JOURNAL OF CONTROLLED RELEASE
·
2026
·
IF 12.4
Yanming Xia,Lixin Hu,Yuhan Hu,Shihao Wang,Qingqing Xiong,Xiaohu Wang,Yiqun Li,Lifang Yin,Jian Wang,Suxin Li
The stimulator of interferon genes (STING) has emerged as a promising target for cancer immunotherapy. However, STING agonists alone have demonstrated limited clinical success. Indoleamine 2,3-dioxygenase 1 (IDO1) has been implicated as a key resistance mechanism that undermines the antitumor effects of STING activation, yet the cell-type-specific roles and the combined impact of STING and IDO1 on tumor immune orchestration remain poorly understood. In this study, we report that a co-delivery nanosystem of STING agonists and IDO1 inhibitors, rather than their simple combination, yields synergistic antitumor responses. This nanomedicine exhibits tropism toward myeloid cell populations in vivo , particularly dendritic cells (DCs), and facilitates pH-responsive cytosolic delivery of both agents. As a result, it enhances antigen cross-presentation, DC maturation, and cytokine secretion, driving effective priming of cytotoxic T lymphocytes. Compared to monotherapies or physical nanoparticle combinations of STING agonists and IDO1 inhibitors, this two-in-one nanomedicine significantly suppresses tumor growth and confers a survival benefit. Depletion of STING in the host ( Tmem173 −/− mice) or deficiency in type I conventional DCs (cDC1s, Batf3 −/− mice) abolishes therapeutic efficacy, whereas depletion of STING in tumor cells exerts minimal impact. A bone marrow chimera experiment further supports the STING-cDC1 dependence. Its capability to overcome tumor resistance and the underlying mechanism were further investigated in a well-established tumor model. Our findings highlight the cooperative role of STING activation and IDO1 blockade within cDC1s and introduce an integrated drug delivery system to combat immune tolerance in cancer therapy.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2026
·
IF 3.8
Wang Zichen,Zhou Wei,Cui Yue
Upconversion nanoparticles (UCNPs)-based fluorescence lateral flow immunoassay (FLFIA) has significant application prospects in clinical diagnosis, but it still suffers from relatively low sensitivity in detecting trace amounts of biomarkers. Here, we report for the first time a strong fluorescence-emitting core-shell-shell NaLuF 4 @NaLuF 4 :Yb,Er@NaLuF 4 UCNP as the FLFIA probe. The UCNPs-based FLFIA platform enables point-of-care detection of cardiac troponin I (cTnI) with high sensitivity, accuracy, and resistance to autofluorescence interference. NaLuF 4 :Yb,Er encapsulated in the intermediate shell layer can effectively reduce the cross-relaxation and surface quenching of the luminescence center, resulting in a higher quantum yield. Compared with the conventional core-shell NaLuF 4 :Yb,Er@NaLuF 4 UCNPs, the fluorescence intensity increases by 2.4 times. The UCNPs-based FLFIA was further integrated with a portable smartphone platform for rapid, on-site detection. The UCNPs probe enabled sensitive cTnI detection, with a detection limit of 0.035 ng/mL in buffer and 0.059 ng/mL in serum, and a detection range of 0.05–100 ng/mL. In testing clinical samples, the results from the platform showed excellent correlation with hospital results. We anticipate that the NaLuF 4 @NaLuF 4 :Yb,Er@NaLuF 4 UCNPs can serve as a promising immunolabeling nanoprobe for highly sensitive and accurate FLFIA detection. Graphical
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ANALYTICAL CHEMISTRY
·
2014
·
IF 5.825
Chenghua Zong,Li Rong Zheng,Wenhui He,Xiaoyan Ren,Chunhuan Jiang,Lehui Lu
A highly phosphorescent molecular Au(I) cluster capable of rapid, sensitive, and selective detection of cyanide has been successfully fabricated. The origin of the outstanding sensing performance of the molecular Au(I) cluster toward cyanide is justified by X-ray absorption near edge structure (XANES) and extended X-ray absorption fine structure (EXAFS) analyses. The response mechanism employed with the molecular Au(I) cluster and the cost-effectiveness in cyanide detection affords several key sensor features, making this molecular Au(I) cluster-based sensor unique compared to other cyanide sensing schemes. Importantly, by exploring the phosphorescent properties of the molecular Au(I) cluster in solid state, we demonstrate the first example of the molecular gold(I) cluster-based macroporous sensing film for colorimetric detection of cyanide in complex samples, including red wine, coffee, juice, and soil. Remarkably, the as-prepared sensing film inherits the sensing ability of the molecular Au(I) cluster, and offers a high mechanical flexibility and novel opportunities for real-time monitoring cyanide release in cassava manufacturing.
