BIORESOURCE TECHNOLOGY
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2019
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IF 6.669
Xin Zhang,Ziguo Yuan,Qian Yao,Ying Zhang,Yao Fu
In this work, corn cob was used as raw material to selectively produce acetonitrile via catalytic fast pyrolysis (CFP) in ammonia over Ga/HZSM-5 catalyst. A series of catalysts with different catalyst carriers (including HZSM-5, USY, MCM-41, HY, and γ-Al 2 O 3 ) and active metals (including Fe, Co, Ni, Cu, Zn, Cr, Ca, Mg and Ga) were prepared and screened. The reaction conditions, such as temperature, ammonia flow rate and residence time were changed to investigate the effect on the product distribution and acetonitrile production. The results indicated that with the desired catalyst (2% Ga/HZSM-5) and optimal reaction conditions (Temperature 700 °C; ammonia flow rate 80 ml/min; residence time 2.4 s), the highest carbon yield of acetonitrile from corn cob with a value of 18.4% could be obtained, and the carbon selectivity in bio-oil was 83.5%. This study provides an economical and environmental-friendly method for the direct production of acetonitrile from abundant biomass.
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ANALYTICA CHIMICA ACTA
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2019
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IF 5.256
Yongkang Ye,Wuwen Yan,Yaqian Liu,Shudong He,Xiaodong Cao,Xuan Xu,Haisong Zheng,Sundaram Gunasekaran
A rapid and sensitive electrochemical biosensor was constructed to detect Salmonella using invA gene biosensor. The biosensing was based on polyrrole-reduced graphene oxide (PPy-rGO) nanocomposite modified glassy carbon electrode (GCE) and signal amplification with horseradish peroxidase-streptavidin biofunctionalized gold nanoparticles (AuNPs-HRP-SA). PPy-rGO was prepared at 60 °C by chemical reduction of PPy-functionalized graphene oxide (PPy-GO) that was synthesized by in situ polymerization at room temperature . The detection signal was amplified via enzymatic reduction of H 2 O 2 in the presence of hydroquinone (HQ) using AuNPs-HRP-SA as nanotag. Under optimal conditions, the differential pulse voltametric (DPV) signal from the biosensor was linearly related to the logarithm of target invA gene concentrations from 1.0 × 10 −16 to 1.0 × 10 −10 M, and the limit of detection (LOD) was 4.7 × 10 −17 M. The biosensor can also detect Salmonella in the range of 9.6 to 9.6 × 10 4 CFU mL −1 , with LOD of 8.07 CFU mL −1 . The biosensor showed good regeneration ability , acceptable selectivity , repeatability and stability, which bode well as an alternative method for Salmonella screening.
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Nanoscale
·
2019
·Vol. 11
·期 21
·10429-10438
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IF 6.97
Yang Liu,Yapei Zhang,Xiaomin Li,Xuefeng Gao,Xiaoyan Niu,Wei Wang,Qiang Wu,Zhi Yuan
Fluorescent dyes, as a key factor in fluorescence imaging, usually exhibit a low signal-to-noise ratio (SNR) due to the limited loading capacities of delivery systems (usually less than 10.0 wt%) and their uncontrolled release. Herein, we developed a type of pH-responsive nanoplatform (MnO2/ZnCOF@Au&BSA) based on a zinc porphyrin covalent organic framework (COF), in which the zinc porphyrin (ZnPor) loading rate is 22.5 wt%. At pH = 7.4, the interlinked ZnPor in the assembly state did not show a fluorescence signal (“off” state). Together with the pH-triggered disintegration of ZnCOF in tumor cells (pH = 5.5), the scattered ZnPor displayed an obvious fluorescence signal recovery (“on” state). Simultaneously, the shed BSA-coated gold nanoparticles ingeniously caused the fluorescence signal to be further amplified through the metal-enhanced fluorescence effect, which was about 3.0-fold higher in vivo than in the free ZnPor group. Combined with the excellent photothermal therapy effect by the nanoplatform itself with the tumor inhibition rate of 79.5%, this nanosystem effectively solves the problem of low loading capacities and imaging SNR by traditional delivery systems, and successfully develops the potential of COFs for fluorescence imaging, achieving the purpose of integration of diagnosis and treatment.
