Journal of Materials Chemistry B
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2026
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IF 6.2
Weiyang Wang,Akou May Tehoungue,Zilong Gao,Yi Wang,Manyi Sun,Yixue Lu,Guozheng Zhang,Yeshun Zhang
Hydrogels derived from natural materials with intrinsic bioactivities and pH responsiveness have attracted considerable interest in biomedical applications due to their versatile functionality. In this study, a robust multifunctional sericin–pyrrole hydrogel (S8P2) was synthesized using sericin isolated from fibroin-deficient silkworm cocoons and crosslinked with pyrrole. The resulting hydrogel exhibits fast gelation, a uniform microporous structure (15 µm pore size, 65% porosity), high transparency (∼65% transmittance), pH-responsive swelling and degradation behavior, and excellent mechanical properties, including prominent elastic recovery and a compressive modulus of 15 kPa. Notably, the hydrogel demonstrates broad-spectrum antibacterial efficacy against both S. aureus and P. aeruginosa, along with significantly improved antioxidant activity compared to sericin alone. Furthermore, it demonstrates excellent cytocompatibility with L929 fibroblasts, high cell adhesion, and minimal hemolysis (<5%). These attributes position the S8P2 hydrogel as a highly promising material for applications in wound dressing, tissue engineering scaffolds, and controlled drug delivery systems.
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Food Chemistry-X
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2026
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IF 9.2
Xinran Li,Enhui Ma,Qiang Geng,Jian Jiao,Songyi Lin
Sea cucumber collagen fibers (SCCF) are important nutritional and functional resources in aquatic foods, yet their interactions with flavor compounds remain insufficiently understood. This study innovatively applied pH-shifting extraction to isolate sea cucumber collagen fiber proteins extracted at alkaline (ALP), neutral (NP), and acidic pH (ACP), revealing conformation-dependent mechanisms in flavor binding. Key amino acids (Glu, Gly, Phe) were identified as crucial for structural stability and binding potential. Multi-spectroscopic analyses demonstrated that flavor interaction induced significant conformational changes: a reduction in α-helix and β-sheet content, with an increase in β-turns and random coils. FL and FTIR spectra confirmed that hydrogen bonding and hydrophobic interactions were the dominant forces driving complex formation. The molecular weight distribution and amino acid composition of the proteins varied substantially with extraction pH, directly influencing their distinct flavor-binding capacities. These findings provide a novel strategy for optimizing flavor retention in seafood by tailoring protein extraction conditions.
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PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
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2014
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IF 0.827
Xiyin Gao,Qian Wang,Hongjie Sun,Yongxia Tan,Zhijie Zhang,Zemin Xie
GRAPHICAL Display full size
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ACS Sustainable Chemistry & Engineering
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2019
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IF 6.97
Feiyun Li,Cheng Cai,Hongming Lou,Yuxia Pang,Xinyi Liu,Xueqing Qiu
Enzymatic conversion of lignocelluloses into fermentable sugar is a key step in the production of cellulosic ethanol. In this work, enzymatic hydrolysis lignin (EHL)-grafted phosphobetaine (EHLPB) was prepared, and the phosphobetaine intermediate, 3-chloro-2-hydroxypropyl(2-(trimethylammonio)ethyl)phosphate, was synthesized from phosphocholine chloride calcium salt and epichlorohydrin. EHLPB showed a pH-sensitive response. When pH ≥ 5.0, it was completely dissolved in the buffer solution, whereas 95.5% of EHLPPB was precipitated when pH ≤ 3.0. Adding 1.2 wt % EHLPB-210 can increase the high-solid enzymatic digestibility of Eu-SPORL (sulfite pretreatment to overcome recalcitrance of eucalyptus) and CCR (corncob residue) from 33.6% and 52.6% to 71.5% and 73.6%, respectively. After the enzymatic hydrolysis of Eu-SPORL, 95% of EHLPB-210 was recovered by adjusting the slurry pH from 5 to 3. The recovered EHLPB-210 still kept the ability to enhance enzymatic hydrolysis of lignocelluloses. Adding 1.2 wt % recovered EHLPB-210 can increase the enzymatic digestibility of Eu-SPORL from 33.6% to 75.1%. Investigation of the adsorption of cellulase on lignin by sodium dodecyl sulfate–polyacylamide gel electrophoresis (SDS-PAGE) showed that EHLPB can significantly reduce the nonproductive absorption of cellulase on lignin and therefore enhance the enzymatic hydrolysis of lignocelluloses. By adding recoverable pH-responsive EHLPB, the enzymatic hydrolysis efficiency of lignocelluloses improved and the value-added utilization of enzymatic hydrolysis lignin was realized.
