CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
·
2024
·Vol. 40
·期 2
·293-304
·
IF 3.1
Chen Peiyu,Zhang Guoyang,Li Jiguang,Ma Lijun,Zhou Jiaying,Zhu Mingguang,Li Shuo,Wang Zhuo
The combination of near-infrared (NIR) fluorescence imaging (FLI) and photoacoustic imaging (PAI) can effectively compensate for each other’s inherent limitations, which can provide reliable and rich information on tumor biology. Therefore, the development of FL/PA dual-modality imaging probes is beneficial for achieving precision cancer diagnosis and treatment. Herein, we designed an efficient phototherapy agent methoxy bithiophene indene (OTIC), which was based on aggregation-induced emission (AIE) active fluorophores. To improve the water dispersion and enrichment of OTIC at the tumor site, OTIC nanoparticles (OTIC NPs) were prepared by a nanoprecipitation method. The balance between radiation and non-radiation energy dissipation was regulated by the strong donor-acceptor interaction and intramolecular motion. So OTIC NPs exhibited bright NIR fluorescence, photoacoustic signals, efficient generation of reactive oxygen species, and high photothermal conversion efficiency under NIR irradiation. Accurate imaging of the tumor and mice sentinel lymph nodes (SLNs) with OTIC NPs was visualized by NIR FL/PA dual-modal imaging. With the comprehensive imaging information provided by OTIC NPs in vivo , tumors were ablated under laser irradiation, which greatly improved the therapeutic efficacy. OTIC NPs would be possible to realize the precise guidance of FL/PA imaging for tumor treatment in the future clinical application.
研究领域:
生物医学工程
·
肿瘤学
·
纳米医学
✓ 已验证
DOI
高影响因子
CELLULOSE
·
2023
·Vol. 31
·期 1
·235-246
·
IF 5.7
Xiong Jie,Feng Shuang,Peng Rufang,Jin Bo
A series of aziridino[60]fullerenes was synthesized by the reaction of octabromo[60]fullerene with various anilines. Their ability to absorb free radicals and acid gases was studied, and their potential applications as stabilizers in nitrocellulose-containing propellants were discussed. The results of differential thermal analysis showed that aziridino[60]fullerene can increase the exothermic peak temperatures of nitrocellulose by 0.55–2.37 °C. The methyl violet test found that aziridino[60]fullerenes can extend the complete decomposition period by 31–71 min. The results of vacuum stability test and thermogravimetric test indicated that aziridino[60]fullerene can delay the decomposition of nitrocellulose. Furthermore, their stabilization mechanism was studied by electron spin resonance spectroscopy, and the free-radical scavenging rate of 3c reached 86.09%. The findings demonstrate that aziridino[60]fullerenes could effectively eliminate the nitrogen oxides released by nitrocellulose autocatalysis and might be used as a new stabilizer for nitrocellulose-containing propellants. Graphical abstract
研究领域:
材料科学
·
化学
✓ 已验证
DOI
高影响因子
JOURNAL OF FLUORESCENCE
·
2024
·
IF 2.6
Gong Yafei,Fu Yan,Lou Dawei
Abnormal tryptophan (Trp) metabolism can be used as an important indicator of chronic hepatitis, paranoia, Parkinson’s disease and other diseases. Deficiency or excessive accumulation of Cu 2+ can cause diseases such as Wilson’s disease and Alzheimer’s disease. Eu-based metal-organic framework (Eu-MOF) was successfully prepared for fluorescence sensing of Trp and Cu 2+ in an aqueous solution (pH = 7.4). Eu-MOF showed high selectivity and sensitivity for Trp and Cu 2+ with detection limits of 0.22 µM and 0.09 µM and K sv of 6.17 × 103 M − 1 and 2.37 × 10 4 M − 1 respectively. Trp and Cu2+ had overlapped UV absorption spectra with that of Eu-MOF and competed for the excitation light source. Trp also attenuated the antennae effect of organic ligands on Eu-MOF, thus quenching the red fluorescence of Eu-MOF. This study provides insights into the application of MOFs in bioanalysis and diagnostics.
