ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2026
·
IF 4.1
Xie Zhoujian,Wu Jiawen,Huang Kejing,Tan Xuecai
Growing needs for monitoring kanamycin (KAN) residues in food require ultrasensitive, field-deployable determination platforms. Herein, we present a universal photoelectrochemical (PEC) aptasensing strategy that synergizes ZIF-8/Bi 2 S 3 heterostructure-engineered photoelectrodes with strand displacement–triggered biocatalytic signal amplification. The urchin-like ZIF-8/Bi 2 S 3 heterojunction, synthesized through in situ MOF growth on semiconductor nanoarchitectures, demonstrates exceptional photocurrent generation via facilitated carrier separation achieved by directional electron transfer from Bi 2 S 3 to ZIF-8 and hole scavenging by ascorbic acid. Capitalizing on aptamer-target recognition in homogeneous phase, KAN concentration is transduced into messenger DNA (S2) through displacement dynamics, overcoming steric limitations of conventional solid-phase biosensing. The liberated S2 hybridizes with electrode-immobilized S1 to assemble MnPP-loaded dsDNA, where the mimic enzyme catalyzes H 2 O 2 -driven precipitation of benzo-4-chlorohexadienone (4-CD). This biocatalytic insulation layer induces quantifiable photocurrent attenuation proportional to KAN levels (10–1.0 × 10 6 nmol/L), achieving a 0.1 nM detection limit superior to ELISA and HPLC. The platform demonstrates 95.7–105.4% recovery in milk matrices and cross-reactivity below 5.8% against structural analogs, validating its specificity. By integrating MOF-semiconductor interfacial engineering with homogeneous-to-heterogeneous signal translation, this work establishes a paradigm for antibiotic monitoring that bridges laboratory innovation with on-site applicability. Graphical abstract
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Food Bioscience
·
2026
·
IF 6.2
Ming Zhou,Jun Cheng,Shunqian Zhuang,Songting Chen,Yingying Sun,Jiang Xu,Yunfei Xie
The residue of acetamiprid (AAP) in agricultural products poses a threat to food safety. Traditional Surface-enhanced Raman scattering (SERS) detection faces issues such as complex and expensive substrate preparation, and the difficulty of effectively utilizing SERS hotspots due to random molecular diffusion at low concentrations, resulting in low detection sensitivity. Here, we introduced the highly adsorptive 2-Methylimidazole zinc salt (ZIF-8) and developed a portable, ultra-sensitive silver nanoparticle filter paper (FP) loaded with 2-Methylimidazole zinc salt (Ag@FP@ZIF-8) substrate. It was found that the enhancement factor (EF) value for Rhodamine 6G (R6G) when measured using a handheld Raman spectrometer was 1.401 × 10 13 . More importantly, after being kept in a sealed and dark environment at room temperature for 45 days, the signal retention rate remained at 92%. Additionally, it exhibits good uniformity, as evidenced by a relative standard deviation of less than 8.5%. Combining a handheld Raman spectrometer with the previously proposed capillary-assisted sampling method has enabled AAP to be extracted from apple, pear and Bok choy leaves in a shoNeed file 22165rt period of time. The detection limit for Bok choy is 0.01 mg/kg, meeting the requirements of the EU Commission's regulation (EU) 2025/158. This method is expected to be developed into a rapid, deployable solution for on-site pesticide screening.
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2026
·
IF 5.4
Shanle Zhang,Yunjie Sun,Zhipeng Xu,Yani He,Xiaodi He,Yue Zhang
The integration of inhibitor-encapsulated nanocontainers within organic coatings offers a viable approach for achieving sustained corrosion mitigation and extended protective functionality. In this study, a ZIF-8@LDH-P (ZLP) nanocontainer was developed, consisting of Ni-Co layered double hydroxide (LDH) derived from zeolitic imidazolate framework-8 (ZIF-8) precursors and incorporating trisodium phosphate (TSP) as a corrosion inhibitor. The release of phosphate ions from ZLP exhibited pH-responsive behavior, enabling triggered inhibitor release under corrosive conditions. When uniformly dispersed in the polyvinyl butyral (PVB) resin matrix and coated on Q235 carbon steel, the PVB/ZLP composite coating demonstrated an enhancement of two orders of magnitude in low-frequency impedance modulus (|Z| 0.01 Hz ) relative to pure PVB. Furthermore, the PVB/ZLP coating exhibited long-term protective capabilities, ascribed to the cooperative effect of regulated phosphate ions release for active corrosion inhibition, chloride ion entrapment by LDH interlayers, and the prolonged diffusion pathways for corrosive agents enabled by the lamellar structure of LDH. This study offers novel design strategies for ZIF-derived LDH nanocontainer-based anti-corrosion coatings with inhibitor loading.
