MICROCHIMICA ACTA
·
2024
·Vol. 191
·期 11
·1-11
·
IF 5.3
Lu Feng,Li Limao,Shen Kang,Qian Yayun,Zhang Pengfei,Yang Yan,Zhu Qunshan,Huang Yong,Yan Chunxiang,Wei Wei
A Raman-active boronate modified surface-enhanced Raman scattering (SERS) microporous array chip based on the enzymatic reaction was constructed for reliable, sensitive, and quantitative monitoring of D-Proline (D-Pro) and D-Alanine (D-Ala) in saliva. Initially, 3-mercaptophenylboronic acid (3-MPBA) was bonded to Au-coated Si nanocrown arrays (Au/SiNCA) via Au–S bonding. Following this, H 2 O 2 obtained from D-amino acid oxidase (DAAO)-specific catalyzed D-amino acids (D-AAs) further reduced 3-MPBA to 3-hydroxythiophenol (3-HTP) with a new Raman peak at 882 cm −1 . Meanwhile, the original characteristic peak at 998 cm −1 remained unchanged. Therefore, the I 882 /I 998 ratio increased with increasing content of D-AAs in the sample to be tested, allowing D-AAs to be quantitatively detected. The Au/SiNCA with large-area periodic crown structure prepared provided numerous, uniform “hot spots,” and the microporous array chip with 16 detection units was employed as the platform for SERS analysis, realizing high-throughput, high sensitivity, high specificity and high-reliability quantitative detection of D-AAs (D-Pro and D-Ala). The limits of detection (LOD) were down to 10.1 µM and 13.7 µM throughout the linear range of 20–500 µM. The good results of the saliva detection suggested that this SERS sensor could rapidly differentiate between early-stage gastric cancer patients and healthy individuals. Graphical Abstract
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ENERGY & FUELS
·
2024
·
IF 5.2
Li Zhao,Hao Fu,Yuan-gu Xia,Ji Liu,Bin Hu,Zhan-jun Cheng,Xi Luo,Dan Yan,Ji-hong Li,Qiang Lu
Pyrolysis is a promising thermochemical conversion technology, which can convert biomass and cellulose into value-added products. Herein, a new approach of oxalic acid-assisted staged fast pyrolysis (OASFP) of cellulose was developed, achieving the coproduction of 1,4:3,6-dianhydro-α-d-glucopyranose (DGP), furfural (FF), and formic acid (FA) in separated pyrolysis stages. The lab-scale tests demonstrated that a selectivity of 71.6% and a yield of 31.5 wt % for FA in the aqueous phase, as well as a selectivity of 55.6% and a yield of 1.2 wt % for FF in the organic phase, were achieved in the primary pyrolysis stage under the optimized conditions (primary pyrolysis temperature of 220 °C and cellulose-to-oxalic acid (OA) ratio of 1:3). During the subsequent secondary pyrolysis process at 400 °C, the decomposition of the solid residue achieved a yield of 7.2 wt % and a selectivity of 32.7% for DGP. The interaction between OA and cellulose during the primary pyrolysis stage was essential for DGP generation. The formation mechanism of major products and the role of OA were revealed based on experiments and density functional theory calculations. In total, the OASFP of cellulose offers new possibilities and opportunities for biomass utilization.
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Journal of Energy Chemistry
·
2025
·
IF 14.9
Dengqi Zhou,Ke Zeng,Liqiang Wang,Feiying Tang
The development of highly efficient non-noble metal catalysts for the hydrogenation of N-heteroarenes under mild condition is of great importance for both theoretical and industrial applications, which can efficiently reduce energy consumption and environmental pollution. In this work, we found that the prepared CoCu nano-alloy catalyst after exposed in the air over 24 h (named Co 1 Cu 1 /C) exhibited a dramatically improved catalytic performance (yield from trace to >99%) for quinoline hydrogenation under mild reaction conditions (60 °C, 3 MPa H 2 ). According to the characterization, the catalyst Co 1 Cu 1 /C exhibited the strong interaction between Co and Cu. Meanwhile, it was endowed with a stable partial oxidation surface. The unsaturated oxygen coordinated surface of Co 1 Cu 1 /C presented a moderate binding for quinoline and 1, 2, 3, 4-tetrahydroquinoline, which could efficiently avoid the deactivation of catalyst and favor the hydrogenation kinetics. The density functional theory (DFT) calculations coupled with X ray-based structural analyses suggested that the unsaturated oxygen coordinated surface could lower the diffusion energy of the active hydrogen species and the reaction barrier for quinoline hydrogenation which resulted from the d - p orbital electron coupling. This work revealed that the catalytic performance of nano-alloy catalysts might not only be ascribed to the interaction between metals, while the unsaturated oxygen coordination of metallic surfaces played an important role.
