NEW JOURNAL OF CHEMISTRY
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2019
·Vol. 43
·期 34
·13363-13370
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IF 3.069
Weifen Niu,Juan Jia,Junkai Li,Chao Zhang,Keming Yun
The lysosome is known to be an acidic organelle that is ubiquitous in cells. Acidic pH is a characteristic feature of lysosomes, and aberrant lysosomal pH values have been manifested to be associated with diverse diseases. In order to monitor the lysosomal pH changes, we developed a ratiometric emission NIR-fluorescent probe (CzQl) for the quantitative analysis of the lysosomal pH in living cells and in vivo. CzQl was constructed via the ethylene bridging of carbazole derivatives and quinoline. The protonation of the probe resulted in a marked green-to-red emission color change. The probe exhibited an ideal pKa value of 4.60 with a linear relationship in the pH range of 3.9–5.3, which covered most of the pH ranges of lysosomes, and was useful for the quantitative detection and imaging of lysosomal pH changes. Moreover, CzQl exhibited easy loading capability, high selectivity, a large Stokes shift, specific lysosome-targeting ability and low cytotoxicity; thereby, it was successfully used for monitoring the lysosomal pH changes at a cellular level as well as the LPS-mediated inflammation in vivo.
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PROGRESS IN ORGANIC COATINGS
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2019
·
IF 3.42
Yuhua Dong,Ming Gong,Dong Huang,Jie Gao,Qiong Zhou
Raspberry-like polydopamine@polypyrrole nanoparticles were synthesized by in situ chemical oxidative polymerization. Morphology was observed by scanning electron microscopy, and photothermal conversion performance was investigated. A shape memory coating with self-healing ability was prepared based on a thermo-responsive shape memory epoxy resin that utilized polydopamine@polypyrrole nanoparticles as the photothermal agent. Damage to the coating was healed via 808 nm near infrared light. The healing performance was evaluated by comparing the macroscopic morphologies of the scratched and healed coatings via optical microscopy. Linear sweep voltammetry was used to assess the recovery of the coating’s barrier properties. The results confirmed that the coating had self-healing ability based on the photothermal conversion effect of the polydopamine@polypyrrole nanoparticles.
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BIOMATERIALS
·
2019
·
IF 10.273
Tao Feng,Jingyuan Wan,Pan Li,Haitao Ran,Huali Chen,Zhigang Wang,Liangke Zhang
Nitric oxide (NO) has shown positive effects in tumor treatment. However, controlling NO release in specific targets is still a crucial challenge for antitumor therapy. Considering that sodium nitroprusside (SNP) and potassium ferricyanide have similar chemical structures , a near infrared (NIR) laser-controlled NO release nanoplatform has been fabricated by allowing SNP to participate in mesoporous Prussian blue (m-PB) nanoparticle formation. The resulting SNP-doped m-PB (m-PB-NO) exhibited a good NIR-controlled NO release behavior, and the amount of NO released can be controlled by adjusting the laser intensity and irradiation time. Given that m-PB-NO still has strong absorption in NIR region , it exhibited an excellent photothermal effect in vitro and in vivo. After carrying antitumor drug, docetaxel (DTX)-loaded m-PB-NO ( [email protected] ) can simultaneously achieve NIR-controlled NO release, good photothermotherapy, and chemotherapy. The combination therapy of [email protected] showed a significant synergistic effect compared with each monotherapy and can significantly improve the therapeutic effect. Combination therapy also significantly inhibited the lung metastasis of 4T1 breast cancer cells in tumor-bearing mice by ablating primary tumors.
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RSC Advances
·
2018
·Vol. 8
·期 48
·27382-27389
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IF 2.936
Chengwan Xia,Diya Xie,Lang Xiong,Qian Zhang,Yang Wang,Zezheng Wang,Yuxin Wang,Bin Li,Chao Zhang
Herein, we reported nitroxide radical-modified CuS nanoparticles (CuS–NO˙ NPs), and they exhibited a typical absorption peak at 1182 nm. Due to such a long wavelength absorbance, CuS–NO˙ NPs exhibited excellent therapeutic outcome and low damage to normal tissues. Besides, we simultaneously achieved CuS–NO˙ NPs for MRI and CT dual-modal imaging, which successfully provided a new strategy for imaging-guided tumor treatment, thus increasing potential clinical applications for cancer treatment.