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JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
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2019
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IF 3.261
Asif Hayat,Fazal Raziq,Muhammad Khan,Ikram Ullah,Mati Ur Rahman,Wasim Ullah Khan,Javid Khan,Akhlaq Ahmad
In this work, we report the fabrication of polypyrrole/g-C 3 N 4 (PPy/g-C 3 N 4 ) nanocomposites via simple wet-chemical method. The photocatalytic activities of the composites are evaluated for water splitting to evolve H 2 , Rhodamine B dye (RhB) and 2,4-dichlorophenol (2,4-DCP) degradation under visible-light. The results reveal that the photocatalytic performance of g-C 3 N 4 for H 2 evolution, RhB dye and 2, 4-DCP degradation are significantly improved after coupling polypyrrole (PPy). Worth noting, the amount optimized (1 wt%PPy/g-C 3 N 4 ) photocatalyst showed highest photoactivity compared to the other photocatalysts. Further, it is confirmed by means of radical trapping experiments that superoxide radical (O 2 − ) is the dominant specie involved in the degradation of pollutants over PPy/g-C 3 N 4 nano-composites. Moreover, clear photocatalytic reactions for H 2 evolution and pollutants degradation are proposed. This work would help us to deeply understand the reaction mechanism and will provide feasible routes to fabricate g-C 3 N 4 based highly efficient photocatalysts for energy and environmental applications.
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Analytical Methods
·
2018
·Vol. 10
·期 41
·4985-4994
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IF 2.073
Juan Wang,Wei Du,Xingqi Huang,Junling Hu,WeiWei Xia,Dangqin Jin,Yun Shu,Qin Xu,Xiaoya Hu
In this work, a kind of molecularly imprinted polymer (MIP) was prepared by using metronidazole (MNZ) as the template, pyrrole as the functional monomer and vertically cross-linked two-dimensional Sn3O4 (2D Sn3O4) nanoplates as the support. The developed MIP/2D Sn3O4 was characterized by SEM, XRD, XPS and FT-IR. It was used to modify a glassy carbon electrode (GCE) to construct a novel MNZ electrochemical sensor. Parameters affecting the performance of the sensor were thoroughly investigated and optimized. The results revealed that 2D Sn3O4 is promising as a support for MNZ imprinting. Owing to the 2D structure, large active surface, functionalization and high electrical conductivity, the MIP/2D Sn3O4 modified electrode showed a wide linear range and low detection limit. The differential pulse voltammetric peak currents produced on the MIP/2D Sn3O4 electrochemical sensor showed a linear relationship for concentrations of MNZ in the range of 0.025–2.5 μM. The detection limit of this sensor was down to 0.0032 μM (S/N = 3). This MIP/2D Sn3O4 sensor was successfully used to detect MNZ in honeybee samples without any separation or accumulation processes, demonstrating that MIP/2D Sn3O4 is a promising biomimetic material for use in electroanalysis and other relevant fields.
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FIBERS AND POLYMERS
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2018
·Vol. 19
·期 11
·2344-2350
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IF 1.353
Chen Zeqi,Wei Chengzhuo,Rao Weida,Fan Lingling,Xu Jie
An electrothermochromic fabric triggered by electric voltages was prepared by combining the electric heating feature of conductive polypyrrole (PPy) and the temperature-response color-changing feature of thermochromic inks. PPy was deposited selectively on the carbon-coated side of the sailcloth fabric via electrochemical polymerization. Thermochromic inks were painted on the reverse side with white color. The obtained fabric could be heated to about 48 °C and change its color significantly under an applied voltage of 3 V.
