TRANSACTIONS OF TIANJIN UNIVERSITY
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2026
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IF 7.8
Shi Han,Cui Jing,Liu Zhikun,Kang Peng
The practical application of aqueous zinc-ion batteries is critically hindered by the instability of the zinc metal anode, which suffers from uncontrollable dendrite growth and detrimental side reactions. Conventional electrolyte additives often focus solely on homogenizing the zinc-ion flux, while neglecting the pivotal role of crystallographic regulation. Herein, we propose a fundamental strategy to manipulate zinc deposition behavior through selective molecular adsorption. We introduce 2-aminoethylphosphonic acid (AEP) as a novel electrolyte additive that preferentially adsorbs onto the (100) and (101) crystal planes of zinc, as confirmed by experimental evidence from electric double-layer capacitance measurements, and theoretical DFT calculations, which reveal a lower adsorption energy on the (002) facet. Consequently, the AEP-modified electrolyte enables a densely packed zinc morphology and a significantly optimized interface, which collectively contribute to markedly enhanced electrode kinetics and cycling stability. The improved negative electrolyte enables the zinc-iodine flow battery (ZIFB) to operate for 600 h (1500 cycles) with a high energy efficiency (> 83%) at 80 mA/cm 2 . This work underscores the critical importance of crystallographic engineering via selective molecular adsorption. The mechanistic insights gained into the dual regulation of solvation structure and interfacial growth provide a new design principle for advanced electrolytes targeting highly reversible metal anodes.
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Nature Communications
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2026
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IF 18.1
Qi Shi-Chao,Han Yan-Yan,Liu Yong-Lan,Zhao Yun-Jie,Huang Qi-Qi,Liu Xiao-Qin,Sun Lin-Bing
Traditionally, adsorption is believed to take place only in the ground state, but here we report an excitation-driven adsorption mode. Composites of metallophthalocyanines and carbonaceous substrates are prepared, among which the potassium-phthalocyanine (KPc)/reduced graphene oxide (RG) composite shows the most typical behavior. Femtosecond transient absorption spectroscopy and first-principles simulations reveal that under ultraviolet (UV) irradiation, the excited electrons in the composite transfer efficiently from KPc to RG, leaving long-lived excited holes on KPc that enable selective adsorption of CO molecules. In the dark, the composite shows negligible CO adsorption (0.06 mmol g⁻ 1 ), whereas its CO uptake increases to 1.20 mmol g⁻ 1 upon UV light, with a UV-modulated adsorption capacity ratio of up to 95%. This adsorption mode is also applicable to other metallophthalocyanine/carbonaceous composites. This work presents a potential strategy for photoexcitation utilization and the development of energy-efficient chemical separation technologies.
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JOURNAL OF NANOBIOTECHNOLOGY
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2026
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IF 15
Li Shuang,Lin Lu,Zhang Mengmeng,Liu Jinyao,Lu Eryi,Cao Zhenping
Periodontitis, a globally prevalent inflammatory disease, is propelled by a vicious cycle involving microbial dysbiosis, hyperactive host immune responses, excessive oxidative stresses, and chronic inflammations. Current treatments largely focus on reducing microbial pathogens, yielding limited therapeutic efficacy. Here, we report a polydopamine-based taurolithocholic acid (TLCA) nanotherapeutic (PDCA) that reprograms versatile immuno-microbial cues to ameliorate periodontal inflammation and restore tissue homeostasis. Leveraging the dual function of polydopamine in drug delivery and redox capacity, after cellular uptake, PDCA scavenges reactive oxidation species, and releases TLCA to interact with its nuclear receptors in various target cells, exerting multifaceted regulatory effects. In inflamed human gingival fibroblasts, PDCA reduces the oxidative stress and enriches intracellular accumulation of TLCA to assist its interaction with vitamin D receptor, thus attenuating the expression of pro-inflammatory cytokines. Furthermore, PDCA modulates hyperactive immune responses, including suppressing the maturation of dendritic cells, inhibiting osteoclast differentiation of monocytes, downregulating pro-inflammatory CD4 + lymphocytes, and upregulating regulatory T cells. Concomitantly, this immunomodulation is associated with the restoration of periodontal