✓ 已验证
产品关联
DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2025
·
IF 3.9
Xin Yan,Pengtao Guo,Youbin Zhou,Ting Wang,Xianren Zhang,Yunpan Ying,Qingyuan Yang,Dahuan Liu
As the CO2 concentration in the atmosphere is relatively low, directly capturing CO2 from the air remains a challenge. Herein, a dual-functionalized strategy is developed to construct a series of IL@ZIF-8 composite materials by regulating the spatial distribution of nitrogen sites of the anion and the amine content of the cation in the ionic liquid (IL). The introduction of functional sites significantly enhances the capture capability of composite materials toward low-concentration CO2. The IL composed of pyrazole (Py) with adjacent nitrogen sites exhibits stronger interaction with CO2 due to its lower viscosity and higher electron cloud density. The IL@ZIF-8 constructed with tetraethylenepentamine (TEPA) as the cation and Py demonstrates optimal CO2 capture capability, which is attributed to TEPA’s balance of abundant amine groups and moderate viscosity. [TEPA][Py]@ZIF-8 exhibits a remarkable dynamic CO2 capture capacity under simulated air conditions, and in situ FT-IR analysis reveals its reversible adsorption mechanism. This study provides a new strategy for the development of novel adsorbents for low-concentration CO2 capture.
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Lijie Wang,Zixuan Wang,Jiarong Chang,Zhiyue Zhou,Xihan Wang,Zhaoming Li,Dawei Li,Fang Wang,Wen Zhang,Kannapathirage Dilini Maheshika Gunarathne,Xin Meng
Infected skin wound healing involves a series of dynamic and complex physiological processes. In this study, we reported a dissolvable microneedle (MN) with pullulan as the matrix material. The antimicrobial peptide LL37 was immobilized in situ within ZIF-8 to form hybrid nanoparticle LL37@ZIF-8 (LZ). This nanoparticle was then loaded onto the tip of the microneedle along with Prussian Blue (PB) nanozymes to obtain PB+LZ@MN, which exhibits both antimicrobial and antioxidative activities, for the healing of infected skin wounds. The MN, with good mechanical properties, could rapidly dissolve its tip upon insertion into the skin, releasing LZ and PB into the wound within 3 min. The MN had good physicochemical properties and biocompatibility and was shown to reduce inflammation and stimulate angiogenesis by enhancing collagen deposition and re-epithelialization in the Sprague-Dawley (SD) rat skin defect infection model. On the 10th day of wound healing, the healing rate of the PB+LZ@MN group was as high as 99%, which was significantly higher than that of the control at 84%, significantly accelerating the healing of the infected wound. This multifunctional MN is expected to provide a competitive biomaterial for accelerated infected wound healing.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
International Journal of Pharmaceutics-X
·
2025
·
IF 6.4
Zhenyu Xiang,Jialing Liu,Yan Zhang,Ru Shen,Ying Lu,Rong Li,Qinying Shi,Guannan Zhang,Sijin Li,Jianbo Song
Triple-negative breast cancer (TNBC), a highly refractory malignancy characterized by aggressive clinical behavior, poses a significant therapeutic challenge due to its resistance to conventional treatments. While microwave thermal therapy (MWTT) emerges as a promising modality for TNBC treatment through deep-tissue penetration and uniform energy delivery, its reliance on prolonged hyperthermia exposure risks collateral damage to adjacent healthy tissues. Herein, we present a rationally engineered iron-doped zeolitic imidazolate framework-8 nanoplatform (Fe@Zif-8). This study aimed to develop a theranostic agent for MRI-guided combination therapy by pursuing the following objectives: (1) synthesizing and characterizing Fe-doped ZIF-8; (2) evaluating the enhancement of microwave thermal conversion efficiency via iron doping; (3) validating the nanoparticle's Fenton catalytic activity for reactive oxygen species (ROS) generation and glutathione depletion in the tumor microenvironment; and (4) demonstrating the synergistic antitumor efficacy of combined MWTT and CDT both in vitro and in vivo . Accordingly, Fe@Zif-8 was synthesized via a one-pot solvothermal method and systematically characterized. Its therapeutic performance was then rigorously assessed through a series of physicochemical and biological experiments. The iron dopants substantially enhance microwave absorption and dielectric loss effects in Zif-8 matrices, enabling Fe@Zif-8 to generate intensified hyperthermia under MW irradiation. Concurrently, iron ions released from the nanoplatform react with endogenous hydrogen peroxide (H 2 O 2 ) via Fenton catalysis to produce substantial ROS. The concerted action of MWTT and CDT achieves rapid tumor ablation while significantly reducing therapeutic energy requirements. Furthermore, the platform served as an effective T2 contrast agent for magnetic resonance imaging (MRI), enabling non-invasive monitoring. This work provides a new approach for the preparation of nanomaterials with highly efficient anti-TNBC performance.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2025
·
IF 6.3
Weidong Li,Weifeng Luo,Yueping Wei,Rongai Huang,Wei Shang,Jiqiong Jiang,Yuqing Wen
