BIORESOURCE TECHNOLOGY
·
2026
·
IF 8.2
Junyu Wang,Qianqian Chen,Yuan Wang,Long Su,Zuotao Tan,Dong Liu,Shaohong You,Hongli Wu,Fei Cao
Multi-enzyme cascade valorizes starch-rich TCHRs into 5KGA; • NADP + regeneration built via Ga5DH-SBFA-CAT coupling; • Reverse activity suppressed, enabling efficient GA-to-5KGA conversion; • Fed-batch production of 5KGA reached 203 g/L with TTN of 9.5 × 10 4 . Herbal residues (HRs) are emerging as an important and sustainable biomass resource, driven by the diversification of global health concepts and the rapid growth in related consumption. Herein, we established a valorization route from starch-rich traditional Chinese herb residues (TCHRs) to high-value 5‑keto‑D‑gluconic acid (5KGA) via a multi-enzymatic cascade. Starch-rich TCHRs were first converted to gluconic acid (GA) through enzymatic hydrolysis and oxidation (>80% conversion). Subsequently, an oxidized cofactor regeneration system was established to efficiently convert GA into 5KGA by coupling gluconate-5-dehydrogenase (Ga5DH) with a synthetic bridged-flavin analogue (SBFA), thereby mitigating constraints arising from Ga5DH’s high reductive activity. This system catalyzed the irreversible dehydrogenation of GA to 5KGA, achieving complete conversion of 100 mM GA within 4 h (total turnover number, TTN = 1.0 × 10 4 ). Furthermore, upon scaling up in a 1-L bioreactor with continuous operation for 48 h, 203.3 g/L (950 mM) of 5KGA was produced with a TTN of 9.5 × 10 4 . This value-upgrading strategy provides an efficient and economically viable biotransformation pathway for starch-based non-edible biomass feedstocks. Download: Download high-res image (112KB) Download: Download full-size image
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DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2026
·
IF 9.1
Ruohan Liang,Dongsheng Zhao,Fangming Jin,Jun Xu,Gengmin Jiang,Shiwei Yang,Jing Lu,Nanfu Qiao,Guicai Liu
Conventional polyamide (PA) nanofiltration (NF) membranes suffer from insufficient mono−/divalent anion selectivity and poor chlorine resistance, limiting their water treatment applications. Herein, a polyester–amide (PEA) NF membrane was fabricated via interfacial polymerization using piperazine and hydroxyl-rich D-mannitol as aqueous comonomers. Compared with the traditional PA membrane, the optimal PEA membrane exhibited higher surface roughness, greater thickness, looser structure, stronger hydrophilicity, and higher electronegativity. Specifically, the optimal PEA membrane delivered a water permeability of 21.9 L⋅m −2 ⋅h −1 ⋅bar −1 and an outstanding NaCl/Na 2 SO 4 selectivity of 68.4. This optimal PEA membrane maintained stable performance under chlorination across a wide pH range and showed excellent alkali stability after 20 h in NaOH solution at pH = 12.0. Furthermore, the optimal PEA membrane exhibited better antifouling properties with smaller decline in flux and greater flux recovery. Additionally, stable flux and rejection were observed for the optimal PEA membrane over 28 days of continuous cross-flow filtration. This work offers a facile strategy to develop high-performance PEA NF membranes with increased anion selectivity and chlorine resistance.
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DOI
高影响因子
POLYMER
·
2026
·
IF 5.1
Chenying Zha,Xiaoyi Liu,Cheng Zhang,Zeshuang Qiao,Hongwei Bai
Stereocomplex-type polylactide (SC-PLA) composed of alternatingly packed enantiomeric chains has recently been regarded as a promising engineering bioplastic with favorable physical properties. However, it is challenging to realize its commercial applications since homocrystallization is fiercely competed with the SC crystallization in the melt-processing of enantiomeric poly( l -lactide) (PLLA) and poly( d -lactide) (PDLA) blends holding relatively high molecular weights (>100 kg/mol). Herein, a facile yet efficient strategy is proposed to facilitate the SC crystallization by using zinc acetate (Zn(OAc) 2 ) to strengthen intermolecular interactions. It is impressive to find that the addition of only 0.01 wt% Zn(OAc) 2 induces the selective formation of SC crystals (SCs) without any homocrystals (HCs), under various melt-crystallization conditions, exhibiting an extremely high efficiency in enhancing SC crystallizability. Moreover, the crystallization kinetic is significantly enhanced. Such enhancement could be ascribed to the metal-oxygen coordination between Zn 2+ ions from Zn(OAc) 2 and carbonyl group of PLAs, which favors the interactive collaboration between enantiomeric chains and thus lowers the barrier to the formation of SCs. This work provides valuable guidance for developing advanced SC-PLA materials with desirable crystallizability.
