CHEMICAL ENGINEERING JOURNAL
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2024
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IF 13.3
Hongyu Yin,Zhoujun Wang,Xiang Zhang,Weifeng Zhao,Ran Wei,Changsheng Zhao
Chronic liver failure (CLF) and chronic renal failure (CRF) lead to toxins accumulation, severely impairing organ functions. To address this challenge, a Janus polyethersulfone (PES)-based architecture integrated dense membrane with porous monolith is developed, pioneering an approach for simultaneous plasma separation and toxins adsorption. The porous monolith, featuring high porosity about 83.3 % and substantial specific surface area about 102.06 m 2 /g, is prepared using the freezing-induced phase separation (FIPS) technique. The porous monolith is composed of polymer networks of PES and amphiphilic copolymer of poly (vinyl pyrrolidone-co-methyl methacrylate) (VM), as well as activated carbon. Among the various monolith, the PES 18 VM 5 C 2 exhibits the optimal balance of adsorption and anti-protein adhesion. The PES-VM-incorporated dense membrane with a controlled submicron pore size is constructed atop the PES 18 VM 5 C 2 . The dense membrane effectively blocks hemocytes and the porous monolith efficiently adsorbs toxins. Together, the Janus architecture PES 18 VM 5 C 2 @M 16 allows over 85 % of bovine serum albumin (BSA) to permeate, showcasing its selective permeability. After being integrated into a custom 3D-printed supporting device, the PES 18 VM 5 C 2 @M 16 achieves significant clearance in creatinine (67.6 %), uric acid (87.4 %), and bilirubin (89.1 %) during 2-hour plasma adsorption test, with minimal impact on essential plasma components such as total protein, albumin, and cholesterol. This work presents a “Janus Interface Architecture” as next-generation platform for plasma separation and toxins adsorption, offering a promising strategy for wearable artificial liver systems.
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Journal of Materials Chemistry B
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2024
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IF 6.1
Jiarong Guo,Ying Ma,Tongyu Han,Jiao Yang,Peng Miao
Metal–organic frameworks (MOFs) with fit ligands and metals can be integrated into electrochemical biosensors for the detection of various biomolecules. In this study, we have synthesized novel magnetic MOF composites as electrocatalysts and constructed a novel biosensor for electrochemical detection of dopamine. The composites named Fe3O4@ZIF-8@AuNPs–COOH are synthesized through layer-by-layer assembly. They exhibit excellent stability and cooperative catalytic activity. In addition, green recycling is readily achieved through magnetizing/demagnetizing the electrode. The large specific surface area and ordered porous structures of the magnetic MOFs ensure good dispersion of gold nanoparticles, while the carboxyl group efficiently shields other redox-active interfering substances. The proposed electrochemical biosensor accomplishes the sensitive detection of dopamine in human serums and living cells. This study broadens the application of MOFs in electrochemical biosensing, validates the feasibility of biosensors for in vivo analysis, and provides new insights into green sensing.
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Journal of the American Chemical Society
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2024
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IF 14.4
Xueru Guo,Zhi Tong,Anqi Li,Yajie Zhou,Zeyi Li,Jing Lin,Yaxin Wang,Mingjiang Zhang,Taotao Zhuang
Chiral plasmonic nanomaterials─with their significant applications in protein detection, drug screening, and enantioselective sensing─necessitate an industrialized fabrication procedure to enhance their commercial viability. However, the prevailing manufacturing of chiral plasmonic nanoparticles and assemblies heavily leans on manual intervention, causing time-consuming and quality-inconsistent concerns. Here, we develop an automated, continuous mechanical synthesis system that consistently sprays metal nanowires to create chiroplasmonic assemblies: a macroscopic twisted layered structure comprising equivalent linear birefringence layers, approximate linear polarizer layers, and a precise angular offset between them. Utilizing the synthesis-with-automation system, we scale up the production of chiral plasmonic films, generating high optical asymmetry (g-factor, with the order of 10–1) across a broadband ranging from ultraviolet to near-infrared wavelengths. We further introduce the portable chiral sensing, expanding plasmonic assemblies into flexible materials and integrating them with wearable real-time display devices. Our mechanically driven, continuous synthesis of chiral plasmonic structures presents an intriguing pathway to facilitate functional chiral structures toward practice.