研究领域:
材料科学
·
分析化学
·
环境传感
·
纳米材料
·
发光传感器
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Jinying Shi,Zhendong He,Yifan Xu,Wen Chen
Ethylene is a crucial gaseous phytohormone that regulates diverse aspects of plant growth and development. In Arabidopsis thaliana , perception of ethylene is mediated primarily by ETHYLENE RESPONSE 1 (ETR1), a prototypic membrane protein that couples ligand sensing to signal transduction through a transmembrane copper cofactor-dependent ethylene-binding site and a cytoplasmic histidine kinase domain. Previous work established that ETR1 binds copper and forms covalent homodimers, but the functional significance of its dimeric architecture in signal transduction has remained elusive. In this study, we expressed and purified full-length ETR1 from Pichia pastoris, enabling the systematic dissection of its oligomeric state, copper redox chemistry, and ligand binding effects. Using an in vitro luminescent kinase assay, we demonstrate that the Cu(I)-ethylene complex strongly suppresses ETR1 autophosphorylation, but only when the receptor is in its disulfide-linked dimer form. Monomeric ETR1 generated by reductive cleavage retained basal kinase activity yet was insensitive to ethylene. Furthermore, the ethylene antagonists Ag + and 1-MCP reversed the ligand-induced suppression. Mutational analysis revealed that the H353Q variant lacked kinase activity, while the C65S/H69A double mutant retained basal activity but was resistant to ethylene-induced inhibition, implicating both the catalytic histidine residue and the copper-binding site in the regulatory mechanism. Together, these findings establish that ETR1 functions as a dimer-dependent ethylene sensor, in which covalent dimerization is essential for allosteric coupling between the ligand-binding and kinase domains. This work thus provides a definitive biochemical model for ethylene perception and offers a robust platform for future structural and mechanistic studies of plant membrane-receptor signaling.
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Small
·
2026
·
IF 11.8
Shifeng Pan,Jialin Zhu,Haibo Li,Youwang Long,Ziyang Zhou,Yuansheng Wang,Zhennan Zhou,Wei Liu,Gangfeng Ouyang
Metal halide hybrid luminescent materials have attracted significant attention due to their tunable emission properties and excellent photoelectric performance. However, achieving metal halides that exhibit near-infrared (NIR) emission under blue light excitation remains a major challenge. This paper reports a novel 2D copper(I) iodide hybrid material, Cu 2 I 2 (THQx) (THQx = 5,6,7,8-Tetrahydroquinoxaline), which is constructed by linking -Cu 2 I 2 - chains with the THQx ligand and achieves broadband NIR luminescence. It can be effectively excited by blue LEDs and has a peak emission at 730 nm with a full width at half maximum of 159 nm. Theoretical calculations indicate that its luminescence originates from the triplet metal/halide-to-ligand charge transfer ( 3 MLCT/HLCT). This material also exhibits excellent thermal stability, air stability, and photostability, demonstrating potential applications in night vision and biological imaging in NIR phosphor-converted LED (pc-LED) devices. This research not only expands the application boundaries of copper(I) halide hybrid materials, but also provides a new approach for the development of low-cost and environmentally friendly NIR luminescent materials.
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ACS Applied Electronic Materials
·
2026
·
IF 4.7
Zhenjing Kang,Ruochuan Liao,Weijuan Chen,Jianbin Wang,Wen-Hsien Sun,Qiong Yan,Weilong Zhang
Hybrid cuprous halides demonstrate a high photoluminescence quantum yield and rich structural dimensionality, acting as promising candidates for the next generation of luminescent materials in the solid-state lighting field. However, the development of highly efficient orange-red light emitters with broadband emission remains a challenge. Herein, we report a zero-dimensional (0D) copper(I) halide, (HTPP)2Cu4Br6 (HTPP+= hexyl(triphenyl)phosphonium cation), where the isolated [Cu4Br6]2– units are wrapped by organic HTPP+ cations. (HTPP)2Cu4Br6 displays an orange-red emission band that peaks at 666 nm and possesses a relatively large Stokes shift of 294 nm, along with a broadband emission covering the wavelength range of 400–900 nm. The luminescence mechanism was thoroughly investigated with first-principles calculations. Significantly, based on this material, a white light-emitting diode (WLED) was fabricated with an ultrahigh color rendering index of 95.3. Moreover, the color rendering index maintained an average value of 94.5 over the 8 h continuous operation period of the WLED device. This work provides an important reference for the development of highly efficient copper(I) halides in solid-state lighting.