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Acta Biomaterialia
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2018
·
IF 6.383
Meirong Hou,Chenggong Yan,Zelong Chen,Qingliang Zhao,Miaomiao Yuan,Yikai Xu,Bingxia Zhao
Ternary copper-based chalcogenide nanomaterials have become rather attractive due to the near-infrared (NIR) response in cancer theranostic fields. However, it is still challenging to further improve the theranostic efficiency of these nanomaterials. Herein, Cu-Sb-S nanoparticles (NPs) around 24 nm are synthesized facilely and functionalized with poly(vinylpyrrolidone) (PVP). Under the NIR irradiation, the resultant PVP-Cu-Sb-S NPs exhibit a relatively high photothermal conversion efficiency of 53.16% and a simultaneous reactive oxygen species (ROS) generation effect. Due to these outstanding photothermal/photodynamic effects, excellent tumor ablation results can be achieved by the combination of PVP-Cu-Sb-S NPs and 808 nm NIR laser treatments without obvious side effect. In addition, they show remarkable contrast enhancement according to in vitro and in vivo photoacoustic (PA) imaging. These PVP-Cu-Sb-S NPs could be served as a multifunctional nanotheranostic agent for PA imaging, photothermal/photodynamic cancer therapy. Statement of Significance Highly theranostic efficiency ternary copper-based chalcogenide nanomaterials has not been fully developed yet. Herein we report the PVP-Cu-Sb-S nanoparticles (NPs) with relatively high photothermal efficiency, simultaneous reactive oxygen species generation effect and photoacoustic imaging capability. The photothermal conversion efficiency of PVP-Cu-Sb-S NPs is higher than most of copper-based chalcogenide nanomaterials reported before. These findings provide a new kind of ternary copper-based chalcogenide with an enhanced theranostic effect, which could be served as a promising multifunctional nanotheranostic agent in the field of biomedical application.
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BIOMACROMOLECULES
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2019
·
IF 5.667
Jia Tian,Baoxuan Huang,Haiquan Li,Hongliang Cao,Weian Zhang
Premature and incomplete drug release is the typical bottleneck of drug release in traditional chemotherapy. Synergistic therapies are highly desirable in medicine and biology because they can compensate for the drawbacks of single therapy and significantly enhance the therapeutic efficacy. Herein, a novel near infrared (NIR)-activated polymeric nanoplatform with upper critical solution temperature (UCST) was constructed for image-guided synergistic photothermal therapy (PTT) and chemotherapy. UCST-responsive amphiphilic block copolymers were synthesized by reversible addition–fragmentation chain-transfer (RAFT) polymerization and then co-assembled with IR780 and cabazitaxel (Cab) to form spherical nanoparticles (NPs). IR780/Cab dual-loaded UCST polymeric NPs can produce local heating upon NIR laser irradiation and further lead to the dissociation of cargo-loaded NPs and controlled release of Cab. IR780 plays the role of both a heating generator and an activator for “on-demand” drug release. The investigation of in vivo fluorescence and photothermal imaging clearly demonstrated tumor targeting. Notably, both in vitro and in vivo studies illustrated that the synergistic PTT and chemotherapy presented better anticancer efficacy than that of PTT and chemotherapy simplely combined. Thus, the well-defined polymeric nanoplatform opens a versatile and effective path to develop image-guided synergistic therapies for tumor treatment.