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TALANTA
·
2024
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IF 5.6
Guangxing Hu,Shuang Cui,Hongda Wang,Yan Shi,Zhuang Li
Molecularly imprinted electrochemical sensor is a kind of convenient, fast, and stable analyzer, but the conductivity of electrode materials and their affinity with the analyte affect its performance. A proton acid (PSS, SA , SSA) doping method was proposed to improve the electrochemical performance of the polypyrrole molecularly imprinted polymer (PPy-MIP), which promoted the electropolymerization of pyrrole , reduced the charge transfer resistance, and increased the electrochemical surface area . In terms of both improving conductivity and affinity, the response of the proton acids doped the polypyrrole molecularly imprinted electrochemical sensors (PPy-MIECS) to urea was improved by 25-fold (PSS), 5-fold (SA), and 3-fold (SSA) over that of PPy-MIECS. In addition, the PSS-PPy-MIECS was validated for the practical application with a linear detection range from 0.1 mM to 100 mM, high selectivity (α = 39.73), reusability (RSD% = 4.54 %), reproducibility (RSD% = 0.93 %), and stability (11 days). The advantage of proton acid doping method in PSS-PEDOT-MIECS to urea and PSS-PPy-MIECS to glucose extended its application in the performance enhancement of MIECS design.
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JOURNAL OF PHYSICS D-APPLIED PHYSICS
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2024
·Vol. 58
·期 4
·045204
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IF 3.1
Jun Huang,Qianqian Luo,Fang Liu,Yujun Xiao,Xingquan Wang,Mengchao Li,Menghao Tan,Wei Chen
Synthetic organic dye pollutants pose a serious threat to the aquatic ecological environment due to their difficulty in complete degradation. This study employed a plasma bubble array reactor to degrade individual and mixed dye pollutant solutions of sunset yellow (SY), methyl orange (MO), and methyl violet (MV). The degradation efficiencies and mechanisms of the plasma were investigated under different working gas atmospheres. It was found that oxygen plasma degraded the target dyes and their mixtures more significantly than air plasma. Specifically, compared with air plasma, the removal of single dyes SY, MO and MV by oxygen plasma was increased by 76.6%, 13.8% and 3%, respectively, after 20 min of treatment. As for mixed dyes, after 25 min treatment, oxygen plasma removed 99.1%, which was 31.6% higher than air plasma. However, the degradation kinetic order in oxygen plasma was SY > MO > MV, while that in air plasma was MV > MO > SY. Combined with the detection of reactive oxygen–nitrogen species, the results showed that the reactive oxygen species (ROS) played an important role in the degradation of SY, and it was also important for the degradation of MO, whereas both the ROS and reactive nitrogen species were important for the degradation of MV. Scavenger experiments revealed that hydroxyl (·OH) and superoxide anion (·O2−) played the most important roles in the degradation process. The three dyes were basically completely degraded within 14–20 min of treatment, with corresponding yields of 3.08–4.43 g kWh−1. Possible degradation pathways for each dye were deduced based on LC-MS and the toxicities of solutions were evaluated by phytotoxicity tests and ion chromatography. The results showed that the biotoxicity of the intermediates was significantly reduced. This study may provide a feasible option for effective application of plasma technology in organic dye wastewater treatment.
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ACS Nano
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2025
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IF 16
Ximu Li,Mengyao Ma,Ni An,Xiaoxuan Yao,Guzailinuer Yasen,Mingyuan Zhong,Zheng Jin,Zhonggui He,Yongjun Wang,Hongzhuo Liu
Antidrug antibodies (ADAs) against biologics present a major challenge for sustained biotherapy, including enzyme replacement therapies and adeno-associated virus (AAV) gene therapies. These antibodies arise from undesirable immune responses, leading to altered pharmacokinetics, reduced efficacy, and adverse reactions. In this study, we introduced a rationally designed lipid-rapamycin (Rapa)-based nanovaccine to restore immune tolerance to biologics and overcome drug resistance. The nanovaccine significantly decreased ADA responses when used in a tolerogenic regimen with keyhole limpet hemocyanin (KLH), uricase, pegylated uricase, and AAV8 vector gene therapy. This approach facilitated three rechallenges with pegylated uricase after a 5 week rest from the nanovaccine, thereby enhancing its urate-lowering efficacy. Furthermore, the nanovaccine allowed for the successful intravenous readministration of AAV8 vector expressing secreted embryonic alkaline phosphatase (AAV8-SEAP), achieving sustained viral DNA and transcript levels in target tissues. The nanovaccine prompted antigen-presenting cells (APCs) in the liver to exhibit dynamic changes in CD80, CD86, MHCII, and PD-L1, which promoted the development of immunoregulatory T cells in response to biologic challenges. Notably, the nanovaccine exerted a minimal impact on CD8+ T cells, natural killer (NK) cells, and NK T cells, preserving the body’s normal immune response to pathogens and tumors. Overall, the universal nanovaccine addressed biologic resistance by mitigating ADA-related issues, thereby enabling a prolonged therapeutic efficacy for antibodies, proteins, and gene therapies.
