INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2026
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IF 8.7
Guo Chen,Yuhao Wang,Wenli Zhang,Zhaoqing Li,Zifan Lu,Hanjie Ji,Zelong Sun,Xinlong Dun,Lei Zhang,Di Wei
Bio-based macromolecules enable uniform MXene/LM dispersion in hydrogels. • Double-network hydrogel with high conductivity (3.65 S/m) and toughness. • Near 100% bactericidal efficiency via MXene sharp edges and Ga ions released from LM disrupting bacterial membranes. • Reliable wearable sensor for subtle and large-scale human motion monitoring. • Morse-code communication for patients with speech/mobility impairments. Despite notable advances in conductive hydrogel-based flexible sensors, achieving a synergistic combination of high mechanical robustness, reliable electrical conductivity, antibacterial activity, and biocompatibility remains a formidable challenge for long-term wearable health monitoring. Herein, we report a stretchable, antibacterial, and biocompatible ionic hydrogel constructed by integrating MXene@SA (sodium alginate) and LM@LS (sodium lignosulfonate)/HEC (hydroxyethyl cellulose) hybrid fillers into a poly(vinyl alcohol)/acrylic acid double-network matrix with dynamic borate ester bonds and choline chloride as a hydrogen-bond acceptor. These three bio-based macromolecules—sodium alginate for MXene dispersion, and hydroxyethyl cellulose/sodium lignosulfonate for liquid metal stabilization—enable uniform filler distribution and establish a synergistic “point-to-plane” conductive network. The resulting PACML hydrogel exhibits excellent mechanical performance (tensile strength of 180.8 kPa, elongation at break of 1352%, and toughness of 965.21 kJ/m 3 ), high conductivity (3.65 S/m), and excellent cyclic stability (83.84% stress retention after 10 cycles at 500% strain). Antibacterial evaluation against Escherichia coli and Staphylococcus aureus reveals 90.61% and 94.41% bactericidal efficiency, respectively, primarily attributed to the sharp-edged MXene nanosheets and their surface functional groups. In vitro cytocompatibility tests using human dermal fibroblasts show abundant live cells with normal spindle-shaped morphology after 5 days of coculture, confirming excellent biocompatibility. As a wearable sensor, the PACML hydrogel reliably detects a wide range of human motions—from subtle motions to large joint flexions—and enables Morse-code communication for patients with speech or mobility impairments. Critically enabled by sodium alginate, hydroxyethyl cellulose, and sodium lignosulfonate, this hydrogel offers a promising platform for patient health monitoring, rehabilitation, and telemedicine.
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高影响因子
Advanced Membranes
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2026
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IF 12.6
Xinyu Zhang,Pan Cheng,Peiling Tang,Dong Yang,Dengke Li,Yuxi Wang,Pengju Zhao,Qihao Guo,Ming Xia,Ke Liu,Dong Wang
The concentration and purification of bio-nanoparticles, including viral vectors and exosomes, remain challenging because membrane-based bioprocessing must simultaneously provide high permeability, effective particle retention, low nonspecific fouling, and robust stability under process-relevant conditions. Here, we report a scalable sodium alginate (SA)/ethylene-vinyl alcohol copolymer (EVOH) nanofibrous membrane designed for bio-nanoparticles processing. The membrane was fabricated through isopropanol-induced self-assembly followed by covalent-ionic dual crosslinking, producing a highly interconnected dual-nanofiber network with an ultrathin selective layer, tunable pore structure, and enhanced aqueous stability. The resulting membrane exhibited enhanced hydrophilicity, robust mechanical integrity, and favorable separation characteristics for nanoscale bioparticle fractionation. Using 25 nm colloidal gold nanoparticles as a model, the membrane demonstrated an improved balance between water permeability and particle rejection. Its practical separation capability was further validated by tangential flow filtration (TFF) of 50 nm polystyrene nanoparticles and PP7 bacteriophage, enabling efficient concentration with high viral retention, with a log reduction value exceeding 7. Importantly, the fabrication strategy was successfully translated to pilot-scale production, demonstrating its potential for large-area deployment. Overall, this work provides a scalable membrane platform that alleviates the conventional permeability-selectivity compromise and offers a promising route for bio-nanoparticles concentration and purification in biopharmaceutical downstream processing. An isopropanol-induced self-assembly strategy is developed to fabricate scalable ultrathin sodium alginate/EVOH dual-nanofiber membranes with uniform ∼22 nm pores and exceptional permeability, enabling high-flux concentration of bio-nanoparticles while maintaining protein removal rate. Download: Download high-res image (247KB) Download: Download full-size image
