JOURNAL OF VIROLOGY
·
2025
·
IF 3.8
Xiaohan Chen,Yipeng Pang,Fructueux Modeste Amona,Zilu Liu,Fang Wang,Yuan Liang,Jiachen Yang,Wanhan Zhang,Xingtang Fang,Xi Chen
Porcine reproductive and respiratory syndrome virus (PRRSV) is a highly contagious pathogen that causes substantial economic losses in the global swine industry, primarily by impairing reproductive performance and respiratory health. However, current therapeutic approaches remain limited in effectively controlling PRRSV infection. Here, we present self-assembled cyanidin-3-O-glucoside (C3G)-based nanoparticles (C3G-Cs-SeNPs) as a promising antiviral agent against PRRSV infection. These nanoparticles demonstrated excellent stability and biocompatibility, with minimal cytotoxicity in Marc-145 cells. C3G-Cs-SeNPs significantly reduced ROS levels in PRRSV-infected cells, enhancing the antioxidant capacity and mitigating oxidative stress. In addition, they effectively inhibited key stages of the PRRSV lifecycle, including viral internalization and replication, leading to a marked decrease in viral proliferation. Moreover, C3G-Cs-SeNPs alleviated ferroptosis by restoring redox homeostasis through enhanced antioxidant enzyme activity. Mechanistically, these nanoparticles potentially activate the SIRT1/Nrf2/HO-1 signaling pathway, which plays a critical role in regulating inflammation and ferroptosis in PRRSV-infected cells. These findings suggest that C3G-Cs-SeNPs could serve as a novel therapeutic approach to modulate inflammation, ferroptosis, and viral replication in respiratory viral infections. Our study highlights the therapeutic potential of C3G-Cs-SeNPs in combating PRRSV infection, with important implications for viral infection management and respiratory disease treatment.
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PubMed
高影响因子
Carbon Energy
·
2025
·
IF 24.2
Pengcheng Wang,Xuqi Lin,Houlin Cheng,Ciqi Yuan,Yongping Zheng,Yingbin Lin,Zhigao Huang,Hao Chen,Jiaxin Li
Na 3 V 2 (PO 4 ) 3 (NVP) is a promising electrode material that exhibits magnetic anisotropy; however, the potential of this magnetic anisotropy to optimize battery performance has been largely unexplored. This study proposes a cost-effective and efficient method to induce the alignment of NVP along the (113) crystal plane by applying a vertical magnetic field during the slurry coating process, thereby enhancing its battery performance. Comprehensive structural characterizations and theoretical analysis elucidate the structure-activity relationship between the preferred crystal orientation and ion transport kinetics, facilitating the formation of more ordered Na + deintercalation pathways in NVP electrodes. This alignment reduces electrode tortuosity, enhances interfacial compatibility, and substantially improves battery performance, particularly in terms of high-rate cycling capability. As a result, the magnetic-field-modulated NVP (NVP−M⊥) electrode exhibits a high capacity retention of 85.1% after 500 cycles at 5 C, significantly surpassing that of the pristine electrode. The NVP−M⊥ electrode also demonstrates considerable reversible capacity at 40 C and maintains excellent stability under high temperature and prolonged cycling conditions. Furthermore, superior battery performance is observed in the assembled NVP−M⊥||hard−carbon pouch cell and commercial NVP electrode following magnetic-field modulation, thereby validating the efficacy of this method. Consequently, this magnetic-field-induced crystal-orientation optimization strategy provides an innovative approach for low-cost and high-throughput preparation of high-performance sodium-ion batteries.
