ANALYTICA CHIMICA ACTA
·
2026
·
IF 6.1
Xiaoxia Han,Dan Li,Yiran Li,Lizhen Huang,Bin Dong,Sui-Dong Wang,Hao Wu
Background Malondialdehyde (MDA) is a pivotal oxidative stress biomarker implicated in cardiovascular diseases, neurodegeneration, and cancer; however, its trace quantification in complex biological matrices remains analytically daunting. Photoelectrochemical (PEC) sensing offers inherently low background noise and exceptional sensitivity for trace bioanalysis. Nevertheless, efficiently translating molecular recognition into amplified PEC signals remains a challenge. Results We report a nanoconfinement-mediated PEC interface that integrates covalent molecular conjugation with plasmonic amplification within a crystalline matrix scaffold. Within this nanoconfined environment, localized Au nanoparticles serve as plasmonic amplifiers that anchor 4-aminothiophenol (4-ATP) receptors. Upon MDA recognition, the optimized sensor exhibits dual linear detection ranges spanning 0.001 to 1.0 nmol L −1 ( R 1 2 = 0.9928) and 1.0 to 1000 nmol L −1 ( R 2 2 = 0.9992), yielding an ultralow detection limit of 0.3 pmol L −1 . Significance The confined Schiff-base reaction between 4-ATP and MDA generates an interfacial reaction product, leading to a new absorption band at approximately 450 nm and modulation of the Au LSPR band. This change is mainly attributed to the altered local dielectric environment around Au NPs. Wavelength-dependent operando transient photovoltage spectroscopy (TPV) provides mechanistic evidence that plasmon-driven hot-carrier injection augments PEC signal output. Overall, this work establishes an interface-engineering paradigm that integrates molecular conjugation with plasmonic coupling, offering a promising blueprint for the PEC detection of small-molecule biomarkers.
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高影响因子
DENTAL MATERIALS
·
2026
·
IF 6.3
Tianjia Huang,Huan Chen,Shuwei Qiao,Boyu Sun,Shuyao Zheng,Haiya Liao,Zuosen Shi,Song Zhu
A multifunctional Myr@ZIF-8 nanoplatform was developed for dentin bonding. • Myr@ZIF-8 exhibited pH-responsive release of myricetin and Zn²⁺. • Myr@ZIF-8 enhanced antibiofilm activity against Streptococcus mutans . • Myr@ZIF-8 stabilized dentin collagen and suppressed MMP activity. • The modified adhesive significantly improved dentin bonding durability. Objectives This study aimed to develop a myricetin-loaded ZIF-8 (Myr@ZIF-8)-modified universal adhesive with antibacterial, collagen-stabilizing, and matrix metalloproteinase (MMP)-inhibitory properties to improve bonding durability. Methods Myr@ZIF-8 nanoparticles were synthesized and characterized. Myr loading efficiency, drug loading, and pH-responsive release were evaluated. Myr@ZIF-8 was incorporated into a universal adhesive at 2.5–10 wt%, and the optimal concentration was selected according to degree of conversion, dentin wettability, and antibiofilm activity. Dentin collagen stability, MMP-mediated gelatinolytic activity, microtensile bond strength (μTBS), interfacial nanoleakage, interfacial mechanical properties, and in vitro cytocompatibility were evaluated. Short-term systemic toxicity was preliminarily assessed by oral gavage of cured adhesive extracts. Molecular docking was performed to investigate potential interactions between myricetin and collagen, MMP-2, and MMP-9. Results Myr@ZIF-8 exhibited a Myr loading efficiency of 50.72%, drug loading of 50.36%, and pH-responsive release. The adhesive containing 5 wt% Myr@ZIF-8 showed the best overall performance, including enhanced antibiofilm activity, improved collagen stability, and reduced MMP-mediated gelatinolytic activity. Incorporation of 5 wt% Myr@ZIF-8 increased immediate μTBS from 22.79 MPa to 32.07 MPa and aged μTBS after 10,000 thermocycles from 13.91 MPa to 27.99 MPa. Molecular docking predicted potential interactions between myricetin and collagen, MMP-2, and MMP-9. The modified adhesive showed acceptable in vitro cytocompatibility, with no obvious short-term systemic toxicity after oral gavage of cured adhesive extracts. Significance These findings demonstrate that Myr@ZIF-8 functions as a multifunctional bioactive nanoplatform and represents a promising strategy for improving bonding durability. Download: Download high-res image (189KB) Download: Download full-size image Schematic diagram of the experimental process.