研究领域:
生物分析
·
诊断学
·
材料科学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF FLUORESCENCE
·
2023
·
IF 2.7
Zhao Xiaoyu,Du Qian,Qiu Huiying,Zhao Yaqin,Wang Songbai,Li Junfen,Dong Chuan
In this work, bright yellow fluorescent and multifunctional carbon dots (N-CDs) were prepared by hydrothermal method from O-phenylenediamine and 4-aminobenzoic acid. The fluorescence characterization showed that the N-CDs possessed good optical properties (QY = 32%) and excitation dependent multi-color emission. By exciting with 390 nm, the strong selective interaction of VB 12 with N-CDs could result in a sharp decrease in the luminescence of N-CDs at 567 nm. An efficient fluorescence sensor in aqueous solution was constructed which could linearly respond VB 12 in wide concentration ranges of 0–90 μM and 140–250 μM. The linear correlation coefficients of N-CDs and VB 12 were 0.9950 and 0.9968, respectively, and the detection limit was 0.119 μM. N-CDs were performed for sensitive determination of VB 12 in real samples. Moreover, the N-CDs were exploited to image cell. This N-CDs was a sensitive fluorescence probe to monitor VB 12 and presented prospective potential in living cells imaging. Graphical abstract Schematic diagram of the synthesis process and application research of N-CDs
研究领域:
生物化学
·
分析化学
·
生物医学工程
✓ 已验证
DOI
高影响因子
CELLULOSE
·
2024
·Vol. 31
·期 6
·3747-3761
·
IF 4.9
Xia Nan Nan,Wu Qin,Bi Shi Lin
Cellulose-based adsorbents have attracted extensive attention owing to their ecofriendly characteristics. However, most cellulose-based adsorbents possess inadequate adsorption capabilities for typical pollutants such as heavy-metal ions and dyes. Herein, we developed a cost-effective and robust cellulose-based adsorbent with a three-dimensional network structure based on hydrogen bonds and electrostatic interactions via the simple supramolecular self-assembly of carboxymethyl cellulose (CMC), cationic polyacrylamide (CPAM), and tannic acid (TA) (referred to as CMC–CPAM–TA). Benefiting from the abundant catechol/carboxyl groups and mesoporous/macroporous channels, CMC–CPAM–TA could trap Cu(II) ions and rhodamine B (RhB) (representing a typical heavy-metal ion and dye, respectively) by rapidly forming Cu–O coordination bonds and inducing electrostatic interactions. CMC–CPAM–TA exhibited high adsorption capacities for Cu(II) ions and RhB, which were 669.8 and 202.2 mg/g, respectively. These values are 1.3–23.6 and 1.1–72.2 times higher than those of commonly reported cellulose-based adsorbents, respectively. Furthermore, CMC–CPAM–TA showed high regenerative ability for Cu(II) ions and RhB after five cycles owing to its robust structure.
研究领域:
材料科学
·
环境科学
✓ 已验证
DOI
高影响因子
MICROCHIMICA ACTA
·
2023
·Vol. 191
·期 1
·1-10
·
IF 5.7
Li Wenjie,Xu Zhenjuan,Li Peipei,Liu Xiang,Chen Chao,Zhang Youyu,Liu Meiling,Yao Shouzhuo
An electrochemical sensor capable of detecting glutathione (GSH) with high sensitivity and selectivity was developed based on the unique novel electroactive silver-based metal organic framework (Ag-MOF). The Ag-MOF obtained by silver nitrate and 1,3,5-benzoic acid (H 3 BTC) was thoroughly characterized and was modified onto the electrode via facile drop-casting method. The electrochemical response of GSH on the Ag-MOF modified electrode showed a significant reduction in the current signal because the Ag-GSH complex had stronger specific affinity than Ag-H 3 BTC and resulted in the collapse of the Ag-MOF. This sensor demonstrated an extensive linear dynamic range of 0.1 nM-1 µM, along with the low detection limit of 0.018 nM. Additionally, it exhibited good reproducibility, stability, and resistance to interfering compounds. The Ag-MOF modified electrode demonstrated superior performance attributed to its rapid electron transfer rate, outstanding electrochemical redox activity, and specific recognition/competitive reaction. These factors improved both sensitivity and selectivity. The high anti-interference ability allowed for the selective detection of GSH in intricate surroundings. In the real sample testing, the RSD was lower than 3.1% and the recovery was between 98.1 and 103%. This research highlights the potential of Ag-MOFs in developing electrochemical sensors and their promising applications in determining GSH for food screening and early disease diagnosis.
