SEPARATION AND PURIFICATION TECHNOLOGY
·
2022
·
IF 9.136
Lelin Zeng,Qin Yi,Xiaohui Peng,Zhi Huang,Bart Van der Bruggen,Yusheng Zhang,Yan Kuang,Yingnan Ma,Kewen Tang
Polymer inclusion membranes (PIMs) have much application potential for metal ion separation. However, its separation selectivity highly depends on the extractant, and new efficient extractants are difficult to develop. This work proposes another approach, i.e., adding a complexing retardant to enhance the selectivity. The impurity ion (e.g., Cu 2+ ) was retarded in the feed solution by the complexing retardant (e.g., citric acid), while the target ion (e.g., Zn 2+ ) was transported across PIM. To reveal the enhancement mechanism, a mass transfer mathematical model was established. Contrast experiments proved that the complexing retardant can significantly enhance the overall separation coefficient β overall,exp . The β overall,exp of a conventional PIM system was 61.80, while β overall,exp increased to 853.45 after the retardant was added. The effects of retardant concentration, initial pH of feed solution, membrane thickness, extractant dosage, and plasticizer dosage on the retardant-enhanced PIM system were investigated. Model calculation results agreed well with the experimental data. The maximal β overall,exp 17525.68 was obtained at the optimal separation conditions of [CA] f,0 = 0.02 M, pH f ,0 = 4.5, [H 2 SO 4 ] s ,0 = 0.5 M, and the optimal composition of the PIM casting solution, i.e., PVC : P507: DBP: THF = 0.125 g: 0.188 mL: 0.032 mL: 10 mL. Further studies indicated that the retardant mechanism was reflected in the difference increase of interfacial partition coefficients P Zn 2 + , f and P Cu 2 + , f . Finally, the optimization strategies of the separation effects for the retardant-enhanced PIM system are discussed in depth based on the simulated calculation.
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高影响因子
RSC Advances
·
2015
·Vol. 5
·期 91
·74629-74637
·
IF 3.84
Yunling Gao,Jieming Shu,Cong Zhang,Xiang Zhang,Haiyan Chen,Kejian Yao
A new coumarin–quinoline based sensor 1 has been synthesized. The paramagnetic Cu2+ ion turned off the fluorescence of sensor 1 with a 1 : 1 binding stoichiometry. The resultant 1–Cu2+ complex could act in situ as an efficient “off–on” fluorescence sensor for the paramagnetic Cr3+ ion triggered by the 1 : 1 replacement of Cu2+ with Cr3+. This selective fluorescence “on–off–on” sensor was used to identify Cu2+ and Cr3+ in living breast cancer MCF-7 cells using confocal fluorescence microscopy, indicating that sensor 1 has a potential application for the selective detection of Cu2+ and Cr3+ in living cells.
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高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Jun Tang,Tao Li,Xinghui He,Yilin Liu,Meiling Zhou,Mengxi Wu,Yao Li,Yue Lan,Xiaoqiu Tan,Ji Tian,Chunhong Li
In the pathological progression of myocardial ischemia-reperfusion injury (MI/RI), M1 macrophages and hyperactivated cardiac fibroblasts (CFs) synergistically drive tissue damage through metabolic reprogramming-mediated inflammatory storms and fibrotic remodeling. However, addressing the challenge of influencing the interactions between macrophages and CFs through energy metabolism intervention remains a significant therapeutic hurdle. Herein, we developed an innovative hydrogel-based drug depot (pH-SC@ZIF-8) by incorporating hyaluronic acid (HA)-modified zeolitic imidazolate framework-8 (ZIF-8) nanoparticles, which are loaded with shikonin/Cu 2+ metal-drug coordination complexes (SC), into a thermosensitive Pluronic F-127 hydrogel. In vitro studies have shown that HA modification enhances the targeting efficiency of nanoparticles toward M1 macrophages and activated CFs, facilitating the accumulation of shikonin and Cu 2+ in target cells. This process inhibits glycolysis and activates cuproptosis, leading to a significant reduction in the secretion of inflammatory cytokines (TNF-α, IL-1β) and inducing CF death. In vivo results indicate that the thermos-responsive gelation of the hydrogel facilitates stable and sustained drug release, effectively reducing the inflammatory response at the injury site while exhibiting anti-fibrotic effects. Our study offers a novel therapeutic strategy for cardiovascular diseases by inhibiting energy metabolism to modulate the interactions between immune and tissue cells.