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DOI
高影响因子
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
·
2026
·
IF 3
Xiaolong Ma,Shujun Chen,Anqin Li,Wuying Chen,Mingze Hou,Kun Long,Gang Hu,Biao Qin
To address the insufficient activity, low noble metal utilization efficiency, and poor stability of transition metal-based catalysts in alkaline media, a PtFeCoNiMnMo high-entropy alloy (HEA) nanocatalyst with synergistic multi-d orbital hybridization was synthesized via a one-pot solvothermal method using glucose as a dispersant and an auxiliary reducing agent. Comprehensive characterization (XRD, TEM, XPS, and ICP-OES) confirmed its single face-centered cubic structure with lattice distortion (δ = 3.29%), homogeneous elemental distribution, and directional electron transfer-induced strong electronic interactions. Electrochemical tests in 1 M KOH showed exceptional alkaline hydrogen evolution reaction (HER) performance: 21 mV overpotential at 10 mA cm−2, 47.06 mV dec−1 Tafel slope, 2.455 s−1 TOF, and minimal charge-transfer resistance (5.39 Ω), outperforming control samples and commercial Pt/C. The catalyst exhibited outstanding stability with only 2.1% current decay after 50 h. Mechanistic studies indicated that the multi-d orbital electronic interactions in the alloy can regulate the adsorption capacities of H and OH species, thereby enhancing its alkaline HER catalytic activity.
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产品关联
DOI
高影响因子
PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
·
2016
·Vol. 33
·期 7
·388-395
·
IF 4.367
Wenbin Wang,Liqiang Liu,Liguang Xu,Hua Kuang,Jianping Zhu,Chuanlai Xu
Staphylococcal enterotoxins (SEs) in food samples can cause severe gastroenteritis even at low doses. Detection of SEs with a single assay would not only improve reliability and portability, but would also save time. In this paper, for the first time, a multiplexed gold-nanoparticle-based immunochromatographic (ICT) strip that allows the simultaneous detection of the five main SEs has been reported: SEA, SEB, SEC, SED, and SEE. Based on the sandwich immunoassay of each SE, a multiplexed ICT strip with five test lines is developed. Sensitive and specific paired monoclonal antibodies facilitate the detection, allowing for high sensitivity and good specificity. The portable biosensor platform can simultaneously detect SEA, SEB, SEC, SED, and SEE at concentrations as low as 2.5, 2.5, 2.5, 1, and 5 ng mL −1 , respectively. The entire test can be performed within 15 min and requires no sophisticated instruments except a portable strip reader. To evaluate the multiplexed strip, naturally SEA and SEC contaminated milk samples and pure milk samples spiked with the five SEs are analyzed.
研究领域:
食品安全检测
·
免疫学
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DOI
高影响因子
Energy Technology
·
2022
·Vol. 10
·期 7
·2200262
·
IF 4.149
Tian Zhang,Xichuan Yang,Li Zhang,Zijian Deng,Kaiyuan Yang,Haiyang Cui,Qingning Hou,Wenxi Ji
The lattice defects in perovskite solar cells comprising polycrystalline films affect the cell's humidity stability and photovoltaic performance. Herein, a donor–pi–acceptor organic dye molecule ( ZT001 ) containing a carboxyl group on the acceptor moiety and long alkyl chains on the donor moiety is synthesized and used as an effective passivator in perovskite solar cells. It is revealed in the results that the carboxyl group of ZT001 successfully passivates the film defects by forming coordination with uncoordinated Pb 2+ , and the humidity stability of the device is improved and maintained above 80% of the original photoelectric conversion efficiency (PCE). Therefore, ZT001 -passivated perovskite devices exhibit a superior PCE of 20.6% compared with the PCE of unpassivated devices (19.5%).
