JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2014
·Vol. 161
·期 10
·B201
·
IF 2.859
Yang Fan,Zijuan Yang,Xinhua Cao,Peifang Liu,Sen Chen,Zhen Cao
Hierarchical macro-mesoporous Ni(OH)2 were prepared by hydrothermal treatment of Ni(NO3)2 with dicyandiamide. This Ni(OH)2 nanostructure can be transformed to mesoporous NiO via calcination at 300°C. The structure, morphology and textural properties of the as-synthesized Ni(OH)2 and NiO were characterized. The electrochemical property and electrochemical sensing performance toward glucose detection were investigated. Owing to the unique macro-mesoporous structure, the Ni(OH)2 nanostructure could provide amperometric sensing of glucose with wide linear range (0.01–8.3 mM), high sensitivity of 243 μA mM cm−2 and low detection limit of 1 μM. Moreover, this glucose sensor also exhibited excellent stability, good selectivity and reproducibility.
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Catalysts
·
2025
·Vol. 15
·期 9
·886
·
IF 4
Qianran Feng,Xiaoting Yu,Jinlian Peng,Siying Du,Liuyun Chen,Xinyuan Xu,Tongming Su
Sustainable production of hydrogen is currently a global research hotspot. In this study, a Ni(OH)2cocatalyst was loaded on Zn0.8Cd0.2S to form Ni(OH)2/ZCS composites and achieve highly efficient photocatalytic hydrogen production. After Ni(OH)2loading, a close contact interface was established between Ni(OH)2and Zn0.8Cd0.2S, which increased the separation efficiency of the photogenerated electrons and holes. Moreover, the addition of Ni(OH)2increases the specific surface area and light absorption of Ni(OH)2/Zn0.8Cd0.2S, and the Ni(OH)2can act as active sites for photocatalytic hydrogen production. The photocatalytic H2production rate of Ni(OH)2/ZCS composites increases with the increase in the Ni amount. 9Ni(OH)2/ZCS exhibited the optimum H2production rate of 12.88 mmol h−1g−1, which was 9.9 times higher than that of Zn0.8Cd0.2S. When the amount of Ni(OH)2is further increased, the excess Ni(OH)2covers the active site of Zn0.8Cd0.2S and reduced the light absorption of Zn0.8Cd0.2S, resulting in a decrease in the H2production rate. Furthermore, the H2production rate of 9Ni(OH)2/ZCS decreased from 12.88 to 5.15 mmol g−1h−1after 3 cycles. The main reason for the decline in the photocatalytic performance of Ni(OH)2/ZCS is the photocorrosion of Zn0.8Cd0.2S. This study provides an innovative design for loading Ni(OH)2cocatalysts on Zn0.8Cd0.2S to improve the performance of photocatalysts.
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CRYSTENGCOMM
·
2025
·
IF 2.6
Wei Jia,Qi He,Zhiqiang Guo,Xiang Wu
It is very important to rationally design electrode materials with remarkable electrical conductivity and high specific surface area for supercapacitors. However, it is limited by insufficient energy density, so the development of high-performance electrodes has become research focuses. Herein, we report the synthesis of CoMoO4@Ni(OH)2 composite structures by hydrothermal growth of Ni(OH)2 nanosheets on CoMoO4 materials. The synthesized product achieves 93% of capacitance retention after 10,000 times cycling and possesses a specific capacitance of 2640 F g-1 at 1 A g-1. Furthermore, the assembled device delivers an energy density of 74.25 Wh kg-1 when the power density is 2700 W kg-1. Besides, the materials still present outstanding flexibility and mechanical stability after bending at different angles and times.
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Journal of Magnesium and Alloys
·
2022
·
IF 11.813
Yongyang Zhu,Mili Liu,liming Zeng,Yin Wang,Daifeng Wu,Rui Li,Qing Zhou,Renheng Tang,Fangming Xiao
The hydrolysis of MgH 2 delivers high hydrogen capacity (15.2 wt%), which is very attractive for real-time hydrogen supply. However, the formation of a surface passivation Mg(OH) 2 layer and the large excess of H 2 O required to ensure complete hydrolysis are two key challenges for the MgH 2 hydrolysis systems. Now, a low-cost method is reported to synthesize MgH 2 @Mg(BH 4 ) 2 composite via ball-milling MgH 2 with cheap and widely available B 2 O 3 (or B(OH) 3 ). By adding small amounts of B 2 O 3 , the in-situ formed Mg(BH 4 ) 2 could significantly promote the hydrolysis of MgH 2 . In particular, the MgH 2 –10 wt% B 2 O 3 composite releases 1330.7 mL·g −1 H 2 (close to 80% theoretical hydrogen generation H 2 ) in H 2 O and 1520.4 mL·g −1 H 2 (about 95%) in 0.5 M MgCl 2 in 60 min at 26 °C with hydrolysis rate of 736.9 mL·g −1 ·min −1 and 960.9 mL·g −1 ·min −1 H 2 during the first minute of the hydrolysis, respectively. In addition, the MgCl 2 solution allows repeated use by filtering and exhibits high cycle stability (20 cycles), therefore leading to much reduced capacity loss caused by the excess H 2 O. We show that by introducing B 2 O 3 and recycling the 0.5 M MgCl 2 solution, the system hydrogen capacity can approach 5.9 wt%, providing a promising hydrogen generation scheme to supply hydrogen to the fuel cells.
