BIOMATERIALS
·
2013
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IF 7.604
Xiangsheng Liu,Nan Huang,Haibo Wang,Huan Li,Qiao Jin,Jian Ji
Multidentate ligands are expected to improve the performance of inorganic nanoparticles (NPs) in biological application. Designing robust multidentate ligands by a facile way and understanding the impact of ligand composition on NP's property are greatly important. We report the effective synthesis of hydrophilic copolymers containing pendent thiol groups along a polyethylene glycol (PEG) methacrylate backbone by classical free radical copolymerization . Gold nanoparticles (AuNPs) coated by these multidentate ligands with two different ratios of thiols to PEG segment (∼1:1 and 1:2) showed much higher colloidal stability in the presence of dithiothreitol (DTT) than AuNPs coated by monothiol-anchored PEG, and AuNPs coated by ligands with higher fraction of thiol groups showed slightly better resistance to DTT competition than did AuNPs coated by ligands with lower thiol fraction, but both of them exhibited excellent stabilities in biological media without obvious difference. In vitro study of uptake by macrophages did not showed significant difference between the two AuNPs with very low endocytosis . However, AuNPs coated by ligands with higher PEG content were found to accumulate in liver with a significantly lower level but a higher level in spleen than AuNPs coated by ligands with lower PEG contents. Moreover, the AuNPs coated with by ligands with higher PEG content showed higher tumor uptake. Additionally, AuNPs coated with both ligands demonstrated good biocompatibility as evaluated by cytotoxicity assays and histological analysis . Together, the composition of multidentate ligands will not only affect the stability of NPs under extreme conditions but also result in quite different fate of NPs in vivo, which can be tailored case by case.
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RSC Advances
·
2015
·Vol. 5
·期 63
·50955-50961
·
IF 3.84
Yong Xia,Hongtao Yao,Zhihui Miao,Yun Ma,Meifang Cui,Liqiang Yan,Huanhuan Ling,Zhengjian Qi
We demonstrate here a facile and efficient synthesis of polysiloxane-based amphiphilic copolymers via thiol-ene click chemistry. The properties of PEG-b-PDMS-b-PEG (T-PPG) and PDMS-g-PEG (S-PPG20 and S-PPG100) amphiphilic copolymers were studied in detail by a combination of 1H NMR, FT-IR, gel permeation chromatography, and thermogravimetric analysis. In comparison with the traditional hydrosilylation method which requires the noble metal catalyst platinum, the newly designed thiol-ene protocol produces polysiloxane-based amphiphilic copolymers with only anti-Markovnikov addition products under benign conditions. The resulting copolymers have lower critical aggregation concentration (CAC), and dynamic light scattering (DLS) results revealed that the obtained amphiphilic copolymers can self-assemble into nanoparticles (128 nm to 198 nm) in aqueous solutions with a narrow size distribution (PDI is less than 0.24).
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
·
IF 9
Dongsheng Zhao,Jiyu Song,Ruohan Liang,Junxia Liu,Jun Xu,Guicai Liu,Xiaohang Ma,Zonghua Wang,Kang Xie
The low permeability and high fouling susceptibility of nanofiltration (NF) membranes limit their widespread application in water treatment. In this study, a polyethylenimine (PEI)-based NF membrane was synthesized via interfacial polymerization with a mixture of PEI and the polyethylene glycol derivative Jeffamine (JA) as the aqueous phase comonomer and trimesoyl chloride as the organic phase monomer. A 1/1 mass ratio of PEI to JA with a total aqueous phase monomer concentration of 1.00 % (weight/volume) yielded NF membranes with optimal water permeance and satisfactory salt exclusion. Compared with the pristine membrane, the JA-doped PEI-based (JA/PEI) membrane exhibited enhanced surface hydrophilicity, a more positively charged surface, an enlarged effective pore size, a thinner polyamide layer, and greater surface roughness. Furthermore, the optimal JA/PEI membrane was more resistant to protein fouling because of the lower adhesion energy between it and protein molecules. Additionally, the optimal JA/PEI membrane exhibited excellent permeation flux and comparable retention performance in the treatment of actual drinking water. This JA-doping strategy provides a facile avenue to fabricate NF membranes with higher permeability and better antifouling ability for water treatment applications.