研究领域:
材料科学
·
能源科学
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DOI
高影响因子
BIOMACROMOLECULES
·
2021
·
IF 6.988
Yu Zhang,Bo Xia,Yanyan Li,Xianfu Lin,Qi Wu
The synthesis of optically pure polymers is one of the most challenging tasks in polymer chemistry. Herein, Novozym 435 (Lipase B from Candida antarctica, immobilized on Lewatit VP OC 1600)-catalyzed polycondensation between d-/l-aspartic acid (Asp) diester and diols for the preparation of helical chiral polyesters was reported. Compared with d-Asp diesters, the fast-reacting l-Asp diesters easily reacted with diols to provide a series of chiral polyesters containing N-substitutional l-Asp repeating units. Besides amino acid configuration, N-substituent side chains and the chain length of diols were also investigated and optimized. It was found that bulky acyl N-substitutional groups like N-Boc and N-Cbz were more favorable for this polymerization than small ones probably due to competitively binding of these small acyl groups into the active site of Novozym 435. The highest molecular weight can reach up to 39.5 × 103 g/mol (Mw,Đ = 1.64). Moreover, the slow-reacting d-Asp diesters were also successfully polymerized by modifying the substrate structure to create a “nonchiral” condensation environment artificially. These enantiocomplementary chiral polyesters are thermally stable and have specific helical structures, which was confirmed by circular dichroism (CD) spectra, scanning electron microscope (SEM), and molecular calculation.
研究领域:
高分子化学
·
生物催化
·
材料科学
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DOI
高影响因子
FUEL
·
2026
·
IF 7.8
Miao Ma,Min Yang,Cai-Yue Zhang,Hai-Yi Sun,Rong-Jing Su,Xiao-Rui Yue,Chen-Xi Li,Yong-Ming Chai,Bin Dong
Developing low-cost, high-performance Ru-based hydrogen evolution reaction (HER) catalysts is crucial for advancing anion exchange membrane water electrolysis (AEMWE) technology. In this study, based on the Sabatier principle, a Ru/CoMoO 4 heterojunction catalyst with a ternary “nanorod-macroparticle-microparticle” structure is designed. Benefiting from the strong electronic interactions, a lower d-band center of Ru/CoMoO 4 is observed, resulting in optimal adsorption between Ru species and the key H* intermediates to greatly enhance the hydrogen desorption kinetics. Importantly, this interface engineering effect prevents the Volmer-Tafel step from becoming rate-limiting step, thereby promoting electron and mass transport. As a consequence, Ru/CoMoO 4 outperforms most of the reported HER catalysts at an ultra-low Ru loading of only 0.2 wt%. In alkaline media, it only requires an overpotential of 55 mV to achieve 100 mA cm −2 , with a low Tafel slope of 16 mV dec -1 , and operates stably for over 230 h at an industrial-grade current density of 1000 mA cm -2 . The AEMWE electrolyzer based on the Ru/CoMoO 4 catalyst achieves efficient and stable hydrogen production at 1000 mA cm⁻ 2 @ 1.93 V. This work not only provides a high-performance catalyst, but also elucidates a strategy for precisely controlling d-band center through heterojunction interface engineering to optimize reaction [email protected]
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DOI
高影响因子
Journal of Nanotechnology
·
2026
·Vol. 2026
·期 1
·7582895
·
IF 3.1
Xiaoxia Tang,Jinbao Chen,Shu Zhang,Jiaqi Huang,Hui Liu,Xiao Wang,Liulin Li,Yangcheng Li,Manli Xie
Background Colorectal cancer (CRC) often metastasizes to the liver, which complicates treatment strategies. This study evaluates MSN–TK@SA, a mesoporous silica nanoparticle (MSN) loaded with saikosaponin D (SA) and reactive oxygen species (ROS)–cleaving thioketal (TK), as a targeted approach for CRC metastasis. Methods MSN–TK@SA nanoparticles were formulated by loading SA onto MSN to create MSN@SA, followed by coating with ROS-responsive methoxy polyethylene glycol-thioketal-N-hydroxysuccinimide (mPEG-TK-NHS) to produce MSN–TK@SA. The nanoparticles were characterized using different analytical techniques, and drug release profiles were evaluated. CRC cells and a liver metastasis model of CRC with liver qi stagnation were treated with the nanoparticles, and various techniques were used to assess the effects of MSN–TK@SA on tumorigenicity, immune response, and liver metastasis. Results The MSN, MSN@SA, and MSN–TK@SA