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Foods
·
2025
·Vol. 14
·期 9
·1648
·
IF 5.1
Feng Yang,Xin Qi,Yan Chen,Kai Tang,Mengyang Fang,Yanwei Song,Jiufen Liu,Lianming Zhang
In this study, β-cyclodextrin (β-CD) functionalized graphene quantum dots (GQDs) was employed to augment the array of chiral recognition sites, thereby enhancing the affinity of GQDs/β-CD composite for imprinting molecules and realizing heightened chiral selectivity. The incorporation of GQDs/β-CD into the synthesis of molecularly imprinted polymers (MIPs), synergizing with the host-guest inclusion properties of β-CD and the abundant carboxyl groups of GQDs, enhanced the chiral recognition capacity of MIPs materials. Consequently, a novel MIPs/(GQDs/β-CD) sensor with chiral recognition capabilities tailored for D-carnitine was successfully fabricated. The binding mechanism between GQDs/β-CD and D-carnitine was elucidated via Ultraviolet-visible spectroscopy and Fourier transform infrared spectroscopy. The variation in the response signal (ΔI) of the probe molecule exhibited a linear correlation with the logarithm of D-carnitine concentration (lgC) in the range of 1.0 × 10−12mol/L to 1.0 × 10−9mol/L, and the detection limit (3δ/S) was calculated as 2.35 × 10−13mol/L. These results underscore a 7.15-fold enhancement in the selectivity of MIPs/(GQDs/β-CD) sensor for D-carnitine recognition. Moreover, the sensor presented commendable efficacy in real-world scenarios, yielding recovery rates ranging from 98.5% to 103.0% during the determination of D-carnitine content in real samples.
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International Journal of Nanomedicine
·
2017
·
IF 4.3
Jifu Hao,Tiantian Tong,Kai Jin,Qiannan Zhuang,Te Han,Yanping Bi,Jianzhu Wang,Xiaodan Wang
A folic acid (FA)-functionalized drug vehicle platform based on Pluronic 127 (P127)/D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) mixed micelles was orchestrated for an effective delivery of the model drug resveratrol in order to address the problem of poor water solubility and rapid metabolism of resveratrol and improve its targeted accumulation at tumor site. The FA-decorated mixed micelles were prepared using thin-film hydration method and optimized by central composite design approach. The micelles were also characterized in terms of size and morphology, drug entrapment efficiency and in vitro release profile. In addition, the cytotoxicity and cell uptake of the micelles were evaluated in folate receptor-overexpressing MCF-7 cell line. In vivo pharmacokinetic and biodistribution studies were also performed. The average size of the micelles was ~20 nm with a spherical shape and high encapsulation efficiency (99.67%). The results of fluorescence microscopy confirmed the targeting capability of FA-conjugated micelles in MCF-7 cells. FA-modified micelles exhibited superior pharmacokinetics in comparison with that of solution. Further, the low accumulation of resveratrol-loaded FA micelles formulation in the heart and kidney avoided toxicity of these vital organs. It could be concluded that folate-modified P127/TPGS mixed micelles might serve as a potential delivery platform for resveratrol.
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CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Lujia Ding,Pengcheng Wang,Qiuhan Lin,Dongxue Li,Yuangang Xu,Ming Lu
Fused cyclic energetic compounds are a unique class of large conjugated structures containing two or more rings, and have been identified as promising competitors for traditional energetic materials. In the present work, we investigated 5-amino-6-oxo-4,6-dihydro-[1,2,5]oxadiazolo[3′,4′:5,6]pyrido[4,3- d ][1,2,3]triazine 8-oxide ( 3 ) in detail as a fused amphoteric energetic molecule that can be protonated and deprotonated by acids and bases to obtain its cationic ( 11 – 13 ) and anionic ( 4 – 10 ) salts. All the new compounds were thoroughly characterized by infrared and multinuclear NMR ( 1 H and 13 C) spectroscopy, and elemental analysis. The structural features of 3 – 6 , 9 , 10 , 12 , and 13 were investigated by single-crystal X-ray diffractions and different theoretical techniques (Hirshfeld surfaces analyses, and noncovalent interactions). The aromaticity of compound 3 was studied via localized orbital locator- π and iso -chemical shielding surfaces (ICSS). Their thermal decomposition temperatures were investigated by differential scanning calorimetry and thermogravimetry to be 310–344 °C (onset). In addition, impact and friction tests revealed that these compounds were insensitive. Densities, heats of formation and detonation properties were measured by a gas pycnometer, calculated using the Born-Haber energy cycle and EXPLO5 v6.05.04 program, respectively. The neutral compound 3 and all its non-metallic salts have better detonation properties than HNS and PYX and lower sensitivities. In particular, salt 11 (N + O: 61.74 %, T d : 330 °C, Δ H f : 1.68 kJ g −1 , D : 8.795 km s −1 , P : 36.0 GPa, IS: > 40 J, FS: > 360 N) is a potential candidate for heat-resistant explosives.
