Journal of Magnesium and Alloys
·
2022
·
IF 11.813
Yongyang Zhu,Mili Liu,liming Zeng,Yin Wang,Daifeng Wu,Rui Li,Qing Zhou,Renheng Tang,Fangming Xiao
The hydrolysis of MgH 2 delivers high hydrogen capacity (15.2 wt%), which is very attractive for real-time hydrogen supply. However, the formation of a surface passivation Mg(OH) 2 layer and the large excess of H 2 O required to ensure complete hydrolysis are two key challenges for the MgH 2 hydrolysis systems. Now, a low-cost method is reported to synthesize MgH 2 @Mg(BH 4 ) 2 composite via ball-milling MgH 2 with cheap and widely available B 2 O 3 (or B(OH) 3 ). By adding small amounts of B 2 O 3 , the in-situ formed Mg(BH 4 ) 2 could significantly promote the hydrolysis of MgH 2 . In particular, the MgH 2 –10 wt% B 2 O 3 composite releases 1330.7 mL·g −1 H 2 (close to 80% theoretical hydrogen generation H 2 ) in H 2 O and 1520.4 mL·g −1 H 2 (about 95%) in 0.5 M MgCl 2 in 60 min at 26 °C with hydrolysis rate of 736.9 mL·g −1 ·min −1 and 960.9 mL·g −1 ·min −1 H 2 during the first minute of the hydrolysis, respectively. In addition, the MgCl 2 solution allows repeated use by filtering and exhibits high cycle stability (20 cycles), therefore leading to much reduced capacity loss caused by the excess H 2 O. We show that by introducing B 2 O 3 and recycling the 0.5 M MgCl 2 solution, the system hydrogen capacity can approach 5.9 wt%, providing a promising hydrogen generation scheme to supply hydrogen to the fuel cells.
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LETTERS IN ORGANIC CHEMISTRY
·
2025
·Vol. 22
·期 8
·633-641
·
IF 1
Hongyin Wang,Yu Liang,Yida Yu,Yihao Wang,Ni An,Dong Cai
The ureido moiety stands as one of the most regarded scaffolds in medicinal and organic synthesis. In this study, we endeavored to synthesize a product containing tertiary amine moieties through the nucleophilic substitution reaction of the 2-chloroethyl urea derivative with a secondary amine, utilizing either inorganic bases, such as K2CO3 or organic bases like triethylamine as acid-binding agents in diverse reaction media. Unfortunately, the reaction failed to yield the desired nucleophilic substitution product in high yield, attributed to the reactivity of the 2-chloroethyl urea derivative. The structures of potential impurities were elucidated based on comprehensive spectroscopic data, including 1H NMR, 13C NMR, HRMS, HMBC, and HSQC.
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Separations
·
2025
·Vol. 12
·期 8
·198
·
IF 2.7
Yan Wu,Zicheng Wang,Hui Yu,Bin Ding,Ke Fei,Xueli Ma,Baoshen Xu,Yonghu Zhang,Xiaoning Fu,Bowen Ding,Nan Li
Developing and utilizing capture and storage technologies for CO2has become a critical research topic due to the significant greenhouse effect caused by excessive CO2emissions. A conventional physical absorption process for CO2capture is polyethylene glycol dimethyl ether (NHD); however, its limited application range is caused by its poor absorption of CO2at low pressures. In this work, the CO2absorption of NHD was enhanced by combining NHD with a novel chemical absorbent 2-methylimidazole (2-mIm)-ethylene glycol (EG) solution to improve CO2absorption. Viscosity and CO2solubility were examined in various compositions. The CO2solubility in the mixed solution was found to be at maximum when the mass fractions of NHD, 2-mIm, and EG were 20%, 40%, and 40%, respectively. In comparison to pure NHD, the solubility of CO2in this mixed solution at 30 °C and 0.5 MPa increased by 161.2%, and the desorption heat was less than 30 kJ/mol. The complex solution exhibits high selectivity and favorable regeneration performance in the short term. However, it is more sensitive to moisture content. The results of this study can provide important data to support the construction of new low-energy solvent systems and the development of novel CO2capture processes.