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高影响因子
LWT-FOOD SCIENCE AND TECHNOLOGY
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2026
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IF 7.1
Yan Jing,Zedan Liu,Yating He,Baolong Weng,Xiaolan Liu,Jinyu Wang
CAPMs were fabricated using sodium alginate/gum Arabic by ionotropic gelation. • CAPMs achieved 86.18% encapsulation efficiency with favorable powder properties. • CAPMs showed pH-responsive release and zero-order release kinetics. • Encapsulation improved CAP stability and intestinal antioxidant activity. Microencapsulation serves as an effective strategy to enhance the stability, bioaccessibility, and controlled release of food-derived bioactive compounds. In this study, corn antioxidant peptide microcapsules (CAPMs) were fabricated via extrusion-ionotropic gelation using sodium alginate (SA) and gum arabic (GA) as composite wall materials. The physicochemical properties, encapsulation efficiency, structural characteristics, in vitro antioxidant activity, gastrointestinal release behavior, and corresponding release kinetics of CAPMs were systematically investigated. The microcapsules exhibited a high encapsulation efficiency of 86.18%, a mean particle size of 0.70 mm, favorable flowability, low moisture content, and satisfactory aqueous solubility. Optical microscopy and scanning electron microscopy showed that CAPMs retained a relatively continuous and compact structure after freeze-drying, suggesting that peptide incorporation may have contributed to the structural stability of the SA/GA matrix. FTIR, XRD, and UV-Vis confirmed that the peptides were successfully incorporated into the matrix via hydrogen bonding, electrostatic interactions, and physical entrapment, without destroying their primary structure. In vitro digestion revealed that CAPMs exhibited restricted release in the gastric phase but enhanced release in the intestinal phase, with the release profile following zero-order kinetics (R 2 = 0.9559), confirming a sustained-release behavior. Furthermore, CAPMs showed digestion-induced increases in DPPH and ABTS radical scavenging activities and total reducing power. Overall, these findings demonstrate that SA/GA-based microencapsulation effectively improves the digestive stability, controlled release behavior, and functional bioavailability of CAPs, highlighting its promising potential as a delivery system for bioactive peptides in functional food applications.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
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2026
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IF 12.5
Bingyun Xi,Xianming Zhang,Shuhan Chen,Shi Qian,Xuanyong Liu
For guided bone regeneration (GBR) membranes, biodegradable magnesium has emerged as a highly promising candidate owing to its intrinsic biofunctionality associated with Mg 2+ release and its superior mechanical properties. However, achieving spatiotemporally controlled degradation that precisely matches the kinetics of new bone formation remains a critical challenge. To address this issue, a self-reinforcing interfacial diffusion system was engineered on magnesium in this study. Based on this concept, a multilayered magnesium oxide (MgO)/sodium alginate (SA) composite coating was fabricated and stabilized via Ga 3+ -mediated coordination and ionic crosslinking. This coating was strategically designed as a three-dimensional barrier to govern Mg 2+ release through diffusion-limited transport across the solid–hydrogel interface. Notably, during degradation, the released Mg 2+ dynamically coordinate with SA chains on top of the pre-existing trivalent ion-mediated crosslinked network, triggering progressive hydrogel network densification and consequent in situ formation of a self-reinforcing protective layer. Comprehensive in vitro biological evaluations demonstrate that the coating exerts multifunctional bioactivity via synergistic release of Mg 2+ and Ga 3+ . Specifically, it enhances osteogenic differentiation and proliferation of osteoblast, while also promoting human umbilical vein endothelial cell proliferation, migration, and tube formation for pro-angiogenic capacity. Furthermore, the sustained, low-dose release of Ga 3+ endows the system with broad-spectrum antibacterial activity. By integrating corrosion resistance, osteogenesis, pro-angiogenic functionality and antibacterial efficacy into a single dynamic platform, this system transcends conventional passive barrier strategies and enables active, biology-informed regulation of the regenerative microenvironment. Consequently, it establishes a robust and translational foundation for next-generation magnesium-based GBR membranes, with strong potential for clinical application in oral and maxillofacial bone reconstruction.
