Results in Physics
·
2023
·
IF 5.3
Rong Huang,Shuang Lian,Jingru Li,Yinyu Feng,Sisi Bai,Tongmiao Wu,Minjian Ruan,Pinghui Wu,Xiaojie Li,Shuangshuang Cai,Peipei Jiang
Surface-enhanced Raman scattering (SERS) is widely used in many fields, such as biosensors, medical diagnostics, materials science, and food security. Here, we report a low-cost, high-throughput laser-induced fractional reaction method for optical fiber SERS probes. Under laser irradiation, the local thermal effect and the electromagnetic interaction between nanoparticles effectively contribute to the formation and growth of silver nanoparticles on the optical fiber facet. Sodium dodecyl sulfate (SDS) solution with a concentration of 2 mM is employed as a surfactant to control the shape and size of the silver nanoparticles. A detection limit of 1.0 × 10 −11 M for R6G is achieved, which is, as far as we know, the highest sensitivity that laser-induced fabricated optical fiber SERS probes have achieved. The SERS enhancement factors (EFs) are calculated to be 6.795 × 10 11 . The SERS intensity of R6G at peaks of 621 cm −1 , 1281 cm −1 , and 1359 cm −1 are measured with probes fabricated under the same condition, and showed perfect repeatability with an RSD of less than 4.5%. This new method shows effectively in fabricating optical fiber SERS probes with high sensitivity and good repeatability.
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FOOD CHEMISTRY
·
2023
·
IF 8.8
Huizhu Zhang,Yimin Tang,Weie Wang,Dongxue Yu,Libin Yang,Xin Jiang,Wei Song,Bing Zhao
Antibiotic residues in animal-derived food (egg) are threatening human health. Semiconductor heterojunction surface-enhanced Raman scattering (SERS) substrates can be used for ultra-sensitive detection of antibiotic residues in egg. Here, a TiO 2 /ZnO heterojunction was developed as a new SERS substrate based on an interface engineering strategy. Due to strong interfacial coupling and efficient carrier separating in heterostructure, utilization rate of photo-induced electrons in substrate was improved greatly, which realized the efficient charge transfer in substrate-molecule system, resulting in a prominent SERS enhancement. Taking the detection of enrofloxacin residue in egg as an example, the limit of detection (LOD) is only 13.1 μg/kg, which is far below the European Union standard, and lower than LODs of other conventional analytical methods and existing noble metal-based SERS methods. More importantly, benefiting from high sensitivity and selectivity of heterojunction and fingerprint characteristics of SERS, multiple antibiotic residues in egg can be identified simultaneously.
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MICROCHEMICAL JOURNAL
·
2023
·
IF 4.8
Miao Chen,Shenghua Yao,Yongguo Yang,Fengjuan Jiang,Yan Yang,Yuexing Gu,Zhenguang Wang,Xiaowei Cao,Wei Wei
Multiplex detection of biomarkers is nontrivial for gastric cancer diagnosis. Herein, we presented a lab-on-a-chip surface-enhanced Raman scattering (LoC-SERS) sensing system for the detection of vascular endothelial growth factor (VEGF) and platelet-derived growth factor-B (PDGF-B). The sensing system includes three parallel channels, each channel consists of two detection chambers, enabling the simultaneous analysis of multiple samples. The capillary structure provides self-driving power without the need of external pumps. The ordered gold nano-bipyramids (GNBPs) array in the detection chamber can form uniform and dense “hot spots”, due to the homogeneous double-tip structure and narrow gaps, resulting in better SERS performance. During the analysis process, VEGF and PDGF-B in the serum can lead to the change of aptamer conformation. Raman reporter-labeled complementary DNA is shed from the aptamer due to competition of the target. The entire process only requires 20 min, which is rapid. By monitoring the changes in Raman intensity and fitting it with the logarithm of concentration, the correlation between the intensity and concentration can be clearly reflected as a mathematical relationship. The LoC-SERS sensing system has been verified to have excellent selectivity and reproducibility. Via the sensing system, the limits of detection (LOD) of VEGF and PDGF-B are as low as 0.342 pg/mL and 0.265 pg/mL in serum, respectively. In addition, the accuracy was verified through enzyme-linked immunosorbent assay (ELISA). Therefore, the proposed LoC-SERS sensing system has great potential for clinical detection of gastric cancer.
