CHEMISTRY & BIODIVERSITY
·
2025
·
IF 2.5
Jiayu Yang,Qiaoling Li,Jianpeng Zhang,Siyang Wu,Min Zhang,Lihui Chen,Hui Wu,Shengchang Lu
Adhesive patches are optimum candidates for distinct biomedical applications including tissue adhesion and leakage sealing in outpatient or surgical procedures. Unfortunately, most adhesive patches are significantly less effective at providing strong adhesion to the surface of wet tissue, which increases the risk and reduces the fault tolerance in surgery. Meanwhile, customization is difficult to achieve in terms of mechanical adaptability. To tackle this problem, we developed a chitosan-containing bioadhesive patch (ANC) comprising dual cross-linked carboxymethyl chitosan methacrylate (CMCS-MA), acrylic acid and acrylic acid N-hydroxysuccinimide ester. This ingenious and convenient design strategy facilitates the integrated polymerization of the patch, while circumventing the necessity for additional crosslinkers. ANC patches in dry state and the rich carboxyl groups contained therein enable rapid removal of moisture from tissue surfaces. Subsequently, robust adhesion based on hydrogen bonding and NHS-amine interaction is formed. The dual-crosslinked ANC patch achieve good adjustable mechanical performance and swelling behavior by controlling the addition of CMCS-MA. Furthermore, compared with commercially available fibrin glue, ANC patches own robust adhesion and superior sealing performance for stomach fluid leakage. This intricately designed ANC patch sheds new light on biomedical patch design and broadening the scope of chitosan-containing materials in tissue adhesive and sealant applications.
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产品关联
DOI
PubMed
高影响因子
Analytical Methods
·
2013
·Vol. 5
·期 20
·5471-5477
·
IF 1.855
Shan Yang,Yuzhi Wang,Minli Xu,Meizhi He,Min Zhang,Dan Ran,Xiaopin Jia
A simple molecularly imprinted polymer (MIP) was prepared to recognize the template lysozyme (Lys). Chitosan (CS) was selected as the functional biopolymer to enhance the adsorption capacity. The aldehyde group was introduced to CS, so that the template protein could be immobilized onto the modified CS beads. After the template protein was successfully immobilized, two kinds of organic siloxane, tetraethoxysiloxane (TEOS) and 3-aminopropyl triethoxysilane (APTES), were added and polymerized via a sol–gel process in aqueous solution at 25 °C. After template removal, adsorption experiments were performed to study the properties of the synthesized MIP. The results showed that the MIP exhibited much higher adsorption capacity for Lys than the non-imprinted polymer (NIP). The theoretical maximum adsorption capacity (Qmax) and equilibrium constant (KL) were determined by the Langmuir model, which turned out to be 15.89 mg g−1 and 6.78. The selectivity of the MIP was verified by direct adsorption of a single reference protein and mixed protein. The UV measurement and sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) analysis results showed the MIP had a relatively high adsorption capacity and excellent selectivity, which made it possible to remove the template protein from different sample solutions.
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DOI
高影响因子
BIOTECHNOLOGY LETTERS
·
2023
·Vol. 45
·期 8
·1039-1052
·
IF 2.7
Chen Li,Jiang Fang,Xu Haidan,Fan Yaoyao,Du Cunbin
Objective The insufficient stability of alginate-chitosan (ALG-CS) microcapsules in biorelevant media limits their applications in the biomedical field. Attempts were made to improve the membrane stability of ALG-CS microcapsules by noncovalent crosslinking with tannic acid. Results The membrane stability of ALG-CS microcapsules in culture medium and serum was significantly improved by crosslinking with tannic acid. Moreover, the reason for the significant improvement in membrane stability had been demonstrated to be that the stability of chitosan-tannic acid (CS-TA) polyelectrolyte complexes was less affected by the competitive binding of those weak acid ions such as HCO 3 − . In addition, the optimal conditions for preparing alginate-chitosan-tannic acid (ALG-CS-TA) microcapsules were tannic acid concentration of 0.5% (w/v) and pH = 7. Conclusion The study provides a novel approach for improving the stability of the ALG-CS microcapsules in biorelevant media to expand their scope of application in the biological field.