microbiome homeostasis, contributing to a reduction in pathogens and an enrichment of beneficial flora. In addition, PDCA not only rescues inflammatory tissue destructions in both therapeutic and prophylactic mouse models of periodontitis, but also elicits robust decrement in pro-inflammatory cytokine production in ex vivo human periodontitis tissues. This work highlights polydopamine-based bile acid nanomedicine as a microenvironment-targeting platform for immuno-microbial rebalance, offering a transformative strategy to treat oral inflammatory diseases. Graphical abstract The alternative text for this image may have been generated using AI. PDCA effectively mitigates tissue-destructive inflammation to rescue the aggravation of inflammatory periodontal diseases via orchestration of versatile immuno-microbial cues in the complex pathological network mainly at four levels: amelioration of oxidative stress, direct suppression of gingival inflammation, multifaceted immune reprogramming, and restoration of periodontal microbiome dysbiosis
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Science China-Materials
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2026
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IF 7.7
Lu Wendong,Wang Xiaoxuan,Wang Wanyu,Xia Wei,Huang Chaoyang,Qin Feifei,Ma Yi,Zu Shuai,Shi Zengliang,Xu Chunxiang
In the era of artificial intelligence, the efficient perception and processing of massive volumes of visual information place high demands on machine vision systems. Inspired by the remarkable adaptive capabilities of human vision in dynamic environments, various optoelectronic materials and biomimetic intelligent vision devices have emerged. However, most existing bio-inspired vision devices rely on external gate voltages or complex circuits to achieve dynamic modulation of visual sensitivity. It is attractive but challenging to realize all-optically controlled adaptive visual perception within an individual device. Based on the switching between positive and negative photoconductivity effects, this work presents a biomimetic sensor for all-optically controlled artificial visual adaptation and self-protection within a one-dimensional ZnO/MAPbBr 3 heterojunction. Through ultraviolet light modulation of oxygen vacancy states, the competition between intrinsic photoconduction and trap-mediated carrier capture is regulated, enabling dynamic control of the visible-light photoconductive behavior within an individual device. The flexibly tunable photoresponse successfully mimics the scotopic adaptation process involving photopigment regeneration under weak illumination, the photopic adaptation process involving photopigment bleaching in bright environments, and an eyelid-like self-protection behavior in response to intense light exposure. This work demonstrates the integration of multi-level adaptive and protective visual functions within an individual device, offering a promising strategy for the development of next-generation intelligent biomimetic sensors for machine vision system.
The alternative text for this image may have been generated using AI.
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Communications Biology
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2026
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IF 5.8
Zhang Han,Gu Xinsheng,Sun Yidan,Chen Pengcheng,Hu Qiangsheng,Li Hao
The roles of glutamic-oxaloacetic transaminase 2 (GOT2) in malate-aspartate shuttle (MAS), fatty acid binding/trafficking, and peroxisome proliferator-activated receptor (PPAR) delta axis have been documented. However, its function in ferroptosis remains unexplored. Here, we report that GOT2 promotes ferroptosis by disturbing mitochondrial redox homeostasis through inhibiting the synthesis of radical scavenger coenzyme Q10 (CoQ 10 ). Mechanism, by fueling MAS, GOT2 increases net influx of NADH into mitochondria and enhances aerobic respiration, increasing cellular ATP generation. The high ATP/ADP ratio inactivates adenosine 5′-monophosphate-activated protein kinase (AMPK) and PPARα, downregulating the transcription of core enzymes in CoQ 10 synthesis pathway (FDPS, PDSS1/2, COQ3/5/6). In lung adenocarcinoma (LUAD), high expression of GOT2 restrains tumor progression by activating ferroptosis and igniting antitumor immunity. Whereas, the activation of GOT2-mediated ferroptosis exacerbates lesion in atherosclerosis disease. Our study reveals that GOT2-AMPK-PPARα-CoQ 10 axis is a novel pro-ferroptosis pathway, and modulating GOT2-mediated ferroptosis suggests an intriguing method to treat LUAD and atherosclerosis. The alternative text for this image may have been generated using AI.