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Biosensors-Basel
·
2023
·Vol. 13
·期 8
·766
·
IF 5.4
Xiaoxiao Zhou,Shouhui Chen,Yi Pan,Yuanfeng Wang,Naifeng Xu,Yanwen Xue,Xinlin Wei,Ying Lu
In order to improve the detection performance of surface-enhanced Raman scattering (SERS), a low-cost Au@Ag nanorods (Au@Ag NRs) substrate with a good SERS enhancement effect was developed and applied to the detection of malachite green (MG) in aquaculture water and crayfish. By comparing the SERS signal enhancement effect of five kinds of Au@Ag NRs substrates with different silver layer thickness on 4-mercaptobenzoic acid (4-MBA) solution, it was found that the substrate prepared with 100 µL AgNO3had the smallest aspect ratio (3.27) and the thickest Ag layer (4.1 nm). However, it showed a good signal enhancement effect, and achieved a detection of 4-MBA as low as 1 × 10−11M, which was 8.7 times higher than that of the AuNRs substrate. In addition, the Au@Ag NRs substrate developed in this study was used for SRES detection of MG in crayfish; its detection limit was 1.58 × 10−9M. The developed Au@Ag NRs sensor had the advantages of stable SERS signal, uniform size and low cost, which provided a new tool for SERS signal enhancement and highly sensitive SERS detection method development.Keywords:Au@Ag nanorods substrate;surface-enhanced Raman scattering (SERS);malachite green
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OPTICS EXPRESS
·
2023
·Vol. 31
·期 16
·26474-26495
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IF 3.8
Linlin Xu,Ming Chen,Qingqiang Cui,Chang Wang,Mnegya Zhang,Linqi Zheng,Shuang Li,Hua Zhang,Guangda Liang
Exploring multifunctional surface-enhanced Raman scattering (SERS) substrates with high sensitivity, broadband response property and reliable practicability should be required for ultrasensitive molecular detection in complex environments, which is heavily dependent on the photo-induced charge transfer (PICT) efficiency realized on the desirable nano-architectures. Herein, we introduce ultra-clean ternary Au/Ag/AgCl nanoclusters (NCs) with broadband resonance crossing the visible light to near-infrared region created by one step laser irradiation of mixed metal ion solution. Interestingly, the surface defects and interaction among these unique cluster-like ternary nanostructures would be further enhanced by thermal annealing treatment at 300°C, providing higher broadband SERS activities than the reference ternary nanoparticles under 457, 532, 633, 785, and 1064 nm wavelengths excitation. More importantly, the further promoted SERS activities of the resultant Au/Ag/AgCl NCs with achievable ∼5-fold enhancement than the initial one can be conventionally realized by simplistically declining the temperature from normal 20°C to cryogenic condition at about -196°C, due to the lower temperature-suppressed non-radiative recombination of lattice thermal phonons and photogenerated electrons. The cryogenic temperature-boosted SERS of the resultant Au/Ag/AgCl NCs enables the limit of detection (LOD) of folic acid (FA) biomolecules to be achieved as low as 10−12 M, which is obviously better than that of 10−9 M at room temperature condition. Overall, the smart Au/Ag/AgCl NCs-based broadband SERS sensor provides a new avenue for ultrasensitive biomolecular monitoring at cryogenic condition.
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Surfaces and Interfaces
·
2023
·
IF 6.2
Wen Zhang,Ziqian Shi,Niu Pan,Pengfei Wu,Xiaoyang Fan,Chao Qu,Hongyan Xi,Tingting You,Yukun Gao,Penggang Yin
Plasmon-mediated chemical reactions (PMCRs) are considered as promising methods for promoting photo-driven chemical reactions by using solar energy. In this work, metal–organic frameworks (MOFs; HKUST-1) /Ag NPs substrate was feasibly prepared by electrodeposition method and electrostatic adsorption, and it was applied for in-situ monitoring of PMCRs from 4-nitrobenzenethiol (4-NBT) to 4, 4′-dimercaptoazobenzene (DMAB). By conducting in-situ surface enhanced Raman spectroscopy (SERS), the HKUST-1/Ag NPs substrate was proved performing efficient localized surface plasmon resonance (LSPR) effect. Surprisingly, higher efficiency of plasmon catalytic reaction was observed comparing with traditional Ag substrate, which was benefited from the adsorption capacity and stabilization effect of HKUST-1. Thus, the reaction mechanism testified by using the high efficiency HKUST-1/Ag NPs substrate, and a novel route monitoring the plasmon catalytic reaction was further offered.