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JOURNAL OF LUMINESCENCE
·
2019
·
IF 2.961
Chengjun Wang,Ying Qian
A red emissive fluorescent probe 1,7-dimethyl-3,5-bis(4-methoxyphenyl-vinyl)-8-(10-n-butyl-10H-phenothiazine-3-yl)BODIPY 1,7-dimethyl-3,5-bis(4-methoxyphenyl-vinyl)-8-(10- n -butyl-10 H -phenothiazine-3-yl)BODIPY (avyl-BODIPY-PTZ) with a special orthogonal donor-acceptor structure was designed and synthesized for rapid, sensitive, and selective discrimination of ClO − , over other reactive oxygen species and anions. The probe displays a linear ratiometric absorption (A 578 /A 640 ) and fluorescence (F 599 /F 660 ) response toward ClO − with a fast response velocity (~10 s). The limit of detection (LOD) for ClO − was obtained as 22.6 nM from the fluorescence titration experiment. The fluorescence enhancement of the probe can be observed from the 32-fold enhancement in ratiometric value (F 599 /F 660 ) and the increasement of quantum yield from 0.01 at 660 nm to 0.28 at 599 nm. The oxidation of S atom in phenothiazine by ClO − to form the sulfoxide-type structure was proposed as the recognizing mechanism according to the Mass spectral analysis. The ratiometric enhancement of fluorescence was rationalized by the theoretical calculations. The orthogonal donor-acceptor structure according to optimized calculation and solvent effects of avyl-BODIPY-PTZ illustrated that the ClO − oxidation induced conversion from the nonradiative TICT process to the radiative LE process and caused the fluorescence ratiometric enhancement. The probe with low cytotoxity can successfully permeate into living cells and the cell images can be achieved in single channel. Moreover, after addition of ClO − , another bright red emission channel of the probe switched on and the probe displayed two-channel emission in living cells.
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JOURNAL OF HAZARDOUS MATERIALS
·
2024
·
IF 12.2
Chi Wu,Kai He,Huizhen Li,Lan Zhang,Liangang Mao,Lizhen Zhu,Jinhua Jiang,Xingang Liu
The transgenerational impacts of pesticide mixture on Daphnia magna ( D. magna ) following long-term exposure, particularly regarding transcriptomic effects, remain poorly understood. We analyzed 470 irrigation water samples from various Chinese provinces. Imidacloprid (IMI, 71.1 %), clothianidin (CLO, 60.43 %), and tebuconazole (TEB, 64.68 %) were the most frequently detected pesticides, with nearly 50 % of samples showing mixtures of TEB with IMI or CLO. D. magna were exposed to environmentally relevant concentrations (0.89–1.62 μg/L) over 12 generations. Key effects included reduced fecundity, delayed development, and smaller body size, with these impacts exacerbating across generations. A Leslie matrix model revealed declines in population size, intrinsic rates of increase, and age structure. Notably, mixed pesticide exposures induced specific pathways related to oocyte meiosis, resulting in greater toxicity than single exposures. Additionally, disrupted lipid metabolism and feeding behaviors were linked to insufficient energy for growth and reproduction, affecting ovarian development. These findings highlight the ecological risks of long-term pesticide exposure and offer insights for mitigation strategies in aquatic ecosystems.
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Advanced Powder Materials
·
2025
·
IF 24.9
Yang Li,Bin Sun,Ying Li,Chong Zhang,Pu-Jun Jin,Xin Wang,Bao Yu Xia,Yu Chen,Xuan Ai
The large-scale implementation of direct ethylene glycol fuel cells (DEGFCs) relies on the design of catalysts that possess exceptional activity, durability, and efficient C–C bond breaking ability. However, Pt and Pd-based nanomaterials continue to face challenges of low selectivity and slow reaction kinetics in driving the complete oxidation of ethylene glycol to CO 2 . In this work, a facile one-pot reduction method is reported for controllable synthesis of PtBi nanodendrites (PtBi-NDs) composed of ultrathin bimetallene subunits. In alkaline media, the composition optimized PtBi-NDs demonstrate outstanding activity and strong resistance to CO poisoning during the ethylene glycol oxidation reaction (EGOR). The PtBi-NDs show 5.8-fold higher mass activity, enhanced stability, and superior C1 selectivity relative to commercial Pt nanoparticles (Pt c-NCs). Most strikingly, PtBi-NDs deliver a higher power density (8.3 mW cm –2 ) than Pt c-NCs in DEGFCs. The theoretical analysis and experimental measurements explain that the introduction of Bi element into Pt induces d–p orbital hybridization and promotes electron transfer from Bi to Pt, thereby facilitating C–C bond cleavage and boosting EGOR kinetics. This work establishes an effective strategy for constructing Pt-based ultrathin bimetallenes and offers fundamental insights into boosting EGOR performance via d-p orbital hybridization.