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CRYSTENGCOMM
·
2021
·Vol. 24
·期 3
·681-690
·
IF 3.545
Yunping Zhoujin,Yuping Li,Mingtao Zhang,Sean Parkin,Ju Guo,Tonglei Li,Faquan Yu,Sihui Long
2-((2,6-Dichlorophenyl)amino)benzoic acid (2-DCABA), a potential non-steroidal anti-inflammatory drug and an analog of 2-((2,6-dimethylphenyl)amino)benzoic acid (HDMPA) was synthesized and its polymorphism was studied to investigate the effect of double Cl–CH3 exchange. Three forms-two polymorphs (I and II) and one cocrystal salt (S)-were obtained through polymorph screening in a variety of solvents, and the elusive single crystals of form II of HDMPA were harvested through melt crystallization. The crystal forms were characterized by single-crystal X-ray diffraction, powder X-ray diffraction (PXRD), DSC, and FT-IR. Isomorphism and isostructurality were observed between the form I of each system. The polymorphism of 2-DCABA seems to stem from the conformational flexibility of the molecule, similar to that of HDMPA. Hirshfeld analysis revealed different intermolecular interactions contributing to the stability of the crystal form I of 2-DCABA and HDMPA-I, despite their structural similarity.
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EUROPEAN JOURNAL OF PHARMACOLOGY
·
2019
·
IF 3.17
Qi-meng Liu,Qing Xiao,Xiang Zhu,Kai-feng Chen,Xia-wen Liu,Ru-chao Jiang,Dan Wu,Jun-min Shi,Li-jun Dai,Jun-jun Huang
Benign prostatic hyperplasia (BPH) is a common disorder of the urinary system in aging men. 2-(1H-indol-3-yl)-N-[3-(4-(2-methoxyphenyl) piperazinyl) propyl] acetamide (HJZ-3), which is derived from naftopidil , exhibited 97.7- and 64.6-fold greater inhibitory effects for a 1D adrenoceptor than for a 1B - and a 1A -adrenoceptors in vitro, respectively. To investigate the therapeutic potential for treating BPH, we evaluated the pharmacological activity of HJZ-3. Specifically, we evaluated through estrogen/androgen-induced rat benign prostatic hyperplasia model in vivo. HJZ-3 effectively prevented the progression of rat prostatic hyperplasia by suppressing the increase in prostate index and reducing the quantitative analysis of the relative acinus volume, relative stroma, epithelial volume and epithelial thickness and expression of proliferating cell nuclear antigen and α -smooth muscle actin. HJZ-3 decreased α 1A - and α 1D -adrenoceptor protein expressions in prostate tissue. HJZ-3 is a good alternative for α 1A - and α 1D -adrenoceptor blocker. It may relax smooth muscle tone and relieve symptoms of BPH.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
·
IF 9
Kuang Wang,Zhanqiang Fang
In this work, a cost-effective ball-milling technique was employed to synthesize submicron oxalated zero-valent iron co-doped with graphite and nickel (G@Fe OX bm /Ni), aiming to enhance the removal efficiency of the recalcitrant pollutant 2, 2′, 4, 4′ – tetrabromodiphenyl ether (BDE-47) while minimizing secondary risks. The incorporation of graphite significantly improved the debromination efficiency of BDE-47, with a rate constant of 0.26 day −1 in a tetrahydrofuran/water system, which represents a 59.88 % increase over the oxalated zerovalent Fe/Ni without graphite (0.16 day −1 ). The determination of Ni leaching showed that no nickel ions were detected post-reaction over a broad pH range (3–11). Moreover, the reactivity of G@Fe OX bm /Ni was largely unaffected across the pH range (0.26–0.49 day −1 ), exhibiting excellent resistance to acidic and alkaline conditions. In both ultrapure water and real groundwater matrices, the degradation rate constants for BDE-47 increased to 2.98 day −1 and 0.79 day −1 , respectively, achieving debromination yields of 97.86 % and 50.18 % for the final product, diphenyl ether. Based on the established degradation pathway and electrochemical analysis, the debromination of BDE-47 follows a catalytic debromination and hydrogenation process by adsorbed atomic hydrogen (H* ADS ). The graphite doping enhanced the debromination of BDE-47 by increasing the production of H* ADS . The adsorption effect of graphite on metal ions effectively controlled secondary pollution and improved the material’s tolerance to acidic and alkaline environments. This work offers an efficient method for the degradation of low brominated diphenyl ether pollutants at a low cost and without secondary risks.