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ACS Applied Nano Materials
·
2023
·
IF 5.9
Haoyu Guan,Guoqiang Fang,Xinxin Li,Haoyu Dong,Siqingaowa Han,Xiang Lin,Li Wang
The plasmon coupling properties of assembled metal nanogap structures are highly sensitive to the distance, shape, orientation, and configuration of faceted nanoparticles. However, the orientation control of nanoparticles is usually limited to in-plane configurations. In this paper, Au@Ag nanocubes (NCs) with sharp edges and corners were assembled on a polystyrene (PS) microsphere array as a hierarchical surface-enhanced Raman spectroscopy (SERS) substrate via a facile self-assembly technique. The Au@Ag NC monolayer undergoes an out-of-plane reconstruction and forms V-shaped nanogaps under the modulation of the PS microsphere array curved surface. This unique V-shaped nanogap can generate electromagnetic fields stronger than those of traditional parallel gaps and make it easier for target molecules to diffuse into the nanogaps. The three-dimensional (3D) SERS substrates have a wider spectral response and 20 times higher SERS activity than those of the Au@Ag NC monolayer films on flat substrates. The high sensitivity was demonstrated by the detection limit down to 10–9 M for 4-MBA with a substrate enhancement factor up to 3.1 × 107. Furthermore, the optimized 3D SERS substrate was applied to determine As5+ in water with detection limits as low as 10–8 M assisted by machine learning, indicating that the 3D SERS substrates have promising applications in food safety, environmental monitoring, and biological diagnosis.
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ANALYTICA CHIMICA ACTA
·
2023
·
IF 6.2
Yaoyu Tan,Mengyao Qi,Huan Jiang,Baihui Wang,Xia Zhang
The level of uric acid is crucial to human health. Octahedral oxygen vacancy MnCo 2 O 4 /Ag (V O -MnCo 2 O 4 /Ag) nanozyme was successfully prepared by simple hydrothermal, calcination and self-reduction methods. V O -MnCo 2 O 4 /Ag nanozyme is rich in Mn 2+ /Mn 3+ and C O 2+ /C O 3+ redox electron pairs, large specific surface area and oxygen vacancies. V O -MnCo 2 O 4 /Ag nanozyme showed high uricase-like activity and peroxidase-like activity. At the same time, the SERS signal of the detected molecule could be significantly enhanced after the catalytic reaction of the V O -MnCo 2 O 4 /Ag nanozyme. The K m values of V O -MnCo 2 O 4 /Ag nanozyme for H 2 O 2 and TMB were 0.04 mM and 0.027 mM respectively. Based on the uric acid oxidase-like and peroxidase-like activities of V O -MnCo 2 O 4 /Ag, we developed a label-free, sensitive, and reliable SERS uric acid detection system. The detection linear range of uric acid is 0.01 μM–1000 μM and the detection of limit is 7.8 × 10 −9 M. The results show that the sensing system has good accuracy, sensitivity, selectivity , and stability. It can be applied to the determination of samples under different conditions. This study provides profound insights into the design of enzyme-like activity regulation and SERS properties regulation of nanozymes, provides guidance for the study of reaction kinetics and catalytic mechanism of nanozymes, and has broad application prospects in the field of nanozymes and SERS sensing analysis.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2023
·
IF 8.4
Jinru Zhou,Yanzhuo Du,Huan Li,Lei Zheng,Yan Zhang,Linglin Fu
Ultra-sensitive, accurate, and quantitative detection of wheat gluten in food products can provide a basis for correct labeling “gluten-free” on food packages. In this strategy, a gold nanorods (AuNRs) self-assembly dimer-based surface-enhanced Raman scattering (SERS) sensor was constructed to achieve ultra-sensitive and accurate SERS quantification of wheat gluten. The AuNR dimers based-SERS sensor demonstrated satisfactory specificity, accuracy, reproducibility, and storage stability (35 days at 4 °C). Benefitting from the signal amplification function of AuNR dimers and the superiority of SERS, the sensor exhibited a wide detection range from 0.1 to 20 μg/mL with a limit of detection (LOD) of 35.06 ng/mL (S/N = 3) and a limit of quantitation (LOQ) of 116.87 ng/mL (S/N = 10). This strategy successfully achieved accurate quantification of gluten in 17 kinds of food products from five categories of commercially processed foods, providing new opportunities for ultra-sensitive and accurate quantification of gluten in food products throughout the supply chain.