Superhydrophobic coatings have emerged as a primary strategy for protecting magnesium alloys. However, their application is often hindered by reliance on harmful fluorinated materials. In this study, a fluorine-free ZnO/ZIF-8 composite coating was fabricated on magnesium alloy surfaces via electrodeposition. By leveraging synergistic effects between ZnO nanostructure roughness and ZIF-8's intrinsic hydrophobicity, superhydrophobicity was achieved without fluorinated surface modifications. Results demonstrate excellent hydrophobic stability, with superhydrophobicity maintained under low-temperature conditions. The water contact angle remained unchanged in sodium chloride solutions of varying concentrations, indicating exceptional salt-induced corrosion resistance. Furthermore, the coating exhibited hydrophilic-hydrophobic transition properties. Electrochemical tests confirmed superior corrosion resistance, showing a corrosion current density of 3.964 × 10 −9 A∙cm −2 and a four-order-of-magnitude increase in charge transfer resistance versus the AZ91D substrate. Molecular dynamics (MD) simulations and density functional theory (DFT) calculations elucidated the corrosion protection mechanism, providing theoretical support for experimental findings. This study integrates experimental and theoretical approaches, offering new insights and technical references for fluorine-free superhydrophobic coatings in magnesium alloy corrosion protection.
✓ 已验证
产品关联
DOI
高影响因子
INORGANIC CHEMISTRY COMMUNICATIONS
·
2025
·
IF 5.4
Shaohui Huang,Jin Li
In order to solve the problems of insufficiently rapid response and recovery and poor moisture resistance when zinc oxide is used as a gas sensitive material, a flexible frame material with hydrophobicity, ZIF-8, was introduced to modify the surface of ZnO, and then doped Ag nanoparticles, which can be electron sensitized with ammonia, to obtain Ag modified ZnO@ZIF-8 nanoparticles. At room temperature (RT, ∼25 °C), the response time of ZnO, ZnO@ZIF-8, and Ag modified ZnO@ZIF-8 nanoparticles to 500 ppm ammonia is 74.3 s, 20.2 s, and 8.0 s, and the recovery time is 36.0 s, 23.1 s, and 16.8 s, respectively. The fitting detection limit of Ag modified ZnO@ZIF-8 nanoparticles for ammonia was 83 ppm. Compared with pure ZnO, the moisture resistance of ZnO@ZIF-8 and Ag modified ZnO@ZIF-8 was significantly improved after coating with ZIF-8.
✓ 已验证
产品关联
DOI
高影响因子
PEST MANAGEMENT SCIENCE
·
2025
·
IF 3.8
Xunliang Huang,Weiqiang Tian,Hao Jiang,Yue Xing,Ya Pu,Zhongwei Liu,Song Yang,Zhensheng Kang,Lin Cai
BACKGROUND Fungal phytopathogens pose a significant threat to global crop yields. The overuse of pesticides leads to pesticide-resistant pathogens, environmental contamination and risks to human health. Consequently, there is an urgent need for effective and ecofriendly antifungal strategies to address these challenges. RESULTS Herein, ZnO-ZIF-8 is synthesized via an in situ growth method to integrate the antifungal property of zinc oxide (ZnO) and the control release property of zeolitic imidazolate framework (ZIF)-8. Results suggest that the inhibition rates of ZnO, ZIF-8 and ZnO-ZIF-8 against Alternaria alternata are 44.4%, 74.1% and 94.4%, respectively, indicating that ZnO-ZIF-8 exhibits the most potent antifungal activity. ZnO-ZIF-8 also causes distortion and fracture of mycelia, significantly impairing spore germination and inhibiting germ tube elongation. CONCLUSION The potential antifungal mechanisms of ZnO-ZIF-8 involve the disruption of fungal cell morphology and structure through the release of Zn 2+ , ultimately leading to fungal cell death. Biosafety assessments indicate that the application of ZnO-ZIF-8 exhibits negligible effects on tobacco seeds and plants. This study provides valuable insights for the effective management of plant fungal diseases and supports sustainable agricultural development. © 2025 Society of Chemical Industry.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MATERIALS & DESIGN
·
2026
·
IF 7.9
XinYu Mao,ShangNong Wu,MengHui Zhang,Peng Shen,XiaoZhong Yang,HongGang Wang
Colorectal cancer (CRC), a leading cause of cancer-related mortality, remains challenging due to drug resistance, insufficient targeting, and systemic toxicity. We engineered a pH/glucose dual-responsive zeolitic imidazolate framework-8 (ZIF-8) nanocarrier for the co-delivery of berberine (BBR) and glucose oxidase (GO X ). BBR and GO X were encapsulated into ZIF-8 nanoparticles via one-pot synthesis and subsequent surface modification with polyethylene glycol–folic acid (PEG–FA), yielding BBR@GO X @ZIF-8–FA (BGZF). At pH 5.4, BBR and GO X release was approximately 74% and 69%, respectively. Cellular uptake and JC-1 assays revealed that the delocalized positive charge of the nanoparticles enhanced mitochondrial targeting, synergizing with GO X -mediated glucose depletion for amplified starvation therapy. Reactive oxygen species (ROS) quantification showed that BBR and GO X synergistically exacerbated oxidative stress, resulting in higher levels of ROS than those observed with monotherapy. Mechanistically, BGZF induced apoptosis through dual pathways: endogenous mitochondrial dysfunction and exogenous ROS overproduction. BGZF’s tumor-specific targeting capabilities were validated in vivo , demonstrating FA-mediated active homing and prolonged biosafety with negligible systemic toxicity. This research pioneers a dual-responsive nanoplatform that integrates mitochondrial targeting and cascade catalytic amplification to achieve synergistic antitumor effects between BBR and GO X , offering a novel paradigm for CRC treatment.