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产品关联
DOI
PubMed
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2025
·
IF 4.6
Xinyu Lan,Guojun Weng,Jianjun Li,Jian Zhu,Junwu Zhao
Surface metal deposition is an important method for tuning the optical property of plasmonic nanoparticles. In this work, we tried to deposit Cu shell on the surface of gold nanorods (Au NRs) by dihydronicotinamide adenine dinucleotide (NADH)-mediated reaction. Cu 2+ were reduced to Cu 0 through the gold-catalyzed oxidization of NADH. The deposition of Cu shell onto the Au NRs surface resulted in the obvious red-shift of longitudinal localized surface plasmon resonance peak. And the red-shift of longitudinal peak increased with the concentrations of NADH and Cu 2+ . The TEM images showed that a transparent layer structure with a different contrast around Au NRs was clearly displayed. And this transparent layer structure with the low contrast was generally considered to be pure Cu shell. However, the results from energy dispersive spectrometer (EDS) and X-ray photoelectron spectroscopy (XPS) indicated that the transparent layer was not just pure Cu composition, but contained NADH/NAD + and Cu 2+ components. This grown complex dielectric shell resulted in the reduced surface enhanced Raman scattering (SERS) activity of Au NRs. Based on the decreased SERS intensity, we demonstrated a SERS method for Cu 2+ detection using R6G as Raman reporter. The decreased SERS intensity had a linear correlation with the concentration of Cu 2+ in the range of 10 −6 –10 −2 M, with a detection limit of 3.89 × 10 −6 M. This study provides new insights about Cu deposition on Au NRs, which will further promote the spectral sensing applications with gold-catalyzed Cu 2+ reduction on plasmonic nanoparticles by NADH.
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产品关联
DOI
PubMed
高影响因子
APPLIED SURFACE SCIENCE
·
2024
·
IF 6.3
Kecan Zhang,Shan Lei,Yu Miao,Bao Guo
In the flotation beneficiation of copper and molybdenum co-occurrence ores, the efficient depression of chalcopyrite is crucial for successful copper-molybdenum separation. However, the consumption of conventional depressant NaHS is huge. There is greater susceptibility of chalcocite and other secondary copper sulfide minerals to electrochemical reaction in comparison to chalcopyrite. Given the irreversible desorption behavior of collector molecules on chalcocite upon negative potential application, electrochemically regulated flotation can be effectively utilized to diminish the utilization of conventional depressants. In this work, electrochemistry and shell-separated nanoparticle-enhanced Raman spectroscopy (SHINERS) were used to explore the transformation of chalcopyrite surface to chalcocite-like species under the combined action of Cu 2+ and negative potential. The results show that the similarity of cyclic voltammetry (CV) between the modified chalcopyrite and chalcocite, increases with the pretreatment potential becoming increasingly negative. Electrochemical impedance spectroscopy (EIS) also reflects their similar adsorption and desorption behavior in response to ammonium dibutyl dithiophosphate (ADD), a typical flotation collector molecule. In addition, the spectroelectrochemical directly reflects the irreversible desorption of ADD molecules from the modified chalcopyrite surface at − 0.7 V. The research results lay a theoretical foundation for the efficient Cu-Mo separative flotation by depressing chalcopyrite under the combination of Cu 2+ and negative potential.
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高影响因子
CHEMOSPHERE
·
2018
·
IF 4.427
Yuanxia Luo,Baoyu Gao,Qinyan Yue,Ruihua Li
Humic acid (HA) influences the aggregation and stability of nanoparticles (NPs), which determine the removal performance of NPs in coagulation. Consequently, in this study, the impact of HA concentration on the simultaneous removal of CuO NPs, Cu 2+ , and natural organic matter (NOM) was investigated. Enteromorpha polysaccharides (Ep), as the novel recycling coagulant aid, were integrated with polyaluminum chloride (PAC) to treat composite contaminants in this coagulation process. Removal performance, floc properties, zeta potential , scanning electron microscope (SEM) images, and Fourier Transform Infrared Spectra (FT-IR) were measured and analyzed. Results showed that PAC with Ep (PAC-Ep) was more beneficial for improving removal performances than PAC alone. Further, the coagulation performance became better with the increase in HA concentration. When the HA concentration was 10 mg/L (used PAC-Ep), the removal efficiencies of CuO NPs and Cu 2+ were both more than 80%; and in particular, the highest removal efficiency of turbidity was 98%. However, excessive HA (more than 10 mg/L) reduced the removal efficiency of Cu by more than 31%. Smaller and denser flocs with better recoverability were formed as the HA concentration increased. Furthermore, because of affluent functional groups, HA was easily adsorbed on the surface of NPs and combined with dissociative Cu 2+ , thereby forming a composite contaminant. During the coagulation process, the colloidal system was destabilized preferentially by the charge neutralization between composite contaminants and PAC. Furthermore, a chelated reticular structure was formed by the conjunction of carboxyl and hydroxyl groups (from Ep) and Al (III) species (from PAC). Flocs were further enlarged and precipitated by bridging and sweeping of this structure.