研究领域:
生物能源
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生物材料
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木质纤维素生物炼制
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酶技术
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可持续化学
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2022
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IF 8.025
Yongyan Yang,Gangying Feng,Jingfei Wang,Ruiting Zhang,Shuangling Zhong,Jia Wang,Xuejun Cui
In this study, a supramolecular hydrogel was fabricated with orotic acid (OA) modified chitosan (OACS) and 2,6-diaminopurine (DAP). The obtained OACS-DAP supramolecular hydrogels have dual responsiveness to temperature and pH. Phase transition experiments indicate this is a temperature-dependent thermoreversible supramolecular hydrogel. Rheological experiments proved the formation of the supramolecular hydrogel and its thixotropic properties. FTIR spectra confirmed that hydrogen bonds and π-π interactions are the main driving forces for OACS and DAP to form hydrogels through intermolecular self-assembly. XRD pattern confirmed the amorphous morphology of OACS-DAP hydrogels. The hydrogel has excellent electrical conductivity with a conductivity of 9.48 μ S·cm −1 . And can achieve the precise release of gastrointestinal drugs. OACS-DAP hydrogel is expected to have better applications in the field of gastrointestinal drug release.
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ACS Biomaterials Science & Engineering
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2023
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IF 5.8
Jianmin Xiao,Qiong Sun,Lang Ran,Yinfeng Wang,Xia Qin,Xiaotong Xu,Chuhua Tang,Lu Liu,Guilong Zhang
Recently, starvation-inducing nutrient deprivation has been regarded as a promising strategy for tumor suppression. As a first-line lipid-lowering drug, atorvastatin (ATV) significantly reduces caloric intake, suggesting its potential in starvation therapy for suppressing tumors. Accordingly, we developed a novel starvation therapy agent (HA-Se-ATV) in this study to suppress tumor growth by using hyaluronic acid (HA)-conjugated chitosan polymer-coated nano-selenium (Se) for loading ATV. HA-Se-ATV targets cancer cells, following which it effectively accumulates in the tumor tissue. The HA-Se-ATV nanoplatform was then activated by inducing a weakly acidic tumor microenvironment and subsequently releasing ATV. ATV and Se synergistically downregulate the levels of cellular adenosine triphosphate while inhibiting the expression of thioredoxin reductase 1. Consequently, the starvation–stress reaction of cancer cells is significantly elevated, leading to cancer cell death. Furthermore, the in vivo results indicate that HA-Se-ATV effectively suppresses tumor growth with a low level of toxicity, demonstrating its great potential for clinical translation.