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Nano Energy
·
2019
·
IF 15.548
Tao Wang,Gang Lian,Liping Huang,Fei Zhu,Deliang Cui,Qilong Wang,Qingbo Meng,Haihui Jiang,GuangJun Zhou,Ching-Ping Wong
Rendering high-quality perovskite films is integral for excellent performance of optoelectronic devices and highly challenging as well. Here, we establish a two-round pressure-assisted solvent-engineering (TPS) strategy to achieve remarkable enhancement in grain size (~400 μm 2 ), crystallinity , orientation and, especially, boundary fusion. Crystal growth and boundary welding of MAPbI 3 grains are mainly attributed to pressure-enhanced ion diffusion and defect elimination, which facilitates lateral enlargement of grains and formation of ultra-smooth film. Dramatic diminution of trap density determines long carrier lifetime and improved lateral charge transport, as demonstrated by the superior performance of MAPbI 3 -based photodetectors , e.g. ultrahigh on/off ratio (~10 6 ), good stability, fast response, high responsivity and high detectivity (1.3 × 10 14 Jones). When upconversion nanoparticles are uniformly assembled on the high-quality MAPbI 3 films, interestingly, the hybrid device exhibits dominantly elevated photoelectric capability in near infrared range (NIR, 980 nm) with long-term stability in ambient air. The results and method pave a novel way for ongoing fabrication of efficient and stable optoelectronic devices based on high-quality perovskite films.
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MATERIALS LETTERS
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2017
·
IF 2.572
Yang Ren,Xiaoge Zhou,Gaoyang Zhao
The selection of Low-e coated glass in the mid-latitude region has been a difficult subject. In this paper, a simple sol–gel method can be used to control the grain size of fluorine-doped tin oxide (FTO) nanocrystalline films by introducing complex chelating agents into the sols and controlling their contents. The film is a polycrystalline film with rutile structure. Through the electrochemical doping technology, the localized surface plasmonic electrochromism of FTO nanocrystals in the near infrared region (NIR) can be achieved, and the optical contrast at 1750 nm can reach 60%. The Low-e glass coated with this film can adjust dynamically the transmittance of NIR light according to people’s feelings, realize the effective control of the solar radiation heat through windows without affecting the daylight use at work time, and is suitable for using in mid-latitude zone.
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Bioactive Materials
·
2024
·
IF 18
Xuan Bai,Wenan Peng,Ying Tang,Ziming Wang,Jingmei Guo,Fangfang Song,Hongye Yang,Cui Huang
Periodontitis is an inflammatory disease caused by bacterial biofilms, which leads to the destruction of periodontal tissue. Current treatments, such as mechanical cleaning and antibiotics, struggle to effectively address the persistent biofilms, inflammation, and tissue damage. A new approach involves developing a Janus nanomotor (J-CeM@Au) by coating cerium dioxide-doped mesoporous silica (CeM) with gold nanoparticles (AuNPs). This nanomotor exhibits thermophoretic motion when exposed to near-infrared (NIR) laser light due to the temperature gradient produced by the photothermal effects of asymmetrically distributed AuNPs. The NIR laser provides the energy for propulsion and activates the nanomotor's antibacterial properties, allowing it to penetrate biofilms and kill bacteria. Additionally, the nanomotor's ability to scavenge reactive oxygen species (ROS) can modulate the immune response and create a regenerative environment, promoting the healing of periodontal tissue. Overall, this multifunctional nanomotor offers a promising new approach for treating periodontitis by simultaneously addressing biofilm management and immune modulation with autonomous movement.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2024
·
IF 5.8
Tong Feng,Yuanlin Jin,Zhangwen Long,Dacheng Zhou,Xiaqing Jiang,Bitao Liu,Jianbei Qiu
Phosphor conversion light-emitting diode (PC-LED) technology has become a focal point of research for portable near-infrared light sources in recent years. One of the crucial aspects is to develop phosphor materials that can be effectively stimulated by commercial available blue light. Unfortunately, efficient phosphors in the NIR-II that can be excited by commercial blue light are particularly scarce. In this study, Mg 4 Ta 2 O 9 :0.04Cr 3+ ,0.03Yb 3+ ,0.07Li + (MTO:0.04Cr 3+ ,0.03Yb 3+ ,0.07Li + ) phosphor was synthesized using the high temperature solid phase method, and its emission spectrum covered the first and second near-infrared windows (700–1200 nm). The internal quantum efficiency (IQE) and external quantum efficiency (EQE) are 88.7 % and 45.6 %, respectively, due to the synergistic effect of energy transfer and Li-ion modification. Additionally, the doping of Yb 3+ ions and Li + ions enhances the thermal stability of luminescence. The thermal stability of MTO:0.04Cr 3+ ,0.03Yb 3+ ,0.07Li + and MTO:0.04Cr 3+ ,0.03Yb 3+ is 9.81 % and 14.43 % higher, respectively, than that of MTO:0.04Cr 3+ ,0.03Yb 3+ and MTO:0.04Cr 3+ . To evaluate its potential applications, we developed a prototype PC-LED utilizing MTO:0.04Cr 3+ ,0.03Yb 3+ ,0.07Li + phosphor as an emission emitter which demonstrated advantages in biomedical imaging, night vision, and non-destructive testing.