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高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2015
·
IF 4.097
Dongfang Wang,Yingchang Ke,Di Guo,Hongxu Guo,Jianhua Chen,Wen Weng
A metal-organic frameworks (MOFs), cauliflower-like MIL-100(Cr), has been facilely prepared through simple reflux method for the first time and characterized by XRD, FT-IR, SEM and XPS. The MOFs was found to be useful for the simultaneous and selective electrochemical detection of microgram Cd(II), Pb(II), Cu(II), and Hg(II) in aqueous solution. The detection was performed by the square wave anodic stripping voltammetry (SWASV). The MIL-100(Cr) modified electrode showed an excellent selectivity and stability for Cd 2+ , Pb 2+ , Cu 2+ , Hg 2+ determinations. The electrochemical properties and applications of the modified electrode were studied. Operational parameters such as pH, deposition potential and deposition time were optimized for the purpose of determination of traces of metal ions .
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高影响因子
Chemical Engineering Journal Advances
·
2020
·
IF 0
Yunqian Ma,Hao Zhang,Duxia Cao,Qifeng Chen,Ruifang Guan,Chuanjian Zhou
Recently, the non-aromatic fluorescent materials without benzene rings in their structures have aroused widespread interest. In this work, a citric acid functionalized polyethyleneimine oligomer, CA-PEI, was synthesized through acyl chloride method. In CA-PEI, the polyethyleneimine was bonded to citric acid molecule with a molar ratio of 1:1 through an amide bond, which was confirmed by NMR, FTIR, GPC and XPS. The results indicated that CA-PEI had dual excitation and dual emission properties, and the two emission centers were derived from n–σ* and n–π* transition, respectively. CA-PEI was used to synthesize the light-emitting polymer dots N-PDs through a hydrothermal reaction. Interestingly, compared with CA-PEI, N-PDs had dual excitation and single emission properties, and its Stoke's shift was as high as 193 nm. This can be attributed to the compact structure of N-PDs, which promoted the fluorescence resonance energy transfer (FRET) process. Importantly, N-PDs can serve as excellent probes in response to Cu 2+ , with a detection limit as low as 2.5 nmol L −1 . The response mechanism involves the formation of a copper amine complex between Cu 2+ and the PEI part of N-PDs, which then quenches the fluorescence emission of N-PDs through the fluorescence inner-filter effect. N-PDs as well were applied as an encryptable fluorescent ink.
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DOI
Sensors & Diagnostics
·
2023
·Vol. 2
·期 4
·902-908
·
IF 0
Xiaotao Liu,Xueyi Zheng,Chunqiu Xia,Liangqia Guo
Nanozymes have attracted great interest in the field of biotechnology, (bio)sensing, and environmental monitoring. Herein, a co-doping strategy is proposed to enhance the peroxidase-like activity of graphitic carbon nitride (g-C3N4). Cu2+ and triazole group co-doped graphitic carbon nitride (g-C3N5-Cu2+) was derived from thermal polymerization of 3-amino-1,2,4-triazole and then coordination with Cu2+. g-C3N5-Cu2+ nanosheets (NSs) could catalyze the oxidation reaction of 3,3′,5,5′-tetramethylbenzidine (TMB) by H2O2 under neutral conditions, yielding 10.9-fold better catalytic activity than g-C3N4 NSs. Reactive oxygen species scavenging experiments indicated that ˙OH played a crucial role during the catalytic process. When glutathione (GSH) was introduced, the absorbance of the system decreased because of the reduction of the oxidation product of TMB by GSH. The colorimetric method demonstrated a sensitive response for GSH with a linear range of 0.8–33.3 μmol L−1 and a limit of detection of 0.3 μmol L−1. The sensitivity is higher than most other peroxidase mimetic-based colorimetric methods for GSH. Finally, the feasibility for the detection of GSH in HeLa cells was demonstrated.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Zhenzhou Yin,Gang Wang,Lu Wang,Pengyu Ren,Jian Sun,Hanghang Zhao,Puhui Ji