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Materials
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2022
·Vol. 15
·期 24
·8787
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IF 3.748
Xuemei Hou,Huijing Zhao,Ke-Qin Zhang,Kai Meng
In recent years, there has been an increase in demand for pH color-changing materials. These materials can visually communicate signals to people by connecting pH changes with color information. Embedding pH indicators into fibers to create flexible color-changing materials is an effective way to develop daily wearable products. For the stability of the indicator and the indirect contact of the indicator with the human body, it is usually necessary to encapsulate it in capsules. In this study, different pH indicators (Thymol Blue-TB, Bromocresol Green-BCG, and Bromocresol Purple-BCP) were mixed into a wide-domain pH color-changing indicator and encapsulated with ethyl cellulose (EC) by the flash nanoprecipitation (FNP) method using a new-type droplet-shaped confined impinging jet mixer. The effects of flow rate, core-to-wall ratio, and mixed solution concentration on the formation of the nanocapsules were investigated. In addition, the morphology, particle size, size distribution, dispersion stability, and encapsulation efficiency were systematically studied. At a core-to-wall ratio of 1:2, a mixed solution with a concentration of 6 mg/mL and a feed flow rate of 40 mL/min produced nanocapsules with an average particle size of 141.83 ± 0.98 nm and a PDI of 0.125 ± 0.01. Furthermore, a zeta potential with a range of −31.83 ± 0.23 mV and an encapsulation efficiency of 75.20 ± 1.72% were observed at 1:2 core-to-wall ratios. It was concluded that the color of the nanocapsules continuously changed from yellow to green and green to blue when the pH range was increased from 3 to 10. The color-changing nanocapsules were then embedded into sodium alginate hydrogel fibers, resulting in the same color-changing trend (pH 3–10) as that obtained for the nanocapsules. This study can be useful for the pH monitoring of various body fluids, such as wound exudate, urine, and sweat.Keywords:pH color-changing;nanocapsules;flash nanoprecipitation;pH indicator
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2022
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IF 5.518
Tengfang Zhang,Ziqi Wu,Huafeng Zhu,Zhikun Wang,Shuangqing Sun,Songqing Hu
Hypothesis Natural polymer chitosan (CS) has been widely used as emulsifier due to its good stability, salt-resistant, and stimuli-responsive demulsification . However, chitosan is a hydrocarbon structure molecule containing -NH 3+ and -OH with low surface activity, which is mainly suitable for some specific oil-water systems such as corn oil and sunflower oil . Appropriate hydrophilic-hydrophobic modification of chitosan by PNIPAM not only increases its surface activity but also introduces a temperature response on chitosan. Experiments Pickering emulsions (O/W) formed by CS-PNIPAM were prepared. The stability and response performance of the emulsions were investigated by observing the macroscopic states, microscopic images, droplet size distributions, emulsion emulsification indices, water partition rates, etc. Molecular dynamics and dissipative particle dynamics simulations were used to reveal the distribution pattern of the emulsifiers at the water-oil interface and clarify the stabilization and pH/temperature response mechanism of the emulsions. Findings CS-PNIPAM performs excellent emulsification in various oil phases. The addition of salt ions enhances the stability performance of the emulsion. At low pH, CS will be protonated to break the emulsion, while increasing the pH will deprotonate CS and reform the emulsion. Also, the increase of temperature to 80 °C leads to emulsion breakage due to the agglomeration of PNIPAM.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2023
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IF 5.2
Tao Hong,Menghui Wan,Shuoshuo Lv,Lichao Peng,Yanbao Zhao
Entrapping pesticides in carriers would be beneficial to reduce the risk to environmental safety caused by the heavy use of pesticides. In this paper, hollow silica (hSiO 2 ) nanorods were synthesized by sodium carbonate etching silica nanorods. The prepared hSiO 2 nanocarriers have an average diameter of 100 nm and 200 nm in length, and possess good biocompatibility. Compared with spherical silica carriers, the LCH of hSiO 2 carrier was increased by 35 %. After loading dinotefuran (DNF) pesticide, tannic acid-Cu complexes (TA/Cu) were coated to block the loaded DNF ( [email protected] 2 @TA/Cu). Compared with free DNF, the half-life of DNF entrapped in hSiO 2 carriers was extended by about 10 times under UV irradiation . The [email protected] 2 @TA/Cu system displays excellent wettability to cucumber leaves and good inhibitory effect on Penicillium and diamondback moth. The [email protected] 2 @TA/Cu system displays pH-responsive release. This work provides an efficient nanoplatform for effective utilization of pesticides.