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Journal of Environmental Chemical Engineering
·
2025
·
IF 7.2
Panpan Wang,Meiyu Shi,Bochen Zhao,Yuan Shu,Qiang Niu,Pengfei Zhang
Carbide residue, a highly alkaline industrial solid waste generated during acetylene production, is primarily composing of Ca(OH) 2 . In this study, a top-down solid-state redispersion strategy. By synergizing mechanochemical activation with surfactant capping, we achieving the recycling of carbide residue to synthesize Ca(OH) 2 -CTAB anosheet-based desulfurization agent. The resultant material exhibits a significantly enhancing BET specific surface area (30.2 m 2 ·g −1 ) and abundant pore architecture. Comparative evaluations with Ca(OH) 2 -P123 and raw carbide residue revealing the superior performance of the Ca(OH) 2 -CTAB adsorbent, demonstrating a sulfur dioxide adsorption capacity of 2.57 mmol·g −1 is a 2-fold improvement over untreating carbide residue. Furthermore, significantly extends the fixed-bed penetration time to 43869 seconds. Comprehensive characterization through TG, FTIR, BET, SEM, TEM, and AFM elucidating the relationship between the nanosheet morphology and its exceptional desulfurization performance. This work provides a green methodology for upcycling industrial alkaline waste into functional nanomaterials for environmental remediation.
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International Journal of Medical Sciences
·
2025
·Vol. 22
·期 8
·1773-1790
·
IF 3.2
Xing Shu-Juan,Gao Ying-Feng,Liu Lu,Sui Bing-Dong,Da Ning-Ning,Liu Jin-Yu,Wang Hao,Yuan Yuan,Qin Yuan,Liu Pei-Sheng,Ying Si-Qi,Zhang Kai,Liu Jie-Xi,Chen Ji,Liu Yi-Han,Xie Xin,Jin Yan,Zhang Sha,Zheng Chen-Xi
Background: Type 2 diabetes (T2D) is a global metabolic condition associated with complications of multiple organs, including the bone. However, the exact impact of T2D on bone along the disease progression, particularly in the early phase, remains largely unknown.Methods: Four-week and sixteen-week high-fat diet (HFD) feeding-induced T2D mouse models were established, and the glucose metabolic status was examined. Bone mass was evaluated by micro-computed tomography (micro-CT), and immunofluorescent (IF) staining was performed for bone histomorphometry with enzyme-linked immunosorbent assay (ELISA) determining serum markers. RNA sequencing analysis was performed to examine the transcriptome of bone, and single-cell RNA-sequencing (scRNA-seq) analysis was further applied. Bone marrow mesenchymal stem cells (BMMSCs) were isolated and analyzed for functional behaviors.Results: The occurrence of glucose metabolic disorders was confirmed at both four weeks and sixteen weeks of HFD feeding, showing increased blood glucose levels with impaired glucose tolerance and insulin sensitivity. Notably, early T2D osteoporosis symptoms were detected at four weeks, especially in the trabecular bone, demonstrating reduced bone mass and mineral density. Histological analysis confirmed that bone remodeling and immune-related inflammation were also altered in T2D mice, remarkably at the early phase, mainly reflected by suppressed bone formation, stimulated bone resorption, increased macrophages, and elevated tumor necrosis factor-alpha (TNF-α) levels. Transcriptomic sequencing further demonstrated significant yet distinct changes in the gene expression profile of bone during T2D progression, which confirmed the histological findings. Notably, overlapping genes with altered expression at four weeks and sixteen weeks of T2D compared to the respective control were identified, and bone marrow scRNA-seq analysis indicated many of them were expressed in BMMSCs, suggesting BMMSCs critically involved in T2D osteoporosis. Dysregulated molecular profiles and functional abnormalities of BMMSCs in T2D mice were validated by ex vivo assays, showing early and persistent occurrence of impaired colony-forming and proliferative capacities with biased differentiation potential.Conclusions: These findings elucidate the bone lesion phenotype in T2D, particularly at the early phase, uncover changes in gene expression profiles of bone during T2D progression, and clarify the functional alterations in bone stem cells, providing a basis for subsequent research and the development of treatment strategies.