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POLYMER BULLETIN
·
2025
·
IF 4
Zhao Xuan,Yang Liu,Sun Xinyu,Zhou Kun,Yuan Shuai
A novel class of 3-methylphenol alkoxy aluminum complexes was developed for the ring-opening polymerization (ROP) of ε-caprolactone (ε-CL) under mild conditions (60 °C, 30 min). Through systematic optimization of Al/CL molar ratios (5:1000 ~ 4:1000), monomer concentrations (1 mol/L), and reaction parameters, high polymer yield (99.9% ± 0.1%) was achieved, yielding polycaprolactone (PCL) with tunable molecular weights (M n up to 34 kg/mol) and narrow dispersity (PDI = 1.38). Structural characterization via 1 H NMR and FTIR confirmed successful PCL formation. GPC analysis validated controlled chain growth and uniformity (PDI < 1.5), while thermal properties were assessed via DSC and TGA, showing semicrystalline behavior and high thermal stability. Kinetic studies showed linear molecular weight progression with polymer yield, while sequential monomer feeding experiments confirmed living polymerization characteristics, with M n increasing proportionally and maintaining low PDI. Compared to conventional metal-based systems, this catalytic platform operates at lower temperatures with reduced toxicity risks, enabling energy-efficient synthesis of biodegradable polyester for biomedical and packaging applications.
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Laser & Photonics Reviews
·
2024
·
IF 9.8
Ruiqing Zhang,Huidong Xie,Fu Wang,Qiyu Zhao,Lingyi Meng,Zuobin Tang,Binbin Su,Hu Liu
The luminescence property of various compounds is developed in the photoelectric applications field, while the near-infrared (NIR) dual-band emission of compounds is extremely challenging. Herein, 0D Cu(I)-based organic–inorganic module (ETA) 3 Cu 6 I 9 is synthesized to achieve NIR and cyan dual-band emission in metal halide systems. Density functional theory (DFT) calculations combined with comprehensive spectroscopic data reveal its emission mechanism. Under the excitation at 371 nm, (ETA) 3 Cu 6 I 9 shows the broadband NIR emission peaking at 775 nm with a large wavelength, attributed to the triple-cluster-center ( 3 CC) transition. Meanwhile, under 286 nm excitation, (ETA) 3 Cu 6 I 9 shows a bright cyan emission peaking at 490 nm, attributed to the metal-to-ligand charge transfer (MLCT) or halide-to-ligand charge transfer (XLCT) transitions. Moreover, (ETA) 3 Cu 6 I 9 presents relatively superior thermal and air stability. Benefiting from the good stability of (ETA) 3 Cu 6 I 9 , the as-fabricated NIR-LED device demonstrates great potential in biological imaging and night vision. This study opens up a new way for designing new non-toxic NIR and cyan dual-band emission materials, which guides to synthesize new materials in metal halide field.
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高影响因子
Metals
·
2024
·Vol. 14
·期 12
·1453
·
IF 2.6
Bo Pei,Xin Qiao,Que Huang,Changcheng Liu,Mengna Shi,Xiaomei Jiang,Feng Li,Li Guo
Na3V2(PO4)3(NVP) is considered to be a promising cathode material for sodium-ion batteries (SIBs). Ion doping can effectively improve its structural deformation, poor conductivity, and electrochemical performance. However, the research on the effect of ion doping on the thermal stability of NVP is still limited. In this paper, Mg/Ti co-doped and Mn/Ti co-doped modified NVP with carbon nanotubes (CNTs) (MgTi@ CNTs and MnTi@CNTs) were prepared, respectively, and X-ray diffraction (XRD) results proved that MgTi@CNTs and MnTi@CNTs have good structural stability and crystallinity. The electrochemical performance indicates that the dual strategy ofp-n-type co-doping and CNT coating provides superior sodium storage performance, enhancing both electronic conductivity and ion diffusion. Secondly, based on the safety point of view, the thermal stability ofp-n-type ion-doped NVP and its mixed system with electrolyte in a charged state was studied by differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), and