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高影响因子
Journal of Food Measurement and Characterization
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2026
·
IF 3.6
Zhao Rui,Li Jian,Ma Yunze,Zhang Huajiang,Geng Zhanhui,Li Hanyu,Wang Yuepeng,Xia Ning,Xu Lina
Cooked beef is susceptible to moisture loss and oxidative reactions during long-term frozen storage, resulting in quality degradation and considerable loss of commercial value. This research develops an edible antioxidant coating utilising gelatin hydrolysate (GH) and sodium alginate (SA) to establish a safe and effective preservation technology. The GH-4 sample with high antioxidant activity was prepared via controlled enzymatic hydrolysis, leveraging the efficient hydrolytic activity of alkaline proteases and their specific cleavage of hydrophobic amino acid sites in gelatin macromolecules. Research indicates that GH-4 primarily consists of bioactive peptides with molecular weights below 2000 Da (91.63%). The incorporation of GH significantly enhanced the rheological properties, thermal stability, and barrier performance of the SA-based coating while substantially improving its antioxidant activity. FTIR and XRD analyses confirmed excellent compatibility between the two components. This composite coating significantly reduced thawing loss, color and texture deterioration, and microbial growth in cooked beef during six months of frozen storage, while effectively inhibiting increases in TVB-N and TBARS levels. This study demonstrates that the GH/SA composite coating combines physical barrier properties with bioactive characteristics, establishing it as a highly promising natural preservation method for maintaining the quality and extending the shelf life of frozen cooked meat products. Graphical abstract The alternative text for this image may have been generated using AI.
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高影响因子
FOOD AND BIOPRODUCTS PROCESSING
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2026
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IF 4.7
Jiaying Huo,Wenqian Guan,Xiaolong Liu,Xiaodan Zhang,Hao Wang,Xiongwei Yu,Chaoqun Lu,Sihai Gao,Shugang Li
Walnut kernels are highly susceptible to oxidative rancidity due to their elevated polyunsaturated fatty acid content; however, existing functional packaging predominantly provide single-mode protection, lacking hierarchical barrier systems specifically constructed for the oxidative characteristics of high-fat nuts. To bridge this gap, an eco-friendly bilayer composite film featuring an “outer oxygen-blocking/inner absorbing” architecture was designed. The outer layer was developed from a carboxymethyl cellulose–sodium alginate matrix cross-linked with 0.3% (w/w) citric acid to maximize oxygen impermeability, whereas the inner functional layer integrated 0.4% (w/w) nano-ZnO with 0.015% (w/w) powdered activated carbon (PAC) to endow UV-shielding capacity and to adsorb volatile lipid-oxidation products. At an optimized outer-to-inner mass ratio of 3:7, the bilayer film exhibited a tensile strength of 18.99 MPa, near-complete UV attenuation (>99%), water vapor permeability of 5.33 g m⁻² /(cm 2 48 h Pa), and oxygen transmission rate of 0.65 cm³ /(m²·day·bar). Additionally, the film demonstrated potent radical-scavenging activity against both DPPH (26%-71%) and •OH (83%-100%). Accelerated oxidation tests revealed that, relative to conventional polyethylene (PE) packaging, the composite film reduced acid value, peroxide value, and malondialdehyde content of walnut kernels by 28.18%, 16.53%, and 17.37%, respectively, during late storage, while markedly suppressing the formation of volatile aldehydes and acids. These findings establish a green and effective strategy for prolonging the shelf life of high-fat nuts.
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2026
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IF 8.7
Zhennan Wang,Guoping Zhu,Yu Huang,Yadong Wang,Zongmin Zhu
Bio-based aerogels are attractive for building thermal protection and fire safety, yet sodium alginate (SA) aerogels are mechanically fragile due to loosely connected, hydrogen-bond-dominated networks, while PVA aerogels often suffer from moisture-sensitive structural stability. Here, we develop a high-performance SPMP composite aerogel by coupling an SA/PVA double-network with phytic-acid (PA)-mediated multipoint interactions and MXene-enabled reinforcement. PA densifies the polymer network via extensive hydrogen bonding and further bridges the matrix to MXene through interaction with Ti-containing sites; freeze–thaw-induced PVA crystallites and MXene nanosheets jointly improve load-bearing capability and thermal shielding. The optimized SPMP aerogel achieves a specific modulus of ~64.4 MPa·cm 3 /g chemical coordinationg −1 , a low thermal conductivity of 0.026 W·m −1 ·K −1 , and robust flame retardancy (LOI 33.9%, UL-94 V-0). After hydrophobic surface modification, it exhibits a water contact angle of 132°, enabling durable water repellency and self-cleaning. This study demonstrates that integrating PA-based co-crosslinking, 2D nanosheet reinforcement, and surface hydrophobic regulation can concurrently upgrade mechanical strength, thermal insulation, and fire resistance in double-network bio-aerogels, offering a sustainable route to next-generation building insulation and protective materials. Download: Download high-res image (131KB) Download: Download full-size image