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高影响因子
FREE RADICAL BIOLOGY AND MEDICINE
·
2021
·
IF 7.376
Wen-Qiao Qiu,Wei Ai,Feng-Dan Zhu,Yue Zhang,Min-Song Guo,Betty Yuen-Kwan Law,Jian-Ming Wu,Vincent Kam-Wai Wong,Yong Tang,Lu Yu,Qi Chen,Chong-Lin Yu,Jian Liu,Da-Lian Qin,Xiao-Gang Zhou,An-Guo Wu
Activation of the NLRP3 inflammasome and its mediated neuroinflammation are implicated in neurodegenerative diseases, while mitophagy negatively regulates NLRP3 inflammasome activation. SHP-2, a protein-tyrosine phosphatase, is critical for NLRP3 inflammasome regulation and inflammatory responses. In this study, we investigated whether triterpenoid saponins in Radix Polygalae inhibit the NLRP3 inflammasome via mitophagy induction. First, we isolated the active fraction (polygala saponins (PSS)) and identified 17 saponins by ultra-performance liquid chromatography coupled with diode-array detection and tandem quadrupole time-of-flight mass spectrometry (UHPLC-DAD-Q/TOF-MS). In microglial BV-2 cells, PSS induced mitophagy as evidenced by increased co-localization of LC3 and mitochondria, as well as an increased number of autophagic vacuoles surrounding the mitochondria. Furthermore, the mechanistic study found that PSS activated the AMPK/mTOR and PINK1/parkin signaling pathways via the upregulation of SHP-2. In Aβ(1-42)-, A53T-α-synuclein-, or Q74-induced BV-2 cells, PSS significantly inhibited NLRP3 inflammasome activation, which was attenuated by bafilomycin A1 (an autophagy inhibitor) and SHP099 (an SHP-2 inhibitor). In addition, the co-localization of LC3 and ASC revealed that PSS promoted the autophagic degradation of the NLRP3 inflammasome. Moreover, PSS decreased apoptosis in conditioned medium-induced PC-12 cells. In APP/PS1 mice, PSS improved cognitive function, ameliorated Aβ pathology, and inhibited neuronal death. Collectively, the present study, for the first time, shows that PSS inhibit the NLRP3 inflammasome via SHP-2-mediated mitophagy in vitro and in vivo, which strongly suggests the therapeutic potential of PSS in various neurodegenerative diseases.
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BIOMEDICINE & PHARMACOTHERAPY
·
2016
·
IF 2.326
ZhenQiu Chen,QiuShi Wei,GuoJu Hong,Da Chen,Jiang Liang,Wei He,Mei Hui Chen
Bone marrow stromal cells (BMSCs) have proven to be useful for the treatment of numerous human diseases . However, the reparative ability of BMSCs is limited by their poor migration. Polydatin , widely used in traditional Chinese remedies, has proven to exert protective effects to BMSCs. However, little is known about its role in BMSCs migration. In this study, we studied the effects of polydatin on rat BMSCs migration using the scratch wound healing and transwell migration assays. Our results showed polydatin could promote BMSCs migration. Further experiments showed activation of ERK 1/2, but not JNK , was required for polydatin-induced BMSCs migration, suggesting that polydatin may promote BMSCs migration via the ERK 1/2 signaling pathways . Taken together, our results indicate that polydatin might be beneficial for stem cell replacement therapy by improving BMSCs migration.