nanoparticles were spherical, monodispersed, and colloidally stable, with a progressive decrease in zeta potential, which demonstrated successful loading with SA and thioketal coating. Fourier-transform infrared spectroscopy (FTIR) confirmed the silanol, amine, and PEG-TK functionalization. MSN–TK@SA had high encapsulation (81%) and loading efficiency (29%), which was consistent with pore entrapment stabilized by hydrogen bonding and dipole interactions. Drug release was based on a sustained/controlled profile, and approximately 80% of the drug was released within 72 h without a burst effect. First-order and Weibull models best described the concentration-dependent, diffusion-controlled release with anomalous transport of the nanoparticles. In vitro, MSN–TK@SA exhibited significant anticancer activity, including decreased viability, invasion, and migration, and amplified apoptosis of CRC cells. MSN–TK@SA markedly reduced tumor burden and metastasis, enhanced antitumor immunity, and inhibited inflammation in a CRC liver metastasis model. Conclusion MSN–TK@SA nanoparticles enable effective drug loading, controlled release, and immune activation, significantly inhibiting CRC liver metastasis. They are a promising platform for drug delivery and immunotherapy, deserving further preclinical and translational research.
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DOI
高影响因子
Journal of Molecular and Engineering Materials
·
2021
·
IF 0
Lili Feng,Pengyu Wang,Hansen Yang,Zhuo Chen,Shuhui Bo
A charge transfer dye with the D– π –A structure was synthesized by Pd catalyzed Hartwig–Buchwald coupling and Knoevenagel condensation reaction, using N, N-dihexylbenzo[b]thiophen-6-amine as donor and 2-(3-cyano-4, 5, 5-trimethylfuran-2 (5H)-ylidene)malononitrile (TCF) as acceptor. The solvatochromic and pH switch properties of the as-synthesized dye were investigated through UV-vis absorption and fluorescence emission spectra. A positive solvatochromism of the dye in different polar solvents was observed along with a visible color change of the solution. By adding acid/base into the DMSO solution of the dye, the color as well as the absorption and emission spectra of the solution exhibited outstanding characteristics of pH switch.
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DOI
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
·
2017
·
IF 0.809
Jin Luo,Anlin Zhao,Caihua Zheng,Tao Wang
GRAPHICAL Display full size
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高影响因子
JOURNAL OF CHROMATOGRAPHY A
·
2011
·Vol. 1218
·期 48
·8664-8671
·
IF 4.194
L.Y. Kong,B.G. Su,Z.B. Bao,H.B. Xing,Y.W. Yang,Q.L. Ren
A simple and direct reversed-phase high performance liquid chromatography (RP-HPLC) method with UV detection was developed and validated for the determination of mono- and di- d -α-tocopherol polyethylene glycol 1000 succinate (TPGS 1000) in TPGS mixture. Before the HPLC analysis, mono- and di-TPGS 1000 were separated by simulated moving bed (SMB) chromatography system and characterized by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). The mass spectrometric results confirmed that the molar mass distribution of TPGS prepared in our laboratory was very close to that of the product of Eastman Chemical Company with similar n ¯ (average polymerization degree), M n ¯ (number-average molecular weight) and M w ¯ (weight-average molecular weight). The HPLC analysis was carried out on a C30 analytical column with mobile phases comprised of acetonitrile (A) and isopropanol (B) in gradient conditions. Validation of the analytical method was done on the following parameters: system suitability, linearity, limits of detection and quantification, accuracy and precision, method robustness and solution stability. The linearity of the calibration curves for mono- and di-TPGS 1000 from both sources was found to be good ( r 2 > 0.9996). The recovery values were from 94.6% to 103.3% for mono-TPGS, and 93.5% to 103.3% for di-TPGS. This method could be successfully used in the direct quantification of mono- and di-TPGS in TPGS 1000 mixture using TPGS standards with similar molecular mass distributions although derived from different sources.
研究领域:
分析化学
·
药学
·
色谱学
·
质谱分析
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DOI
高影响因子
危险品化学品经营许可证（带存储）