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PubMed
高影响因子
Journal of Chemistry
·
2022
·
IF 3.241
Anxiang Huang,Wenlian Bai,Shoulu Yang,Zhongwei Wang,Nengying Wu,Yanxiong Zhang,Ning Ji,Dan Li
The purpose of this study was to fabricate a low-cost and eco-friendly adsorbent using bamboo biochar (BB), a kind of charcoal composed of high Brunauer–Emmett–Teller surface area and variety of functional groups, and chitosan as substrates for remediation of Cd(II) in Cd(II) contaminated water and characterized the functional group characteristics, surface morphology, and Cd(II) adsorption effect using the Fourier transform infrared (FT-IR), scanning electron microscope (SEM), and energy-dispersive X-ray spectrometer (EDS). Results showed that chitosan-modified bamboo biochar (CBB) provided more active adsorption sites (such as –NH2, –COOH, –OH, and C=O) on the surface to enhance the Cd(II) removal efficiency in Cd(II) contaminated wastewater. Meanwhile, the optimal pH, contact time, and dose of CBB on the Cd(II) removal efficiency are 7, 120 min, and 600 mg, respectively. In addition, the adsorption isotherm results revealed that the possible adsorption mechanisms might include surface adsorption, electrostatic adsorption, and ion exchanges. Furthermore, the maximum adsorption capacity (Qm) values predicted from the Langmuir model were 37.74 and 93.46 mg/g for BB and CBB, respectively, also indicating a potential application of CBB in practical wastewater. Desorption and regeneration of CBB were attained simultaneously and the results showed that even after five cycles of adsorption-elution, the adsorption and desorption of CBB exhibited a slight decline and still reached at 71.70% and 65.92%. Results from this study would provide a reference to functionalized CBB for Cd(II) adsorption in contaminated water.
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高影响因子
POLYMER SCIENCE SERIES A
·
2021
·Vol. 63
·期 5
·576-584
·
IF 1.206
Cong Ding,Xu Bohao,Zhang Juzhong,Sun Qingqing,Chen Zhihao,Liu Shuiren,Liu Xuying,Chen Jinzhou
Abstract The development of flexible capacitive pressure sensors with high sensitivity and fast response demands the need for thin dielectric films with excellent mechanical flexibility and remarkable dielectric properties. Herein, a graphene/polyurethane (TPU) dielectric was designed by dispersing graphene fillers into TPU elastomer through chitosan (CS) modification. The dispersion of graphene fillers in the TPU matrix can be effectively improved by using CS as mediating agents, thus further elevating the dielectric properties of the composites. The as prepared dielectric films exhibit high permittivity (90), low dielectric loss (0.02) and remarkable flexibility. Afterwards, the flexible dielectric films were employed to construct capacitive sensors by integrating the top electrode, dielectric layer, and bottom electrode into a sandwich structure. Taking advantage of the high permittivity of the dielectrics and the microcapacitors generated between graphene fillers, the corresponding sensors exhibit high sensitivity to loaded pressure ( S = 0.53 kPa –1 for the range 1.6–4.8 kPa) and out-of-plane bending ( S = 0.08 deg –1 for the range 0 ~ 150°). In addition, a 3 × 3 sensor array was successfully fabricated and applied in the real-time monitoring of water drop, sensing subtle touch, and mapping the spatial distribution of pressure. The fabricated sensors demonstrate promising potential in the application of human-machine interfaces and wearable devices.
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高影响因子
JOURNAL OF BIOMATERIALS APPLICATIONS
·
2016
·
IF 1.988
Fang Wang,Siqian Yang,Jian Yuan,Qinwei Gao,Chaobo Huang
In the present study, alginate nanoparticles were firstly prepared for paclitaxel (PTX) delivery with an average size of 200 ± 21 nm. To improve the stability and targeting effect, the chitosan (CS) and folate-chitosan (FA-CS) were introduced to form PTX-loaded CS/ALG NPs and FA-CS/ALG NPs by a new double emulsion cross-linking electrostatic attraction method. The optimization chitosan concentration was 0.5% obtained from the experiment results. The CS/ALG-PTX NPs and FA-CS/ALG-PTX NPs had the average particle size of 306.9 ± 12.9 nm and 283.6 ± 19.2 nm with the zeta potential of 31.1 ± 1.3 mV and −2.98 ± 0.7 mV, and had higher drug loading and entrapment efficiencies than ALG-PTX NPs. The in vitro drug release profile along with release kinetics and mechanism from PTX-loaded NPs were studied under two simulated physiological conditions. Further, the in vitro anti-cancer activity of nanoparticles and the cellular uptake of nanoparticles on HepG2 cells were investigated. The results demonstrated that alginate, CS/ALG and FA-CS/ALG can be used as nanoformulation drug carriers by our new method, and FA-CS/ALG was a promising vehicle for anticancer drug targeted delivery system.
