POLYMER BULLETIN
·
2026
·Vol. 83
·期 8
·406
·
IF 4.2
Li Jiheng,Li Pengfei,Yin Manli,Wang Li,Yang Xiao
Conjugated microporous polymers (CMPs), due to their high surface area, permanent pores and varied molecular structure, have attracted great attention in the past decade. However, it is difficult for most of them to disperse in water because of their hydrophobic molecular skeleton. Thus, they can barely be used in wastewater treatment. Herein, we synthesized three CMPs, two of which contained triphenylamine moieties, and introduced sulfonic group by mild sulfonation reaction. The sulfonated CMPs exhibited excellent dispersity in water and fast removal of cationic dyes property. Especially, the maximum Q e of methylene blue was up to 1330 mg/g due to high surface area, porous structure and a great deal of sulfonic groups. We hope this research can further expand the application scope of CMPs in wastewater treatment.
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高影响因子
NEUROTOXICITY RESEARCH
·
2026
·Vol. 44
·期 5
·51
·
IF 3.9
Wei Lijian,Hua Junkai,Tang Shuangfeng,Lei Jianming,Li Guozhi,Wei LiWei,Mo MingShu
Neuroprotective effects of statins in Parkinson’s disease (PD) remain uncertain, and their activity in genetic α-synuclein (αSyn) disease models has been insufficiently characterized. We evaluated atorvastatin (ATO) in a mouse model with nigral overexpression of human A53T-mutant αSyn. Mice received ATO by oral gavage at 10 mg/kg/day for 5 weeks and were assessed using behavioral testing, neuropathological assessment, brain transcriptomics, and molecular docking. ATO inhibited cholesterol biosynthesis-related transcriptional programs and broadly remodeled lipid metabolism-associated networks, but did not lead to functional or histopathological benefit. ATO did not ameliorate motor deficits, restore dopaminergic markers, or reduce αSyn protein levels or pSer129-αSyn immunoreactivity. Transcriptomic analysis further showed that ATO failed to reverse the core disease-associated signature induced by A53T αSyn overexpression and instead increased SNCA mRNA. Targeted RNA-seq and western blot analyses showed no parallel increase in Prkn , Gba1 , or Lamp2 transcript abundance or in PARKIN, GBA1, or LAMP2A protein expression. Molecular docking, used here as an exploratory structural comparison, suggested a relatively weak predicted interaction between ATO and αSyn when compared with several other statins and provided supportive context for the lack of efficacy. Overall, our findings indicate limited efficacy of ATO in this αSyn-driven setting and support further comparative evaluation of individual statins across complementary PD models. Graphical
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高影响因子
PHARMACEUTICAL RESEARCH
·
2026
·
IF 4.1
Chen Yong,Xu Mingxin,Liu An
Purpose Triple-negative breast cancer (TNBC) lacks effective therapeutic targets. Aurisin A (AA), a natural sesterterpenoid, shows anti-TNBC potential but is limited by poor water solubility. This study aimed to develop a tumor microenvironment (TME)-responsive co-delivery hydrogel to enhance AA efficacy. Methods AA was complexed with hydroxypropyl-β-cyclodextrin (HP-β-CD) to form AA@HP-β-CD, which was co-loaded with acetazolamide (ACZ) into a triple-responsive injectable hydrogel (PCG). The anti-TNBC mechanism was investigated using HCC1937 cells, focusing on ferroptosis induction. In vivo antitumor efficacy and safety were evaluated in a xenograft nude mouse model. Results AA@HP-β-CD significantly improved AA solubility and stability. Mechanistically, AA induced ferroptosis in TNBC cells by upregulating HSP90 and promoting GPX4 degradation, leading to glutathione depletion, iron accumulation, and lipid peroxidation. ACZ disrupted intracellular pH homeostasis, further sensitizing cells to AA-induced ferroptosis. The PCG hydrogel enabled sustained, TME-triggered drug release. In the xenograft model, intratumoral injection of PCG/ACZ/AA@HP-β-CD achieved a 76.3% tumor inhibition rate with no observable toxicity to major organs. Conclusions The TME-responsive PCG/ACZ/AA@HP-β-CD hydrogel integrates drug solubilization, intelligent delivery, and dual-mechanism enhancement. The combination of AA-induced ferroptosis via the HSP90/GPX4 axis and ACZ-mediated pH disruption represents a promising strategy for TNBC therapy with good biosafety.