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COLLOIDS AND SURFACES B-BIOINTERFACES
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2022
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IF 5.999
Jie Zheng,Jingjing Bi,Wei Zhao,Muhammad Sohail,Ninghua Fu,Xing Zhang
Heparin, the most widely used anticoagulant drug in the world today, suffers from the risk of overdose and a short serum half-life, limiting its clinical applications. Concerning the controlled, sustained, and targeted release of heparin, a delivery system was fabricated in this research using the layered composites of Fe 3 O 4 magnetic particles and pH-sensitive metal-organic framework, Fe 3 O 4 @ZIF-8. The composite demonstrated a high loading capacity for the heparin, 66.8 mg/g. The composite had a saturation magnetization of 1.5 emu/g and thus owned a magnetic targeting function, i.e. drug can be centered at a certain point using an external magnetic field. The anticoagulant activity was assessed by monitoring their activated partial thromboplastin time . The results showed that the pH-responsive and sustained release of the heparin reduced the systemic adverse effects associated with high concentrations. Moreover, control over the dose exhibited excellent anticoagulant features with fewer side effects.
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Frontiers in Materials
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2022
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IF 3.985
Hao Xiangping,Yan Weilu,Sun Ziqing,Yang Jingzhi,Bai Yun,Qian Hongchang,Chowwanonthapunya Thee,Zhang Dawei
In this work, we report the design of pH-controlled releasing behaviors of polydopamine/tannic acid-allicin@chitosan (PDA/TA-ALL@CS) multilayer coatings to realize antibacterial and antifouling effects. The pH-responsive ALL@CS capsules were prepared using the microemulsion method with about 262–452 nm diameter. The bacteriostasis of ALL@CS microcapsules against E. coli, S. aureus, and P. aeruginosa all exceeded 94% as evaluated using the colony counting method. Because of the protonation in acid environments and deprotonation in alkaline environments for the amino groups of CS, ALL as biocides can be released from the nanocapsules and exert outstanding antibacterial properties. Confirmed by the plate colony counts, the ALL@CS capsules possessed an outstanding antibacterial effect for E. coli in acid solutions but were less effective in alkaline solutions. The PDA/TA-ALL@CS-7 coatings showed durable pH-responsive antibacterial activities with an efficiency of ∼87% after immersion in pH 8 solutions for seven days. The PDA/TA-ALL@CS coating with controlled release performance and antibacterial properties may provide a new solution for developing antifouling coating applications in the marine environment.
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Nature Communications
·
2022
·Vol. 13
·期 1
·1-10
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IF 17.694
Li Yinghao,Peng Chun-Kuo,Hu Huimin,Chen San-Yuan,Choi Jin-Ho,Lin Yan-Gu,Lee Jong-Min
Developing high-performance electrocatalysts for hydrogen evolution reaction (HER) is crucial for sustainable hydrogen production, yet still challenging. Here, we report boron-modulated osmium (B-Os) aerogels with rich defects and ultra-fine diameter as a pH-universal HER electrocatalyst. The catalyst shows the small overpotentials of 12, 19, and 33 mV at a current density of 10 mA cm −2 in acidic, alkaline, and neutral electrolytes, respectively, as well as excellent stability, surpassing commercial Pt/C. Operando X-ray absorption spectroscopy shows that interventional interstitial B atoms can optimize the electron structure of B-Os aerogels and stabilize Os as active sites in an electron-deficient state under realistic working conditions, and simultaneously reveals the HER catalytic mechanisms of B-Os aerogels in pH-universal electrolytes. The density functional theory calculations also indicate introducing B atoms can tailor the electronic structure of Os, resulting in the reduced water dissociation energy and the improved adsorption/desorption behavior of hydrogen, which synergistically accelerate HER.
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