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DOI
PubMed
高影响因子
POLYMER SCIENCE SERIES B
·
2021
·Vol. 63
·期 3
·272-279
·
IF 1.049
Liangliang Yang,Liu Fang,Zhao Qun
Abstract The antibacterial properties of chitosan and self-repairing properties of collagen-I play important roles in the medical field. New types of collagen-I/chitosan/methyl vinyl silicone rubber materials have been synthesized by blending and grafting copolymerization. The effects of chitosan contents on mechanical and antibacterial properties of collagen-I/chitosan/methyl vinyl silicone rubber were investigated, while the morphology and molecular structure were observed and analyzed. It was determined that the antibacterial and self-repairing properties of collagen-I/chitosan/methyl vinyl silicone rubber were better than those of methyl vinyl silicone rubber. Additionally, the optimal contents of chitosan and collagen-I were determined to be 5 wt % and 5 mg/mL, respectively.
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高影响因子
Sustainable Materials and Technologies
·
2020
·
IF 4.375
Zeheng Li,Nan Xu,Ying Sha,Jiapeng Ji,Tiefeng Liu,Lijing Yan,Yi He,Junchao Zheng,Min Ling,Yingying Lu,Chengdu Liang
Rechargeable lithium metal batteries are among the most versatile platforms for high energy electrochemical energy storage . Unfortunately, uncontrollable growth of lithium dendrite triggers serious safety hazards, low Coulombic efficiency, and short cycling life, impeding the commercial application of lithium metal anode in the advanced energy storage technology , such as lithium-air and lithium‑sulfur (Li S) batteries. Herein, Chitosan oligosaccharide (CSO), an abundant bioderived material was employed to guide uniform lithium deposition and growth. CSO offers three features simultaneously, polar functional groups (-OH and -NH 2 ), natural porous structure , and abundant sources. CSO with a large number of polar groups has strong interactions with Li ions , which could guide the Li ions to form uniform Li deposition. Moreover, the porous structure of CSO could serve as a Li host to accommodate the huge volume change during Li plating and stripping process. Additionally, CSO is a low-cost, abundant, and nontoxic bioderived material, which is suitable for large-scale production of the CSO-Li anode. The proposed strong interactions of CSO with Li ions were confirmed by density functional theory calculations. As expected, the CSO modified electrode demonstrates an outstanding average Coulombic efficiency of over 98% for 600 cycles at a current density of 2 mA cm −2 . And stable cycling performances were achieved in the CSO-Li/CSO-Li symmetrical cells. Moreover, when paired with the LiFePO 4 cathode, Li 4 Ti 5 O 12 anode, high-mass-loading LiNi 0.5 Co 0.2 Mn 0.3 O 2 cathode, and S cathode, the cells using the CSO-Li anodes show the higher capacities and better cycling stabilities compared with those of the cells using the bare Li anodes.