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ANALYTICAL CHEMISTRY
·
2026
·Vol. 98
·期 37
·27381-27390
·
IF 7.3
Ju Huan,Ni Xiangna,Tan Yanqi,Song Zhiping,Chen Xiaoping,Ni Jiancong,Lin Zhenyu,Yang Weiqiang
Urease serves as a key diagnostic biomarker, whose abnormal
activity
is closely associated with oral diseases such as caries and periodontitis.
However, detecting trace urease in saliva remains technically challenging.
In this work, we report for the first time a C 4 -rGO-FET
biosensor by integrating a conformation-switchable C 4 -DNA
probe with an electrochemically reduced graphene oxide field-effect
transistor. The sensing mechanism relies on the pH-induced conformational
transition of C 4 -DNA between a folded i-motif and an unfolded
state, which effectively modulates the interfacial charge and thus
the carrier distribution in the rGO channel, resulting in a measurable
shift in the Dirac point voltage ( V CNP ). The designed sensor exhibits significantly enhanced pH response
(51.57 mV/pH) and reduces the Debye shielding effect. Upon urease-catalyzed
hydrolysis of urea, the resulting local pH increase triggers a positive V CNP shift, enabling highly sensitive detection
of urease activity. The biosensor demonstrates a wide linear range
(1–500 U/L), a low detection limit (0.18 U/L), and good reproducibility.
Moreover, it performs reliably in spiked human saliva samples, highlighting
its strong potential for point-of-care testing and real-time monitoring
in clinical diagnostics.
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JOURNAL OF LIPOSOME RESEARCH
·
2026
·
IF 4.7
Li Zhang,Yize Lv,Xuedi Weng,Yan Gao,Jie Gao,Xia Cao,Michael Adu-Frimpong,Qilong Wang
Chitosan-polyethylene glycol (CS-PEG)-modified long-circulating liposomes were developed and loaded with tanshinone I (TaI@CS-PEG-L) to overcome its poor solubility and low bioavailability, as well as enhance the lipid-lowering efficacy of atorvastatin (At) and mitigate its tissues toxicity. After synthesis of CS-PEG copolymer, it was characterized with infrared and proton nuclear magnetic resonance. Thin-film hydration was used to prepare TaI@CS-PEG-L before optimization was performed using Box-Behnken design. Optimal liposomal formulation was obtained when mass ratio of lecithin:cholesterol:TaI mass ratio was 12:1:1 along with 0.2% CS-PEG, which displayed appropriate particle size (117.41 nm), polydispersity index (0.182), zeta potential (+17.31 mV), encapsulation efficiency (93.15%), and drug loading (5.19%). Besides, the liposomal preparation exhibited good long-term storage stability (over 30 days at 4 °C and 25 °C) and satisfactory gastrointestinal stability in simulated gastric (pH 1.2) and intestinal (pH 6.8) fluids for 4 h. TaI@CS-PEG-L displayed increased cellular uptake and in vitro release compared with free TaI and unmodified liposomes. Regarding pharmacokinetic studies, TaI@CS-PEG-L increased AUC0-ₜ, t1/2, and Cmax in rats by 7.26-fold, 2.43-fold, and 3.12-fold, respectively, which indicates significantly enhanced oral bioavailability. TaI@CS-PEG-L monotherapy markedly lowered serum lipid levels in hyperlipidemic mice, thereby improving liver function indices, and alleviating pathological liver injury. TaI@CS-PEG-L demonstrated synergistic lipid-lowering effects and efficiently reversed At-induced hepatic and pancreatic injuries after combination with At, thus outperforming free TaI and TaI@L. Therefore, CS-PEG-modified long-circulating liposomes could efficiently address delivery challenges of TaI, thereby yielding a formulation that could potently lower serum lipid levels and protect liver against injury. The findings of this study offer a promising ‘efficacy-enhancing and toxicity-reducing’ strategy for potential treatment of hyperlipidemia in the clinics.
