AQUACULTURE INTERNATIONAL
·
2025
·Vol. 33
·期 6
·1-17
·
IF 2.4
Wang Jingjing,Guo Meijie,Mei Jun,Xie Jing
Nitrite is a prevalent environmental contaminant in the natural water domain and poses a significant threat to fish populations due to its toxic effects. The aim of the study was to investigate the impact of nitrite concentration on cell apoptosis, oxidation reaction mechanism, and immune pathway of sea bass during simulated live transport. Fish were exposed to nitrite concentrations of 0, 15.05, and 30.11 mg/L for 48 h, respectively. Blood and liver samples were collected at intervals of 0, 12, 24, 36, 48, R12, and R24 h post-exposure to assess hematological parameters, oxidative stress indicators, immunological enzyme activities, and gene expression levels. The results indicated that the nitrite-exposed group had lower serum levels of LZM and IgM compared to the CK group. The SOD, CAT, and GSH-Px enzyme activities were significantly elevated in the livers of the nitrite-exposed group ( p < 0.05). The mRNA expression level of Nrf2 was upregulated in the nitrite-exposed group, while Keap1 was downregulated. The mRNA relative expression levels of NF-κB , TLR-3 , and TNF-α in the immune pathway were upregulated in the nitrite-exposed group. The mRNA expression of the apoptosis gene P53 was upregulated with increased nitrite concentration, along with the upregulation of the apoptosis-promoting gene Bax and the downregulation of the anti-apoptotic gene Bcl2 . The mRNA expression of Caspase 3 and Caspase 9 genes in sea bass was significantly increased in the nitrite-exposed group ( p < 0.05). In conclusion, sea bass exposed to nitrite not only showed abnormal changes in serum composition but also showed oxidative stress, apoptosis, and liver tissue damage, highlighting the multifaceted impacts of nitrite exposure on aquatic biology. Graphical The graphical abstract of the nitrite-induced toxic effect in sea bass via liver and blood. ↑: increase, ↓: decrease.
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JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
·
2025
·
IF 3.3
Li Junjie,Liu Kunyi,Kang Kaijie,Zhao Lina,Zhang Banglei,Li Lang,Huang Hai,Jiang Liwen
Fermented salt-free bamboo shoots, a traditional fermented vegetable product, are esteemed in southern China for their unique flavor and aroma. The distinctive taste of these shoots is attributed to the volatile organic compounds (VOCs) and organic acids produced during fermentation. This study explored how organic acids and VOCs change over a 60-day fermentation period. The findings revealed notable variations in pH, total sugars, and organic acids throughout the process. Utilizing GC-IMS (gas chromatography-mass spectrometry) analysis, 65 volatile organic compounds (VOCs) were detected, which comprised alcohols, aldehydes, esters, ketones, and aromatic compounds. The concentration and composition of VOCs changed significantly during the fermentation process. Esters and aldehydes were the predominant VOCs. The changes in organic acids levels were correlated with the production of specific VOCs, indicating complex interactions between organic acids and VOCs during the fermentation process. Employing correlation analysis and OPLS-DA (orthogonal partial least squares discriminant analysis), we identified 14 pivotal volatile organic compounds (VOCs) and organic acids that exert the most significant influence on the flavor profile of fermented salt-free bamboo shoots. This study provides invaluable insights for enhancing both the processing and economic potential of bamboo shoots.