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高影响因子
Nature Communications
·
2026
·
IF 18.1
Jia Junqi,Liu Yu,Yu Jiamin,Wang Jingwei,Zhang Yiting,Fang Yuan,Yu Ying,Sun Zhongxing,Li Zhuoning,Tang Yin,Shao Juejia,Zhang Yanjun,Song Hai,Ulianov Sergey V.,Huang Jing,Fang Dong
Histone H3 lysine 36 dimethylation (H3K36me2) plays a key role in transcriptional elongation and chromatin organization, yet how its deposition is spatially controlled across the genome remains unclear. Here, we identify TOP1 as a critical recruiter of the H3K36me2 methyltransferase NSD2 to gene bodies. Disruption of the TOP1–NSD2 interaction reduces H3K36me2 at gene bodies, impairs RNA polymerase II release, and represses transcription. Remarkably, loss of this recruitment increases H3K36me2 at repetitive sequences, licensing their aberrant transcriptional activation. We show that NSD2 is primarily responsible for depositing H3K36me2 at these loci. We further identify MTA1 as a recruiter of NSD2 to repetitive elements via recognition of the GATC consensus sequence. Together, TOP1 and MTA1 spatially partition NSD2 across the genome, enabling H3K36me2 to serve dual roles in regulating canonical gene expression and acting as an active mark for the transcriptional activation of repetitive sequences.
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高影响因子
WATER AIR AND SOIL POLLUTION
·
2026
·Vol. 237
·期 21
·1248
·
IF 3.5
Zhang Liping,Mu Ran,Liu Siying,Li Huitong,Cui Yujing,Yan Zhao,Sun Runchao
Polyethylene glycol-400 (PEG-400), a critical lubricant in photovoltaic silicon wafer slicing, is highly recalcitrant to biodegradation and environmentally persistent. Direct discharge of PEG-400 not only induces water eutrophication and disrupts aquatic ecosystems but also poses chronic health risks to humans through long-term environmental accumulation and water contamination. However, conventional wastewater treatment technologies exhibit limited efficiency in removing PEG-400. In this study, the degradation of PEG-400 was systematically investigated using an O 3 + H 2 O 2 + Mn-Cu/γ-Al 2 O 3 catalytic oxidation process. Single-factor experiments combined with response surface methodology were employed to optimize the catalyst preparation and reaction parameters. Finally, the degradation mechanism and pathway are revealed. The results showed that the Mn-Cu/γ-Al 2 O 3 catalyst prepared under the conditions of 0.1 mol/L impregnation concentration, 500℃ calcination temperature, and 2 h calcination time achieved the optimal catalytic activity. Under the optimal conditions of O 3 concentration of 60 mg/L, H 2 O 2 dosage of 1.8 mmol/L, catalyst dosage of 4 g/L, gas flow rate of 400 mL/min, and reaction time of 90 min, the removal rate of PEG-400 reached 100%, with COD and TOC removal rates of 76.3% and 53.76%, respectively. Radical quenching experiments confirmed that ·OH, ·O 2 − and 1 O 2 were the dominant reactive oxygen species. FTIR and GC–MS analysis revealed that PEG-400 degraded via ether bond cleavage into intermediate products (e.g., aldehydes, carboxylic acids), which verified non-toxicity by T.E.S.T software, and ultimately mineralized into CO 2 and H 2 O.
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高影响因子
Science China-Materials
·
2026
·
IF 7.7
Zhang Chenxu,Li Ziyan,Zhao Linfei,Li Yajun,Yin Qing,Zhao Danyang,Li Yongzhi,Xiao Bin,Meng Qingkun,Ren Yaojian,Xue Xiaolan,Wei Fuxiang,Sui Yanwei,Wu Xiangfeng,Qi Jiqiu,Ho Johnny C.
Electrochemical water splitting is crucial for the scalable production of green hydrogen; however, the practical implementation requires cost-effective electrocatalysts with high activity and durability. This study introduces a low-cost, three-dimensional (3D) nanoporous ZrVFeCoNi material, fabricated via chemical dealloying, at just 0.16% of the cost of Pt. The structure-activity relationship between its microstructure and hydrogen evolution reaction (HER) performance was systematically explored. The lattice defect effects from multiphase intermetallic compounds, combined with multi-metal synergy, optimize H + adsorption energy and electron transfer kinetics. The 3D nanoporous design provides a high electrochemical surface area with abundant active sites, thereby enhancing electrolyte penetration and reducing interfacial mass transfer resistance. Consequently, the ZrVFe-CoNi electrode exhibits outstanding HER performance, requiring only a 38 mV overpotential to reach 10 mA cm −2 and maintaining stable operation for 1000 h at 500 mA cm −2 . Integrated into a full water electrolyzer (ZrVFeCoNi ∥ IrO 2 /Ni), the system achieves a cell voltage of 1.60 V at a current density of 400 mA cm −2 . Advanced characterization and density functional theory (DFT) calculations reveal that interfacial interactions and charge transfer at heterointerfaces drive the catalytic activity, showcasing the potential of 3D nano-structured multiphase intermetallic compounds as high-performance electrocatalysts for green hydrogen systems.
