit synergistic changes in color and shape, and is expected to promote further research into soft actuators.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Fang Kou,Weihao Wang,Sangguan You,Xuetuan Wei,Xian Wu
A novel encapsulation system was designed, utilizing sodium alginate (SA) polysaccharide as the matrix and easily absorbed Fe 2+ as the metal-organic framework, to construct microbead scaffolds with both high catechins (CA) and vitamin C (Vc) loading and antioxidant properties. The structure of microbead hydrocolloids was investigated using SEM, XPS, FTIR, XRD and thermogravimetry, and the antioxidant activity , in vitro digestion and the release of CA and Vc were evaluated. These results revealed that the microbead hydrocolloids SA-CA-Fe and SA-CA-Vc-Fe exhibited denser and stronger cross-linking structures, and the formation of inter- and intramolecular hydrogen and coordination bonds improved thermal stability . Moreover, SA-CA-Fe (44.9 % DPPH and 47.8 % ABTS) and SA-CA-Vc-Fe (89.9 % DPPH and 89.3 % ABTS) displayed strong antioxidant activity . Importantly, they were non-toxic in Caco2 cells. The SA-CA-Fe and SA-CA-Vc-Fe achieved significantly higher CA (56.9 and 62.7 %, respectively) and Vc (42.2 %) encapsulation efficiency while maintaining higher CA and Vc release in small intestinal environment. These results suggested that SA polysaccharide-based encapsulation system using Fe 2+ framework as scaffold had greater potential for delivery and controlled release of CA and Vc than conventional hydrocolloids, which could provide new insights into the construction of high loading, safe, targeted polyphenol delivery system.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Yaowei Wu,Zuming Jiang,Yuhao Wang,Xiancai Jiang,Jian Hou,Bei Wei
Poly(acrylamide) (PAM) has excellent thickening ability as a conventional flooding agent. However, PAM confronts the problems of high injection pressure and high shear loss in the process of oil extraction, which have limited its application in this field. In this work, 2, 2, 6, 6-Tetramethylpiperidinooxy oxidized cellulose nanofibers (TOCNFs) enhanced sodium alginate (SA) shell was used to encapsulate PAM to form microcapsule. The composition, morphology, structure and the releasing behaviours of TOCNFs enhanced microcapsules was tested. Mechanical stirring was used to simulate the state of polymer subjected to shear during stratigraphic transport. The release performance of the microcapsules was characterized by measuring the change of viscosity with time. The ratio of the shell material with the best performance was explored, and the enhancement mechanism of the SA shell by TOCNFs was discussed. The experiments showed that the release time of PAM from the microcapsules was significantly prolonged with the addition of TOCNFs. The longest release time was observed when the ratio of SA and TOCNFs was 5: 1, with the release time of the microcapsules from the original 8 h to 16 h. The enhanced shear resistance of the microcapsules was attributed to the semi-interpenetrating network structure of SA and TOCNFs via Ca 2+ cross-linking as well as hydrogen bonding. The prepared microcapsules have promising applications in enhancing oil recovery.
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CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Xingyu Zhan,Zhilong Zhang,Jie Lin,Jingcai Xu,Xinqing Wang,Bo Hong,Yingchun Xia,Yunxiong Zeng
Degradation of ciprofloxacin (CIP) in water by photocatalysis using metal-free carbon nitride (CN) is an effective route. Here, we rationally adopt a “kill two birds with one stone” strategy to prepare N-vacancy (V N ) and O-doping co-modified CN (V N -OCN 2.0 ) by a one-pot sintering process, wherein surface atomic microenvironment is judiciously reconfigured. V N -OCN 2.0 accomplishes 100 % CIP removal within 12 min with a 69.5-fold higher pseudo-first-order kinetic constant than CN. Furthermore, V N -OCN 2.0 generates an ultra-high concentration of reactive oxygen species (ROSs), which is 113.4 times higher than CN. Such excellent activity is attributed to a synergistic effect of V N as electron-rich centers and O-doping as reaction active centers. Simultaneously, V N -OCN 2.0 integrated sodium alginate hydrogel (V N -OCN 2.0 /SAG) can remove 100 % CIP without decay after 20 cycles. In addition, photodegradation pathways and biotoxicity are investigated by HPLC-MS, quantitative mathematical modeling of conformational relationships, and in vitro E. coli culture experiments. This study enriches a precise rearrangement of surface atoms, elucidates its collaborative functions in facilitating the efficient generation of ROSs and profound mineralization of antibiotics, and integrates SAG to tackle engineering challenges related to secondary pollution and intricate recycling of powder catalysts.