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Chinese Medicine
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2026
·Vol. 21
·期 1
·146
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IF 7.4
Yang Junfa,Shu Min,Fang Hui,Yang Fan,Li Jiahe,Sun Yuansong,Li He,Xu Tao
Background Liver fibrosis is a representative scarring response that can ultimately lead to liver cancer. However, relevant antifibrotic drugs for the effective treatment of liver fibrosis in humans have not yet been identified. 6-Shogaol is derived from natural products and exhibits multiple biological activities, including anti-inflammatory and antioxidant properties; however, its efficacy and potential mechanism of action against liver fibrosis remains unclear. This study aimed to examine the anti-fibrotic properties and potential mechanisms of action of 6-Shogaol. Methods Two liver fibrosis mouse models (carbon tetrachloride (CCl 4 ) and bile duct ligation (BDL)) were constructed to evaluate the anti-fibrotic properties of 6-Shogaol in vivo . Transforming growth factor-β1 (TGF-β1)-induced human hepatic stellate cells (HSCs) LX-2 cells were used as in vitro models. Network pharmacology analysis was introduced to explore the key targets of 6-Shogaol regarding the mechanisms on liver fibrosis. Molecular docking, molecular dynamics simulations, drug affinity reactivity target stability (DARTS) and isothermal titration calorimetry (ITC) were used to detect the affinity and binding between 6-Shogaol and its target. Additionally, we invested the mechanism of 6-Shogaol through RNA sequencing combined with Western blotting, oxygen consumption rate (OCR), extracellular acidification rate (ECAR), immunofluorescence co-localization, histopathology, immunohistochemical staining and RT-qPCR. Results The results showed that 6-Shogaol remarkably alleviated CCl 4 - and BDL-induced liver fibrosis in mice, including observations of improved liver function, decreased activity of HSCs, and decreased extracellular matrix (ECM) deposition. In an in vitro model, 6-Shogaol suppressed TGF-β1-induced LX-2 activation. Mechanistically, RNA sequence analysis revealed that the effect of 6-Shogaol on liver fibrosis is linked to glycolytic reprogramming. 6-Shogaol suppressed HSCs glycolysis by decreasing glycolytic enzymes (HK2, PKM2, and GLUT1) and glycolytic metabolite levels (lactic acid and pyruvic acid). Furthermore, network pharmacology suggested HIF-1α as a potential 6-Shogaol target. Molecular docking, molecular dynamics simulations, DARTS, and ITC confirmed that 6-Shogaol could directly bind to HIF-1α. Interestingly, we demonstrated that HIF-1α knockout significantly inhibited HSCs glycolysis and activation, whereas the overexpression of HIF-1α increased HSCs glycolysis and activation. Moreover, specific knockout of HIF-1α did not enhance the suppressive effect of 6-Shogaol on HSCs activation or fibrosis-associated protein expression in vivo . Conclusion These findings showed that 6-Shogaol ameliorated liver fibrosis by modulating the expression of HIF-1α associated with glycolysis reprogramming and validate 6-Shogaol as a promising therapeutic strategy for liver fibrosis. Graphical
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JOURNAL OF NANOBIOTECHNOLOGY
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2026
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IF 15
Wang Weilin,Hu Qiaoying,Wu Chunyan,Ding Jiayue,Zhu Chuanxiu,Wen Jiayao,Li Yingchao,Yang Menghan,Wang Yujie,Sun Deqing,Zhai Guangxi,Zhang Yanan
Ferroptosis and sonodynamic therapy (SDT) have both been recognized as powerful weapons in cancer treatment, especially in non-small-cell lung carcinoma (NSCLC) recently. However, the lack of effective sono-sensitizer and ferroptosis regulator limited their usage. In order to overcome the limitation, a novel nanoplatform of DTX-CS/ART/PFCA@RGD (cRCAPD) was fabricated based on SDT and ferroptosis. Nanoparticles, under the action of c(RGDfk) cyclic peptides and their skeleton chondroitin sulfate (CS), could specifically target αvβ3 and CD44 receptors, respectively, thereby targeting tumor sites. Meanwhile, the peroxy-bridge structure of ART disrupted the intracellular iron homeostasis while generating highly toxic reactive oxygen species (ROS) under the SDT. Docetaxel (DTX) in nanoparticles led to the excellent apoptosis of A549 cells. Oxygen carried by PFCA alleviated the tumor hypoxic microenvironment, downregulated HIF-1α, and provided substrates for SDT. Further, the nanoparticles showed a strong immunogenic cell death (ICD) effect, modulating the number of T cells and dendritic cells in tumor-bearing mice. In summary, the proposed therapeutic strategy based on SDT and ferroptosis holds promising potential for synergistic treatment of lung cancer in future clinical applications. Graphical The alternative text for this image may have been generated using AI.