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VACUUM
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2024
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IF 3.8
Fengjuan Miao,Honggang Wang,Xiaoqin Li,Bairui Tao,Hui Li
To develop materials that can meet the sensing and capacitive performance of glucose. Hydrothermal and electroplating procedures were used to prepare linear NiCo 2 O 4 and nano-CuO particles, respectively. The sensor's sensitivity was 1174.57 μA mM −1 cm −1 , with a low detection limit of 0.024 μM (S/N = 3), and its detection range was 0.3–12.6 mM, with good stability as verified using an electrochemical workstation. In addition, at a current density of 2 A g −1 , this material exhibits a specific capacitance of up to 2140.0F g −1 in supercapacitors. After 5000 cycles, its stability remained at 93.89 %. Similarly, asymmetric supercapacitor devices based on nickel foam exhibit A high specific capacitance of 605.5 F g −1 at a current density of 2 A g −1 . It is demonstrated that linear NiCo 2 O 4 modified with CuO nanoparticles can be employed not only as a sensitive material for glucose sensors but also for the production of supercapacitors.
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Inorganic Chemistry Frontiers
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2024
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IF 6.1
Teng You,Shuang Xiao,Ping Huang,Chunyan Wang,Qiuxia Deng,Ping Jiang,Daiping He
Co3O4 has been explored extensively for glucose electrochemical detection, while it suffers from limited performance, due to the poor electrical conductivity originated from its semiconductor nature. Photethermal effect (PE) localized on the electrode surface has been illustrated as an attractive strategy in boosting water electrolysis, yet little insight was thrown on glucose electrochemical detection. In this paper, a one-stone-two-birds strategy to integrate PE and electrocatalytic activity of Co3O4 nanowires array supported on nickel foam (Co3O4 NWs/NF) was proposed for glucose electrochemical detection. Under near-infrared (NIR) light irradiation, the temperature of Co3O4 NWs/NF electrode was elevated, along with an enlarged electrochemical surface area (ECSA) and accelerated electron transfer process. PE assisted Co3O4 NWs/NF (PE- Co3O4 NWs/NF) shows high performance in glucose sensing, with a wide linear range from 1 μM to 0.73 mM, an excellent sensitivity of 26.17 mA mM-1 cm-2 and a low limit of detection of 0.56 μM. Moreover, PE-Co3O4 NWs/NF shows good feasibility and reliability for glucose determination in human serum samples. This work proposes a photothermal electrocatlytic dual functional system for glucose electrochemical sensing, and provides a novel approach in boosting Co3O4 catalytic activity in glucose detection.
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MICROCHEMICAL JOURNAL
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2025
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IF 5.1
Renjie Wang,Yifan Zhu,Shanshan Liu,Kai Jiang,Runan Wang,Shuangshuang Ji,Mengyao Ma,Qianqian Chen,Huijuan Ran,Xudong Song
Uric acid (UA) levels serve as pivotal health biomarkers, underscoring the need for accurate detection methodologies. This paper presents a novel and straightforward electrochemical approach for UA detection, utilizing a sensing platform that integrates hybrid electrodes of Fe-MOF and polypyrrole (PPy). The findings reveal that the sensor shows exceptional sensitivity to UA across a wide concentration range of 1–300 µM, featuring an impressively low limit of detection (LOD) at 0.212 µM. Moreover, the sensor retains a peak current response of 87.2 % even after one month, underscoring its excellent stability and robust anti-interference properties. The improved sensing performance is due to the composite material’s retention of PPy’s superior electronic transport characteristics, combined with the enhanced specific surface area, active sites, and porosity contributed by the Fe-MOF component, leading to a substantial enhancement in electrochemical sensing capabilities. This research paves the way for the utilization of MOF nanomaterials in electrochemical sensing, thereby facilitating the practical application of nanocomposites.