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JOURNAL OF POLYMER RESEARCH
·
2025
·Vol. 32
·期 9
·1-11
·
IF 2.8
Liu Xiang,Deng Yuxin,Wang Ping,Tang Hongyu,Li Shuangqing,Xing Zheng
The utilization of hydrogels in the domain of flexible capacitors (FCs) and multifunctional sensors (MSs) has attained considerable prevalence. However, balancing the various properties of such versatile hydrogels remains a major challenge. In the present study, a novel xIL/PAM/SA dual-network hydrogel composed of polyacrylamide/sodium alginate (PAM/SA) and an ionic liquid (IL) 1-Butyl-3-methylimidazolium hydroxide ([BMIM][OH]) is proposed. The OH − in the IL inhibits the protonation of -NH 2 groups on the polymer chain and avoids the reduction of the number of hydrogen bonds in the system due to the formation of -NH 3+ , thus enhancing the strength of the network. The results showed that the series of tough hydrogels had high tensile strength (386.64 kPa), elongation at break (338.16%), and toughness (670.83 kJ/m 3 ). Moreover, the rich functionality such as capacitive performance (198.5 mF/cm 2 ), water retention performance (LR = 25.4%), temperature sensitivity (GF = 2.12), and strain sensitivity (GF = 4.56), make it have broad application potential. This work improves the traditional dual-network hydrogels by ionic liquids (ILs) and provides a feasible idea for the design of multi-functional tough conductive hydrogels.
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CARBOHYDRATE POLYMERS
·
2025
·
IF 12.5
Ying-Ying Jing,Yun-Cheng Li,Yong-Qi Luo,Long-Hua Zou,Yuan-Mou Tang,Yu-Xi Lin,Fan-Bing Meng
To investigate the effects of gum incorporation on the performance of sodium alginate (SA)-based composite hydrogel beads (CHBs) in protecting Limosilactobacillus fermentum , gum arabic, κ-carrageenan, low methoxyl pectin, konjac glucomannan (KGM), low acyl gellan gum, and xanthan gum were compounded with SA to prepare CHBs of A-A, C-A, P-A, K-A, G-A and X-A, respectively. The encapsulation efficiency of CHBs for L. fermentum ranged from 80 % to 100 %, with P-A and X-A showing the greatest encapsulation efficiencies of 94.6 % and 99.3 %, respectively. P-A had the highest L. fermentum survival rate of 8.1 log CFU/g, and the leakage rates of A-A, C-A, P-A, and K-A compared to SA hydrogel beads were 85.74 %, 70.06 %, 87.49 %, and 87.66 %, respectively. Gum incorporation improved the water retention capacity and reducing hardness. Rheological analysis revealed that the addition of gum arabica, κ-carrageenan, and gellan gum increased the critical strain of hydrogel, xanthan gum and KGM reduced the γ C , whereas low methoxyl pectin had no effect on γ C . The introduction of L. fermentum changed the hydrogel properties and increased elasticity, suggesting probiotics might positively influence the hydrogel network. The comprehensive analysis revealed that the CHBs incorporated low methoxyl pectin with SA provided the best protection for L. fermentum .