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Journal of Biomedical Nanotechnology
·
2021
·Vol. 17
·期 4
·627-639
·
IF 4.099
Yu Xiao,Pan Jielu,Shen Nan,Zhang Haiyan,Zou Lu,Miao Hongyu,Xing Lianjun
The mortality rate of ethanol induced liver disease has substantially raised to alert level with an increasing use of alcohol, but development of definite hepatoprotective drug is still challenging. The efficacy of Saikosaponin D, one of the natural herbal medicine has been studied
in different diseases. Nonetheless, its clinical application is restricted by poor bioavailability, stability and solubility. This study sought to develop a Saikosaponin D loaded liposome via thin film hydration method. The surface morphology, encapsulation efficiency and drug loading capacity
were detected with transmission electron microscopy and HPLC, in vitro dissolution was via dialysis method, but efficacy and safety evaluation was through pharmacokinetics, while the assessment of hepatoprotective activity on alcohol induced acute hepatitis mice models was conducted.
The optimized liposomes showed significant greater therapeutic effect on liver, through decreased serum levels of alanine transaminase (ALT) and aspartate transaminase (AST), malondialdehyde (MDA), tumor necrosis factor alpha (TNF-α), total cholesterol (TC) and triglyceride (TG)
in liver homogenate. In contrast, levels of glutathione peroxidase (GSH-Px) and total superoxide dismutase (T-SOD) were increased significantly. Pathological study exhibited remarkable alteration of hepatitis liver architecture to almost normal state after administration of Saikosaponin D
liposome. The increased hepatoprotective effect of Saikosaponin D liposome was observed during the attenuation of alcoholic hepatitis in mice, which might be ascribable to the anti-oxidative and anti-inflammatory properties of the drug. This study provides a theoretical basis for developing
advanced system of Saikosaponin D delivery for the promotion of the therapeutic effects of the liposome against various kinds of diseases.
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ACS Sustainable Chemistry & Engineering
·
2026
·
IF 7.6
Shengqin Guan,Xinyu Liu,Xingbo Yu,Jianlong Wang,Baoen Xu,Kaixi Li,Taotao Guan
Abstract The advanced high-entropy configuration approach is employed to stabilize the structural integrity of transition metal sulfides during cycling by suppressing volume expansion. This configuration simultaneously preserves abundant active sites and maintains high electronic conductivity. However, the sodium storage mechanism in high-entropy materials remains inadequately understood. In this study, a solvothermal method is employed to synthesize a unique class of (FeCoNiCuW)S2 high-entropy metal sulfides (HEMSs), which exhibit distinct d-orbital coupling characteristics. Density functional theory (DFT) calculations reveal that stronger d-orbital coupling among the metals leads to higher electron density near the Fermi energy (EF), resulting in an upward shift of the entire d-band center relative to EF, thus enhancing the adsorption of the Na2S intermediate. As a result, (FeCoNiCuW)S2 demonstrates superior rate capability, achieving a specific capacity of 518.6 mA·h·g–1 at 5.0 A·g–1. Moreover, ex situ characterization confirms a reversible sodium storage mechanism, further demonstrating that the high-entropy effect stabilizes the conversion reaction reversibility upon prolonged cycling. This work highlights structurally stable HEMSs as promising anode materials for sodium-ion batteries.
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JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
·
2025
·
IF 4.7
Jinkai Wang,Yingzhe Wang,Yingchao Zhang,Xiangzhuo Han,Zhanchen Cui,Zuosen Shi
We present a polymer optical waveguide sensor for fluoride ion (F − ) detection utilizing D–π–A dipolar molecules functionalized with tert-butyl dimethyl siloxane (TBS) groups. The sensing mechanism relies on F − -induced cleavage of Si O bonds through a desilylation reaction, which triggers a corresponding fluorescence quenching at 607 nm. By employing a 532 nm excitation laser and exploiting evanescent field interactions at waveguide interfaces, we developed an optical sensing platform that enables both qualitative identification and quantitative measurement of trace F − concentrations through real-time fluorescence monitoring. The sensor demonstrates exceptional performance with an ultra-low detection limit of 2.25 ppb and rapid response characteristics (≈3 s). The device architecture permits configuration into multiple parallel detection channels, making it particularly promising for high-efficiency environmental monitoring and biomedical applications requiring simultaneous multi-sample analysis. Furthermore, the sensor exhibits excellent anti-interference capability and specific detection performance, demonstrating reliable detection characteristics both in the presence of other interfering substances and in practical sample applications. The combination of superior sensitivity, rapid response, and scalable design positions this platform as a significant advancement in optical chemical sensing technology
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