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PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Chenhui Ji,Zhongzhong Lu,Pengfei Chen,Junfang Gao,Bingfeng Shi,Qingyun Cai,Wensheng Liu
TFe@SC hydrogel forms via tannin-Fe 3+ and Ca 2+ crosslinked alginate-chitosan network. • Tannin-Fe 3+ complex grants the hydrogel stable 808 nm photothermal performance. • Amino and catechol groups trap bacteria through electrostatic & hydrogen bonds. • Laser-triggered TFe@SC hydrogel achieves >87% activity against two typical bacteria. • TFe@SC dressing cures infected wounds, eases inflammation with good biocompatibility. Antibiotics overuse frequently leads to bacterial resistance. A number of innovative approaches are being developed for bacteria inhibition. Fabrication of a biocompatible, easily prepared antibacterial dressings is highly desirable for promoting infected wound healing. In this work, a photothermal antibacterial dressing (TFe@SC) was constructed based on a natural polyphenolic molecule tannic acid, sodium alginate (SA) and chitosan (CHI). Tannic acid chelated with iron ion to form a tannin‑iron ion TA-Fe 3+ coordination complex (TFe), which have photothermal properties. Furthermore, TFe was integrated into the sodium alginate (SA)-Ca 2+ -chitosan (CHI) composite hydrogel (SC hydrogel). The amino and carboxyl groups of SC hydrogel and phenolic hydroxyl groups of TFe generate hydrogen bonding interactions, enabling TFe to be firmly incorporated into the interior structure of SC hydrogel. TFe@SC hydrogel possesses some properties of antimicrobial dressings, such as high biosafety, adhesion to bacteria, and inhibition of bacterial proliferation with photothermal therapy (PTT). Meanwhile, the TFe@SC hydrogel was constituted by a variety of natural biomass molecules, including tannins, sodium alginate and chitosan, which endow the hydrogel with biocompatibility. Fe@SC hydrogel is a facile and easily synthesized composite material, which holds great promise for application as a functional hydrogel dressing.
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Junbo Jiang,Miaomiao Zhang,Yutao Zheng,Shixin Xu,Jinxin Zhang,Zhiyi Gao,Jieru Li,Bo Li,Wenting Xu,Li Xie,Wen Zhao
Dual-Crosslinking Strategy: A dual network combining genipin-mediated Schiff base dynamic bonding and Ca 2+ coordination cross-linking for mechanical reinforcement and nanoparticle anchoring. • Nucleic acid drug delivery and gene intervention: IL-11 siRNA-loaded LNPs anchored in hydrogel enable sustained release, silencing IL-11 and fibrotic genes to inhibit myofibroblast activity and remodel collagen for anti-fibrosis. • Scar-free healing promotion: SQG/si IL11 @NPs dressing reduces scar index and thickness, restores collagen I/III ratio, downregulates α-SMA and TGF-β1, enabling near scar-free skin regeneration. Hypertrophic scars often cause functional impairment and aesthetic damage, thereby affecting patients' daily life and comfort. Moreover, existing therapies have limited efficacy and are prone to recurrence. To achieve precise genetic intervention, this study constructed a time-controlled release polysaccharide hydrogel dressing for the targeted delivery of IL-11 siRNA. This dressing is based on a chitosan quaternary ammonium (QCS)/sodium alginate (SA) double-network structure hydrogel (SQG) and loaded with cationic lipid nanoparticles (si IL11 @NPs), forming an “integrated drug-loading and cross-linking” system. SQG hydrogel also shows good antibacterial activity and anti-inflammatory properties, which is helpful to establish a wound microenvironment that inhibits scar hyperplasia. It continuously releases siRNA during the mid-to-late stage of wound healing (days 5–9). Cell experiments showed that the released nanoparticles were efficiently internalized by TGF-β1-induced myofibroblasts, significantly inhibiting their migration and proliferation and downregulating the expression of IL-11 and the typical fibrotic genes COL1A1, FN1, and ACTA2. In the rabbit ear scar model, this dressing promoted wound healing, inhibited late-stage hypertrophy, reduced the scar elevation index and thickness, improved collagen alignment and the type I/III collagen ratio, and downregulated the expression of α-SMA and TGF-β1. In summary, the SQG/si IL11 @NPs hydrogel dressing shows good potential and provides a new option for inhibiting hypertrophic scar formation in wound treatment.