accelerated calorimeter (ARC). The results show that the optimized MgTi@CNTs and MnTi@CNTs electrodes exhibit excellent thermal stability in the absence of electrolytes, indicating their high intrinsic safety. However, it is worth noting that in the electrode/electrolyte system,p-n-type ion-doped NVP have higher reactivity with the electrolyte, and their comprehensive thermal safety is lower than that of NVP. Therefore, in practical applications, it is necessary to comprehensively consider the thermal stability of the material and the thermal safety of its mixed system with the electrolyte. This paper provides a data basis for the practical application of NVP in SIBs.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Peng-Xing Xie,Qing-Yuan Zhao,Haojie Dong,Tao Long,Meng-Sha Ding,Bin Xie,Xiao-Feng Wang,Wei Ling,Mengting Liu,Xiong-Wei Wu,Peng-Fei Wang,Xian-Xiang Zeng
Delivery of high energy density in polyanion compound-Na 3 V 2 (PO 4 ) 3 based on three-electron redox is still challenging because of their controversial multi-electron reaction mechanism and unsatisfactory electrochemical reversibility. Herein, the reversible V 4+ /V 5+ redox ( ca. 4.0 V) could be successfully activated in Na 4 VFe(PO 4 ) 3 cathode material through a Na-rich strategy, demonstrating a reversible specific capacity of 154.7mAh g −1 at 0.1C and 90.3mAh g −1 after 800 cycles at 20C, with 80 % of the initial capacity retained. The entire electrochemical reaction undergoes a highly recoverable phase transition by in-situ X-ray diffraction. Impressively, the Na-rich strategy could not only allow Na2 site to be occupied to activate the V 4+ /V 5+ redox pair confirmed by X-ray absorption near-edge structure spectroscopy, but also enable Na + transportation across the generated vacancies rather than synergistic Na + diffusion. This work provides rational design strategy of multi-electron transfer reaction in high-energy sodium-ion batteries.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2013
·
IF 2.906
Jianxia Sun,Shun Bai,Weibin Bai,Feiyan Zou,Lei Zhang,Zhijian Su,Qihao Zhang,Shiyi Ou,Yadong Huang
3-Monochloropropane-1,2-diol (3-MCPD) is a well-known food processing contaminant that has been shown to impede the male reproductive function. However, its mechanism of action remains to be elucidated. In this study, the effects of 3-MCPD on progesterone production were investigated using R2C Leydig cells. 3-MCPD caused concentration-dependent inhibition of cell viability at the IC25, IC50, and IC75 levels of 1.027, 1.802, and 3.160 mM, respectively. Single cell gel/comet assay and atomic force microscopy assay showed that 3-MCPD significantly induced early apoptosis. In addition, 3-MCPD significantly reduced progesterone production by reducing the expression of cytochrome P450 side-chain cleavage enzyme, steroidogenic acute regulatory protein, and 3β-hydroxysteroid dehydrogenase in R2C cells. The change in steroidogenic acute regulatory protein expression was highly consistent with progesterone production. Furthermore, the mitochondrial membrane potential and cAMP significantly decreased.
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高影响因子
POLYMER SCIENCE SERIES B
·
2020
·Vol. 62
·期 4
·368-374
·
IF 0.976
Qian Zhao,Zhan Yi-Kai,Liu Yu-Fei,He Min,Gong Yong-Ji
Abstract Poly( N -(3-carboxyphenyl)maleimide- alt -styrene) with superior heat-resistance was synthesized by free radical copolymerization and its structure was confirmed by FTIR and NMR spectroscopy. To show the advantages in heat-resistance of the synthesized copolymers, the thermal properties of poly( N -phenylmaleimide- alt -styrene) and poly( N -phenylmaleimide- alt -maleic anhydride) with similar structures were determined. DSC/TG analysis showed that the synthesized copolymer exhibited the better thermal properties than two other copolymers due to the formation of a chemically crosslinked three-dimensional network during heating.