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BIOMACROMOLECULES
·
2024
·
IF 5.5
Weiling Lu,Xianjin Wang,Changchang Kong,Shijunyin Chen,Chengtao Hu,Jianfa Zhang
Hydrogels composed of natural polysaccharides have been widely used as filling materials, with a growing interest in medical cosmetology and skin care. However, conventional commercial dermal fillers still have limitations, particularly in terms of mechanical performance and durability in vivo. In this study, a novel injectable and implantable hydrogel with adjustable characteristics was prepared from succinoglycan riclin by introducing PEG diglycidyl ether as a cross-linker. FTIR spectra confirmed the cross-linking reaction. The riclin hydrogels exhibited shear-thinning behavior, excellent mechanical properties, and cytocompatibility through in vitro experiments. Furthermore, when compared with subcutaneous injection of a commercial hyaluronic acid hydrogel, the riclin hydrogels showed enhanced persistence and biocompatibility in Balb/c mice after 16 weeks. These results demonstrate the great potential of the riclin-based hydrogel as an alternative to conventional commercial soft tissue fillers.
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Polymers
·
2025
·Vol. 17
·期 7
·888
·
IF 4.9
Muzammil Hussain Memon,Md. Asraful Alam,Qiyuan Xie,Abdul Rahman Abbasi,Lele Wang,Jingliang Xu,Wenlong Xiong
Multi-component electrolyte additives may significantly contribute to improving the performance of rechargeable aqueous zinc-ion batteries. Herein, we propose a mixed electrolyte system employing polyethylene glycol 200 (PEG200) and quaternized kraft lignin (QKL) as co-additives in Zn//MnO2batteries. Reduced corrosion and the suppression of the hydrogen evolution reaction on the zinc electrode were achieved when 0.5 wt.% of PEG200 and 0.2 wt.% of QKL were added to the reference aqueous electrolyte. This optimized electrolyte, 0.5% PEG200 + 0.2% QKL, was conducive to improving Zn reversibility in Zn//Zn symmetric batteries and resulted in higher cycling stability, with a coulombic efficiency of 98.01% under 1 mA cm−2and 1 mAh cm−2for Zn//Cu cells. Furthermore, Zn//MnO2full batteries with 0.5% PEG200 + 0.2% QKL presented good overall electrochemical performance and exhibited a decent discharge capacity of around 85 mAh g−1after 2000 cycles at 1.5 A g−1. As confirmed by X-ray diffraction and scanning electron microscopy, a dominant (002) oriental dendrite-free Zn deposition was achieved on the zinc anode of the battery using 0.5% PEG200 + 0.2% QKL, and the byproducts were also reduced significantly. This study has contributed to the development of electrolyte co-additives for zinc-ion batteries.
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PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
·
2020
·
IF 2.169
Yutong Wang,Yanfang Ding,Changyuan Wang,Meng Gao,Youwei Xu,Xiaodong Ma,Xinyi Ma,Hongxia Cui,Lei Li
Fenretinide (4-HPR), a synthetic retinoid, has shown its antitumor activity in many tumor types with low cytotoxicity to normal cells and high clinical safety. However, the low water solubility limits its further biological applications. To increase solubility, 4-HPR was conjugated with methoxy polyethylene glycol carboxylic acid (mPEG2K-COOH) by an ester linkage between the phenol hydroxyl of 4-HPR and the carboxyl of mPEG2K-COOH. The 4-HPR-PEG2K conjugate micelles had mean size of 76.70 ± 1.248 nm with a narrow distribution and a low critical micelle concentration. In vitro cytotoxicity studies showed the micelles have higher cytotoxicity to A2780s and MCF-7 cells. Its IC50 was 4.7 and 4.1-fold lower than the free 4-HPR, respectively. Importantly, in vivo pharmacokinetic studies, the AUC of 4-HPR was found to be 2.3-fold higher in 4-HPR-PEG2K micelles compared to free 4-HPR. And the 4-HPR-PEG2K micelles had higher antitumor activity. Meanwhile, the histopathology analysis exhibited that the micellar treatment decreased the viability of A2780s cells and increased the level of induced apoptosis. Therefore, the enhanced activity of 4-HPR by the method of conjugation with mPEG2K-COOH could hopefully provide new insights into the matter of ovarian cancer and breast cancer treatment.