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高影响因子
CURRENT MICROBIOLOGY
·
2026
·Vol. 83
·期 10
·554
·
IF 2.8
Zheng Xiaoyan,Dong Xinyi,Aziz Sadat Abdulla,Mao Sichao,Liu Yongwang,Xu Xinyi,Chen Xingxiang
Chronic diarrhea in pets features high incidence, often causing vitamin B12 deficiency. Probiotics, which can alleviate or even treat chronic diarrhea by improving intestinal microbial balance, have shown promise. Previously, our laboratory isolated a strain of Limosilactobacillus reuteri (CLAB) with vitamin B12-producing capability from canine feces. However, it had suboptimal palatability and insufficient efficacy against chronic diarrhea and vitamin B12 deficiency. In this study, the CLAB was combined with Enterococcus faecalis and Saccharomyces cerevisiae to formulate a compound probiotic paste. The properties of the paste were comprehensively evaluated via a series of experiments including sensory evaluation, pH testing, microbial colony counting, palatability tests, disease activity index scoring, histopathological analysis, biochemical indicator analysis, and RNA quantification. The results demonstrated that the paste exhibited good stability, safety, and favorable palatability in both dogs and cats. Meanwhile, it significantly alleviated chronic diarrhea and vitamin B12 deficiency in mice. Specifically, the high-dose compound probiotic paste decreased myeloperoxidase and malondialdehyde levels in diarrheic mice from approximately 15.9 and 2.5 nmol/mgprot to about 4.2 and 1.7 nmol/mgprot; increased the total antioxidant capacity content and superoxide dismutase activity from approximately 0.5 nmol/mgprot and 1.0 U/mgprot to about 0.6 nmol/mgprot and 1.6 U/mgprot; and downregulated the relative mRNA levels of interleukin-6, interleukin-1β and tumor necrosis factor-α from approximately 2.1, 2.1 and 2.7 to about 1.2, 1.1 and 1.3, respectively. In conclusion, this study supports the potential use of the compound probiotic paste for preventing and treating chronic diarrhea and improving vitamin B12 deficiency in pets.
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高影响因子
MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 10
·669
·
IF 5.4
Yang Zitong,Deng Jingyu,Zhang Yili,Qi Wenkai,Zhang Yuxia
A self-signaling electrochemical sensor based on molecular imprinting technology for the detection of Bisphenol A (BPA) in food samples. The sensor was constructed through sequential modification of the electrode with reduced graphene oxide (RGO) and CoNiFe Prussian blue analogue (CoNiFe-PBA), followed by electropolymerization of an MIP film using BPA as template and o-phenylenediamine as monomer. CoNiFe-PBA provides an intrinsic signal at ~ 0.47 V without external probes, originating from synergistic redox interactions among Co, Ni, and Fe. BPA rebinding reduces the signal via steric hindrance, enabling sensitive detection in food samples. Under optimal conditions, the sensor demonstrated a wide linear detection range (0.5–500 nM) and a low detection limit (0.19 nM). Owing to its high selectivity, sensitivity, and accuracy, the sensor offers a reliable approach for precise quantification of trace BPA in complex food matrices. Graphical abstract
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高影响因子
MICROCHIMICA ACTA
·
2021
·Vol. 188
·期 7
·1-9
·
IF 5.833
Ding Yuedi,Fan Zhenqiang,Yao Bo,Xu Dong,Xie Minhao,Zhang Kai
A novel nanoparticle-based fluorescence probe was developed for NF-κB transcription factor detection and in situ imaging via steric hindrance. The probe contains gold nanoparticles (AuNPs) to quench fluorescence, and nucleic acids immobilized on the surface of AuNPs to output fluorescence. In the basal state, Cy5 labeled DNA1 folds its long chain into a hairpin structure and quenches fluorescence by forcing the Cy5 fluorophore close to the surface of AuNPs. After the probe enters the cell, the NF-κB transcription factor can bind to the κB site in the DNA duplex of the nucleic acids. The steric hindrance caused by NF-κB leads to the extension of the long chain of DNA1 and the removal of the Cy5 fluorophore from the surface of AuNPs, thereby restoring the fluorescence of the probe. By measuring NF-κB in cell lysis in vitro, the probe obtains a detection limit of 0.38 nM and the linear range from 0.5 to 16 nM. Repeated measurements showed the recovery in the cell nuclear extract was between 93.38 and 109.32%, with relative standard deviation less than 5%. By monitoring the sub-localization of the Cy5 fluorophore in single cell, the probe system can effectively distinguish active NF-κB (nucleus) and inactive NF-κB (cytoplasm) through in situ imaging. The well-designed probe will make up for the shortcomings of the existing technology, and reveal the regulatory role of transcription factors in many disease processes.
