TRANSITION METAL CHEMISTRY
·
2019
·Vol. 44
·期 8
·689-697
·
IF 1.016
Jin Di,Wang Bowei,Wu Xingchun,Li Jiayi,Mu Manman,Chen Ligong
Functionalization of covalent organic frameworks (COFs) with specific groups will endow them special characteristics, and further complexation with transition metals may improve their catalytic performance and widen their applications. Herein, we constructed an amino-functionalized covalent organic framework TpPa–NH 2 by the facile reduction in TpPa–NO 2 and took it as a carrier for transition metal ion Cu(II) to yield a hybrid Cu–COF. All characterizations verified that the crystallinity and porosity of original COF were retained after functionalization. Subsequent evaluation of their catalytic performance indicated that the framework TpPa–NH 2 has potential application in alkali-catalyzed reactions, while the hybrid Cu–COF displayed satisfactory catalytic performance both in selective oxidation of styrene and the reduction in 4-nitrophenol to 4-aminophenol. The above results demonstrated that TpPa–NH 2 is a promising platform with diverse applications, and the introduction of Cu(II) will endow the material with more potential applications in oxidation and reduction reactions.
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BIOMATERIALS
·
2019
·
IF 10.273
Tao Sun,Guangping Zhang,Qingbing Wang,Zhongyuan Guo,Qinjun Chen,Xinli Chen,Yifei Lu,Yu Zhang,Yujie Zhang,Qin Guo,Xiang Gao,Yongzhong Cheng,Chen Jiang
Real-time monitor of drug-release from drug formulations in a noninvasive way can provide spatio-temporal information for drug activation and guide further clinical rational administration. In this work, a molecular shuttle, as a typical nanosized artificial molecular machine, was managed to act as a conceptually-new nanotheranostics for oxaliplatin. A post-recognition strategy was utilized, where a default supramolecular-dye couple was pre-blocked. The rational design, synthesis, characterization and proof-of-concept of this strategy were described in detail. The drug-release upon reducing environment can be translated into near-infrared (NIR) fluorescence signal (OFF-to-ON), allowing to track the drug-release procedure by multi-modal images including IVIS, FLECT and photoacoustic imaging. The versatile nanotheranostics system can target to triple negative breast tumor via conjugated F3 peptide, and show an improved anti-tumor efficacy with much lower side effect. The intelligent nanotheranostics system based on molecular shuttle provides new reference for precision medicine in preclinical trial and postclinical evaluation.
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JOURNAL OF MATERIALS SCIENCE
·
2017
·Vol. 53
·期 3
·1623-1633
·
IF 2.599
Qiao Yujie,Liu Xuelong,Fu Gongbu,He Zhongyuan,Hou Chengyi,Li Yaogang,Zhang Qinghong,Yan Hexin,Wang Hongzhi
Nanofiber scaffolds are widely used as the platform for three-dimensional culture of hepatocytes in vitro. The pore size of scaffolds plays an important role in promoting the infiltration and proliferation of hepatocyte. We show that the average pore size of electrospun scaffold increases from ~ 7.6 to 13.2 μm, while the average fiber diameter decreases from ~ 2.0 to 1.5 μm when collected by probe array collectors. Though increase in pore size decreases the tensile stress of scaffolds, it leads to enhance the proliferation and attachment of hepatocytes. Specifically, a 6 × 6 array scaffold which was prepared by probe collector was orderly arrayed. Compared with the conventional scaffold, the pore size of the arrayed scaffold doubled and the hydrophilicity was improved. When HepG 2 cells were seeded on the arrayed scaffold, cells showed superior adhesion ability, better cell morphology and three-dimensional growth. These results indicated that the ordered 6 × 6 array scaffold has the potential as a suitable substratum for in vitro culture of hepatocytes.