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高影响因子
LABORATORY INVESTIGATION
·
2023
·
IF 5
Zhiguang Chen,Haibin Zhao,Lingshuai Meng,Shengwei Yu,Zhenning Liu,Jinqi Xue
Fracture healing is a complex physiological process in which angiogenesis plays an essential role. Microfibril-associated glycoprotein-2 (MAGP2) has been reported to possess a proangiogenic activity via integrin αvβ3, yet its role in bone repair is unexplored. In this study, a critical-sized femoral defect (2 mm) was created in mice, followed by the delivery of an adenovirus-based MAGP2 overexpression vector or its negative control at the fracture site. At days 7, 14, 21, and 28 postfracture, bone fracture healing was evaluated by radiography, micro–computed tomography, and histopathologic analysis. Adenovirus-based MAGP2 overexpression vector–treated mice exhibited increased bone mineral density and bone volume fraction. MAGP2 overexpression contributed to an advanced stage of endochondral ossification and induced cartilage callus into the bony callus. Further analysis indicated that MAGP2 was associated with enhanced angiogenesis, as evidenced by marked MAGP2 and integrin αvβ3 costaining and increased levels of endothelial cell markers such as endomucin and CD31, as well as elevated phosphorylation of protein tyrosine kinase 2 (PTK2) and AKT serine/threonine kinase 1 (AKT) in the callus. In vitro , recombinant human MAGP2 treatment enhanced the viability, migration, and tube formation ability of human microvascular endothelial cells, which was partially reversed by integrin αvβ3 inhibition or MK-2206, a specific AKT inhibitor. Inhibition of integrin αvβ3 abolished MAGP2-induced PTK2 and AKT activation. Taken together, our data provide the first evidence that MAGP2 promotes angiogenesis and bone formation by activating the integrin αvβ3/PTK2/AKT signaling pathway.
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高影响因子
RARE METALS
·
2025
·
IF 11
Zhen-Xuan Ma,Jia-Guang Zheng,Mei-Ling Lv,Cong Li,Chang-Hai Wu,Pan-Pan Zhou,Chao Su,Lei Ge
en This research uncovered the influence of nitrogen-doped MXene Ti 3 CN on the reversible hydrogen storage properties of Mg(BH 4 ) 2 . The Mg(BH 4 ) 2 -20Ti 3 CN composite began releasing hydrogen at a temperature of 80°C. In addition, the composite discharged over 8.8 wt% hydrogen at a comparatively lower temperature of 270°C, whereas the pure Mg(BH 4 ) 2 emitted merely 5.9 wt% hydrogen under identical circumstances, which exhibited remarkably enhanced dehydrogenation kinetics. Furthermore, upon completion of four cycles, Mg(BH 4 ) 2 -20Ti 3 CN retained a reversible hydrogen storage capacity of 4.5 wt%, representing an 80% improvement over the undoped Mg(BH 4 ) 2 . In the course of the dehydrogenation phase, the boron atoms in Mg(BH 4 ) 2 were anchored by nitrogen atoms in Ti 3 CN to form B-N bonds, which helped suppress the formation of MgB 12 H 12 . During the subsequent rehydrogenation process, the B-N bonds broke, and the boron atoms reparticipated in the reversible transformation into [BH 4 ] − clusters. Meanwhile, the formation of Ti 0 by the reaction of Mg(BH 4 ) 2 with Ti 3 CN weakened the B-H bond energy, and the layered structure provided an effective way for hydrogen spillover. These factors collectively improved the reversible hydrogen storage capabilities of Mg(BH 4 ) 2 . 摘要 zh 本研究揭示了氮掺杂MXene Ti 3 CN对Mg(BH 4 ) 2 可逆储氢性能的影响。Mg(BH 4 ) 2 -20Ti 3 CN复合材料在温度80°C时开始放氢。此外,在270°C的较低温度下,该复合材料的氢排放量超过8.8 wt%,而在相同的条件下,纯Mg(BH 4 ) 2 的氢排放量仅为5.9 wt%,脱氢动力学显著增强。在完成四个循环后,Mg(BH 4 ) 2 -20Ti 3 CN保留了4.5 wt%的可逆储氢容量,比未掺杂的Mg(BH 4 ) 2 提高了80%。在脱氢过程中,Mg(BH 4 ) 2 中的硼原子被Ti 3 CN中的氮原子锚定形成B-N键,有助于抑制MgB 12 H 12 的形成。在随后的再氢过程中,B-N键断裂,硼原子重新参与可逆转化为[BH 4 ] − 簇。同时,Mg(BH 4 ) 2 与Ti 3 CN反应生成Ti 0 ,削弱了B-H键能,层状结构也为氢溢出提供了有效路径。这些因素共同提高了Mg(BH 4 ) 2 的可逆储氢能力。