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Journal of Saudi Chemical Society
·
2026
·Vol. 30
·期 4
·56
·
IF 5.2
Xu Wei-li,Sun Pei-jian,Sun Xue-hui,Wang Yi-peng,Li Jia-li,Ge Chang,Liu Qun,Zhou Jing,Yang Fang,Song Xin-hua,Nie Cong
Benzene, as a ubiquitous and carcinogenic volatile organic compound (VOC), presents substantial health risks through inhalation exposure from ambient indoor environments and cigarette mainstream smoke, necessitating the development of advanced adsorbent materials. Herein, zeolitic imidazolate framework-8/cellulose acetate (ZIF-8/CA) composite porous carbon materials were synthesized via a dual emulsion-solvent evaporation method coupled with subsequent high-temperature carbonization. Systematic studies were conducted to evaluate the effects of ZIF-8/CA mass ratios on the microstructure, pore architecture, and the benzene adsorption property. The results of the relevant characterizations revealed that the composite prepared at a 4/6 mass ratio exhibited an excellent BET specific surface area with the highest value of 1380 m 2 /g and mesopore volume of 0.77 cm 3 /g, alongside a well-defined hierarchical pore network spanning microporous, mesoporous, and macroporous regimes. Dynamic benzene vapor adsorption tests demonstrated that this optimized formulation achieved a dynamic saturation adsorption capacity of 235.0 mg/g. Kinetic analysis employing the Apiratikul-Chu and Adams-Bohart models yielded high correlation coefficients, indicating that benzene adsorption was governed by surface adsorption and mass‑transfer mechanisms. When applied in cigarette mainstream smoke purification, the ZIF-8/CA composite exhibited a benzene removal efficiency of 49.0%, significantly outperforming the ZIF-8/polylactic acid (PLA) composite (20.7%). This enhanced efficacy stemmed from the cooperative interplay between the hierarchical porosity and enhanced π-π stacking interactions. This work underscores the ZIF‑8/CA composite porous carbon as a promising candidate for benzene abatement, with potential applications in cigarette filter modification and indoor air purification.
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Journal of Environmental Chemical Engineering
·
2026
·Vol. 14
·期 5
·124490
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IF 7.5
Kaixin Qian,Xiao Ma,Mei Hong,Fuping Qian
Conventional air filtration media struggle to simultaneously address secondary biological pollution, the efficiency-permeability trade-off, and the environmental burden associated with disposable polymer filters. Direct blending of agglomerated or dense fillers can destabilize the electrospinning jet, disrupting the fiber network and increasing airflow resistance. In this study, biodegradable PLA nanofibers were combined with eugenol-loaded ZIF-8 nanoparticles to construct an antibacterial air filtration membrane. Prepared through an aqueous route, ZIF-8 served a dual function by regulating the architecture of the fibrous network and acting as a microporous reservoir for the natural antibacterial molecule eugenol. Comparison of pristine PLA, PLA/ZIF-8, and PLA/EUG@ZIF-8 membranes clarified each component's contribution. Pristine PLA provided a biodegradable fibrous matrix but showed inadequate filtration and negligible antibacterial activity. The incorporation of ZIF-8 optimized membrane morphology, enhanced particle capture, and imparted moderate bacterial inhibition. Notably, confinement of eugenol within ZIF-8 pores further enhanced antibacterial activity without disrupting the optimized membrane structure or air permeability. The PLA/EUG@ZIF-8 membrane delivered PM0.3, PM1.0, and PM2.5 filtration efficiencies of 99.62%, 99.99%, and 99.99%, respectively, with a low pressure drop of 69 Pa and a maximum quality factor of 0.1335 Pa⁻¹ . The composite also achieved near-complete inhibition of Escherichia coli (99.74%) and Staphylococcus aureus (99.48%). Numerical simulations showed a filtration trend consistent with the experimental results, indicating that the improved performance was mainly associatedwith the optimized fiber-pore structure rather than simple membrane densification. Thus, MOF-mediated natural antibacterials effectively fabricate biodegradable filters with excellent PM capture, low resistance, and strong antibacterial activity, promoting eco-friendly membranes.