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NEW JOURNAL OF CHEMISTRY
·
2018
·Vol. 42
·期 24
·19578-19590
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IF 3.201
Xucan Yuan,Di Wu,Chu Liu,Xianhui Li,Zhili Xiong,Longshan Zhao
A sensitive and accurate analytical method, magnetic solid-phase extraction combined with dispersive liquid–liquid microextraction followed by ultra-high performance liquid chromatography-tandem mass spectrometry, was established for the simultaneous quantification of eight sulfonamide antibiotics in environmental water samples. In this study, a magnetic nanocomposite, polypyrrole-modified magnetic multi-walled carbon nanotubes, was prepared, characterized and applied as an efficient adsorbent for magnetic solid-phase extraction. The synthetic material exhibited satisfactory adsorption capacity for sulfonamides. Moreover, the sample pretreatment-combined technology of magnetic solid-phase extraction and dispersive liquid–liquid microextraction exhibited better purification ability than only magnetic solid-phase extraction. Furthermore, the various extraction parameters affecting the extraction efficiency were thoroughly optimized. Under the optimized conditions, high sensitivity was achieved with method detection limits in the range of 1.02–2.97 ng L−1 and method quantitation limits in the range of 3.05–9.89 ng L−1. The recovery of eight sulfonamides in five environmental water samples was in the range of 78.3–95.6% and the relative standard deviations were no more than 8.5%. Finally, the method was successfully applied to the analysis of sulfonamides in real environmental water samples (river water, lake water, influent wastewater, effluent wastewater and farm wastewater). Accordingly, the newly established method is reliable for monitoring sulfonamide residues in complex environmental matrices, which has great significance for evaluating the effects of sulfonamide residues on humans and the ecosystem.
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CARBON
·
2018
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IF 7.082
Dandan Han,Yucong Jiao,Wenqian Han,Guanhong Wu,Tongtao Li,Dong Yang,Angang Dong
Heteroatom doping of carbonaceous materials can effectively modulate their physiochemical properties, providing great potentials to design innovative architectures with enhanced performance for energy-related applications. Herein, we report a versatile molecular-based strategy for the in-situ synthesis of highly-ordered, heteroatom-doped mesoporous carbon frameworks (MCFs). Our approach is based on the transformation of self-assembled superlattices consisting of Fe 3 O 4 nanocrystals (NCs) with desired surface-coating molecular species, which are realized by exploiting versatile surface chemistry of colloidal NCs. By this strategy, various heteroatoms, such as N, B, and S, can be directly incorporated into the simultaneously formed MCFs with a homogeneous distribution . Taking advantage of their highly ordered and interconnected mesoporosity, tunable doping level, and high surface area, such heteroatom-doped MCFs show great promise for energy-related applications. We show that the N-doped MCFs (N-MCFs) exhibit significantly enhanced catalytic activity relative to their undoped counterparts when evaluated as electrocatalyst for oxygen reduction reaction . Likewise, the N-MCFs can also be used as electrode material for constructing supercapacitors with outstanding cycling stability and rate performance. This work offers a surface chemistry approach for the direct synthesis of highly-ordered MCFs containing homogeneously distributed heteroatoms, which are suitable for applications in various energy conversion and storage devices.
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BIOCONJUGATE CHEMISTRY
·
2018
·
IF 4.485
Yu Zhao,Zhentan Lu,Xiaomei Dai,Xiaosong Wei,Yunjian Yu,Xuelei Chen,Xinge Zhang,Chaoxing Li
Due to the rapid development of bacterial resistance, there is an urgent need to explore new antibacterial agents to substitute for traditional antibiotic therapy. Photodynamic therapy has been identified as a promising bactericidal method to conquer antibiotic-resistant pathogens. To solve the problem of photosensitizer damage to normal tissues in vivo, we developed a boron-dipyrrolemethene (BODIPY)-based glycosylated photosensitizer for ablating Pseudomonas aeruginosa (P. aeruginosa). This glycosylated photosensitizer exhibited good water solubility and generated 1O2 rapidly in an aqueous solution under light exposure. The photosensitizer did not cause detectable toxicity to human cells in the dark. Importantly, the photosensitizer was able to selectively attach to P. aeruginosa over normal cells, thus resulting in effective pathogen ablation by reactive oxygen species. Moreover, the photosensitizer inhibited over 90% of the biofilm formation produced by P. aeruginosa. The results indicate that the design of the macromolecular photosensitizer-induced bacterial death and inhibited biofilm formation provide a novel strategy for overcoming bacterial infection.