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CLINICAL BIOCHEMISTRY
·
2020
·
IF 2.573
Tianhua Zhang,Xiaoyu Tang,Ling Mao,Jin Chen,Jie Kuang,Xin Guo,Danyan Xu,Daoquan Peng,Bilian Yu
Background The mechanism for an abnormal pattern of triglyceride (TG) metabolism in response to a meal still needs further investigation. Extensive pieces of evidence have shown that apolipoprotein CIII (apoCIII) is a critical modulator of plasma TG metabolism mostly by inhibiting the hydrolysis of TG. Little is known about the role of apoCIII contained in high density lipoprotein (HDL) in plasma TG metabolism after a meal. Methods Fasting and 4-hour postprandial peripheral venous blood were collected in 91 subjects selected from our hospital. Serum lipid parameters, apoCIII levels and HDL subcomponents were tested by standard laboratory procedures, ELISA, and nuclear magnetic resonance (NMR), respectively. The t -test, and Non-parametric tests were performed to examine differences between groups, Pearson’s correlation and multiple regression analysis were used to assess the correlations between apoCIII (HDL-associated or nonHDL-associated) and postprandial TG. Results There was a significant increase in TG after a meal compared to fasting status [155.40(96.70–251.07) mg/dl .vs. 118.53(83.38–173.29)mg/dl, p < 0.001]. However, the total apoCIII levels were unchanged before (11.56(7.89–16.22) mg/dl) and after a meal (11.66(7.75–16.02)mg/dl, p = 0.124), while a significant increase in HDL-associated apoCIII (HDL-apoCIII) was observed from fasting (5.25(3.92–7.83)mg/dl) to post-meal (6.46(4.57–8.76)mg/dl, p = 0.001). Unlike nonHDL-apoCIII, HDL-apoCIII was positively correlated with both fasting and postprandial plasma TG in subjects with baseline plasma TG > 118.53 mg/dl (R = 0.503, p < 0.001 for fasting, R = 0.584, p < 0.001 for postprandial). Besides, in the subjects who had an abnormal TG response to a meal, which was defined as postprandial plasma TG increase of>30% compared to baseline TG levels, postprandial HDL-apoCIII was also increased significantly [5.37(3.52–7.02)mg/dl .vs. 6.64(4.61–8.86)mg/dl, p = 0.001]. The enrichment of apoCIII in HDL led to changes of TG, cholesterol, free cholesterol, phospholipid and apoAII contents in HDL particles defined by NMR. Conclusion Enrichment of apoCIII in HDL particles potentially plays an independent role in postprandial hypertriglyceridemia.
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ACS Omega
·
2019
·
IF 2.584
Chaochao Qu,Ji Wang,Hongyao Yin,Guangliang Lu,Zuyou Li,Yujun Feng
Foams are widely used to remove liquid loading at the bottom of gas wells to improve natural gas production. However, it becomes ineffective when a gas well contains a large amount of hydrocarbon condensate because oil will rupture the foams. In this work, condensate oil-tolerant foams were developed and stabilized by a mixture of cocamidopropyl hydroxyl sulfobetaine (CHSB) and sodium dodecyl sulfate (SDS). The foam properties are examined at different temperatures under atmospheric conditions and high pressures with various contents of condensate oil. It is found that the foam stability is improved when the oil content is increased; in addition, high temperature, high salinity, and high pressure are beneficial for foam stabilizing. To reveal the mechanism of stable foam in the presence of high content of oil, a confocal microscope was employed to visualize oil–foam interactions. It was observed that the high stability of the SDS–CHSB foams is ascribed to the formation of stable pseudoemulsion between oil droplets and the gas–liquid interface. Such condensate oil-tolerant foams show promising potential to be used in the foam-assisted lift process during natural gas production.
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POLYMER
·
2020
·
IF 4.231
Yi Wang,Zhenxing Cao,Changshu Ma,Rui Wu,Anji Du,Guangsu Huang,Jing Zheng,Jinrong Wu
The emerging soft electronics and robots are eagerly seeking for soft materials possessing not only comprehensive mechanical properties but also smart stimuli-responsive property, whose fabrication however remains a great challenge. Herein, we develop a series of high-performance smart hydrogels crosslinked and reinforced by an organic-inorganic hybridized crosslinker composed of multi-functional polymer adsorbed molybdenum disulfide (v-MoS 2 ). The multi-functional polymer is synthesized by grafting polyethyleneimine with multiple vinyl groups. Such molecular design enables it to serve as a surfactant to assist the exfoliation and stabilization of v-MoS 2 nanosheets through hydrophobic and electrostatic interactions , thereby forming the hybridized crosslinker to crosslink polyacrylamide (PAM) hydrogels through both chemical bonds and physical interactions. The crosslinking points can effectively transfer load between the molecular chains and v-MoS 2 , and moreover dissipate energy through hydrophobic and electrostatic interactions. Therefore, the hydrogels not only are mechanically robust with tensile strain up to 3500% and strength up to 645 kPa, but also show outstanding notch-insensitivity and anti-fatigue property. Combining with the photothermal effect of MoS 2 , robust biomimetic fish and butterfly with dual photoresponsivity and thermosensitivity are designed, which can well mimic the self-defense process of marine and terrestrial organisms under external stimulations.