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FOOD SCIENCE AND BIOTECHNOLOGY
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2026
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IF 3.9
Li Jie,Perera Vindya,Cao Shihao,Zhang Mengluo,Ding Yuheng,Tang Minmin,Zhu Tingting
Edible composite films were developed by incorporating Clausena lansium leaf essential oil (CLEO) into chitosan (CS) matrix to enhance the functionality of food-contact films. The optimal formulation (2.0% CS, 1.5% glycerol and 0.4% CLEO) was determined using principal component analysis and response surface methodology. The optimized films exhibited favorable physicochemical, mechanical, and barrier properties. Fourier transform infrared spectroscopy and SEM verified successful CLEO incorporation into the polymer matrix without compromising structural integrity. Furthermore, CLEO significantly enhanced antioxidant and antibacterial activities, with DPPH and ABTS⁺ scavenging rates of 49.15 ± 1.25 and 52.25 ± 3.33%, respectively, and inhibition rates of 72.84 to 98.63% against tested pathogenic bacteria. Preliminary biological evaluation indicated good cytocompatibility, with cell viability above 90%; however, this does not constitute a comprehensive food safety assessment. Overall, CLEO represents a promising natural functional additive for chitosan-based edible films, although further validation in real food systems is required to confirm practical preservation efficacy.
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Nature Communications
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2026
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IF 18.1
Jia Ning,Ji Yuan,Wang Wei,Wang Shichang,Wu Hong,Guo Shaoyun,Qiu Jianhui
Mesophase pitch-based carbon fibers (CFs) with ultrahigh axial thermal conductivity can significantly enhance through-plane heat transfer in thermal interface materials by vertical alignment, yet raise short-circuiting and electromagnetic interference (EMI) risks. Although incorporating insulating fillers or coating CFs can suppress electron migration, it often compromises thermal performance. Herein, we engineer multi-functionally trunk-branch hierarchical heterostructures to address above limitations. Vertically aligned trunk-like CF scaffolds ensure superior through-plane heat transfer. Branch-like boron nitride (BN) networks optimize impedance matching by enhancing electrical insulation and consequently improve electromagnetic wave (EMW) absorption. Meanwhile, in situ BN networks interconnect CF scaffolds, extending bidirectional thermally conductive and EMW propagation paths. At only 20.17 vol% filler, the composite exhibits a through-plane thermal conductivity of 57.96 W·m −1 ·K −1 (specific thermal conductivity enhancement of 1431.62 %·(vol%) −1 ) and an in-plane thermal conductivity of 2.93 W·m −1 ·K −1 , together with excellent electrical insulation and absorption-dominated EMI shielding, addressing the challenge of thermal-electrical-electromagnetic coupling for next-generation electronics.