研究领域:
分析化学
·
生物医学工程
·
材料科学
✓ 已验证
DOI
高影响因子
JOURNAL OF POLYMER RESEARCH
·
2024
·Vol. 31
·期 2
·1-12
·
IF 2.6
Lei Jinxuan,Meng Lingxin,Zhao Pengyun,Wang Jiayin,Lan Tian,Xu Jingmei
A series of poly(aryl ether ketone sulfone) polymers (C-PAEKS-DBS) were synthesized from 4-carboxyphenyl hydroquinone, allyl bisphenol S, and 4,4-difluorobenzophenone by nucleophilic polycondensation. And further a series of side chain sulfonated poly(aryl ether ketone sulfone) proton exchange membranes (CPDA-x) were prepared by simply introducing hydrophilic long alkyl side chains (AMPS) into the polymers by means of double bond cross-linking. The structure of the prepared CPDA-x were characterized by FT-IR, 1 H NMR and SEM. This series of composite membranes showed excellent dimensional stability which including moderate water absorption (ranging from 27.91% to 33.33% at 80 °C) and low swelling ratio (ranging from 10.26% to 16.67% at 80 °C). In addition, the prepared films also exhibited high oxidative stability and mechanical property. This simple strategy for the producing of proton exchange membranes (PEMs) has certain potential and may be applied to the producing of fuel cell membranes with hydrophilic and hydrophobic phase separation structures.
研究领域:
材料科学
·
能源科学
✓ 已验证
DOI
高影响因子
BIOLOGICAL TRACE ELEMENT RESEARCH
·
2023
·Vol. 202
·期 7
·3180-3192
·
IF 3.9
Nong Weihua,Wei Gaomeng,Wang Junli,Lei Xiaocan,Wang Jinyuan,Wei Yanhong,Dong Mingyou,He Liqiao
This study aimed to investigate the protective effect of nicotinamide mononucleotide (NMN) on testicular spermatogenesis in aluminum chloride (AlCl 3 )-exposed rats and to elucidate the potential underlying mechanism. The results indicated that AlCl 3 -induced testicular damage, leading to reduced sperm quality, increased apoptosis, decreased cell proliferation, and impaired Sertoli cell function in rats. Additionally, glycolytic metabolism was observed to be hindered. However, after NMN treatment, there was a noticeable improvement in testicular damage among the rats, marked by increased sperm quality, reduced apoptosis, enhanced cell proliferation, improved Sertoli cell function, and an activated glycolytic metabolism. The findings of this study suggest that NMN alleviates testicular spermatogenesis impairment induced by AlCl 3 exposure through the inhibition of spermatogenic cell apoptosis, promotion of spermatogenic cell proliferation, and activation of glycolytic pathways. The study contributes an experimental foundation for potential future clinical applications of NMN in cases of AlCl 3 -exposed spermatogenic dysfunction.
研究领域:
生殖生物学
·
毒理学
·
代谢生物学
✓ 已验证
DOI
高影响因子
JOURNAL OF POLYMER RESEARCH
·
2023
·Vol. 30
·期 6
·1-13
·
IF 2.8
Zhang Haoran,Xu Shuyan
With the advent of the 5G era, various thermal conductivity nanocomposites are being investigated to solve the heat accumulation on the surface of electronic devices. In this study, magnetic nanofiller ferroferric oxide-polydopamine-boron nitride nanosheets (Fe-PDA-BNNSs) are fabricated by mussel-inspired and coprecipitation methods with polydopamine (PDA) and ferroferric oxide (Fe 3 O 4 ). The aligned Fe-PDA-BNNSs/poly(vinyl alcohol) (PVA) composites with higher in-plane thermal conductivity and decent mechanical properties are prepared by applying a horizontal magnetic field. The in-plane thermal conductivity of the aligned composite at 30 wt% filler loading reaches 5.237 W/(m·K), which is 1.1 times and 20.5 times that of the unaligned composites and neat PVA. Moreover, the aligned composite maintains mechanical strength and obtains commendable thermal stability and heat dissipation capability, which can be applied to the thermal management of flexible electronic devices.