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Advanced Composites and Hybrid Materials
·
2025
·Vol. 8
·期 1
·1-17
·
IF 21.8
Wang Qiuyang,Wang Lanlan,Liu Xinyun,Chen Haojun,Wang Xucai,Wang Peng,Wang Weijun,Jiang Qing
Prosthetic joint infection (PJI) presents a significant medical challenge, with current surgical and antibiotic strategies often limited by high recurrence rates, the need for multiple interventions, and rising antibiotic resistance. This study introduces vancomycin-loaded magnetic iron oxide nanoparticles (IONPs) incorporated into ZIF-8-based nanocomposites, termed Van-IONPs@ZIF-8, designed to deliver antibiotics directly to the PJI infection site under an external magnetic field (MF) for targeted antibacterial therapy. The Van-IONPs@ZIF-8 demonstrated excellent pH sensitivity, in vitro biocompatibility, and marked antibacterial efficacy against Staphylococcus aureus . When subjected to an external MF, these magnetic nanocomposites effectively localized at infection sites. In vivo results indicated that the Van-IONPs@ZIF-8 + MF treatment significantly reduced bacterial loads on implants, decreased blood leukocyte counts, and mitigated inflammatory cell infiltration in surrounding tissues compared to controls. Concurrently, a marked reduction in both the number of pro-inflammatory cells and the levels of pro-inflammatory cytokines was observed, alongside a corresponding increase in inflammatory repair cells and reparative cytokines within the local tissues surrounding the infected implants. Thus, Van-IONPs@ZIF-8, in conjunction with an external MF, facilitates precise targeting of local infection sites and promotes rapid vancomycin release, representing a promising strategy for the safe and effective treatment of PJI.
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Probiotics and Antimicrobial Proteins
·
2025
·
IF 4.4
Wu Yuehua,Liu Zhaoyi,Zhang Hongyang,Zhou Lixiao,Liang Weijuan,Su Peng,Zeng Zhijun,Zhao Feng,Qiu Jingfu,Chen Chengzhi
Obesity is a common health problem marked by the accumulation of excess body fat beyond the range characteristics of a healthy weight, affecting millions worldwide. Although advancements have been made in the realm of probiotic therapy for obesity, studies on the combined use of probiotics for the treatment of obesity have yet to be well explored. In this study, we investigated the potential of Parabacteroides goldsteinii ( P. goldsteinii ) and Bacteroides sartorii ( B. sartorii ) combinations and their microencapsulated forms for treating obesity. We identified different probiotic strains by 16S rRNA analysis in obese and healthy mice. The activity of these probiotics was evaluated in vitro under simulated gastrointestinal conditions. In vivo, the effects of probiotics on obese mice were assessed by monitoring body weight, glucose tolerance, colon integrity, and various molecular markers. Our results suggested that P. goldsteinii and B. sartorii were shown to be less abundant in obese mice ( P < 0.05). Compared with the control group mice, the obese phenotypes of the probiotics intervention group mice were significantly improved ( P < 0.05). Further results showed that compared with the control group mice, the expression of the FTO in the liver tissue of the probiotics intervention group mice was downregulated ( P < 0.05), while the expression of the Ampk gene was upregulated ( P < 0.05), indicating that probiotic intervention had reduced the expression of obesity-related genes in mice and had alleviated their obese condition. Furthermore, Microcapsule was remarkably effective in maintaining the viability of probiotics and facilitating their persistence, leading to a significant reduction in weight gain in mice compared with controls within just one week ( P < 0.05). Taken together, our study demonstrates that the intervention using the combination of P. goldsteinii and B. sartorii is more effective in treating obesity than using either probiotic alone. The encapsulation approach further enhances the anti-obesity efficacy of the combined probiotic mixture.
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POLYMER BULLETIN
·
2025
·
IF 4
Wang Ying,Ibupoto Fahim Ahmed,Li Jie
In the current study, the waste hemp fibre (HF)-reinforced sandwich-structured green laminates with biobased epoxy/benzoxazine resin were developed and subjected to simulated weathering for several sets of humidity (50–90%) and temperature (20–40 °C). Effects of each set of simulated weathering conditions on moisture absorption and mechanical and thermal properties of sandwich-structured green laminates were systematically studied. The developed laminates showed moderate mechanical and thermal properties. The findings showed gradual enhancements in moisture absorption as the humidity and temperature were increased in the simulated weathering conditions. Moreover, experimental investigation established apparent adverse effects on tensile and flexural properties; samples exposed at 40 °C and 90% humidity yielded the lowest strength and modulus values, resulting in a 23.58 and 13.59% decline in tensile and flexural strengths, respectively. The impact strength results confirmed considerable differences compared to tensile and flexural properties; the recorded value (18.23 ± 0.26 kJ/m 2 ) after exposure to the simulated weathering at 40 °C and 90% humidity was 2.71 kJ/m 2 higher than the control specimen. Thermal stability analysis was conducted in terms of initial degradation temperature (T 5 and T 10 ), char yield, limiting oxygen index, and heat resistance index (HRI) values for the control sample, which were recorded as 344.8, 419.8 °C, 47.81%, 36.62%, and 206.58 °C, respectively. After exposure to the simulated weathering at 40 °C and 90% humidity, a significant decline was observed in all parameters. The heat tolerance of the composite specimen was recorded as 165 °C.