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Nature Communications
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2026
·Vol. 17
·期 1
·4120
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IF 18.1
Song Yun,Zhu Zhaohua,Das Tridip,Riasati Aarya D.,Su Jianjun,Guo Weihua,Liu Yong,Li Geng,Xin Yinger,Zhang Qiang,He Mingming,Wang Ruixuan,Xue Rui,Zhao Shenlong,Xia Chuan,Tang Ben Zhong,Robert Marc,Wang Xin,Goddard William A.,Ye Ruquan
Formaldehyde (FA) electrolysis is attractive for paired production of value‑added chemicals. However, conventional electrolysis adopts alkaline electrolytes, which triggers FA self-disproportionation and severe feed loss. Here we introduce a sustainable and selective strategy for valorizing FA through electrochemically mediated disproportionation in acidic electrolytes. By leveraging a dual-electrode system consisting of a hydrophobic copper tetraminophthalocyanine layer (CuTAPc-layer) cathode and a Pt 2 Ru bimetallic anode, we efficiently convert FA into methanol and formic acid at high Faradaic efficiencies of 93.2% and 91.3%, respectively. Compared with alkaline FA oxidation, which can lose up to 76% FA and complicate downstream separation, the acidic system suppresses side reactions to ensure high product purity. Mechanism studies reveal that the hydrophobic microenvironment of CuTAPc-layer suppresses hydrogen evolution, while the stronger oxophilicity of Pt 2 Ru enhances FA activation and lowers the key deprotonation barrier for FA oxidation. The integrated device demonstrates application potential in polyoxymethylene upgrading, delivering 374.2 mA at 4 V with ~90% single-pass conversion, establishing a scalable and eco-friendly electrochemical pathway for chemical upcycling.
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Nature Communications
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2026
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IF 18.1
Han Xiaoxiao,He Ning,Yuan Dandan,Li Na,Zhu Wei,Zhu Xiaolong,Li Jing,Yuan Xun,Wang Wenxin,Gu Xingshi,Chen Feng,Wang Wei
Engineering functional soft tissue constructs remains difficult because scaffolds must meet the mechanical, physicochemical, and biological requirements simultaneously. Here, we present a cell-laden hydrogel gyroid scaffold designed to support vascularisation, long-term multicellular culture, and implantation for the development of 3D tissue constructs. The scaffold is structurally optimised to balance nutrient transport and mechanical stability, and is fabricated with high fidelity by mitigating cell-induced light scattering. The gyroid architecture supports the formation of dense microvascular networks throughout the 3D construct, and its curved Gaussian curvature promotes endothelial self-assembly. The scaffold also enables high-density co-culture of HepG2 cells and HUVECs without active perfusion, resulting in a vascularised 3D liver tumour model with enhanced tissue-specific function. Upon subcutaneous implantation in mice, the constructs show enhanced neovascularisation and facilitate tumour formation. These findings identify the gyroid scaffold as a biologically favourable architecture for generating bulk vascularised constructs, with potential applications in disease modelling, drug screening and regenerative medicine.
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Nature Communications
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2026
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IF 15.7
Guo Jia,Lyu Jiawei,Gao Zili,Jia Tan,Wang Leyun,Dong Jingxi,Gu Zhen,Ji Shen,Li Wei,Wang Hongmei,Zhai Jinglei,Yu Leqian,Feng Guihai,Zhou Qi,Gu Qi
Embryo development undergoes critical morphological transformations post-implantation, largely driven by the complex and dynamic microenvironment of the uterus. Despite advances, current 3D culture models inadequately recapitulate the uterine environment necessary for studying embryo-uterus interactions. In this work, we engineer a hydrogel inspired by the properties of the decidua, incorporating Matrigel to support blastocyst implantation and embryo development in vitro. Our findings reveal that embryos cultured within this hydrogel system successfully progress to an early organogenesis-like stage, including the development of first and second heart fields, mimicking natural embryogenesis. Moreover, we identify that the mechanical properties, particularly stress relaxation, play a crucial role in facilitating focal adhesion (FA) formation between the trophoblast and the hydrogel. Additionally, the degradation of the hydrogel by embryo-secreted metalloproteinases ( MMP2 and MMP9 ) creates a favorable environment for continued embryonic growth and development. These insights contribute to a deeper understanding of how the external environment regulates embryo development and offer an enhanced approach for in vitro embryo culture.
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