✓ 已验证
产品关联
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
·
IF 9
Xiaomin Guo,Wei Wang,Huan Lyu,Xiuling Zhang,Chunhui Li,Fan Yang,Mingxin Zhou,Yongzheng Zhang,Dongyang Miao,Ruiyun Zhang
The selective removal of dyes from wastewater remains a critical challenge due to the structural complexity and persistence of dye molecules. In this work, a polyethyleneimine (PEI)-functionalized ZIF-8 hybrid nanofibrous membrane was fabricated via a seed-assisted secondary growth strategy, aiming to achieve high selectivity toward anionic dyes. Synergistic interactions between the porous metal-organic framework (MOF) grown on the surface and the polymer functional groups enable efficient and selective adsorption of anionic dyes. Adsorption experiments demonstrated that the hybrid membrane exhibited high adsorption capacities for anionic dyes, reaching 506.48 and 929.30 mg·g −1 for Congo red (CR) and methyl orange (MO), respectively. In contrast, significantly lower adsorption capacities were observed for cationic dyes (rhodamine B, RhB and methylene blue, MB). Moreover, the membrane maintained strong selectivity toward anionic dyes in mixed dye systems containing all four dyes and retained over 80 % removal efficiency for CR and MO after ten consecutive adsorption–desorption cycles. Additionally, the membrane exhibits superhydrophilicity, excellent water stability, enhanced mechanical properties, and antibacterial activity, highlighting its potential for advanced wastewater treatment, particularly in the remediation of dye effluents. This work also provides valuable insights into the practical application of MOF-based composite materials.
✓ 已验证
产品关联
DOI
高影响因子
PEST MANAGEMENT SCIENCE
·
2023
·Vol. 79
·期 7
·2603-2610
·
IF 4.1
Yue Ma,Kefei Zhao,Yi Ding,Shuai Wu,Xun Liao,Xianhui Yin,Zilu Li,Rongyu Li,Youhua Long,Fengpei Du
BACKGROUND Neonicotinoids are among the most essential chemical insecticides worldwide because of their high activity against many important pests and wide application. However, their application is limited by their toxicity to honeybees. Therefore, the development of a facile route to fabricate efficient and eco-friendly pesticide formulations is of great significance. RESULTS In this study, clothianidin-loaded zeolitic imidazolate framework-8 (CLO@ZIF-8) nanoparticles were fabricated by a facile one-pot route using zinc nitrate as a Zn 2+ source and characterized by scanning electron microscopy, transmission electron microscopy, X-ray diffraction, thermogravimetric analysis, energy-dispersive spectrometry and Fourier transform infrared spectroscopy. Based on the pH response of ZIF-8, a ‘burst release effect’ was observed for CLO@ZIF-8 at pH 3 and 5 within 12 h, in contrast to the slow and sustainable release at pH 8. CLO@ZIF-8 improved the retention ability of the pesticide liquid and remained 70% control efficacy on Nilaparvata lugens after water rinsed of sprayed CLO@ZIF-8. The pH response of CLO@ZIF-8 allowed it to maintain 43% control efficacy against N. lugens after 10 days of application, which was twice the efficacy of clothianidin solution (SCA). Moreover, CLO@ZIF-8 reduced the acute toxicity to honeybees ( Apis mellifera ) by ≥120-fold compared with SCA. CONCLUSION This study provides new insights into the application of ZIF-8 to neonicotinoids and suggests the need for the development of a biocompatible and eco-friendly pesticide formulation. © 2023 Society of Chemical Industry.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）