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IONICS
·
2025
·
IF 2.6
Mise Youpo,Wang Shaohua,Shi Wen,Yin Yakun,An Juan,Zhou Xuejiao,Xia Wentang,Yang Wenqiang
This study presents a green strategy for synthesizing amorphous cobalt sulfide (Co–S) bifunctional electrocatalysts via a choline chloride–ethylene glycol deep eutectic solvent (DES) under ambient conditions, addressing ionic coordination dynamics and defect engineering for enhanced solid–state ionic/electronic transport in energy conversion. By modulating the equilibrium between Co 2+ and S₂O₃ 2- ions in Ethaline, we fabricated monodisperse Co–150S nanoparticles (~ 78 nm) with tailored sulfur content (S/Co = 1.9), an amorphous architecture, and abundant oxygen vacancies. These structural features synergistically optimized ionic diffusion pathways and electronic conductivity, achieving exceptional hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) activities in alkaline media. The Co–150S/NF electrode demonstrated a volcano-like sulfur-dependent activity profile, achieving the highest electrochemically active surface area (ECSA, 3.7 cm 2 ) and ultralow overpotentials of − 105 mV (HER) and 277 mV (OER) at 10 mA cm⁻ 2 , comparable to benchmark Pt/C and RuO₂ catalysts. Post-electrolysis characterization revealed dynamic structural reorganization during HER and OER operations, involving over 80 at% sulfur depletion and the formation of metastable Co-rich phases that maintained catalytic functionality. In overall water splitting, the system required only 1.62 V to drive 10 mA cm⁻ 2 with minimal activity decay (1.5 mV h⁻ 1 over 26 h). Mechanistic investigations revealed that sulfur incorporation initiates a multiscale optimization process: (i) DES–mediated ionic confinement prevents particle aggregation, promoting uniform nanosphere formation; (ii) modulation of the electronic structure through nonstoichiometric Co–S coordination; and (iii) defect engineering through the enrichment of oxygen vacancies. This study provides insights into ionic coordination mechanisms in non–aqueous solvents and defect–mediated ion transport in amorphous solids, suggesting a potential strategy for developing electrocatalysts applicable to related energy storage technologies.
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Journal of Translational Medicine
·
2025
·
IF 7.5
Ying Feng,Jiamei Yue,Si Fan,Jiayan Wu
Background EMS (Endometriosis) is characterized by the presence of functional endometrial tissue outside the uterus and is one of the most common gynecological disorders. SOX18 (SYR-related high-mobility group box 18) is a transcription factor whose expression is higher in ectopic endometrial tissues than in eutopic endometrial tissues. However, its role in EMS has not been confirmed. Methods Here, immunohistochemistry (IHC) staining was used to analyze the expression pattern of SOX18 in EMS. Next, the effects of SOX18 on cell viability, migration and invasion were investigated. Dual-luciferase reporter assay, chromatin-immunoprecipitation (ch-IP) and DNA pull-down were employed to verify SOX18 binding to the OTUB1 (OTU domain-containing ubiquitin aldehyde binding protein 1) promoter. In addition, co-immunoprecipitation (co-IP) was used to analyze the binding of OTUB1 to YAP1 (Yes-associated protein 1). Allograft mouse model of EMS was established to explore the role of SOX18 in vivo. Results In vitro results demonstrated that upregulation of SOX18 promoted the proliferation, migration and invasion of Ishikawa cells and induced the EMT process, while knockdown of SOX18 showed the opposite effect. In vivo results also confirmed that SOX18 overexpression led to the deterioration of EMS, as reflected by significant pathological changes in mice. Mechanistically, our data proved that SOX18 directly bound to the OTUB1 promoter region and activated its transcription. Further investigation demonstrated that OTUB1 deubiquitinated YAP1 and enhanced its protein stability. Rescue experiments suggested that SOX18 modulated YAP1 expression through upregulating OTUB1, indicating the role of SOX18-OTUB1-YAP1 axis in EMS. Conclusions These discoveries underscore that SOX18 contributes to the pathogenesis of EMS through promoting OTUB1 transcription and activating Hippo/YAP1 signaling pathway, which may provide a new therapeutic target for EMS. Supplementary Information The online version contains supplementary material available at 10.1186/s12967-025-06677-y.