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高影响因子
MOLECULES
·
2016
·Vol. 21
·期 3
·299
·
IF 2.465
Bo Jin,Rongzong Zheng,Rufang Peng,Shijin Chu
Five new bis(3-hydroxy-4-pyridinone) tetradentate chelators were synthesized in this study. The structures of these tetradentate chelators were characterized by1H-NMR,13C-NMR, FT-IR, UV-vis, and mass spectral analyses. The binding abilities of these tetradentate chelators for uranyl ion at pH 7.4 were also determined by UV spectrophotometry in aqueous media. Results showed that the efficiencies of these chelating agents are dependent on the linker length. Ligand4bis the best chelator and suitable for further studies.Keywords:chelating agent;3-hydroxy-4-pyridinone;uranium;tetradentate chelator
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LUMINESCENCE
·
2019
·Vol. 35
·期 2
·203-207
·
IF 1.691
Junfeng Qu,Han Jiang,Shuhong Xu,Chunlei Wang,Dayan Ban
The emission wavelength of organic–inorganic hybrid perovskite quantum dots (QDs) can be tuned by controlling reaction time relevant to the halide exchange. It is because halide exchange with different time would lead to different molar ratio of halides in perovskite QDs such as Cl and Br. Here, to research the ligand's effect on the halide exchange, this work synthesized 3-mercaptopropionic acid (MPA)-capped CH 3 NH 3 PbBr x Cl 3-x QDs. It was found that SH − of MPA appeared to inhibit the halide exchange during the reation. Moreover, although the MPA-capped CH 3 NH 3 PbBr x Cl 3-x QDs did not contain the chiral centre, they exhibit the optical rotation. This may provide a method for chirality manipulation of perovskite.
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PubMed
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MICROCHIMICA ACTA
·
2021
·Vol. 188
·期 4
·1-8
·
IF 5.833
Wu Daohong,He Yuhan,Tong Liujuan,Wang Jianxiu,Liu Lin,Yi Xinyao,Hu Shengqiang
An electrochemical sensor capable of quantitative determination of caspase-3 activities was developed. A thiolated peptide whose sequence contained a caspase-3 cleaved site and a cell penetration sequence was preimmobilized onto an electrode. The quantification of caspase-3 was accomplished after cell penetration and the subsequent adsorption of silver nanoparticles (AgNPs). The oxidation current of AgNPs was found to be inversely proportional to the concentration of caspase-3 between 0.02 and 0.2 U/mL. A detection limit of 0.02 U/mL for caspase-3 was achieved due to the large number of positively charged AgNPs adsorbed onto the negatively charged cells. The proof of concept was demonstrated by monitoring the cleavage of surface-confined peptide substrates by caspase-3 in cell lysates. The current sensor could be extended to detect cells by replacing the surface-confined peptide with aptamers that recognize cells. Thus, the use of a cell as a matrix for AgNPs shows excellent potential for constructing electrochemical sensors and provides a useful alternative for sensor development in the future. Graphical abstract
Cells modified with silver nanoparticles were utilized as the electrochemical readout of an electrochemical assay.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2022
·
IF 5.895
Xiankun Liu,Shiqiang Wen,Weichen You,Xiaofei Wang,Qing X. Li,Qiang Bian,Pei Lv,Rimao Hua
An efficient synthesis method will allow a large number of tetramic acid analogues to be synthesized for property and potency optimization. In this study, a facile and efficient method was described for the synthesis of 3-acyltetramic acids. The synthesis was accomplished mainly via (1) mild intramolecular cyclization and (2) the formation of β-ketoamides between nucleophiles and acyl Meldrum’s acids. 3-Acyltetramic acid exhibited phytotoxicity against Echinochloa crusgalli and Portulaca oleracea. At a dosage of 750 g ha–1, 6k and 6a showed high herbicidal activity against E. crusgalli, Digitaria sanguinalis and P. oleracea, Amaranthus retroflexus, respectively. 6k inhibited the synthesis of endogenous abscisic acid, thus seedling germination and plant growth. The incorporation of various acyl Meldrum’s acids and amino acid esters was applicable to the parallel synthesis of 3-acyltetramic acids. The mode of action and herbicidal activity indicate that 3-tetramic acid had good herbicidal performance and was a promising herbicide candidate. This study will provide a reference for novel herbicide development.
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