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MOLECULAR PHARMACEUTICS
·
2018
·
IF 4.556
Hui Liu,Yuxiang Han,Jiyuan Li,Ming Qin,Qunfeng Fu,Chunhong Wang,Zhibo Liu
Amino acids derivative are well established molecular probes for diagnosis of a variety of cancer using positron emission tomography (PET). Recently, boramino acid (BAAs) was found as a prospective molecular platform for developing PET tracer. The objective of this study was to develop a 18F-labeled alanine derivative through displacing its carboxylate by trifluoroborate as a selective ASCT2 marker for cancer imaging. 18F-Ala-BF3 was first evaluated in healthy FVB/N mice in vivo, exhibiting rapid renal clearance with almost negligible uptake in stomach (1.53 ± 0.31%ID/g). Notable uptake was observed in thyroid (3.71 ± 0.49%ID/g, 40 min post injection), of which the uptake was significantly inhibited by co-injection with natural L-alanine. In addition, we further established 18F-Ala-BF3 on a human gastric cancer cell (BGC-823) xenografts bearing mouse model. Dynamic PET-CT scan revealed the optimal time window for tumor imaging, it was between 40 and 60 min post injection, when the BGC-823 xenografts uptake was 5.49 ± 1.47%ID/g (n = 4), and the tumor-to-stomach, tumor-to-blood, tumor-to-muscle, and tumor-to-brain ratios were 3.27 ± 1.53, 3.80 ± 1.48, 3.47 ± 1.48, and 6.20 ± 1.47, respectively.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2019
·
IF 3.131
Jing Wang,Mingying Yu,Cheng Yang
Colloidal inorganic nanoparticles featured with ultrasmall sizes and near-neutral surface wettability are considered as efficient emulsifiers to stabilize Pickering emulsions . Herein, we demonstrated that colloidal TiO 2 nanoparticles synthesized by the well-established sol-gel approach using Ti(OC 4 H 9 ) 4 as precursor, could be directly used as an efficient Pickering emulsifier without any other additives. The sol-gel TiO 2 nanoparticles showed near-neutral wettability at the oil-water interface (θ ow ˜90°) derived from the surface residual butanol-related species as revealed by TGA/DTA and FT-IR analyses, which should be responsible for the formation of Pickering emulsion with ultrahigh stability. The Pickering emulsions stabilized by size-tunable TiO 2 nanoparticles under various emulsification conditions were characterized by photography, optical microscopy and rheology measurements. The results suggested that the droplet sizes and rheology properties of the emulsion could be adjusted by tuning the TiO 2 nanoparticle sizes. Moreover, as a potential application, we also demonstrated the simple fabrication of TiO 2 -coated silicone elastic hybrid microspheres through the Pickering emulsion templated polymerization. The present work demonstrated that sol-gel TiO 2 nanoparticles could serve as efficient particle emulsifiers for achieving stable emulsions, and may also extend the wide application of colloidal TiO 2 nanoparticles based on the Pickering emulsion platforms.
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ACS Omega
·
2020
·
IF 2.87
Xinming Feng,Jing Guo,Rubing Zhang,Wei Liu,Yujin Cao,Mo Xian,Huizhou Liu
An aminotransferase ω-TAEn was identified from Enhydrobacter aerosaccus. The ω-TAEn was successfully expressed in Escherichia coli and the obtained enzyme showed activity toward β-phenylalanine (β-phe) at optimal conditions. For optically pure (R)-β-phe, 50% yield was observed by kinetic resolution of racemic amino with pyruvate as the amino acceptor. To obtain (S)-β-phe, the lipase/ω-TAEn catalytic system was adopted. The ω-TAEn showed strict stereoselectivity to the amino donor. The formation of (S)-β-phe was observed using 3-aminobutyric acid as the amino donor, and (S)-β-phe was obtained by asymmetric synthesis with a yield of 82%.