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JOURNAL OF FOOD SCIENCE
·
2025
·Vol. 91
·期 1
·e70646
·
IF 3.4
Qi Fang,Xinyao Liu,Wei Huang,Kai Qian,Yanjianxiong Yang,Jing Li,Zeyuan Deng
Docosahexaenoic acid (DHA), one of the most critical polyunsaturated fatty acids, is vital for the neurological growth and cognitive function of infants and children. Approximately 98% of DHA in breast milk exists as triglycerides, with 60% esterified at the sn-2 position. To demonstrate the necessity of mimicking the form of DHA present in breast milk in nutritional food for young children, this study administered diets with varying sn-2 DHA contents (10%, 30%, and 50%) to four groups of mice and analyzed their behavioral performance, brain DHA concentration, expression of brain fatty acid transport proteins, histopathology, and expression of synaptic-related proteins in the hippocampus after 4 weeks. The results showed that compared with the control group, mice in the 50% sn-2 DHA group exhibited superior learning and memory capabilities in behavioral tests, with the most pronounced behavioral improvements in mice, which correlated with higher brain DHA accumulation (from 0.870 ± 0.055 mg/g brain to 1.809 ± 0.132 mg/g brain, p < 0.05), increased levels of MFSD2A (1.40-fold, p > 0.05), FABP5 (2.36-fold, p < 0.05), FATP1 (1.47-fold, p < 0.05), and ACSL6 (1.48-fold, p < 0.05), improved hippocampal neuron morphology, and enhanced the level of BDNF (1.55-fold, p < 0.05), SYN (1.45-fold, p < 0.05), and PSD-95 (1.57-fold, p < 0.05). These findings establish a foundation for developing DHA nutritional supplements.
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高影响因子
JOURNAL OF ENDOCRINOLOGY
·
2018
·Vol. 238
·期 2
·137-149
·
IF 4.012
Lihong Fu,Yixuan Qiu,Linyan Shen,Canqi Cui,Shuang Wang,Shujie Wang,Yun Xie,Xinjie Zhao,Xianfu Gao,Guang Ning,Aifang Nie,Yanyun Gu
An increasing amount of evidence suggests that the delayed effect of antibiotics (abx) on gut microbiota after its cessation is not as favorable as its immediate effect on host metabolism. However, it is not known how the diverse abx-dependent metabolic effects influence diabetic subjects and how gut microbiota is involved. Here, we treated db/db mice with abx cocktail for 12 days and discontinued for 24 days. We found that db/db mice showed decreased body weight and blood glucose after abx treatment, which rapidly caught up after abx cessation. Twenty-four days after abx withdrawal, db/db mice exhibit increased plasma, hepatic total cholesterol (TC) levels and liver weight. The gut microbiota composition at that time showed decreased relative abundances (RAs) of Desulfovibrionaceae and Rikenellaceae, increased RA of Erysipelotrichaceae and Mogibacteriaceae, which were correlating with the reduced short-chain fatty acids (SCFAs) in gut content, such as propionic acid and valeric acid and with the elevated fecal taurine-conjugated bile acids (BAs) levels. The molecular biology studies showed inhibited hepatic BA synthesis from cholesterol, impeded intracellular transportation and biliary excretion of cholesterol that all conferred to liver TC accumulation. The associations among alterations of gut microbiota composition, microbial metabolite profiles and host phenotypes suggested the existence of gut microbiota-linked mechanisms that mediate