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DOI
高影响因子
Marine Drugs
·
2020
·Vol. 18
·期 6
·315
·
IF 4.073
Qinying Yan,Jiaqi Weng,Xieqi Wu,Weiwei Wang,Qingliang Yang,Fangyuan Guo,Danjun Wu,Ying Song,Fan Chen,Gensheng Yang
Chitosan nanoparticles (CS-NPs) are under increasing investigation for the delivery of therapeutic proteins, such as vaccines, interferons, and biologics. A large number of studies have been taken on the characteristics of CS-NPs, and very few of these studies have focused on the microstructure of protein-loaded NPs. In this study, we prepared the CS-NPs by an ionic gelation method, and bovine serum albumin (BSA) was used as a model protein. Dynamic high pressure microfluidization (DHPM) was utilized to post-treat the nanoparticles so as to improve the uniformity, repeatability and controllability. The BSA-loaded NPs were then characterized for particle size,Zetapotential, morphology, encapsulation efficiency (EE), loading capacity (LC), and subsequent release kinetics. To improve the long-term stability of NPs, trehalose, glucose, sucrose, and mannitol were selected respectively to investigate the performance as a cryoprotectant. Furthermore, trehalose was used to obtain re-dispersible lyophilized NPs that can significantly reduce the dosage of cryoprotectants. Multiple spectroscopic techniques were used to characterize BSA-loaded NPs, in order to explain the release process of the NPs in vitro. The experimental results indicated that CS and Tripolyphosphate pentasodium (TPP) spontaneously formed the basic skeleton of the NPs through electrostatic interactions. BSA was incorporated in the basic skeleton, adsorbed on the surface of the NPs (some of which were inlaid on the NPs), without any change in structure and function. The release profiles of the NPs showed high consistency with the multispectral results.Keywords:characteristics;cryoprotection evaluation;dynamic high pressure microfluidization;chitosan nanoparticles
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DOI
PubMed
高影响因子
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
·
2016
·Vol. 122
·期 7
·1-8
·
IF 1.444
Sun Huanghui,Zhang Lingfan,Xia Wei,Chen Linxiao,Xu Zhizhen,Zhang Wenqing
Functionalized graphene oxide with its unique physical and chemical properties is widely applied in biomaterials, especially in drug carrier materials. In the past few years, a number of different drugs have been loaded on functionalized graphene oxide via π–π stacking and hydrophobic interactions. The present report described a new approach, dexamethasone phosphate successfully loaded onto graphene oxide–chitosan nanocomposites as drug carrier materials by covalent bonding of phosphate ester linkage. Compared with the graphene oxide–chitosan nanocomposites that dexamethasone phosphate was loaded on via simple physical attachment, covalently linked composites as drug carrier materials were more biocompatible which effectively reduced the burst release of drug, and controlled the release of drug in different pH conditions.
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高影响因子
PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY
·
2018
·
IF 1.241
Mingcong Shao,Lili Xiu,Haijiang Zhang,Jianying Huang,Xingwen Gong
Chitosan/cellulose-based beads (CCBs) for the affinity purification of histidine-tagged proteins were prepared from chitosan/cellulose dissolved in ionic liquid as a solvent, and their structures were characterized by Fourier transform infrared spectroscopy, transmission electron microscopy, and thermogravimetric analysis. The affinity purification was used to separate hexahistidine-tagged (his-tagged) enhanced green fluorescent protein (EGFP) from Escherichia coli. The results showed that Zn2+–CCB exhibited more specific adsorption capacity toward the target protein compared with Ni2+–CCB and Cu2+–CCB. The maximum adsorption of EGFP was 1.84 mg/g of Zn2+–CCB, with 90% purity under the optimized conditions (ionic strength (1.0 M NaCl), pH (7.2) and imidazole concentration (500 mM)). In addition, a regeneration method for the sorbent was further developed by washing with ethylenediaminetetraacetic acid disodium and then reimmobilizing with metal ions. This technique is an alternative method for the purification of his-tagged proteins, making the process more economical, fast, stable, and large batch.
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DOI
PubMed
高影响因子
Pharmaceutics
·
2020
·Vol. 12
·期 3
·202
·
IF 4.421
Lan Zhang,Min Yan,Kun Chen,Qikang Tian,Junying Song,Zijuan Zhang,Zhishen Xie,Yong Yuan,Yaquan Jia,Xin Zhu,Zhenqiang Zhang,Xiangxiang Wu,Huahui Zeng
A new platform for triptolide (TP) delivery was prepared by conjugating TP to a carboxylmethyl chitosan (CMCS). Compared with the natural TP, the TP-conjugate (TP-CMCS) containing TP of ~5 wt% exhibited excellent aqueous solubility (>5 mg/mL). Results of in vitro experiments showed that TP-CMCS could relieve TP-induced inhibition on RAW264.7 cells and apoptosis, respectively. Compared with the TP group, TP-CMCS could effectively alleviate the toxicity injury of TP and decreased the mortality rate of the mice (p< 0.05). TP-CMCS did not cause much damage to the liver (AST and ALT) and kidney (BUN and CRE) (p< 0.05). After administration, the levels of IL-6, IL-1β, and TNF-α decreased, and the arthritis detumescence percentages increased significantly, and the bony erosion degree was distinctly decreased in the TP-CMCS groups and TP group. Our results suggested that TP-CMCS was a useful carrier for the treatment of RA, which enhanced aqueous solubility of free TP and reduced drug toxicity in vitro and in vivo.Keywords:triptolide;toxicity;water solubility;carboxylmethyl chitosan;drug carrier system
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PubMed
高影响因子
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