研究领域:
材料科学
·
纳米技术
·
热管理
✓ 已验证
DOI
高影响因子
JOURNAL OF POLYMER RESEARCH
·
2023
·Vol. 31
·期 1
·1-11
·
IF 2.8
Guo Zhenyu,Song Weiqiang,Wei Xueqin,Feng Yu,Song Yihong,Cheng Wenxi
Composites of poly(lactic acid) (PLA) and poly(butylene adipate-co-terephthalate) (PBAT) with different mass ratio, containing nano-sized calcium carbonate, benzophenone and triallyl isocyanurate, were prepared by using a double screw extruder, and blown into films by extrusion blow molding. After ultraviolet (UV) exposure at irradiation doses (ID) of 20 J/cm 2 and 40 J/cm 2 , the mechanical, dynamic mechanical and thermal properties of the radiated films were tested and compared with that of the unradiated. The tensile strength of the PLA/PBAT (100/0) film with single PLA phase increased after exposure to UV light, but its fracture energy decreased. In contrast, both the tensile strength and fracture energy of PLA/PBAT (70/30) film with PLA and PBAT co-continuous phases increased after exposure, but both the tensile strength and fracture energy of PLA/PBAT (50/50) film with PBAT continuous phase decreased. The glass transition temperature ( T g ) of PLA/PBAT (100/0) film increased after exposure to UV light, but the T g of both PLA/PBAT (70/30) and (50/50) films unchanged or varied within the error range. The crystallization temperature ( T c ) of all the films did not changed after UV exposure, but the crystallizability significantly decreased. It suggested that UV irradiation was a simple and effective technique to simultaneously improve the strength and toughness of the film with PLA and PBAT co-continuous phases.
研究领域:
材料科学
·
聚合物工程
✓ 已验证
DOI
高影响因子
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
·
2024
·Vol. 333
·期 3
·1155-1171
·
IF 1.5
Wu Lang,Liang Lili,Liu Datong,Wang Haijun,Lin Xiaoyan
Radioactive aerosols produced by nuclear accidents and decommissioning of nuclear power plants would cause tremendous radioactive damage to the environment and human body. The development of a radioactive aerosol suppressant is of great significance in the treatment of radioactive aerosols. In this study, a three-dimensional biomass-based polymer pectin-g-acrylic acid-acrylamide (pectin-g-poly (AA-co-AM)) SAP with high water absorbency and high agglomeration was prepared by solution polymerization. The results showed that the water absorbency of pectin grafted with acrylic acid and acrylamide reached 1064 g/g. Furthermore, under the synergistic effect of water absorption and agglomeration of the material, the sedimentation efficiency of simulated radioactive aerosol by 30 min after using suppressant is 91.21%.
研究领域:
环境科学
·
核能与辐射防护
·
高分子化学
✓ 已验证
DOI
高影响因子
MICROCHIMICA ACTA
·
2024
·Vol. 191
·期 2
·1-10
·
IF 5.3
Wu Wei,Shi Yuhan,Liu Jingya,Liu Xiaoyu,Liu Hao,Wang Tao,Zhang Guoqi,Xu Zhihong
Household storage of pharmaceuticals to extract raw materials synthesized from carbon points facilitates the utilization of solid waste resources. A novel ratiometric fluorescence sensing technique was developed to ascertain the presence of horseradish peroxidase (HRP) in fruits and vegetables. The method employed a fluorescent probe, synthesized from expired amoxicillin (referred to as carbon dots, or A-CDs), serving as a reference fluorophore. Additionally, 2,3-diaminophenazine (DAP) was utilized as a specific response signal. DAP resulted from a catalytic reaction system involving phenylenediamine and hydrogen peroxide under the catalysis of HRP. The fluorescence intensity corresponding to DAP at 562 nm exhibited a substantial increase, simultaneous with the fluorescence quenching of A-CDs at 450 nm. The ratiometric fluorescence nanosensors displayed a broad linear range and high sensitivity for the detection of HRP. Across the concentration range 0.01 to 6 U L −1 , the fluorescence intensity ratio between DAP and A-CDs demonstrated a proportional increase with rising HRP concentration, achieving an impressive detection limit of 0.002 U L −1 . The recovery of HRP in fruit and vegetable samples ranged from 96.1 to 103%, with an RSD value of less than 3.8%. The proposed method facilitated the screening of inhibitors of HRP enzyme activity, contributing to the preservation of freshness in fruits and vegetables. Graphical
研究领域:
食品科学
·
分析化学
·
环境科学
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）