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Catalysts
·
2023
·Vol. 13
·期 4
·751
·
IF 3.9
Jikun Chen,Yan Gu,Shishi Xu,Yunxiang Zhang,Zhe Zhang,Lin Shi,Zhichao Mu,Chenliang Zhou,Jiali Zhang,Qinfang Zhang
Developing efficient photocatalyst for the photoreduction of CO2and degradation of organic pollutants is an effective alternative to address increasingly serious energy problems and environmental pollution. Herein, the isostructural Sillén–Aurivillius oxyhalides, Bi7Fe2Ti2O17X (X = Cl, Br, and I; BFTOX), are fabricated for CO2reduction and degradation of organic pollutants for the first time. Density functional theory (DFT) calculations show that the valence band maximum (VBM) of BFTOC and BFTOB is contributed by the dispersive 2porbitals of O-atoms, providing the narrow band gap (Eg) and possibly the stability against self-decomposition deactivation. The photocatalytic activities of BFTOX are strongly affected by the halogens (Cl, Br, and I), namely, the BFTOCl sample displays outstanding activity improvement (3.74 μmol·g−1·h−1) for photocatalytic performance. This is mainly attributed to the high separation of charge carriers, small optical band gap, and extended optical absorption. This work focuses on affording a reference to develop efficient and stable photocatalysts from Sillén-Aurivillius layered oxyhalide materials.Keywords:Sillén–Aurivillius;Bi7Fe2Ti2O17X;photocatalyst;degradation;CO2reduction
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Advanced Optical Materials
·
2023
·Vol. 11
·期 9
·2203028
·
IF 9
Guozhen Li,Qiwen Pan,Zhihao Zhou,Ranran Gu,Hao Zhang,Xiongjian Huang,Guoping Dong,Xiudi Xiao
Perovskite CsPbX 3 (X = Cl, Br, I) nanocrystals with advantages of high quantum yield, narrow emission peaks, and tunable fluorescence are considered as the next generation of light-emitting sources. However, fluorescence degradation due to the poor stability of perovskite nanocrystals in moisture, high temperature, and illumination remains one of the greatest challenges in their further development. In this work, a fully dense coating strategy is proposed to improve the overall stability of perovskite nanocrystals, especially under high-density laser irradiation. A mesoporous silica SiO 2 layer is introduced to construct a stable coating for isolating the perovskite from external environment. To eliminate the pores of the CsPbX 3 @SiO 2 , an inorganic glass is also employed via solution-combustion technique to generate a fully compact encapsulation for further stability promotion. The as-prepared nanocrystal-in-glass composite exhibits efficient and stable fluorescence performance in luminous efficiency, chromaticity, and long-term reliability in the conditions of thermal shock, humidity, and blue laser irradiation. With the integration of red/green/blue emitting nanocrystals, the color gamut of the white laser lighting source covers 134% of the National Television Standards Committee standard, providing exciting opportunity for high performance laser-driven white light generation.
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ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Li Zhang,Xinxin Li,Ye Tian,Bin Hao,Jiufang Han,Hong Chen,Bingsuo Zou,Chunhua Du
Inorganic perovskites have received much attention due to their stability and high performance in luminescence, photoelectric conversion, and photodetection. However, perovskite optoelectronic devices prepared by the solution technique are still suffering from time-consuming and complex operations. In this paper, a single-crystal perovskite-based photodetector (PD) is prepared by very fast one-step deposition of synthesizing microplatelets (MPs) on the electrode directly. The saturated precursor is carefully optimized by adding appropriate antisolvent chlorobenzene (CB) to fabricate the MPs with their PL wavelength ranging from 418 to 600 nm. Furthermore, the PDs with a low dark current on order of nanoangstroms, high responsivity and detectivity of up to 10.7 A W–1 and 1012 Jones, respectively, and an ultrafast response rate featured by 278/287 μs (rise/decay time) are achieved. These all-inorganic perovskite PDs with a simple fabricating process and tunable detection wavelength meet the evolution tendency of PDs toward low cost and high performance, which is a high-profile strategy to realize high-performance perovskite PDs.
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
·
2023
·Vol. 120
·期 10
·e2206619120
·
IF 11.1
Wencui Li,Zhi Li,Hang Zhang,Pengxiao Liu,Zean Xie,Weiyu Song,Baijun Liu,Zhen Zhao
Selective oxidation of methane to organic oxygenates over metal–organic frameworks (MOFs) catalysts at low temperature is a challenging topic in the field of C1 chemistry because of the inferior stability of MOFs. Modifying the surface of Cu-BTC via hydrophobic polydimethylsiloxane (PDMS) at 235 °C under vacuum not only can dramatically improve its catalytic cycle stability in a liquid phase but also generate coordinatively unsaturated Cu(I) sites, which significantly enhances the catalytic activity of Cu-BTC catalyst. The results of spectroscopy characterizations and theoretical calculation proved that the coordinatively unsaturated Cu(I) sites made H2O2 dissociative into •OH, which formed Cu(II)-O active species by combining with coordinatively unsaturated Cu(I) sites for activating the C−H bond of methane. The high productivity of C1 oxygenates (CH3OH and CH3OOH) of 10.67 mmol gcat.−1h−1 with super high selectivity of 99.6% to C1 oxygenates was achieved over Cu-BTC-P-235 catalyst, and the catalyst possessed excellent reusability.
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