the unfavorable delayed effects of abx on db/db mice cholesterol metabolism. Thus, we call upon the caution of applying abx in diabetic animal models for studying microbiota-host interaction and in type 2 diabetes subjects for preventing chronic cardiovascular consequences. An increasing amount of evidence suggests that the delayed effect of antibiotics (abx) on gut microbiota after its cessation is not as favorable as its immediate effect on host metabolism. However, it is not known how the diverse abx-dependent metabolic effects influence diabetic subjects and how gut microbiota is involved. Here, we treated db/db mice with abx cocktail for 12 days and discontinued for 24 days. We found that db/db mice showed decreased body weight and blood glucose after abx treatment, which rapidly caught up after abx cessation. Twenty-four days after abx withdrawal, db/db mice exhibit increased plasma, hepatic total cholesterol (TC) levels and liver weight. The gut microbiota composition at that time showed decreased relative abundances (RAs) of Desulfovibrionaceae and Rikenellaceae, increased RA of Erysipelotrichaceae and Mogibacteriaceae, which were correlating with the reduced short-chain fatty acids (SCFAs) in gut content, such as propionic acid and valeric acid and with the elevated fecal taurine-conjugated bile acids (BAs) levels. The molecular biology studies showed inhibited hepatic BA synthesis from cholesterol, impeded intracellular transportation and biliary excretion of cholesterol that all conferred to liver TC accumulation. The associations among alterations of gut microbiota composition, microbial metabolite profiles and host phenotypes suggested the existence of gut microbiota-linked mechanisms that mediate the unfavorable delayed effects of abx on db/db mice cholesterol metabolism. Thus, we call upon the caution of applying abx in diabetic animal models for studying microbiota-host interaction and in type 2 diabetes subjects for preventing chronic cardiovascular consequences.
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FUEL
·
2025
·
IF 7.5
Wanpeng Li,Xuewei Zhang,Guangmai Zhao,Tianhan Zhu,Mi Luo,Tianyu Gao,Chenguang Wang,Xiaoyu Chen,Jin Tan,Yuhe Liao,Haiyong Wang
The efficient and sustainable transformation of biomass-derived furfural into value-added chemicals is a key challenge in green chemistry. In this study, a series of Pt/CeO 2 catalysts with varying Pt loadings (0.1–2.0 wt%) were synthesized via a carbonization–reduction method and applied for the selective conversion of furfural to 2-furfural diethanol in ethanol under mild conditions. Comprehensive characterization using XRD, XPS, EPR, TEM, and Py-FTIR revealed that the 1.0 wt% Pt/CeO 2 catalyst exhibited optimal properties, including high dispersion of metallic Pt⁰, abundant oxygen vacancies, enriched Ce 3+ species, and dominant Lewis acid sites. Catalytic tests demonstrated that under mild conditions (20 °C, 4 MPa N 2 ), the 1.0 wt% Pt/CeO 2 catalyst achieved the highest yield (92.17 %) and furfural conversion (95.41 %). Mechanistic studies suggest a proposed redox-driven tandem hydrogenation–condensation pathway, where the synergistic effect between Pt⁰ sites and oxygen vacancies facilitates furfural activation, hydrogen transfer, and product formation. This work provides a mechanistic understanding of furfural upgrading over Pt/metal oxide interfaces and offers a promising strategy for the rational design of high-performance catalysts for biomass valorization.
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危险品化学品经营许可证（带存储）