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Biomaterials Science
·
2018
·Vol. 6
·期 10
·2750-2756
·
IF 5.831
Cai Zhang,Haiyan Pan,Xu Wang,Shao-Kai Sun
Photothermal therapy with minimal invasiveness and high selectivity has been regarded as a powerful technique for tumor therapy to overcome the risks of toxic side effects and limited therapeutic efficacy of clinic cancer treatments. Among various photothermal therapeutic agents, polypyrrole (PPy) nanoparticles show a promising prospect in tumor ablation in vivo due to their admirable biocompatibility and outstanding photothermal performance. Besides, polypyrrole nanoparticles are extensively applied in biosensors, electrochemical sensors, tissue engineering, flexible microelectronics, and so on. However, the available synthesis methods of PPy nanoparticles are all time-consuming and seriously hindered their highly efficient production for diverse applications. Here we present a microwave-assisted strategy for the fabrication of PPy nanoparticles in 2 min, and the required synthesis time is shortened by 120–720 times compared to that in traditional ways. The prepared PPy nanoparticles possess uniform size, favorable aqueous solubility, and enhanced photothermal performance derived from the stronger near-infrared absorbance. Low cytotoxicity and in vivo toxicity of the nanoparticles were confirmed via comprehensive assessments. The PPy nanoparticle-based photothermal therapy in vitro led to a remarkable death of tumor cells, and in vivo tumor ablation using the nanoparticles was achieved under mild laser irradiation with a FDA-approved safe power. The proposed microwave-assisted synthesis strategy opens up a facile and ultrafast way for the construction of organic nanoparticles and facilitates a wide range of applications of them in biomedicine and other fields.
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ACS Applied Materials & Interfaces
·
2018
·
IF 8.097
Xiao Liu,Wei Qi,Yuefei Wang,Daiwu Lin,Xuejiao Yang,Rongxin Su,Zhimin He
A facile approach was reported to establish mimic multienzyme systems with hierarchically porous (HP) biomimetic metal–organic frameworks (MOFs) and natural enzymes for tandem catalysis. The hierarchically porous MOF HP-PCN-224(Fe) with peroxidase-like activity and tunable hierarchical porosity was synthesized via a modulator-induced strategy. HP-PCN-224(Fe) not only acts as the enzyme-immobilization matrix but also as an effective enzyme mimic, which could cooperate with the immobilized natural enzyme to catalyze the cascade reactions. The mimic multienzyme systems were used for the efficient colorimetric detection of a series of biomolecules, including glucose and uric acid. This work displays the great potential to construct highly functional biocatalysts by integrating the merits of both natural enzymes and MOF mimics, which are promising for applications in biosensing and biomimetic catalysis.
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Journal of Materials Chemistry B
·
2018
·Vol. 6
·期 19
·3128-3135
·
IF 4.776
Wenhao Zhou,Ling Lu,Dafu Chen,Zhengao Wang,Jinxia Zhai,Renxian Wang,Guoxing Tan,Jianping Mao,Peng Yu,Chengyun Ning
Conductive polymers (CPs) are frequently used as neural and osteogenic implants for signal recording and electrical stimulation due to their electroactive and good biocompatibility. However, these implants often fail due to bacterial infection. In this research, a novel nano-functionalized polypyrrole (PPy) with high surface potential was electrochemically developed to improve the antibacterial properties of CPs. Sulfosalicylic acid (SSA)—a biomolecule with abundant negatively charged functional groups—was introduced to not only successfully assist in the electrical assembly of Py micelles into a bacterial extracellular matrix mimetic nanostructure, but also to modulate the surface electrical properties of PPy. Scanning Kelvin probe microscopy (SKPM) results confirm the increased positive charges on SSA-assisted PPy (PPy/SSA nanorod and irregular PPy/SSA film) relative to the irregular PPy/Cl film. Plate colony-counting experiments confirm that SSA-assisted PPy has excellent antibacterial properties relative to the irregular PPy/Cl film. The higher antibacterial rate for PPy/SSA nanorods suggests a synergistic effect via the nanorod structure and the high surface potential induced by dopants. Cytotoxicity testing demonstrates that PPy/SSA samples were nontoxic to the cells. Our work provides an effective way to develop antibacterial CPs.
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