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MICROCHEMICAL JOURNAL
·
2024
·
IF 4.9
Junlei Zheng,Haifeng Gao,Chengcheng Jin,Miaomiao Tian
A novel solid phase extraction (SPE) adsorbent, polyethylene glycol (PEG) immobilized zirconium ion-modified zeolite-imidazole framework (ZIF) molecular-imprinted polymer (ZIF@PEG@Zr@MIPs), was developed for detecting hippuric acid (HA) and 4-methylhippuric acid (4-MHA) in human urine using HPLC-UV. Zirconium ions (Zr 4+ ) anchored on the porous ZIF act as binding sites, facilitating coordination and electrostatic interaction with HA and 4-MHA carboxyl groups. Dopamine (DA) imprinting introduces additional sites, enabling π-π conjugation and hydrogen bonding with HA and 4-MHA, enhancing specific adsorption. The adsorbent, using HA as a template, demonstrated adsorption capacities of 37.98 mg g −1 for HA and 32.99 mg g −1 for 4-MHA. Imprinted factors ( IF ) were 2.68 for HA and 2.17 for 4-MHA, with a limit of detection (LOD) of 0.015 mg L −1 for HA and 0.011 mg L −1 for 4-MHA. The SPE-HPLC-UV method achieved 84.8–96.2% recovery and 0.3–2.2% relative standard deviation (RSD), illustrating its potential in health monitoring and environmental safety.
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Sustainable Energy & Fuels
·
2024
·
IF 5
Xueyang Ren,Jie Zheng,Jinxian Zhao,Jun Ren,Yanhong Quan
The one-step oxidative esterification of ethylene glycol (EG) is an effective and promising route for methyl glycolate (MG) synthesis, during which the development of efficient catalysts is critically crucial. Herein, Au/ZnO catalysts were prepared using impregnation (IM), colloidal-deposition (CD), deposition-precipitation (DP) and co-precipitation (CP) methods, respectively. The catalytic activities results revealed that the Au/ZnO-DP catalyst was far superior than the other three catalysts, achieving an EG conversion rate of 90.4% and a selectivity towards MG of 93.8%. Catalysts were systematically characterized by N2 adsorption-desorption, XRD, TEM, XPS, H2-TPR, EPR, O2-TPD and CO2-TPD. The results showed that the large number of Au-ZnO interfaces facilitated the adsorption and activation of O2. Moreover, it is found that the basic sites promoted the cleavage of O-H bonds in the EG molecules, and the acidic sites are responsible for the selectivity of MG. This work offers a simple strategy for design of gold catalysts in EG oxidative esterification.
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JOURNAL OF CHROMATOGRAPHY A
·
2025
·
IF 4
Yutong Sun,Qi Liu,Zhe Wang,Jinlan Zhang
Polyethylene glycol (PEG) is one kind of polymeric pharmaceutical excipient widely used in pharmaceutics. The critical quality attributes (CQAs) are essential to their physicochemical properties and functions. However, there is no effective strategy to rapidly and simply analyze PEG multi-CQAs. Herein, a novel strategy was developed to simultaneously evaluate four PEG CQAs including average degree of polymerization, average molecular weight, weight-average molecular weight and polydispersity based on comprehensive identification and mathematical models of PEG components. In this strategy, an ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF/MS) method was established and different types and concentrations of mobile phase additives were optimized to overcome the mass discrimination effect of PEG components. MS data was deconvoluted by molecular feature extraction to identify PEG components with multi-charged quasimolecular ions. A total of 168 PEG components were identified in PEG mixture samples. Mathematical models were established based on the logarithmic relation between the degree of polymerization and retention time and a theoretical database including 220 detected and predicted PEG components was constructed to rapidly recognize and identify PEG components in PEG excipients and preparations samples. The calculation formulae for multi-CQAs using UHPLC-Q-TOF/MS analysis results were created, then the strategy workflow to evaluate multi-CQAs was established and validated by PEG standards, showing high efficiency for quality control of PEG excipients and their preparations.