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ENVIRONMENTAL SCIENCE & TECHNOLOGY
·
2025
·
IF 11.3
Yi Peng,Yang Zheng,Chongli Shi,Chen Wang,Mengyan Huang,Lingjun Zeng,Susu Wang,Xuan Zhou,Yangzhizhe Gao,Jiawei Hong,María Dolores Hernando Guil,Amadeo R. Fernández-Alba,Damià Barceló,Hui Li
Tris(1,3-dichloro-2-propyl) phosphate (TDCPP) is an emerging environmental contaminant of concern due to its widespread presence and potential toxicity. Its metabolite, bis(1,3-dichloro-2-propyl) phosphate (BDCPP), plays a critical role in mediating TDCPP-induced toxicities and may exacerbate aging-related processes. In this study, we quantitatively compared the bioconcentration and toxicity of TDCPP and BDCPP in Caenorhabditis elegans. BDCPP exhibited higher environmental persistence and bioaccumulation potential than TDCPP. Exposure to 0.1–1000 μg/L TDCPP and BDCPP increased Oil red O staining (7.88%–55.44%, 6.42%–33.92%), lipofuscin levels (5.44%–35.98%, 3.54%–28.66%), and reduced the mean lifespan (3.09%–10.31%, 1.84%–8.74%). Overall, TDCPP caused greater triglyceride (TG) accumulation, lipofuscin formation, and lifespan reduction compared to BDCPP. TDCPP reduced brood size by 5.30%–18.95%, while BDCPP exposure increased brood size by up to 13.90%. Mechanism investigations revealed that TDCPP and BDCPP induce aging through distinct pathways. The adverse outcome pathways revealed that BDCPP disrupted germline stem cells (GSCs) apoptosis, transmitting reproductive signals through the kri-1-daf-16-lipl-4 signaling cascade, impairing TG hydrolysis and lifespan, while TDCPP acted through a GSC-independent route. These findings underscore the central role of GSCs in BDCPP-induced aging, enhance our understanding of BDCPP as a secondary pollutant, and provide critical data for assessing the ecological and health risks of chlorinated organophosphate esters.
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PubMed
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DRUG DEVELOPMENT RESEARCH
·
2019
·Vol. 80
·期 6
·750-757
·
IF 1.742
Chang Zheng,Wen Hou,Jun Liu,Xiao-Fang Xu,Jing Lin,Ping-Hua Sun,Wei-Min Chen
The prevalence of multidrug resistance among clinically significant bacterial pathogens underlines a critical need for the development of new classes of antibacterial agents with novel structural scaffolds. Cajaninstilbene acid (CSA), which is isolated from pigeonpea leaves, has shown potent antibacterial activity. In this study, a series of 2-hydroxyl-4-methoxyl-3-(3-methylbut-2-en-1-yl)-6-(4-phenylbenzoylamino)benzoic acid derivatives derived from CSA were designed and synthesized, and their antibacterial activities were evaluated. Several synthesized compounds exhibit better antibacterial activity than CSA against Staphylococcus aureus , Staphylococcus epidermidis , and two strains of methicillin-resistant S. aureus . Meanwhile, the results of 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide assays illustrate the good selectivity between bacteria and normal cells of the most active compounds 6u and 6v . Furthermore, well combinations with bacterial RNA polymerase of 6u arising from docking study imply the possible mechanism of antibacterial activity of these synthetic compounds.