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PubMed
高影响因子
MICROCHIMICA ACTA
·
2025
·Vol. 192
·期 11
·1-14
·
IF 5.3
Li Minzhe,Zhou Yuzhu,Wei Guimei,Wang Wenyi,Liang Zhixing,Wen Changchun,Lin Xiang-Cheng
In practical applications, constructing bifunctional substrates with highly sensitive surface-enhanced Raman scattering (SERS) detection capabilities and environmentally friendly degradation technologies has significant importance in environmental remediation. Herein, Ag/CuO/CF (ACC) bifunctional composites were successfully fabricated via a two-step process. First, CuO nanowire arrays were grown in situ on a copper foam (CF) substrate using a facile thermal oxidation method. Subsequently, Ag nanoparticles were deposited uniformly onto the CuO nanowire surface via chemical reduction. As a SERS substrate, the ACC platform exhibited exceptional detection capabilities for methylene blue (MB) and malachite green (MG), achieving ultra-high sensitivity with remarkably high enhancement factors and extremely low detection limits for both target molecules. Moreover, the ACC substrates exhibited excellent uniformity, repeatability, and stability, as well as remarkable performance recovery in real sample testing. As a photocatalytic substrate, ACCs exhibited outstanding photocatalytic efficiency for degrading MB and MG, maintaining degradation of 91.97% after five cycles. Such a bifunctional design offers a novel approach for developing a new generation of intelligent environmental remediation technologies. It is particularly suitable for scenarios requiring on-site rapid analysis and immediate treatment, such as the monitoring and elimination of high-risk trace-level pollutants. Therefore, exploring integrated “detection-treatment” strategies holds significant importance for practical environmental applications. Graphical
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PubMed
高影响因子
JOURNAL OF SOLID STATE ELECTROCHEMISTRY
·
2025
·
IF 2.6
Ma Chenxi,Li Yuhang,Zhao Peizhu,Chang Zenghua,Li Bin,Yang Man,Zhang Wei,Wang Bo
The pursuit of higher energy density in lithium-ion batteries (LIBs) often pushes safety limits, primarily due to the flammability of liquid electrolytes, which poses significant hazards. This study presents an in situ curing process for the fabrication of high-density pouch cells with gel electrolyte. The electrochemical performance of these pouch cells was evaluated using galvanostatic charge/discharge, electrochemical impedance spectroscopy (EIS), linear voltammetry, and hot box tests. The results show that the electrochemical performance of Ni-rich/silicon-graphite pouch cells with gel electrolyte is comparable to that of pouch cells with traditional liquid electrolyte. After 500 cycles, the pouch cells with gel electrolyte retained 87.59% residual capacity retention, outperforming the 85.40% retention observed in pouch cells with liquid electrolyte. Additionally, the gel electrolyte significantly enhanced the thermal stability of the pouch cells, delaying the thermal runaway by approximately 25 minutes during the 180 °C hot box test. These findings provide valuable insights for the further application and development of high specific energy batteries.
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高影响因子
IONICS
·
2025
·
IF 2.6
Hu Kaihan,Cai Jiahui,Shi Zixu,Tan Xiaojun,Wang Li,Chen Jingbo,He Xiangming
Silicon dioxide (SiO₂), an anode material for lithium-ion batteries (LIBs), faces critical challenges such as irreversible phase transitions, severe volume expansion, and interfacial side reactions, leading to low initial Coulombic efficiency and poor cycling stability. To address these issues, this study proposes a novel design of SnO₂-based SiO₂ nanotubes composites (SiO₂/SnO₂) synthesized using ammonium tartrate as a water-soluble template. The hollow tubular structure effectively accommodates volume changes of SiO 2 during lithiation/delithiation, while SnO₂ component can contribute lithium storage capacity and improve the electrochemical reaction kinetics. The optimized SiO₂/SnO₂ composite exhibits a high discharge capacity of 778.07 mAh g⁻ 1 with a Coulombic efficiency exceeding 98% after 200 cycles at 1 A g⁻ 1 . Additionally, it demonstrates excellent rate capability, achieving 715.6 mAh g⁻ 1 at 1 A g⁻ 1 and recovering to 927.9 mAh g⁻ 1 when the current density returns to 0.1 A g⁻ 1 . The synergistic combination of structural engineering and SnO₂ functionality not only mitigates mechanical degradation but also enhances reaction kinetics. This work provides a scalable strategy for developing high-performance anode materials with improved energy density and long-term cyclability for advanced LIBs.
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高影响因子
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