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RSC Advances
·
2017
·Vol. 7
·期 59
·36923-36928
·
IF 3.108
Yueyue Yin,Yong Yang,Liangzhu Zhang,Yongsheng Li,Zhiyuan Li,Weiwei Lei,Yunfeng Ma,Zhengren Huang
Here, we report a facile synthesis of Pd/Au nano-dogbones (NDBs) by loading massive Pd nanoparticles on the two ends of Au nanorods (NRs) via a seed-mediated method. The as-prepared samples were investigated by using TEM, elemental analysis, UV-vis and FDTD simulation. The photocatalytic activity of Pd/Au NDBs was assessed by dehydrogenation of formic acid under visible-to-NIR light irradiation. The Pd/Au NDBs shows much higher enhanced reaction activity compared with samples with core–shell structure due to the increased electron and hole pair separation and total catalytic sites. More importantly, the introduction of Au NRs broadens the photoresponse range and improves the utilization of sunlight efficiently. This finding provides a rational approach to improve photocatalytic performance by forming dogbone structures via integrating plasmonic metals and conventional catalysts.
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Theranostics
·
2014
·
IF 7.827
Heng Deng,Yanqi Zhong,Meihong Du,Qinjun Liu,Zhanming Fan,Fengying Dai,Xin Zhang
The controllable self-assembly of amphiphilic mixed polymers grafted gold nanoparitcles (AuNPs) leads to strong interparticle plasmonic coupling, which can be tuned to the near-infrared (NIR) region for enhanced photothermal therapy (PTT). In this study, an improved thiolation method was adopted for ATRP and ROP polymer to obtain amphiphilic brushes of PMEO 2 MA-SH and PCL-SH. By anchoring PCL-SH and PMEO 2 MA-SH onto the 14 nm AuNPs, a smart hybrid building block for self-assembly was obtained. Increasing the PCL/PMEO 2 MA chain ratio from 0.8:1, 2:1 and 3:1 to 7:1, the structure of gold assemblies (GAs) was observed to transfer from vesicle to large compound micelle (LCM). Contributed to the special dense packed structure of gold nanoparticles in LCM, the absorption spectrometry of gold nanoparticles drastically red-shifted from 520 nm to 830 nm, which endowed the GAs remarkable NIR photothermal conversion ability. In addition, gold has high X-ray absorption coefficient which qualifies gold nanomaterial a potential CT contrast agent Herein, we obtain a novel gold assembly structure which can be utilized as potential photothermal therapeutic and CT contrast agents. In vitro and In vivo studies testified the excellent treatment efficacy of optimum GAs as a PTT and CT contrast agent. In vitro degradation test, MTT assay and histology study indicated that GAs was a safe, low toxic reagent with good biodegradability. Therefore, the optimum GAs with strong NIR absorption and high X-ray absorption coefficient could be used as a theranostic agent and the formation of novel gold large compound micelle might offers a new theory foundation for engineering design and synthesis of polymer grafted AuNPs for biomedical applications.
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