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Biosensors-Basel
·
2023
·Vol. 13
·期 6
·611
·
IF 5.4
Lei Wu,Xuefeng Liu,Shenfei Zong,Zhuyuan Wang,Yiping Cui
Point-of-care analysis of neurotransmitters in body fluids plays a significant role in healthcare improvement. Conventional approaches are limited by time-consuming procedures and usually require laboratory instruments for sample preparation. Herein, we developed a surface enhanced Raman spectroscopy (SERS) composite hydrogel device for the rapid analysis of neurotransmitters in whole blood samples. The PEGDA/SA composite hydrogel enabled fast separation of small molecules from the complex blood matrix, while the plasmonic SERS substrate allowed for the sensitive detection of target molecules. 3D printing was employed to integrate the hydrogel membrane and the SERS substrate into a systematic device. The sensor achieved highly sensitive detection of dopamine in whole blood samples with a limit of detection down to 1 nM. The whole detection process from sample preparation to SERS readout can be finished within 5 min. Due to the simple operation and rapid response, the device shows great potential in point-of-care diagnosis and the monitoring of neurological and cardiovascular diseases and disorders.Keywords:surface enhanced Raman spectroscopy (SERS);hydrogel;neurotransmitter;point-of-care test
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JOURNAL OF HAZARDOUS MATERIALS
·
2023
·
IF 13.6
Sen Li,Baodi Shi,Defu He,Huanying Zhou,Zhixian Gao
Diethylstilbestrol (DES) is a threatening factor to the human endocrine system. Here, we reported a DNA origami-assembled plasmonic dimer nanoantenna-based surface-enhanced Raman scattering (SERS) biosensor for measuring trace DES in foods. A critical factor influencing the SERS effect is interparticle gap modulation of SERS hotspots with nanometer-scale accuracy. DNA origami technology aims to generate naturally perfect structures with nano-scale precision. Exploiting the specificity of base-pairing and spatial addressability of DNA origami to form plasmonic dimer nanoantenna, the designed SERS biosensor generated electromagnetic-enhancement and uniform-enhancement hotspots to improve sensitivity and uniformity. Owing to their high target-binding affinity, aptamer-functionalized DNA origami biosensors transduced the target recognition into dynamic structural transformations of plasmonic nanoantennas, which were further converted to amplified Raman outputs. A broad linear range from 10 −10 to 10 −5 M was obtained with the detection limit of 0.217 nM. Our findings demonstrate the utility of aptamer-integrated DNA origami-based biosensors as a promising approach for trace analysis of environmental hazards.
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Chemosensors
·
2023
·Vol. 11
·期 6
·347
·
IF 4.2
Chao Liu,Hui Wang,Shengmin Xu,Hongbao Li,Yilin Lu,Chuhong Zhu
Mercury ions can be enriched along the food chain and even low concentrations of mercury ions can seriously affect human health and the environment. Therefore, rapid, sensitive, and highly selective detection of mercury ions is of great significance. In this work, we synthesized Fe3O4@SiO2@Au three-layer core/shell nanoparticles, and then modified 4-MPy (4-mercaptopyridine) to form a SERS sensor. Mercury ions in water can be easily captured by 4-MPy which were used as the reporter molecules, and the concentration of mercury ions can be evaluated based on the spectral changes (intensification and reduction of peaks) from 4-MPy. After the mercury ion was combined with the pyridine ring, the peak intensity at 1093 cm−1increased with the concentration of mercury ion in the range of 10 ppm–1 ppb, while the Raman intensity ratio I (416 cm−1)/I (436 cm−1) decreased with the increase of mercury ion concentration. This magnetically separatable and recyclable SERS sensor demonstrates good stability, accuracy, and anti-interference ability and shows the potential to detect actual samples. Furthermore, we demonstrate that the probe is applicable for Hg2+imaging in macrophage cells.Keywords:core/shell nanoparticles;4-pyridinethiol;surface-enhanced Raman spectroscopy (SERS);Mercury (II) ion;Raman cell imaging
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