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PubMed
高影响因子
EUROPEAN POLYMER JOURNAL
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2026
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IF 6.8
Zhongwei Sun,Lingrui Xu,Jun Gao,Junyao Li,Guojun Zheng,Laidi Xu,Yong Kong
Multifunctional hydrogel wound dressings are prepared for wound repair. Chitosan (CS)-AgNPs gel beads are first synthesized through electrostatic attractions, which are then co-encapsulated with gallic acid (GA) in the sodium alginate (SA)/gelatin hydrogels prepared by using Ca 2+ as the crosslinker. Due to the antibacterial effects of CS, AgNPs and GA, the resulting SA/gelatin/GA/CS-AgNPs (SGGCA) hydrogels can significantly inhibit the growth of E. coli and S. aureus. On the other hand, the integration of GA can also endow the hydrogels with high antioxidant activity, which show strong scavenging capability for free radicals. In addition, the SGGCA hydrogels also exhibit excellent blood compatibility and cytocompatibility. Finally, the hydrogels are used as wound dressings for in vivo wound repair of mice, and the results demonstrate that the hydrogel wound dressings can effectively promote the healing of wounds.
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高影响因子
CARBOHYDRATE POLYMERS
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2026
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IF 12.5
Xinxin Cai,Hui Liu,Wen Li,Jiwen Hu,Xiaobin Li,Shudong Lin
With the rapid advancement of wearable electronics and smart devices, multifunctional wearable sensors have gained increasing attention. Therefore, a multifunctional silver nanowire/silicon dioxide/aramid nanofiber/sodium alginate (AgNWs/SiO 2 /ANF/SA) porous composite was fabricated via liquid‑nitrogen freeze-drying, combining lightweight structure, electromagnetic interference (EMI) shielding, flame retardancy, and sensing. The porous composite was crosslinked through dual interactions of calcium ions (Ca 2+ ) coordination and hydrogen bonding, forming a layered porous structure. The incorporation of AgNWs remarkably improved the electrical conductivity and EMI shielding capability of the porous composite. In particular, the AgNWs/SiO 2 /ANF/SA composite containing 40% AgNWs (40Ag-A) achieved a low density of 44.01 kg/m 3 together with outstanding EMI shielding effectiveness. Moreover, Ca 2+ crosslinking with ANF and SA, combined with the synergistic reinforcement of SiO 2 , enhanced the flame-retardant and smoke-suppression properties, lowering the heat release rate (PHRR), total heat release (THR), total smoke production (TSP), and carbon monoxide production rate (COP) of 40Ag-A to 41.64 kW/m 2 , 2.98 MJ/m 2 , 0.12 m 2 , and 2.00 × 10 −3 g/s. The wearable strain sensor fabricated using the 40Ag-A demonstrated outstanding sensitivity (S = 7.40, 19.45, and 40.23) and fast response/recovery characteristics (36 ms), allowing real-time detection of human joint movements. Therefore, the porous composite achieved synergistic enhancement in lightweight structure, electromagnetic shielding, flame retardancy, and sensing performance, showing great potential for wearable electronics, safety protection, and Smart Internet of Things applications.
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PubMed
高影响因子
Journal of Environmental Chemical Engineering
·
2026
·Vol. 14
·期 1
·121008
·
IF 7.2
Bihe Chen,Ruoshan Yang,Mengyang Li,Yajing Niu,Jinyao Hu,Yingying Wang,Wenzhi Tang,Jingbo Zhou,Zhonghong Li
The threat of Pb(II) and Cd(II) in water demands advanced adsorbents. While metal-organic frameworks (MOFs) have demonstrated great potential for heavy metal ions adsorption, their microporous nature and powdery form limit practicality. Thus, we engineered a sodium alginate composite aerogel bead loaded with salicylic acid-modified defective NH 2 -MIL-125, for the efficient removal of Pb(II) and Cd(II) from aqueous solutions. By adjusting the solvent volume ratio to regulate the crystal morphology and introducing salicylic acid as a fragmented ligand to compete with NH 2 -BDC to coordinate with Ti-oxo clusters, a defective Ti-MOFs with mesoporous structure (pore size increased from 2.30 to 8.93 nm) and abundant active sites was successfully developed. Further integration with sodium alginate formed millimeter-scale aerogel beads, improving the reusability and enhancing adsorption performance: the maximum adsorption capacities of 428.01 mg g −1 for Pb(II) and 179.67 mg g −1 for Cd(II), respectively. The adsorption process, described by the pseudo-second-order kinetic and Sips isotherm models, is driven by multilayer chemical adsorption via electrostatic attraction, ion exchange and coordination reactions with −COOH, −NH 2 and −OH groups. The beads also exhibit excellent selectivity and reusability, maintaining high efficiency of ∼97 % for Pb(II) over 5 cycles. This work provides a promising strategy for designing high-performance and recyclable adsorbents for adsorbing heavy metal ions from water.
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高影响因子
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