The sustainable development of society requires the support of developed industrial production, which inevitably produces a series of industrial by-products, including heavy metal-containing wastewater and solid waste. Using solid waste to adsorb heavy metal ions in wastewater is a sustainable way. This not only reduces the environmental threat caused by solid waste accumulation, but also reduces the treatment cost of heavy metal ions in wastewater. In this study, fly ash was modified to prepare magnetic adsorbent (M-AT), which was used to adsorb Cu 2+ and Pb 2+ in wastewater. The results showed that M-AT has a good adsorption effect on Cu 2+ and Pb 2+ in wastewater. Its maximum adsorption capacity for Cu 2+ and Pb 2+ was 53.18 and 85.86 mg/g, respectively. Ion exchange and complexation reaction were major adsorption mechanisms of M-AT for Cu 2+ and Pb 2+ , they played an important role in the adsorption process. M-AT maintained a good adsorption effect on Cu 2+ and Pb 2+ under different influence factors. This ensured that M-AT can be used in complex application environments. In addition, M-AT exhibited good reusability, its removal rate for Cu 2+ and Pb 2+ reached 50.21 % and 75.15 % after 5 adsorption–desorption cycles. And the removal rate of M-AT for Cu 2+ and Pb 2+ in domestic sewage treatment plant influent, tailings drainage, industrial wastewater was 82.80 %, 87.12 %, 85.12 % and 95.10 %, 91.20 %, 93.13 %, respectively. These results proved the feasibility of M-AT in treating Cu 2+ and Pb 2+ in wastewater. This study provides a new way for the resource utilization of fly ash. Applying solid waste to treat heavy metal-containing wastewater is a sustainable way to treat industrial waste.
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高影响因子
International Journal of Electrochemical Science
·
2023
·
IF 1.5
Xia Wang,Xuan Zhang,Cai Gao,Xiaolei Liao,Le Hang,Shulian Jiang,Feng Gao,Lizhang Huang,Qingxiang Wang
A novel electrochemical DNA biosensor based on in-situ labeling of L -Aspartic acid-copper ion (Asp-Cu 2+ ) complex on the terminal of molecule beacons (MBs) was constructed. The MB with bifunctional groups of 3’–SH and 5’–COOH was first anchored on a gold electrode surface through Au-S assembly chemistry, then L -Aspartic acid (Asp) was grafted with the 5’–COOH of MB via succinimide coupling, which was used as a platform molecule for the following coordination assembly of copper ions (Cu 2+ ). Therefore an electroactive MBs probe with the copper complex (Asp-Cu 2+ ) as a signal source was obtained. The hybridization between the loop sequence and the target DNA transferred the hairpin-like MBs to the linear form, and the electroactive moiety of Asp-Cu 2+ was forced to leave away from the electrode surface, resulting in the reduction of the electrochemical response of the biosensor. The hybridization experiment results showed that the oxidation peak currents of developed biosensor attenuated linearly with the logarithmic values of the target DNA concentrations in the kinetic range from 1.0×10 -15 ~1.0×10 -10 M. The detection limit was estimated to be 0.17 fM. Moreover, the biosensor showed excellent selectivity for discriminating the complementary sequences from the mismatched and noncomplementary sequences.
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高影响因子
2D Materials
·
2022
·Vol. 9
·期 2
·025028
·
IF 6.861
Meng Yuan,Haodong Shi,Cong Dong,Shuanghao Zheng,Kai Wang,Shaoxu Wang,Zhong-Shuai Wu
Some vital challenges are main obstacles for further development of lithium–sulfur (Li–S) batteries such as low capacity and poor cycle stability resulted from polysulfide shuttling behavior, the physical/chemical entrapment is regarded as an effective method to inhibit and catalyze polysulfides. Herein we design a cross-linked framework of reduced graphene oxide anchored with Cu2−xSe nanoparticles (Cu2−xSe@rGO) by building an electrolyte/Cu2−xSe/graphene triple-phase interface to be a high-efficiency electrocatalyst for Li–S batteries. Importantly, this three-dimensional conductive network possesses a large specific surface area with high ion transport capability, meanwhile providing strong physical constraint for efficient adsorption of soluble polysulfides. Further, this triple-phase catalytic interface provides strong chemical adsorption and abundant Cu2−xSe nanoparticle sulfiphilic active sites, effectively inhibiting the dissolution of polysulfides and guaranteeing the efficient polysulfide adsorption catalysis as well as rapidly uniform Li2S nucleation. Consequently, with the Cu2−xSe@rGO separator, a lower capacity decay rate about 0.059% per cycle after 500 cycles at 2 C is obtained. What's more, with a higher areal sulfur loading of 3.0 mg cm−2, the capacity is still maintained at 805 mAh g−1 over 100 cycles. Therefore, this work will open new avenue to construct 2D transition metal selenide for superior performance Li–S batteries.
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高影响因子
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