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高影响因子
Toxins
·
2022
·Vol. 14
·期 2
·93
·
IF 5.075
Hongmei Liu,Zhihong Xuan,Jin Ye,Jinnan Chen,Meng Wang,Stephan Freitag,Rudolf Krska,Zehuan Liu,Li Li,Yu Wu,Songxue Wang
An immunoaffinity magnetic beads (IMBs) based automatic pretreatment method was developed for the quantitative analysis of deoxynivalenol (DON) by ultra-performance liquid chromatography and ultraviolet detector (UPLC-UV). First, N-hydroxysuccinimide-terminated magnetic beads (NHS-MBs) with good magnetic responsivity and dispersibility were synthesized and characterized by optical microscopy, scanning electron microscopy (SEM), and laser diffraction-based particle size analyzer. Then, the amino groups of anti-DON monoclonal antibody (mAb) and the NHS groups of NHS-MBs were linked by covalent bonds to prepare IMB, without any activation reagent. The essential factors affecting the binding and elution of DON were meticulously tuned. Under optimal conditions, DON could be extracted from a real sample and eluted from IMB by water, enabling environmentally friendly and green analysis. Hence, there was no need for dilution or evaporation prior to UPLC-UV analysis. DON in 20 samples could be purified and concentrated within 30 min by the mycotoxin automated purification instrument (MAPI), allowing for automated, green, high-throughput and simple clean-up. Recoveries at four distinct spiking levels in corn and wheat ranged from 92.0% to 109.5% with good relative standard deviations (RSD, 2.1–7.0%). Comparing the test results of IAC and IMB in commercial samples demonstrated the reliability and superiority of IMB for quantitatively analyzing massive samples.Keywords:deoxynivalenol;immunoaffinity magnetic beads;automatic;UPLC-UVKey Contribution:An immunoaffinity magnetic beads-based automatic pretreatment method was developed for the quantitative analysis of deoxynivalenol by UPLC-UV, with water used as the solvent for extraction and elution.
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Journal of Materials Chemistry B
·
2025
·
IF 5.7
Yaqi Zhang,Minfeng Wu,Yile Wang,Xiang Chen,Meiqi Wang,Feng Chen,Wentao Cao,Shengcai Qi
Maxillofacial electromyographic (EMG) signals serve as crucial indirect indicators of occlusal function, playing a significant role in clinical oral diagnosis. However, conventional gel electrodes with occlusive nature induce skin irritation and wearer discomfort, which limits long-term monitoring. Here, we developed an ultrathin, gas-permeable, and flexible electronic skin (e-skin) designed for imperceptible, long-term maxillofacial EMG monitoring. This e-skin comprises a stretchable substrate formed by core–shell elastic fibers fabricated via coaxial electrospinning, coated with PEDOT:PSS@MXene nanocomposite layers. The cross-linking effect between PEDOT:PSS and MXene (specifically, the hydrogen bonding between MXene and PSS chains and the electrostatic interaction between MXene and PEDOT chains) reduces the interlayer spacing, concurrently delaying MXene oxidation by repelling water and air and enhancing electron transfer between MXene layers. In sEMG measurement trials, the e-skin successfully acquired clear, stable myoelectric signals corresponding to various chewing intensities and patterns (e.g., gum chewing and intermittent occlusion). In particular, ultrathin dimensionality substantially diminishes foreign body perceptibility and associated wearer discomfort, thereby elevating sustained comfort thresholds and long-term therapeutic viability. This work presents a novel material-device strategy for next-generation wearable bioelectric sensing platforms, enabling comfortable, precise monitoring with applications in facial muscle assessment, rehabilitation medicine, and neuromuscular diagnostics.
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高影响因子
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
·
2025
·
IF 6
Afang Gao,Hui Sun,Bin Yu,Huiping Wu,Gaoyuan Chen,Sijia Yao,Xinyu Liu,Shijie Wang,Yutong Feng
Organic dyes in wastewater pose severe ecological and health risks due to their toxicity and persistence. Covalent organic polymers (COPs) is an efficient adsorbent. However, it is difficulty for COPs to recycle and reuse due to their typical powder form. To solve this problem, we synthesized the COPs@VSN (Viscose spunlaced nonwoven material) via an in-situ solvothermal method. The results revealed fine grooves on VSN surface, with 0.5–1 nm spherical structure COP particles were anchored on COPs@VSN. When the dose of COPs 6 @VSN was 100 mg, the initial dye concentration was 50 mg/L, the adsorption temperature was 30 °C, the pH of the dye solution was 7, COPs 6 @VSN demonstrated exceptional selectivity for cationic dyes, the adsorption efficiency and capacity for MB can reach 99.7 % and 48.9 mg/g within 30 min, respectively. The adsorption of COPs 6 @VSN for MB is monolayer chemisorption, demonstrating spontaneous and endothermic characteristics. The adsorption efficiency and capacity of COPs 6 @VSN for MB maintained 69.8 % and 34.6 mg/g after five regeneration cycles, and had strong anti-interference capability against common ions. In view of its excellent cationic dye adsorption performance, fast adsorption equilibrium, and good reusability, COPs 6 @VSN exhibits significant potential for practical wastewater remediation applications.
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