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高影响因子
JOURNAL OF DRUG TARGETING
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2025
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IF 3.9
Haolong Qi,Yingjie Geng,Yuan Li,Yanqing Wu,Xiaoqing Cai
Immunotherapy has attracted widespread attention as a new tumour treatment method. Because of the low response rate, immunotherapy is only effective for some patients. With the continuous exploration of tumour immunity, the concept of immunogenic cell death (ICD) has brought new vitality to many cancer treatment methods, including chemotherapy. However, the immune effect of ICD induced by chemotherapy is often influenced by immune cell types, the tumour microenvironment, and other factors. Based on this, we constructed a hybrid nano-platform based on ZIF-8 to realise chemo-immunotherapy for tumour treatment by loading the chemotherapy drug doxorubicin (DOX), the indoleamine 2,3-dioxygenase (IDO) inhibitor 1-methyltryptophan (1MT), and the immune adjuvant CpG. In order to ensure the smooth arrival of the nanoparticles at the tumour site, carboxymethyl chitosan (CMCS) was introduced for surface modification to enhance the stability of the nanoparticles in vivo. The hybrid nano-platform not only successfully induced ICD in tumour cells but also achieved an 85.6% inhibition rate in the 4T1 tumour model, proving its excellent tumour-killing ability. In conclusion, the successful construction of the hybrid nano-platform provides a new idea and method for multi-modal combined therapy of tumours.
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PubMed
高影响因子
Journal of Materials Chemistry A
·
2025
·
IF 9.5
Tianxu Ji,Zinan Wang,Peng Wang,Xiaoyu Yang,Jihao Ye,Xuze Tang,Chunyan Li,Yunpeng Liu
Aqueous zinc-ion batteries (AZIBs) are considered promising candidates for advanced energy storage systems due to their operational reliability and economic viability. However, practical application is hindered by challenges such as Zn dendrite growth, hydrogen evolution (HER) and corrosion reactions. In this study, an in situ growth strategy is introduced to fabricate a superhydrophobic ZIF-71 coating (ZIF-71(IS)@Zn) directly on the Zn anode surface. This method enhances interfacial adhesion and coating uniformity in comparison to conventional spray-coated techniques (ZIF-71(Sp)@Zn). The ZIF-71(IS) coating possesses intrinsic hydrophobicity due to –Cl groups and a dense structure, effectively preventing water molecule penetration and mitigating HER and corrosion. Density functional theory (DFT) calculations indicate that ZIF-71 promotes Zn2+ desolvation by reducing hydration energy and improves Zn2+ adsorption on the (002) crystal plane. Electrochemical evaluations reveal that ZIF-71(IS)@Zn exhibits an extended cycling lifespan of 3000 h at 1 mA cm−2/0.5 mA h cm−2, surpassing the performance of ZIF-71(Sp)@Zn (1232 h) and bare Zn (531 h). Full cells paired with AlVO-NMP cathodes achieve an initial capacity of 335.1 mA h g−1 at 5 A g−1, maintaining 81.1% of capacity after 3000 cycles. Pouch cells retain 86.8% capacity after 2000 cycles at 2 A g−1, demonstrating the feasibility of this strategy for stabilizing Zn anodes.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2025
·
IF 6.3
Danfeng Du,Ke Zhang,Zhisong Han,Zexin Liu,Xiurong Guo
Thermal-insulating and flame-retardant materials, as a class of functional materials with unique properties, play a pivotal role in various fields. The study utilized silica aerogel as the thermal-insulating base material and incorporated ZIF-8-encapsulated polyethylene glycol-based shape-stabilized phase change materials (ZIF-8@PEG) to fabricate silica aerogel-based ZIF-8@PEG composites (ZP-SA) via a sol-gel method. The microstructure, thermal stability, and molecular architecture of the composite phase change materials were characterized through scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), and differential scanning calorimetry (DSC). The experimental results demonstrated that the prepared ZP-SA exhibited a three-dimensional skeletal structure, with a phase change enthalpy of 80.98 J/g and phase transition temperatures of 53.18 °C (melting) and 26.89 °C (solidification). The material displayed excellent thermal stability during heating-cooling cyclic tests. In terms of flame retardancy, ZP-SA achieved a limiting oxygen index (LOI) value of 30.2 %. These findings confirm that the incorporation of ZIF-8@PEG effectively enhances the thermal-insulating and flame-retardant performance of the composite material. The research provides a novel theoretical framework and practical insight for the design of advanced thermal-insulating and flame-retardant composite materials, demonstrating significant academic and applied value.