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MOLECULES
·
2025
·Vol. 30
·期 6
·1254
·
IF 4.6
Yuexia Qin,Zhuyu Zheng,Di Liu,Shuhua Sun,Xiaolei Zhao,Lei Lv,Dengyu Xie,Zhonghui Han,Jinxing He
The effects of furfural and 5-methyl-2-furfural produced by the Maillard reaction on PhIP formation were investigated in chemical models and roasted pork patties. In the chemical models, the results indicated that increasing levels of furfural (r = −0.7338, R2= 0.9557) and 5-methyl-2-furfural (r = −0.7959, R2= 0.9864) significantly reduced PhIP formation, displaying a strong linear correlation. The effects of furfural and 5-methyl-2-furfural on the precursors of phenylalanine (Phe) and phenylacetaldehyde showed a significant reduction in the Phe level, while the level of phenylacetaldehyde was not increased. In addition, neither furfural nor 5-methyl-2-furfural could significantly reduce creatinine or PhIP. Further mechanism studies showed that furfural (5-methyl-2-furfural) directly captured Phe to form the corresponding Schiff base compounds a (2-((furan-2-ylmethylene) amino)-3-phenylpropanoic acid) and b (2-(((5-methylfuran-2-yl)methylene)amino)-3-phenylpropanoic acid). This process reduced the production of phenylacetaldehyde, thereby inhibiting the PhIP formation pathway. More importantly, these two compounds were detected in roasted pork patties to which glucose was added. The above pathway was finally confirmed in roasted pork patties. These results revealed that furfural and 5-methyl-2-furfural, formed during the Maillard reaction, play a significant role in inhibiting the formation of PhIP by reacting with Phe.
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Biomed Research International
·
2020
·Vol. 2020
·期 1
·5084057
·
IF 2.276
Li Yang,Yiwei Fang,Ronghua Liu,Junwei He
Dendropanax dentiger root is a traditional medicinal plant in China and used to treat inflammatory diseases for centuries, but its phytochemical profiling and biological functions are still unknown. Thus, a rapid, efficient, and precise method based on ultra high-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry (UHPLC-Q-TOF-MS/MS) was applied to rapidly analyse the phytochemical profiling of D. dentiger with anti-inflammatory and antioxidant activities in vitro . As a result, a total of 78 chemical compositions, including 15 phenylpropanoids, 15 alkaloids, 14 flavonoids, 14 fatty acids, 7 phenols, 4 steroids, 4 cyclic peptides, 3 terpenoids, and 2 others, were identified or tentatively characterized in the roots of D . dentiger . Moreover, alkaloid and cyclic peptide were reported from D . dentiger for the first time. In addition, the ethanol crude extract of D. dentiger roots exhibited remarkable anti-inflammatory activity against cyclooxygenase- (COX-) 2 inhibitory and antioxidant activities in vitro . This study is the first to explore the phytochemical analysis and COX-2 inhibitory activity of D. dentiger . This study can provide important phytochemical profiles and biological functions for the application of D. dentiger roots as a new source of natural COX-2 inhibitors and antioxidants in pharmaceutical industry.
研究领域:
天然药物化学
·
药用植物学
·
炎症生物学
·
自由基生物学
·
药物代谢
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Frontiers in Pharmacology
·
2021
·
IF 5.811
Xiao Qing,Liu Qi-Meng,Jiang Ru-Chao,Chen Kai-Feng,Zhu Xiang,Ma Lei,Li Wei-Xi,He Fei,Huang Jun-Jun
Previous studies have indicated that α1D/1A antagonist naftopidil (NAF) suppresses prostate growth by decreasing cell proliferation without affecting apoptosis and prostate volume in benign prostatic hyperplasia (BPH). A NAF-derived α1D/1A antagonist 1- benzyl-N-(3-(4-(2-methoxyphenyl) piperazine-1-yl) propyl)-1H-indole-2- carboxamide (HJZ-12) has been reported from our laboratory, which exhibits high subtype-selectivity to both α1D- and α1A- AR (47.9- and 19.1- fold, respectively) with respect to a1B-AR in vitro. However, no further study was conducted. In the present study, a pharmacological evaluation of HJZ-12 in BPH was performed on an estrogen/androgen-induced rat BPH model and human BPH-1 cell line. In vivo, HJZ-12 exhibited better performance than NAF in preventing the progression of rat prostatic hyperplasia by not only decreasing prostate weight and proliferation (similar to NAF) but also, shrinking prostate volume and inducing prostate apoptosis (different from NAF). In vitro, HJZ-12 exhibited significant cell viability inhibition and apoptotic induction in BPH-1 cell line, without presenting cell anti-proliferation properties. Intriguingly, the role of HJZ-12 on cell viability and apoptosis was an α1-independent action. Furthermore, RNA-Seq analysis was applied to screen out six anti-apoptotic genes (Bcl-3, B-lymphoma Mo-MLV insertion region 1 [Bmi-1], ITGA2, FGFR3, RRS1, and SGK1). Amongst them, Bmi-1 was involved in the apoptotic induction of HJZ-12 in BPH-1. Overall, HJZ-12 played a remarkable role in preventing the progression of prostatic hyperplasia through α1-independent apoptotic induction, indicating that it will be a multi-target effective candidate for BPH treatment.
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