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CATALYSIS LETTERS
·
2025
·Vol. 155
·期 7
·1-14
·
IF 2.4
Li Shunming,Hu Pengyu,Qu Jingzong,Zhou Jie,Wang Zibo,Wang Yanan,Sun Tao,Chen Anran
Hydrogen evolution reaction (HER) in alkaline media demands cost-effective and highly active electrocatalysts to replace noble metals. Herein, we report a ternary MoS₂/Ni₃S₂/Ni(OH)₂ nanoflower composite supported on nickel foam (NF) via a facile one-step electrodeposition strategy. This method enables precise control of MoS₂ morphology while mitigating aggregation-induced active site blockage. The synergistic interplay among MoS₂ (exposing edge sites), conductive Ni₃S₂, and Ni(OH)₂ (modulating electronic structure) significantly enhances HER kinetics. Notably, the optimal catalyst (5-min deposition) achieves ultralow overpotentials of 48 mV at 10 mA cm⁻² and 175 mV at 100 mA cm⁻² in 1.0 M KOH, surpassing most reported Ni- or Mo-based catalysts. Furthermore, it exhibits exceptional stability with negligible activity loss after 5000 cycles and 72-hour continuous operation. XPS analysis reveals that a high Mo⁴⁺/Mo⁶⁺ ratio facilitates electron delocalization, accelerating hydrogen intermediate desorption. This work establishes a new paradigm in HER catalyst design through interface-engineered ternary systems. By unifying electronic synergy theory with the SPRE synthesis method, we overcome the activity-stability trade-off plaguing binary catalysts. The demonstrated 500-hour stability at industrial current densities (100 mA cm⁻²) positions this approach as a transformative solution for scalable green hydrogen production. Graphical
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WATER AIR AND SOIL POLLUTION
·
2025
·Vol. 236
·期 9
·1-18
·
IF 3
Huang Xiong,Pan Yuanfeng,Cai Pingxiong
To address the prevailing issue of arsenic contamination in water bodies, a novel composite microsphere (Fe-CB) was developed for the effective removal of As(V) ions from aqueous solutions. This microsphere was prepared using a sol–gel-titration-freeze-drying method, with chitosan and ferric chloride as raw materials, polyethyleneimine as a modifier and glutaraldehyde as a cross-linking agent. The effects of pH, adsorbent dosage, initial heavy metal concentration, and contact time on the performance of the adsorbent were investigated by a series of adsorption experiments. It was showed that pH played a significant role in determining the adsorption efficiency, while temperature had a relatively minor influence. The adsorption isothermal of As(V) on Fe-CB was best described by Langmuir isotherm model, whereas the dynamic adsorption process fitted the pseudo-second-order or secondary kinetic model well. Notably, the theoretical maximum adsorption capacity was 80.97 mg/g. Furthermore, regeneration experiments demonstrated that Fe-CB maintained a regeneration rate of over 85% even after five cycles, highlighting its excellent recyclability. This study underscores the potential of Fe-CB as an efficient and reusable adsorbent for the removal of As(V) ions from contaminated waters.