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Shuai Yan,Junsheng Wang,Hanxu Zhou,Hua Yuan,Cong Du,Yeqiang Tan
Biomass xerogels with porous structures fabricated in ambient conditions possess great advantages including scalability, biocompatibility, and biodegradability, thus have shown demonstrated potential in various fields. However, disadvantages such as poor moisture resistance, poor mechanical properties, and low production efficiency challenge their practical applications. In this study, microfibers self-assembled from sodium alginate and chitosan are adopted to facilely fabricate biomass porous xerogel membranes with a fast one-step solvent-exchange, which is achieved due to the low crystallinity and small aspect ratio of the microfibers. The structure and properties of the membranes are found closely related to the surface tension of the solvent used for solvent exchange. The xerogel membrane prepared by one-step solvent-exchange to ethanol followed ambient drying exhibits a pore size of ~100 nm, porosity of 71.2 %, tensile strength of 11 MPa, and elongation at break of 7.5 %. The low roughness and high hydrophilicity of the xerogel membrane guarantee its usage as filtration and adsorption membranes. The particle rejection efficiency of the membrane reaches 99.9 % and adsorption capacity of the membrane for methyl blue solution is 43.94 mg/g. This novel strategy using microfibers prepared by the bottom-up method paves the way for the scalable fabrication and wildly application of biomass xerogels.
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Journal of Bioresources and Bioproducts
·
2025
·
IF 13
Fengfan Zhu,Huanhui Zhan,Chenfei Wang,Bo Fu,Jiancheng Zhou
In response to the growing demand for sustainable thermal management solutions, this study developed an eco-friendly flame-retardant aerogel through a green manufacturing process that incorporates bio-derived phosphorylated chitosan (PCS) into a sodium alginate (SA) matrix. The strategic incorporation of PCS, synthesized from renewable chitin resources, significantly enhanced the interfacial compatibility and thermal stability of the composite material while introducing a phosphorus-nitrogen synergistic flame-retardant mechanism. Systematic characterization revealed that the sodium alginate mixed with 30% that mass of phosphorylated chitosan (SA-30 PCS) exhibits exceptional fire safety performance, achieving a limiting oxygen index (LOI) of 33.7% and a V-0 rating in the vertical burning test (Underwriters Laboratories Standard 94), which indicates the highest level of flame resistance. Additionally, this formulation shows a 45% reduction in total heat release compared to pristine SA aerogels. The composite maintains low thermal conductivity (0.035 0 W/(m·K)), fulfilling dual requirements for high-temperature insulation and fire protection. A sustainable hydrophobic modification strategy employing methyltrichlorosilane vapor deposition further endowed the aerogel with moisture resistance. As a wholly biomass-derived system (SA/PCS), the aerogel eliminates persistent toxic residues associated with halogenated flame retardants, while its phosphorus components are covalently bonded in polymeric chains, significantly reducing environmental mobility compared to inorganic phosphates. The inherent biopolymer composition enables potential end-of-life management via enzymatic digestion (e.g., chitinase/alginate lyase), positioning it as an eco-design alternative for sustainable insulation.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Shurui Chen,Haonan Wang,Panting Ren,Ruiyun You,Qingqiang Lin,Yudong Lu
In this study, a surface-enhanced Raman scattering (SERS) substrate based on oxidized sodium alginate (OSA)-modified silver nanoparticles (Ag NPs) was developed for the highly sensitive detection of urine biomarkers. Compared to conventional citrate-reduced Ag NPs, the OSA-Ag NPs eliminate the need for additional reducing agents, offering cost-effectiveness and alignment with green chemistry principles. OSA acts as both a stabilizer and a binding site for Ag NPs, enabling uniform nanoparticle distribution and enhanced substrate robustness. This modification significantly improves the substrate's high-salinity stability, sensitivity, and reproducibility. Furthermore, the OSA-Ag NPs substrate exhibited remarkable storage stability, maintaining 92.49 % SERS intensity after 50 days under ambient conditions, which outperforms traditional Ag colloid substrates. The OSA-Ag NPs exhibited detection limits as low as 1.9 × 10 −4 M for urea, 2.4 × 10 −7 M for creatinine, and 2.7 × 10 −7 M for bilirubin, demonstrating high sensitivity and a wide linear range. In artificial urine, the OSA-Ag NPs with high accuracy and repeatability, confirming their practical utility. These results highlight the OSA-Ag NPs substrate as a promising tool for urine biomarker detection, particularly in high-salinity environments. Its ability to maintain performance in complex biological matrices suggests potential for rapid and precise diagnostics, advancing the field of biosensing.
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