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高影响因子
MICROCHEMICAL JOURNAL
·
2025
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IF 5.1
Shuyang Sun,Mengdi Yao,Yu Gao,Ping Wang,Chengke Wang
A colorimetric method for fish freshness monitoring was developed. After coating magnetic Fe 3 O 4 nanoparticle with zeolitic imidazolate framework-8 (ZIF-8), the horseradish peroxidase (HRP) was adsorbed onto it with high efficiency due to the large surface area of ZIF-8, the mesoporous SiO 2 was further decorated onto the Fe 3 O 4 @ZIF-8@HRP to form Fe 3 O 4 @ZIF-8@HRP@SiO 2 nanostructure, in order to minimize the release of HRP, and enhance the stability and catalytic activity of HRP. The morphology, elemental composition, surface functional groups of Fe 3 O 4 @ZIF-8@HRP@SiO 2 were characterized by transmission electron microscopy, X-ray diffraction, energy dispersive spectroscopy, Fourier transform infrared spectroscopy. Hypoxanthine (HX), which formed due to the degradation of adenosine triphosphate in fish, can be oxidized by xanthine oxidase and generated H 2 O 2 intermediate. Thereafter, in the presence of H 2 O 2 , HRP within Fe 3 O 4 @ZIF-8@HRP@SiO 2 nanostructure would catalyze the oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB) to a blue product of TMBox, allowing an indirect colorimetric sensing of HX content. Under optimal conditions, HX was selectively and sensitively detected in the range of 0–100 μM, with a detection limit of 0.133 μM. Finally, the proposed method was applied to determine the HX content in grass carp continuously stored at 4 °C and 30 °C for 96 h.
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高影响因子
APPLIED ORGANOMETALLIC CHEMISTRY
·
2026
·Vol. 40
·期 2
·e70510
·
IF 0
Haoyue Xu,Si Lu,Xiyue Feng,Yunhui Zhang,Xingru Liu,Tingting Shu,Ling Li,Yingxi Wang
Metronidazole (MNZ), a refractory nitroimidazole antibiotic, poses significant environmental risks due to its persistence in aquatic systems. In this study, a hollow-structured ZIF-67-derived CoS (ZD-CoS) catalyst was synthesized to activate peroxymonosulfate (PMS) under simulated sunlight for MNZ degradation. The ZD-CoS/PMS system achieved 91.0% MNZ removal within 10 min under light irradiation, exhibiting a kinetic rate 2.4 times faster than that in the dark, which was attributed to the photothermal effect enhancing radical generation. The mechanistic study elucidated that the degradation of MNZ was driven by the collective contribution of reactive species, namely SO 4 − ˙, ˙OH, 1 O 2 , and O 2 − ˙. This synergistic effect was primarily facilitated by the Co 2+ /Co 3+ redox cycle, which served as the core mechanism for PMS activation. Furthermore, the degradation pathways of MNZ were elucidated through LC–MS analysis, indicating processes including hydroxylation, ring cleavage, and oxidation. The catalyst also demonstrated excellent stability over four cycles with low cobalt leaching (< 0.15 mg/L). This work provides a solar-driven, catalytic solution for antibiotic wastewater treatment and offers mechanistic insight into the degradation process.