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Plasmonics
·
2016
·Vol. 12
·期 3
·717-727
·
IF 2.146
Zhang Yan,Jiang Jingjing,Li Min,Gao Pengfei,Zhang Guomei,Shi Lihong,Dong Chuan,Shuang Shaomin
A highly selective and ultra-sensitive colorimetric assay has been developed for detecting the magnesium ion (Mg 2+ ) based on pectinase (PE)-protected Au nanoparticles (PE-AuNPs). This is the first study reporting the use of pectinase for green synthesizing gold nanoparticles. Aggregation of PE-AuNPs was induced immediately following the addition of Mg 2+ ion under Tris-HCl buffer at pH 4.0, yielding a color change from red to blue, and the characteristic surface plasmon resonance (SPR) peak of PE-AuNPs was red-shifted to 665 nm. The effects of parameters such as pH, the amount of PE-AuNPs, and incubation time on the sensitivity of colorimetric assay were investigated in detail. The Mg 2+ -induced aggregation of PE-AuNPs could be monitored by both the naked eye and UV–vis spectrophotometry. The lowest detection concentration with the naked eye is 0.52 μM. A linear relationship between the absorbance ratio ( A
665 / A
523 ) and Mg 2+ concentration was observed in two ranges of Mg 2+ concentration by UV–vis spectrophotometry, including 5.34 × 10 −7 μM to 51.4 μM and 5.12 × 10 2 μM to 3.19 × 10 3 μM. The Mg 2+ detection limit was determined to be 4.0 × 10 −9 μM with UV–vis spectrophotometer. The proposed colorimetric assay possesses a highly selective response for Mg 2+ over other metal ions. This method has been successfully applied to determine the Mg 2+ ion in some water samples.
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CHINESE JOURNAL OF POLYMER SCIENCE
·
2026
·
IF 4.6
Yang Li-Kai,Hou Qian-Qian,Ying Shu-Di,Zhai Cong-Cong,Yang Xu,Yin Yu-Lin,Liu Qian,Wei Bing,Shao Ming-Wei,Zhao Pan-Pan,Zhao Xiu-Xian,Li Wen-Ting,Ma Jia-Chen,Zong Chuan-Yong,Nie Yong,Jiang Xu-Chuan
The efficient regulation of sunlight to minimize unnecessary energy exchange through windows plays a vital role in advancing building energy efficiency. However, the inferior stability of cerium-doped tungsten trioxide (CWO) as a near-infrared (NIR) shielding material, combined with the poor mechanical properties of its coatings, poses significant challenges for long-term thermal insulation performance. Here, a hierarchical thermal insulation coating with multifunctional integration has been developed. The inner layer’s excellent NIR shielding performance (94.4%) results in a temperature reduction of 13.6 °C, demonstrating outstanding thermal insulation. Meanwhile, the external layer composed of polysilsesquioxane grafted by carboxylated hexafluoropropylene trimer offers exceptional weather resistance due to the low surface energy. The fluorosilicone coating effectively mitigates oxidation of CWO, as evidenced by the retention of NIR shielding performance even after 30 days of exposure to 60 °C and 90% relative humidity. Furthermore, the coating demonstrates superior anti-graffiti properties and achieves an ultra-high mechanical strength of 0.49 GPa through precise fluorine content modulation. This hierarchical design integrates high hardness, excellent abrasion resistance, anti-graffiti functionality, transparency, and long-term operational durability into a single smart window system, offering a promising solution for reducing building energy consumption.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2026
·
IF 4.1
Zhang Yanjiao,Guo Yanxian,Wang Wen,Fang Xianglin,Cong Yanguang,Li Shaoxin
Sweat is an ideal biofluid for noninvasive monitoring of athletes’ physiological status during exercise, as its rich chemical composition directly reflects health and metabolic state. Herein, we develop a wearable device based on segmented circular microfluidic paper–based surface-enhanced Raman scattering (SCMP-SERS) for real-time sweat analysis during physical activity. The core sensor incorporates gold@carbon dots–based plasmonic paper, which exhibits exceptional SERS performance with a maximum enhancement factor of up to 3.6 × 10 9 . Combined with a flow-regulating microfluidic network, the system allows controlled sweat collection and quantitative analysis. It can identify key sweat biomarkers, such as urea, uric acid, and lactic acid, and distinguish differences between individuals. Furthermore, the device’s multi-channel design facilitates continuous sweat sampling and longitudinal SERS quantitation throughout extended exercise sessions. Furthermore, by integrating machine learning, the SCMP-SERS device successfully identifies stimulants in artificial sweat with over 97.9% accuracy. This innovative approach demonstrates significant potential for real-time antidoping surveillance and personalized sports physiology monitoring. Graphical abstract
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危险品化学品经营许可证（带存储）