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Applied Materials Today
·
2024
·
IF 7.2
Hao Huang,Minjie Fan,Anchun Yang,Dongbiao Chang,Jinsheng Li,Liwen Yang,Xinlun Li,Mengyuan Wang,Pengfei Zheng,Tailin Guo,Jie Weng
β-tricalcium phosphate (β-TCP) has been widely applied in tissue engineering due to its excellent biocompatibility, degradability, and ability to induce mineralization. Zinc ion (Zn 2+ ) displays excellent antibacterial properties and a vital role in regulating cell metabolism. In this context, the incorporation of Zn 2+ into β-TCP to prepare Zn-doped β-tricalcium phosphate (Zn-β-TCP), emerges as a promising strategy for treating dentin hypersensitivity. However, delivering Zn-β-TCP effectively to the dentin surface for inducing mineralization of dentinal tubules remains a considerable challenge. In this study, we developed a sodium alginate-polyethylene glycol paste loaded with Zn-β-TCP particles, aiming to deliver Zn-β-TCP to the dentin surface for inducing mineralization. Zn-β-TCP particles were synthesized by the hydrothermal method and were combined with a sodium alginate-polyethylene glycol solution to create the Zn-β-TCP/sodium alginate/polyethylene glycol (Zn-β-TCP/SA/PEG) paste. In vitro experiments demonstrated that Zn-β-TCP could induce mineralization, exert good biocompatibility and antibacterial activity, promote dentin differentiation of dental pulp stem cells. Furthermore, Zn-β-TCP/SA/PEG exhibited excellent viscosity and effectively prompted the formation of a mineralized layer on dentin surfaces, successfully blocking dentinal tubules. Taken together, the present study demonstrated the potential of the Zn-β-TCP/SA/PEG paste as a promising therapeutic material for the treatment of dentin hypersensitivity.
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Molecular Catalysis
·
2025
·
IF 4.9
Shiping Wu,Yanhong Quan,Shunan Yin,Jun Ren
A series of Pt/Al 2 O 3 catalysts were fabricated by finely adjusting the amount of platinum and investigated in the selective oxidative of ethylene glycol (EG) to glycolic acid (GA) under mild neutral conditions. The 0.90Pt/Al 2 O 3 catalyst showed the maximum turnover frequency (TOF: 1106.6 h −1 ) with the EG conversion of 74.2 % and GA selectivity of 90.2 %. A strong linear relationship between TOF values and Pt 0 concentration was revealed, confirming that Pt 0 species serves as the active sites for GA formation. In addition, in situ diffused reflectance infrared Fourier transform spectroscopy (DRIFTS) results verify the reaction pathways of EG oxidation as follows: C 2 H 6 O 2 → HOCH 2 CHO → HOCH 2 COOH. This work unraveled structure-performance relationship for the selective EG oxidation over Pt/Al 2 O 3 catalyst, providing important guidance for the design of efficient noble catalysts especially for the oxidation reaction of polyols.
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VACUUM
·
2024
·
IF 3.8
Kaile Shi,Haodong Zheng,Yuze Sun,Honghai Wang,Jing Fang,Chunli Li,Jiapeng Liu
The utilization of 1,4-butanediol (BDO) spans across numerous sectors, underscoring its significance as a pivotal chemical. However, the separation of crude BDO still presents great challenges. Ethylene glycol (EG) and 3-methyl-1,5-pentanediol (MPD) are classical impurities in BDO crude products. In this paper, the pressure and temperature data of MPD components under high vacuum pressure were measured, and Antoine constant was obtained by fitting to supplement the basic data. The isobaric vapor-liquid equilibrium (VLE) data for the EG-BDO and BDO-MPD mixtures were experimentally measured at pressures of 1.0, 10.0, and 50.0 kPa. Meanwhile, the thermodynamic consistency of the experimental binary data was examined using the Herington area test. The experimental VLE data for binary systems were analyzed using the nonrandom two-liquid (NRTL) universal quasichemical (UNIQUAC) and Wilson activity coefficient models, demonstrating that the predicted outcomes showed excellent agreement with the measured data. Finally, the interaction energy between the components was calculated by molecular simulation to explain the gas-liquid equilibrium behavior. Therefore, this work provided guidance and basis for the separation of EG-BDO and BDO-MPD in high vacuum separation.
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