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JOURNAL OF MEMBRANE SCIENCE
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2026
·
IF 9
Ruoman Ji,Lijuan Gao,Yibo Zan,Xingchi Zhang,Qing Zhao,Ting Wang
A novel chiral mixed matrix membrane (MMM) was prepared by biomimetic mineralization to encapsulate bovine serum albumin (BSA) within ZIF-8, followed by film formation. In this process, a new ratio of ZIF-8 material and two biocomposites with different precursor ratios were synthesized via a one-pot co-precipitation method under ambient conditions. BSA@ZIF-8 (Zn 2+ /2-methylimidazolate (2-mIM) = 40:320 mM) demonstrated the optimal separation of 1-phenylethanol (PE), with an enantiomeric excess ( ee ) of 52.79%. Subsequently, the combination of BSA@ZIF-8 with polyethersulfone (PES) to form a chiral MMM was investigated, and the effects of the concentration of the feed solution, the proportion of biocomposite in the membrane, the thickness of the membrane and the permeation time of the chirality on the enantiomeric separation were examined. The chiral MMM achieved complete enantioseparation ( ee = 100 %). Both the biocomposite-containing membrane and the free biocomposite retained this performance throughout the stability tests, demonstrating that immobilizing BSA within ZIF-8 markedly enhanced the robustness of the biomacromolecule. Finally, molecular docking studies revealed the presence of hydrogen bonding and hydrophobic forces, especially hydrogen bonding, between BSA@ZIF-8 and the racemate, which explained the selective chiral recognition ability of BSA@ZIF-8 towards the racemate PE.
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高影响因子
Journal of Environmental Chemical Engineering
·
2021
·Vol. 9
·期 6
·106490
·
IF 5.909
Yiyang Zeng,Sheng Liu,Jichen Xu,Ai Zhang,Yuxin Song,Long Yang,Ailin Pu,Yuran Ni,Fangting Chi
With the vigorous development of nuclear power and the shortage of terrestrial uranium resources, the extraction uranium from seawater is extremely attractive for human development. Herein, we first report ZIF-8 in-situ growth on amidoximerized polyacrylonitrile (PAO) porous materials. The porous material is a small sphere with certain mechanical strength synthesized by solvent-induced phase separation method. Because ZIF-8 nanocrystals are well-formed and evenly distributed within the PAO beads, ZIF-8/PAO has a high specific surface area (386 m 2 g -1 ) and rich pore structure . At adsorption experiment, the highest adsorption capacity of ZIF-8/PAO reached 803 mg g -1 at pH = 4. Furthermore, competitive adsorption experiment and simulated seawater test was studied. The selectivity for uranium was excellent (K d = 1.7 × 10 5 mL g -1 ) and uranium adsorption rate reached 99% at 3 ug L -1 . XPS analysis shows that U(VI) is chelated by imidazole-N atoms and amidoxime groups in ZIF-8/PAO. Therefore, ZIF-8/PAO can be considered a highly promising adsorbent for uranium extraction from wastewater and seawater.
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高影响因子
ACTA PHYSICO-CHIMICA SINICA
·
2016
·Vol. 32
·期 9
·2377-2382
·
IF 0.844
XU Li-Hong,ZHAO Dong-Yu,LI Yang,GUO Lin
ZIF-8 (zeolitic imidazolate framework-8), a kind of metal-organic framework material, is one of the most important energy materials and widely used in various fields because of its high specific surface area and excellent thermal stability. In this research, we synthesized ZIF-8 by
the traditional hydrothermal synthesis method in a purely methanol system. The obtained particles were ~250 nm in diameter with a rhombic dodecahedron morphology. Moreover, the prepared ZIF-8 materials exhibited good thermal stability and a large surface area. We also found that the rhombic
dodecahedral ZIF-8 enhanced the electro-optical (E-O) properties of nematic liquid crystal (N-LC) depending on the ZIF-8 doping concentrations. ZIF-8 in N-LC cells adsorbs ionic impurities and suppresses the screen effect, leading to a lower driving voltage and faster response time. At a ZIF-8
doping concentration of 0.05%(w, mass fraction), the N-LC cells showed the best E-O properties, including the lowest threshold voltage (V
th) of 0.92 V, the lowest saturation voltage (V
sat) of 1.31 V, and a short response time of 10.04 ms. However, above
a doping concentration of 0.05%(w) ZIF-8 aggregated in N-LC cells, affecting the arrangement of the LC molecules and trapping less impurity ions, which deteriorated the E-O properties of N-LC.
研究领域:
材料科学
·
光电子学
·
纳米技术
·
液晶技术
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高影响因子
危险品化学品经营许可证（带存储）