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ANALYTICA CHIMICA ACTA
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2024
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IF 5.7
Chiyu Ma,Yong Qiu,Tao Liang,Nan Jiang,Liubing Kong,Jianguo Wu,Xianyou Sun,Guangqing Ren,Xinwei Wei,Ping Wang,Hao Wan
Background Ionic calcium (Ca 2+ ) plays a crucial role in maintaining normal physiological and biochemical functions within the human body. Detecting the concentration of Ca 2+ is of utmost significance for various purposes, including disease screening, cellular metabolism research, and evaluating drug effectiveness . However, current detection approaches such as fluorescence and colorimetry face limitations due to complex labeling techniques and the inability to track changes in Ca 2+ concentration. In recent years, extensive research has been conducted in this field to explore label-free and efficient approaches. Results In this study, a novel light-addressed potentiometric sensor (LAPS) using silicon-on-sapphire technology , has been successfully developed for Ca 2+ sensing. The Ca 2+ -sensitive LAPS achieved a wide-range detection of Ca 2+ , ranging from 10 −2 M to 10 −7 M, with an impressive detection limit of 100 nM. These advancements are attributed to the ultra-thin silicon layer, silicon dioxide layer, and solid-state silicon rubber sensitive membrane around 6 μm. Furthermore, the sensor demonstrated the ability to dynamically monitor fluctuations in Ca 2+ concentration ranging from 10 −9 M to 10 −2 M within a solution. Its remarkable selectivity , specificity, and long-term stability have facilitated its successful application in the detection of Ca 2+ in human serum and urine. Significance and novelty This work presents a Ca 2+ -sensitive sensor that combines a low detection limit and a wide detection range. The development represents the emergence of a label-free and rapid Ca 2+ detection tool with immense prospects in home-based health monitoring, community disease screening, as well as cellular metabolism, and drug screening evaluations.
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Food Science and Human Wellness
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2024
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IF 5.6
Hongyuan Zhao,Xiaoyu Chen,Li Zhang,Fanqiang Meng,Libang Zhou,Zhaoxin Lu,Yingjian Lu
Hyperuricemia is a high-risk factor for the development of gout and renal fibrosis, but the adverse effects of hyperuricemia on the liver have been seriously neglected. This research investigated the ameliorating effect of Lacticaseibacillus rhamnosus Fmb14 on hyperuricemia induced liver dysfunction both in vitro and in vivo . Cell free extracts of high dose L. rhamnosus Fmb14 treatment reduced the death rate of HepG2 cell lines from 24.1 % to 14.9 % by inhibiting NLRP3 recruitment, which was mainly activated by reactive oxygen species release and mitochondrial membrane potential disorder. In purine dietary induced hyperuricemia (PDIH) mice model, liver oedema and pyroptosis were ameliorated after L. rhamnosus Fmb14 administration through downregulating the expression levels of NLRP3, caspase-1 and gasdermin-D from 1.61 to 0.86, 3.15 to 1.01 and 5.63 to 2.02, respectively. L. rhamnosus Fmb14 administration restored mitochondrial inner membrane protein (MPV17) and connexin 43 from 2.83 and 0.73 to 0.80 and 0.98 respectively in PDIH mice, indicating that dysbiosis of mitochondrial membrane potential was restored in liver. Intriguingly, PDIH pyroptosis stimulates the process of apoptosis, which leads to severe leakage of hepatocytes, and both of pyroptosis and apoptosis were decreased after L. rhamnosus Fmb14 treatment. Therefore, L. rhamnosus Fmb14 is a promising biological resource to maintain homeostasis of the liver in hyperuricemia and the prevention of subsequent complications.
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Applied Materials Today
·
2024
·
IF 7.2
Xiao Li,Dong Su,Yuyang Gu,Jia Zhang,Shu Li,Yao Xiao,Jiankang He,Wei Wang,Dichen Li
There is an increasing demand for epidermal sensors that can adapt to the contours and the movements of the human body, but the fabrication of prevalent polymer-based epidermal sensors often involves costly materials and complex procedures. Paper has emerged as a cost-effective substrate for next-generation epidermal sensors, featuring such advantages as bendability, breathability, biocompatibility, and environment-friendliness. However, transducing materials are commonly introduced to paper substrates in post hoc manners or through time-consuming syntheses, in addition to the direct manufacturing of paper. Here we report an integrative method to fabricate epidermal paper-based graphene sensors, where graphene induction and paper cutting can be achieved in a single lasing procedure to generate both transducing components and overall sensor formats. Lasing conditions are systematically explored, mainly to control the multifaceted properties of the obtained graphene transducers. The resultant paper-based graphene structures exhibit sufficient reliability in various scenarios regarding storage, lighting, and deformation. Paper-based graphene sensors are strategically designed in terms of overall formats, geometric patterns, hydrophilicity/hydrophobicity, surface functionalization, and readouts for measuring biophysical and biochemical information relevant to human health. The sensor performance can be optimized by adjusting laser power, and the calibrated sensitivities for mechanical strain, temperature, humidity, pH, and glucose are 76.93, –0.15% °C –1 , 37.06 μA % –1 , 28.13 mV pH –1 , and 1.26 μA mM –1 , respectively. Multimodal health monitoring is demonstrated with paper-based graphene sensors. Our approach can facilitate the generation of epidermal paper-based sensors and meet diverse requirements of health monitoring.
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危险品化学品经营许可证（带存储）